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Volumn 39, Issue 6, 2011, Pages 1161-1171

Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma

Author keywords

American Ginseng; Compound K; Ginsenoside Rb1; Human Plasma Concentration; Microbiota Metabolism; Panax quinquefolius; UPLC TOF MS Analysis

Indexed keywords

20 GINSENOSIDE RG2; 20 GINSENOSIDE RG3; COMPOUND K; DIGOXIN; DRUG METABOLITE; GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 3; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RH 1; GINSENOSIDE RH 2; PSEUDOGINSENOSIDE; UNCLASSIFIED DRUG;

EID: 81155138954     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X11009470     Document Type: Article
Times cited : (63)

References (28)
  • 1
    • 52449087498 scopus 로고    scopus 로고
    • Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefo-lius) in healthy volunteers receiving the HIV protease inhibitor indinavir
    • Andrade, A.S., C. Hendrix, T.L. Parsons, B. Caballero, C.S. Yuan, C.W. Flexner, A.S. Dobs and T.T. Brown. Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefo-lius) in healthy volunteers receiving the HIV protease inhibitor indinavir. BMC Complement. Altern. Med. 8: 50, 2008.
    • (2008) BMC Complement. Altern. Med. , vol.8 , pp. 50
    • Andrade, A.S.1    Hendrix, C.2    Parsons, T.L.3    Caballero, B.4    Yuan, C.S.5    Flexner, C.W.6    Dobs, A.S.7    Brown, T.T.8
  • 2
    • 0034945280 scopus 로고    scopus 로고
    • Herbal medicines and perioperative care
    • Ang-Lee, M.K., J. Moss and C.S. Yuan. Herbal medicines and perioperative care. JAMA 286: 208-216, 2001.
    • (2001) JAMA , vol.286 , pp. 208-216
    • Ang-Lee, M.K.1    Moss, J.2    Yuan, C.S.3
  • 3
    • 0344549853 scopus 로고    scopus 로고
    • Ginseng pharmacology: Multiple constituents and multiple actions
    • Attele, A.S., J.A. Wu and C.S. Yuan. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol. 58: 1685-1693, 1999.
    • (1999) Biochem. Pharmacol. , vol.58 , pp. 1685-1693
    • Attele, A.S.1    Wu, J.A.2    Yuan, C.S.3
  • 4
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides chemistry, biosynthesis, analysis, and potential health effects
    • Christensen, L.P. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv. Food Nutr. Res. 55: 1-99, 2009.
    • (2009) Adv. Food Nutr. Res. , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 6
    • 77950825403 scopus 로고    scopus 로고
    • Update information on drug metabolism systems -2009, part i
    • Guengerich, F.P. and S. Rendic. Update information on drug metabolism systems -2009, part I. Curr. Drug Metab. 11: 1-3, 2010.
    • (2010) Curr. Drug Metab. , vol.11 , pp. 1-3
    • Guengerich, F.P.1    Rendic, S.2
  • 7
    • 73249131951 scopus 로고    scopus 로고
    • Coupling ultra-high-pressure liquid chro-matography with mass spectrometry
    • Guillarme, D., J. Schappler, S. Rudaz and J.L. Veuthey. Coupling ultra-high-pressure liquid chro-matography with mass spectrometry. Trends Anal. Chem. 29: 15-27, 2010.
    • (2010) Trends Anal. Chem. , vol.29 , pp. 15-27
    • Guillarme, D.1    Schappler, J.2    Rudaz, S.3    Veuthey, J.L.4
  • 8
    • 3142621044 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng: Basic and clinical trials: Metabolic activation of ginsenoside: Deglycosylation by intestinal bacteria and esterification with fatty acid
    • Hasegawa, H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J. Pharmacol. Sci. 95: 153-157, 2004.
    • (2004) J. Pharmacol. Sci. , vol.95 , pp. 153-157
    • Hasegawa, H.1
  • 9
    • 77956432021 scopus 로고    scopus 로고
    • Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages
    • Jang, H.I. and H.M. Shin. Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages. Am. J. Chin. Med. 38: 949-960, 2010.
