-
1
-
-
84860368072
-
Novel approaches to flavivirus drug discovery
-
Botting C, and Kuhn RJ. (2012). Novel approaches to flavivirus drug discovery. Expert Opin Drug Discov 7, 417-428.
-
(2012)
Expert Opin Drug Discov
, vol.7
, pp. 417-428
-
-
Botting, C.1
Kuhn, R.J.2
-
2
-
-
70350310339
-
Influence of antidrug antibodies on plectasin efficacy and pharmacokinetics
-
Brinch KS, Frimodt-Moller N, Hoiby N, and Kristensen HH. (2009). Influence of antidrug antibodies on plectasin efficacy and pharmacokinetics. Antimicrob Agents Chemother 53, 4794-4800.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 4794-4800
-
-
Brinch, K.S.1
Frimodt-Moller, N.2
Hoiby, N.3
Kristensen, H.H.4
-
3
-
-
33745025763
-
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
-
DOI 10.1038/nsmb1073, PII N1073
-
Erbel P, Schiering N, D'Arcy A, et al. (2006). Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nat Struct Mol Biol 13, 372-373. (Pubitemid 43873510)
-
(2006)
Nature Structural and Molecular Biology
, vol.13
, Issue.4
, pp. 372-373
-
-
Erbel, P.1
Schiering, N.2
D'Arcy, A.3
Renatus, M.4
Kroemer, M.5
Lim, S.P.6
Yin, Z.7
Keller, T.H.8
Vasudevan, S.G.9
Hommel, U.10
-
4
-
-
9644272490
-
Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases
-
DOI 10.1016/j.bmc.2004.09.036, PII S0968089604007321
-
Ganesh VK, Muller N, Judge K, et al. (2005). Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases. Bioorg Med Chem 13, 257-264. (Pubitemid 39575709)
-
(2005)
Bioorganic and Medicinal Chemistry
, vol.13
, Issue.1
, pp. 257-264
-
-
Ganesh, V.K.1
Muller, N.2
Judge, K.3
Luan, C.-H.4
Padmanabhan, R.5
Murthy, K.H.M.6
-
5
-
-
77953432117
-
Focus on flaviviruses: Current and future drug targets
-
Geiss BJ, Stahla H, Hannah AM, Gari AM, and Keenan SM. (2009). Focus on flaviviruses: Current and future drug targets. Future Med Chem 1, 327-344.
-
(2009)
Future Med Chem
, vol.1
, pp. 327-344
-
-
Geiss, B.J.1
Stahla, H.2
Hannah, A.M.3
Gari, A.M.4
Keenan, S.M.5
-
6
-
-
0036468861
-
Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
-
DOI 10.1016/S0966-842X(01)02288-0, PII S0966842X01022880
-
Gubler DJ. (2002). Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol 10, 100-103. (Pubitemid 34119347)
-
(2002)
Trends in Microbiology
, vol.10
, Issue.2
, pp. 100-103
-
-
Gubler, D.J.1
-
7
-
-
49449101582
-
Plectasin has antibacterial activity and no effect on cell viability or IL-8 production
-
Hara S, Mukae H, Sakamoto N, et al. (2008). Plectasin has antibacterial activity and no effect on cell viability or IL-8 production. Biochem Biophys Res Commun 374, 709-713.
-
(2008)
Biochem Biophys Res Commun
, vol.374
, pp. 709-713
-
-
Hara, S.1
Mukae, H.2
Sakamoto, N.3
-
8
-
-
33845401745
-
Human α- and β-defensins block multiple steps in herpes simplex virus infection
-
Hazrati E, Galen B, Lu W, et al. (2006). Human alpha-and betadefensins block multiple steps in herpes simplex virus infection. J Immunol 177, 8658-8666. (Pubitemid 44893830)
-
(2006)
Journal of Immunology
, vol.177
, Issue.12
, pp. 8658-8666
-
-
Hazrati, E.1
Galen, B.2
Lu, W.3
Wang, W.4
Ouyang, Y.5
Keller, M.J.6
Lehrer, R.I.7
Herold, B.C.8
-
9
-
-
0028924688
-
Efficient gene synthesis by Klenow assembly/extension-Pfupolymerase amplification (KAPPA) of overlapping oligonucleotides
-
Holowachuk EW, and Ruhoff MS. (1995). Efficient gene synthesis by Klenow assembly/extension-Pfupolymerase amplification (KAPPA) of overlapping oligonucleotides. Genome Res 4, 299-302.
