Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus

Metabolic Engineering

Volumn 20, Issue , 2013, Pages 187-197

  Zabala, Daniel ^a   Braña, Alfredo F ^a   Flórez, Ana B ^a   Salas, José A ^a   Méndez, Carmen ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

Antitumor; Glucose 1 phosphate; Malonyl CoA; Metabolic engineering; Production; Streptomyces

Indexed keywords

BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; CHAINS; CLONING; GENES; KETONES; LAKES; METABOLIC ENGINEERING; PRODUCTION;

ADPGLUCOSE PYROPHOSPHORYLASE; ANTI-TUMORS; BIOSYNTHESIS GENE CLUSTER; GLUCOSE 1-PHOSPHATE; INTRACELLULAR CONCENTRATION; MALONYL-COA; PHARMACOLOGICAL PROPERTIES; STREPTOMYCES;

GLUCOSE;

ACETYL COENZYME A; ACETYL COENZYME A CARBOXYLASE; DEMYCAROSYL 3BETA DEMYCAROSYL 3D BETA DEXTRO DIGITOXOSYL-MITHRAMYCIN,; DEMYCAROSYL MITHRAMYCIN; DEOXYSUGAR; DIACYLGLYCEROL ACYLTRANSFERASE; GLUCOSE 1 PHOSPHATE; GLUCOSE 1 PHOSPHATE ADENYLYLTRANSFERASE; GLUCOSE 6 PHOSPHATE; MALONYL COENZYME A; MITHRAMYCIN; PHOSPHOGLUCOMUTASE; UNCLASSIFIED DRUG;

AFTAA GENE; ARTICLE; BACTERIAL GENE; DRUG SYNTHESIS; GENE CLUSTER; GLUCOSE 1 PHOSPHATE ADENYLYLTRANSFERASE GENE; NONHUMAN; OVMGIH GENE; PHOSPHOGLUCOMUTASE GENE; PRIORITY JOURNAL; PYROPHOSPHORYLASE GENE; STREPTOMYCES; STREPTOMYCES ARGILLACEUS;

STREPTOMYCES; STREPTOMYCES ARGILLACEUS; STREPTOMYCES COELICOLOR;

ANTITUMOR; GLUCOSE-1-PHOSPHATE; MALONYL-COA; METABOLIC ENGINEERING; PRODUCTION; STREPTOMYCES;

ANTIBIOTICS, ANTINEOPLASTIC; BACTERIAL PROTEINS; GLUCOSEPHOSPHATES; MALONYL COENZYME A; METABOLIC ENGINEERING; PLICAMYCIN; STREPTOMYCES;

EID: 84887006003     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2013.10.002     Document Type: Article

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