Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations

Carcinogenesis

Volumn 34, Issue 9, 2013, Pages 2010-2016

  Deng, Qifei ^a   Guo, Huan ^a   Dai, Juncheng ^a,b   Yang, Lei ^a,c   Wu, Chen ^a,d   Wang, Qing ^a,e   Hu, Zhibin ^b   Yang, Ming ^f   Liu, Li ^g   Yu, Dianke ^d   Hu, Die ^a   Hong, Xiaohua ^g   Qiu, Fuman ^c   Yang, Handong ^h,i   Wang, Tian ^a   Tan, Wen ^d   Chu, Minjie ^b   Feng, Jing ^a   Teng, Kai ^g   Gong, Jianhang ^b   Sun, Chongqi ^b   Hu, Xiaoyan ^g   Zhang, Kai ^g   Lu, Jiachun ^a,c   Lin, Dongxin ^a,d   Shen, Hongbing ^a,b   Wu, Tangchun ^a   more..

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d CANCER HOSPITAL   (China)

^e WUHAN IRON AND STEEL GROUP CORPORATION   (China)

^f BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^g HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^h Dongfeng Motor Corporation   (China)

ⁱ HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; PROTEIN SH3; SH3 DOMAIN CONTAINING RING FINGER 1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CELL CYCLE REGULATION; CHINESE; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LUNG CANCER; LUNG CARCINOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RING FINGER MOTIF; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING;

CHINA; CYCLIN-DEPENDENT KINASE 6; EPISTASIS, GENETIC; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LUNG NEOPLASMS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SMOKING; UBIQUITIN-PROTEIN LIGASES;

EID: 84887013456     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt145     Document Type: Article

References (39)

1. Jemal, A. et al. (2011) Global cancer statistics. CA. Cancer J. Clin., 61, 69-90.
2. Hu, Z. et al. (2011) A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat. Genet., 43, 792-796.
3. Dong, J. et al. (2012) Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. Nat. Genet., 44, 895-899.
4. Marchini, J. et al. (2007) A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet., 39, 906-913.
5. Halperin, E. et al. (2009) SNP imputation in association studies. Nat. Biotechnol., 27, 349-351.
6. Servin, B. et al. (2007) Imputation-based analysis of association studies: candidate regions and quantitative traits. PLoS Genet., 3, e114.
7. Guan, Y. et al. (2008) Practical issues in imputation-based association mapping. PLoS Genet., 4, e1000279.
8. Thorgeirsson, T.E. et al. (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature, 452, 638-642.
9. Wacholder, S. et al. (2008) Intermediacy and gene-environment interaction: the example of CHRNA5-A3 region, smoking, nicotine dependence, and lung cancer. J. Natl Cancer Inst., 100, 1488-1491.
10. Henderson, B. et al. (2008) Cigarette smoke is an endothelial stressor and leads to cell cycle arrest. Atherosclerosis, 201, 298-305.
11. Gebel, S. et al. (2010) The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smokeinduced emphysematous changes. Toxicol. Sci., 115, 238-252.
12. Chen, Z.H. et al. (2010) Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proc. Natl Acad. Sci. USA, 107, 18880-18885.
13. Barreiro, E., et al. (2010) Cigarette smoke-induced oxidative stress: a role in chronic obstructive pulmonary disease skeletal muscle dysfunction. Am. J. Respir. Crit. Care Med., 182, 477-488.
14. Arnson, Y. et al. (2010) Effects of tobacco smoke on immunity, inflammation and autoimmunity. J. Autoimmun., 34, J258-J265.
15. Coussens, L.M. et al. (2002) Inflammation and cancer. Nature, 420, 860-867.
16. Crasta, K. et al. (2012) DNA breaks and chromosome pulverization from errors in mitosis. Nature, 482, 53-58.
17. Malumbres, M. et al. (2007) Cell cycle kinases in cancer. Curr. Opin. Genet. Dev., 17, 60-65.
18. Klaunig, J.E. et al. (2004) The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol., 44, 239-267.
19. Evan, G.I. et al. (2001) Proliferation, cell cycle and apoptosis in cancer. Nature, 411, 342-348.
20. Brody, J.S. et al. (2006) State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc. Am. Thorac. Soc., 3, 535-537.
21. Wang, W. et al. (2007) Genetic variants in cell cycle control pathway confer susceptibility to lung cancer. Clin. Cancer Res., 13, 5974-5981.
22. Lin, J. et al. (2012) Systematic evaluation of apoptotic pathway gene polymorphisms and lung cancer risk. Carcinogenesis, 33, 1699-1706.
23. Lan, Q. et al. (2004) Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions. Carcinogenesis, 25, 2177-2181.
24. Engels, E.A. et al. (2007) Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer. Cancer Res., 67, 6520-6527.
25. Guo, H. et al. (2010) Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival. J. Clin. Oncol., 28, 1928-1935.
26. Guo, H. et al. (2011) Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations. Cancer Res., 71, 7576-7586.
27. Wang, F., et al. (2012) Cohort profile: the Dongfeng-Tongji cohort study of retired workers. Int. J. Epidemiol, 1-10. doi:10.1093/ijc/dys053.
28. Liu, B. et al. (2012) A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer. Am. J. Hum. Genet., 91, 384-390.
29. Purcell, S. et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet., 81, 559-575.
30. Bax, L. et al. (2006) Development and validation of MIX: comprehensive free software for meta-analysis of causal research data. BMC Med. Res. Methodol., 6, 50.
31. Malumbres, M. et al. (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer, 9, 153-166.
32. Ruiz-Llorente, S., et al. (2007) Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma. Cancer Res., 67, 9561-9567.
33. Gayther, S.A., et al. (2007) Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Cancer Res., 67, 3027-3035.
34. Tapon, N. et al. (1998) A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J., 17, 1395-1404.
35. Xu, Z. et al. (2003) POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J., 22, 252-261.
36. Kennedy, N.J. et al. (2003) Role of JNK in tumor development. Cell Cycle, 2, 199-201.
37. Meinhold, C.L. et al. (2011) Reproductive and hormonal factors and the risk of nonsmall cell lung cancer. Int. J. Cancer, 128, 1404-1413.
38. Hyde, Z. et al. (2012) Associations between testosterone levels and incident prostate, lung, and colorectal cancer. A population-based study. Cancer Epidemiol. Biomarkers Prev., 21, 1319-1329.
39. Benowitz, N.L. et al. (2006) Female sex and oral contraceptive use accelerate nicotine metabolism. Clin. Pharmacol. Ther., 79, 480-488.