Distortion of the Catalytic Domain of Tissue-type Plasminogen Activator by Plasminogen Activator Inhibitor-1 Coincides with the Formation of Stable Serpin-Proteinase Complexes

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 48197-48203

  Perron, Michel J ^a   Blouse, Grant E ^a,b   Shore, Joseph D ^a,b  

^a HENRY FORD HEALTH SCIENCES CENTER   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; ENZYME KINETICS; FLUORESCENCE; TISSUE;

CATALYTIC DOMAINS;

ENZYMES;

4 FLUOROTRYPTOPHAN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE; SERINE PROTEINASE INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME INHIBITION; ENZYME STABILITY; FLUORESCENCE; HUMAN; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEIN DOMAIN;

CATALYTIC DOMAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERPINS; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TRYPTOPHAN;

EID: 0348111457     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306184200     Document Type: Article

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