-
(1995)
Genome Res
, vol.4
, pp. 299-302
-
-
Holowachuk, E.W.1
Ruhoff, M.S.2
-
10
-
-
79957994324
-
New antipoverty drugs, vaccines, and diagnostics: A research agenda for the US President's Global Health Initiative (GHI)
-
Hotez PJ. (2011). New antipoverty drugs, vaccines, and diagnostics: A research agenda for the US President's Global Health Initiative (GHI). PLoS Negl Trop Dis 5, e1133.
-
(2011)
PLoS Negl Trop Dis
, vol.5
-
-
Hotez, P.J.1
-
11
-
-
77956181718
-
High-level expression of the antimicrobial peptide plectasin in Escherichia coli
-
Jing XL, Luo XG, Tian WJ, et al. (2010). High-level expression of the antimicrobial peptide plectasin in Escherichia coli. Curr Microbiol 61, 197-202.
-
(2010)
Curr Microbiol
, vol.61
, pp. 197-202
-
-
Jing, X.L.1
Luo, X.G.2
Tian, W.J.3
-
12
-
-
33750451238
-
Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors
-
DOI 10.1021/jm0607606
-
Knox JE, Ma NL, Yin Z, et al. (2006). Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors. J Med Chem 49, 6585-6590. (Pubitemid 44657452)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.22
, pp. 6585-6590
-
-
Knox, J.E.1
Ma, N.L.2
Yin, Z.3
Patel, S.J.4
Wang, W.-L.5
Chan, W.-L.6
Rao, K.R.R.7
Wang, G.8
Ngew, X.9
Patel, V.10
Beer, D.11
Lim, S.P.12
Vasudevan, S.G.13
Keller, T.H.14
-
13
-
-
77649336871
-
Retrocyclin 2: A new therapy against avian influenza H5N1 virus in vivo and vitro
-
Liang QL, Zhou K, and He HX. (2010). Retrocyclin 2: A new therapy against avian influenza H5N1 virus in vivo and vitro. Biotechnol Lett 32, 387-392.
-
(2010)
Biotechnol Lett
, vol.32
, pp. 387-392
-
-
Liang, Q.L.1
Zhou, K.2
He, H.X.3
-
14
-
-
66349133644
-
Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods
-
Mandal K, Pentelute BL, Tereshko V, et al. (2009). Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Sci 18, 1146-1154.
-
(2009)
Protein Sci
, vol.18
, pp. 1146-1154
-
-
Mandal, K.1
Pentelute, B.L.2
Tereshko, V.3
-
15
-
-
84885936067
-
Design, expression, and characterization of a novel targeted plectasin against methicillin-resistant Staphylococcus aureus
-
Mao R, Teng D, Wang X, et al. (2013). Design, expression, and characterization of a novel targeted plectasin against methicillin-resistant Staphylococcus aureus. Appl Microbiol Biotechnol 97, 3991-4002.
-
(2013)
Appl Microbiol Biotechnol
, vol.97
, pp. 3991-4002
-
-
Mao, R.1
Teng, D.2
Wang, X.3
-
16
-
-
0037495036
-
A ligand-binding pocket in the dengue virus envelope glycoprotein
-
DOI 10.1073/pnas.0832193100
-
Modis Y, Ogata S, Clements D, and Harrison SC. (2003). A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc Natl Acad Sci USA 100, 6986-6991. (Pubitemid 36706380)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.12
, pp. 6986-6991
-
-
Modis, Y.1
Ogata, S.2
Clements, D.3
Harrison, S.C.4
-
17
-
-
1642499388
-
Structure of the dengue virus envelope protein after membrane fusion
-
DOI 10.1038/nature02165
-
Modis Y, Ogata S, Clements D, and Harrison SC. (2004). Structure of the dengue virus envelope protein after membrane fusion. Nature 427, 313-319. (Pubitemid 38133652)
-
(2004)
Nature
, vol.427
, Issue.6972
, pp. 313-319
-
-
Modis, Y.1
Ogata, S.2
Clements, D.3
Harrison, S.C.4
-
19
-
-
50949084334
-
Identification and biochemical characterization of small molecule inhibitors of West Nile virus serine protease by a high throughput screen
-
Mueller NH, Pattabiraman N, Ansarah-Sobrinho C, et al. (2008). Identification and biochemical characterization of small molecule inhibitors of West Nile virus serine protease by a high throughput screen. Antimicrob Agents Chemother 52, 3385-3393.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3385-3393
-
-
Mueller, N.H.1
Pattabiraman, N.2
Ansarah-Sobrinho, C.3
-
20
-
-
79959627733
-
Dengue epidemic in Malaysia: Not a predominantly urban disease anymore
-
Muhammad Azami NA, Salleh SA, Neoh HM, Syed Zakaria SZ, and Jamal R. (2011). Dengue epidemic in Malaysia: Not a predominantly urban disease anymore. BMC Res Notes 4, 216.
