Serine and cysteine proteases are translocated to similar extents upon formation of covalent complexes with serpins: Fluorescence perturbation and fluorescence resonance energy transfer mapping of the protease binding site in CrmA complexes with granzyme B and caspase-1

Journal of Biological Chemistry

Volumn 282, Issue 4, 2007, Pages 2305-2313

  Swanson, Richard ^a   Raghavendra, Manikanahally P ^a   Zhang, Weiqing ^a   Froelich, Christopher ^c   Gettins, Peter G W ^b   Olson, Steven T ^a,d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; FLUORESCENCE ENHANCEMENTS; PROTEASE COMPLEXATION; TRYPTOPHANS;

AMINO ACIDS; BINDING SITES; COMPLEXATION; ENZYME INHIBITION;

ENZYME ACTIVITY;

ASPARTIC PROTEINASE; CYSTEINE PROTEINASE; CYTOKINE RESPONSE MODIFIER A; DANSYL CHLORIDE; FLUORESCENT DYE; GRANZYME B; INTERLEUKIN 1BETA CONVERTING ENZYME; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; TRYPTOPHAN; GRANZYME; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL LABELING; COMPLEX FORMATION; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN BINDING;

BINDING SITES; CASPASE 1; CYSTEINE ENDOPEPTIDASES; FLUORESCENCE RESONANCE ENERGY TRANSFER; GRANZYMES; HUMANS; MODELS, MOLECULAR; PEPTIDE MAPPING; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES; SERPINS;

EID: 34047254892     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609546200     Document Type: Article

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