Medicine: Plectasin - A new peptide antibiotic with high therapeutic potential;Plectasin - Ein neues peptidantibiotikum mit hohem therapeutischem potential

Pharmazie in Unserer Zeit

Volumn 39, Issue 5, 2010, Pages 336-338

  Schmitz, Jens ^a   Holzgrabe, Ulrike ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

PLECTASIN;

DRUG INFORMATION; DRUG RESEARCH; DRUG STRUCTURE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SHORT SURVEY;

ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL INFECTIONS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PEPTIDES;

EID: 77956466541     PISSN: 00483664     EISSN: 16151003     Source Type: Journal    
DOI: 10.1002/pauz.201090076     Document Type: Short Survey

References (4)

1. Mygind, P.H., Fischer, R.L., Schnorr, K.M., et al.: Plectasin is a peptid antibiotic with therapeutic potential from a saprophytic fungus. Nature 437 (2005), 975-980.
2. Andes, D., Craig, W., Nielsen, L. A., Kristensen, H. H.: In vivo pharmacodynamic characterisation of a novel plectasin antibiotic, NZ2114, in a murine infection model. Antimicrob Agents Chemother. 53 (2009), 3003-3009.
3. Schneider, T., Kruse, T., Wimmer, R., et al.: Plectasin, a fungal defensin, targets the bacterial cell wall precursor lipid II. Science 328 (2010), 1168-1172.
4. Jing, X-L., Luo, X-G., Tian, W-J., et al.: High-level expression of the antimicrobial peptide plectasin in Escherichia coli. Curr Microbiol. (in press, doi: 10.1007/s00284-010-9596-3)