-
(2011)
BMC Res Notes
, vol.4
, pp. 216
-
-
Muhammad Azami, N.A.1
Salleh, S.A.2
Neoh, H.M.3
Syed Zakaria, S.Z.4
Jamal, R.5
-
21
-
-
17444436038
-
The θ-Defensin, Retrocyclin, Inhibits HIV-1 Entry
-
DOI 10.1089/088922203322493049
-
Munk C, Wei G, Yang OO, et al. (2003). The theta-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retrovir 19, 875-881. (Pubitemid 37338913)
-
(2003)
AIDS Research and Human Retroviruses
, vol.19
, Issue.10
, pp. 875-881
-
-
Munk, C.1
Wei, G.2
Yang, O.O.3
Waring, A.J.4
Wang, W.5
Hong, T.6
Lehrer, R.I.7
Landau, N.R.8
Cole, A.M.9
-
22
-
-
27144504220
-
Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
-
DOI 10.1038/nature04051, PII N04051
-
Mygind PH, Fischer RL, Schnorr KM, et al. (2005). Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 437, 975-980. (Pubitemid 41486973)
-
(2005)
Nature
, vol.437
, Issue.7061
, pp. 975-980
-
-
Mygind, P.H.1
Fischer, R.L.2
Schnorr, K.M.3
Hansen, M.T.4
Sonksen, C.P.5
Ludvigsen, S.6
Raventos, D.7
Buskov, S.8
Christensen, B.9
De Maria, L.10
Taboureau, O.11
Yaver, D.12
Elvig-Jorgensen, S.G.13
Sorensen, M.V.14
Christensen, B.E.15
Kjaerulff, S.16
Frimodt-Moller, N.17
Lehrer, R.I.18
Zasloff, M.19
Kristensen, H.-H.20
more..
-
23
-
-
9344221638
-
RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates
-
DOI 10.1089/aid.2004.20.1157
-
Owen SM, Rudolph DL, Wang W, et al. (2004). RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. AIDS Res Hum Retrovir 20, 1157-1165. (Pubitemid 39557866)
-
(2004)
AIDS Research and Human Retroviruses
, vol.20
, Issue.11
, pp. 1157-1165
-
-
Owen, S.M.1
Rudolph, D.L.2
Wang, W.3
Cole, A.M.4
Waring, A.J.5
Lal, R.B.6
Lehrer, R.I.7
-
24
-
-
84871836593
-
Protegrin-1 inhibits dengue NS2B-NS3 serine protease and viral replication in MK2 cells
-
Rothan HA, Abdulrahman AY, Sasikumer PG, et al. (2012a). Protegrin-1 inhibits dengue NS2B-NS3 serine protease and viral replication in MK2 cells. J Biomed Biotechnol 2012, 251482.
-
(2012)
J Biomed Biotechnol
, vol.2012
, pp. 251482
-
-
Rothan, H.A.1
Abdulrahman, A.Y.2
Sasikumer, P.G.3
-
25
-
-
84869218137
-
Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1
-
Rothan HA, Han HC, Ramasamy TS, et al. (2012b). Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1. BMC Infect Dis 12, 314.
-
(2012)
BMC Infect Dis
, vol.12
, pp. 314
-
-
Rothan, H.A.1
Han, H.C.2
Ramasamy, T.S.3
-
26
-
-
77956466541
-
Plectasin-A new peptide antibiotic with high therapeutic potential
-
Schmitz J, and Holzgrabe U. (2010). [Plectasin-a new peptide antibiotic with high therapeutic potential]. Pharm Unserer Zeit 39, 336-338.
