Identification of 20(S)-protopanaxatriol metabolites in rats by ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry and nuclear magnetic resonance spectroscopy

Journal of Pharmaceutical and Biomedical Analysis

Volumn 88, Issue , 2014, Pages 497-508

  He, Chunyong ^a   Zhou, Dandan ^b   Li, Jia ^a   Han, Han ^b,c   Ji, Guang ^b   Yang, Li ^b,c   Wang, Zhengtao ^a,b,c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

Author keywords

20(S) Protopanaxatriol; Metabolite identification; NMR; Rats; UPLC Q TOF MS

Indexed keywords

AGLYCONE; CARBOXYLIC ACID; CYSTEINE; DRUG METABOLITE; EPOXY DAMMARANE 3,6,12,25 TETRAOL; GINSENOSIDE; PROTOPANAXATRIOL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CONJUGATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCURONIDATION; HEART PROTECTION; METABOLISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; OXYGENATION; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

20(S)-PROTOPANAXATRIOL; METABOLITE IDENTIFICATION; NMR; RATS; UPLC-Q/TOF-MS;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; CYSTEINE; EPOXY COMPOUNDS; FECES; GINSENOSIDES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; SAPOGENINS; SOFTWARE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84886995125     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.09.031     Document Type: Article

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