Mechanism by which exosites promote the inhibition of blood coagulation proteases by heparin-activated antithrombin

Journal of Biological Chemistry

Volumn 282, Issue 46, 2007, Pages 33609-33622

  Izaguirre, Gonzalo ^a   Swanson, Richard ^a   Raja, Srikumar M ^a   Rezaie, Alireza R ^b   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED ANTITHROMBIN; BLOOD COAGULATION; BLOOD-CLOTTING PROTEASES;

ACTIVATION ANALYSIS; ACYLATION; BLOOD; COAGULATION; MOLECULAR INTERACTIONS;

ENZYME INHIBITION;

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 9A; ETHYLENEDIAMINE DERIVATIVE; EXOSITE; HEPARIN; N,N' DIMETHYL N (ACETYL) N' (7 NITROBENZ 3 OXA 1,3 DIAZOL 4 YL)ETHYLENEDIAMINE; PENTASACCHARIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE; SERINE PROTEINASE INHIBITOR; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING COMPETITION; BINDING KINETICS; BLOOD CLOTTING; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME MECHANISM; FLUORESCENCE; MICHAELIS CONSTANT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; STOICHIOMETRY;

ANTITHROMBINS; BINDING, COMPETITIVE; BLOOD COAGULATION; CATALYSIS; DIAMINES; DIFFUSION; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA; FLUORESCENT DYES; HEPARIN; HUMANS; KINETICS; MODELS, BIOLOGICAL; OXADIAZOLES; PEPTIDE HYDROLASES; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; THROMBIN;

EID: 36348959744     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702462200     Document Type: Article

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