-
(2010)
Pharm Unserer Zeit
, vol.39
, pp. 336-338
-
-
Schmitz, J.1
Holzgrabe, U.2
-
27
-
-
77952976637
-
Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II
-
Schneider T, Kruse T, Wimmer R, et al. (2010). Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II. Science 328, 1168-1172.
-
(2010)
Science
, vol.328
, pp. 1168-1172
-
-
Schneider, T.1
Kruse, T.2
Wimmer, R.3
-
28
-
-
0034966663
-
Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2
-
DOI 10.1006/prep.2001.1416
-
Sijwali PS, Brinen L, and Rosenthal PJ. (2001). Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. Protein Expression Purif 22, 128-134. (Pubitemid 32548229)
-
(2001)
Protein Expression and Purification
, vol.22
, Issue.1
, pp. 128-134
-
-
Sijwali, P.S.1
Brinen, L.S.2
Rosenthal, P.J.3
-
29
-
-
0030764780
-
Proteolytic activation of tick-borne encephalitis virus by furin
-
Stadler K, Allison SL, Schalich J, and Heinz FX. (1997). Proteolytic activation of tick-borne encephalitis virus by furin. J Virol 71: 8475-8481. (Pubitemid 27446428)
-
(1997)
Journal of Virology
, vol.71
, Issue.11
, pp. 8475-8481
-
-
Stadler, K.1
Allison, S.L.2
Schalich, J.3
Heinz, F.X.4
-
30
-
-
52449113528
-
Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity
-
Stoermer MJ, Chappell KJ, Liebscher S, et al. (2008). Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity. J Med Chem 51, 5714-5721.
-
(2008)
J Med Chem
, vol.51
, pp. 5714-5721
-
-
Stoermer, M.J.1
Chappell, K.J.2
Liebscher, S.3
-
32
-
-
2342573669
-
θ Defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry
-
DOI 10.1128/JVI.78.10.5147-5156.2004
-
Yasin B, Wang W, Pang M, et al. (2004). Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol 78, 5147-5156. (Pubitemid 38581467)
-
(2004)
Journal of Virology
, vol.78
, Issue.10
, pp. 5147-5156
-
-
Yasin, B.1
Wang, W.2
Pang, M.3
Cheshenko, N.4
Hong, T.5
Waring, A.J.6
Herold, B.C.7
Wagar, E.A.8
Lehrer, R.I.9
-
33
-
-
22844443626
-
Modulation of the nucleoside triphosphatase/RNA helicase and 5′-RNA triphosphatase activities of dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase
-
DOI 10.1074/jbc.M501393200
-
Yon C, Teramoto T, Mueller N, et al. (2005). Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase. J Biol Chem 280: 27412-27419. (Pubitemid 41040783)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.29
, pp. 27412-27419
-
-
Yon, C.1
Teramoto, T.2
Mueller, N.3
Phelan, J.4
Ganesh, V.K.5
Murthy, K.H.M.6
Padmanabhan, R.7
-
34
-
-
0034616194
-
Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro
-
DOI 10.1074/jbc.275.14.9963
-
Yusof R Clum S, Wetzel M, Murthy HM, and Padmanabhan R. (2000). Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro. J Biol Chem 275: 9963-9969. (Pubitemid 30202042)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.14
, pp. 9963-9969
-
-
Yusof, R.1
Clum, S.2
Wetzel, M.3
Murthy, H.M.K.4
Padmanabhan, R.5
-
35
-
-
79958768807
-
Expression of plectasin in Pichia pastoris and its characterization as a new antimicrobial peptide against Staphyloccocus and Streptococcus
-
Zhang J, Yang Y, Teng D, Tian Z, Wang S, and Wang J. (2011). Expression of plectasin in Pichia pastoris and its characterization as a new antimicrobial peptide against Staphyloccocus and Streptococcus. Protein Expr Purif 78, 189-196.
-
(2011)
Protein Expr Purif
, vol.78
, pp. 189-196
-
-
Zhang, J.1
Yang, Y.2
Teng, D.3
Tian, Z.4
Wang, S.5
Wang, J.6
|