    • (2010) Am. J. Chin. Med. , vol.38 , pp. 949-960
    • Jang, H.I.1    Shin, H.M.2
  • 10
    • 76449087141 scopus 로고    scopus 로고
    • The effects and mechanism of saponins of Panax notoginseng on glucose metabolism in 3T3-L1 cells
    • Kim, J.J., H. Xiao, Y. Tan, Z.Z. Wang, J. Paul Seale and X. Qu. The effects and mechanism of saponins of Panax notoginseng on glucose metabolism in 3T3-L1 cells. Am. J. Chin. Med. 37: 1179-1189, 2009.
    • (2009) Am. J. Chin. Med. , vol.37 , pp. 1179-1189
    • Kim, J.J.1    Xiao, H.2    Tan, Y.3    Wang, Z.Z.4    Paul Seale, J.5    Qu, X.6
  • 11
    • 60349094657 scopus 로고    scopus 로고
    • Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry
    • Kong, H., M. Wang, K. Venema, A. Maathuis, R. van der Heijden, J. van der Greef, G. Xu and T. Hankemeier. Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry. J. Chromatogr. A 1216: 2195-2203, 2009.
    • (2009) J. Chromatogr. , vol.A1216 , pp. 2195-2203
    • Kong, H.1    Wang, M.2    Venema, K.3    Maathuis, A.4    Heijden Der R.Van5    Greef Der J.Van6    Xu, G.7    Hankemeier, T.8
  • 12
    • 77649270087 scopus 로고    scopus 로고
    • Interactions of gut microbiota with functional food components and nutraceuticals
    • Laparra, J.M. and Y. Sanz. Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol. Res. 61: 219-225, 2010.
    • (2010) Pharmacol. Res. , vol.61 , pp. 219-225
    • Laparra, J.M.1    Sanz, Y.2
  • 13
    • 41849106806 scopus 로고    scopus 로고
    • Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quin-quefolius
    • Lee, L.S., S.D. Wise, C. Chan, T.L. Parsons, C. Flexner and P.S. Lietman. Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quin-quefolius. J. Clin. Pharmacol. 48: 599-609, 2008.
    • (2008) J. Clin. Pharmacol. , vol.48 , pp. 599-609
    • Lee, L.S.1    Wise, S.D.2    Chan, C.3    Parsons, T.L.4    Flexner, C.5    Lietman, P.S.6
  • 14
    • 74249103358 scopus 로고    scopus 로고
    • Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS
    • Li, L., G.A. Luo, Q.L. Liang, P. Hu and Y.M. Wang. Rapid qualitative and quantitative analyses of Asian ginseng in adulterated American ginseng preparations by UPLC/Q-TOF-MS. J. Pharm. Biomed. Anal. 52: 66-72, 2010a.
    • (2010) J. Pharm. Biomed. Anal. , vol.52 , pp. 66-72
    • Li, L.1    Luo, G.A.2    Liang, Q.L.3    Hu, P.4    Wang, Y.M.5
  • 15
    • 77955573984 scopus 로고    scopus 로고
    • Decocting-induced chemical transformations and global quality of Du-Shen-Tang, the decoction of ginseng evaluated by UPLC-Q-TOF-MS/MS based chemical profiling approach
    • Li, S.L., S.F. Lai, J.Z. Song, C.F. Qiao, X. Liu, Y. Zhou, H. Cai, B.C. Cai and H.X. Xu. Decocting-induced chemical transformations and global quality of Du-Shen-Tang, the decoction of ginseng evaluated by UPLC-Q-TOF-MS/MS based chemical profiling approach. J. Pharm. Biomed. Anal. 53: 946-957, 2010b.
    • (2010) J. Pharm. Biomed. Anal. , vol.53 , pp. 946-957
    • Li, S.L.1    Lai, S.F.2    Song, J.Z.3    Qiao, C.F.4    Liu, X.5    Zhou, Y.6    Cai, H.7    Cai, B.C.8    Xu, H.X.9
  • 16
    • 76449095468 scopus 로고    scopus 로고
    • Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide
    • Li, X.T., R. Chen, L.M. Jin and H.Y. Chen. Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide. Am. J. Chin. Med. 37: 1139-1152, 2009.
    • (2009) Am. J. Chin. Med. , vol.37 , pp. 1139-1152
    • Li, X.T.1    Chen, R.2    Jin, L.M.3    Chen, H.Y.4
  • 17
    • 77951216196 scopus 로고    scopus 로고
    • Evaluation of the cultivation age of dried ginseng radix and its commercial products by using (1)H-NMR fingerprint analysis
    • Lin, W.N., H.Y. Lu, M.S. Lee, S.Y. Yang, H.J. Chen, Y.S. Chang and W.T. Chang. Evaluation of the cultivation age of dried ginseng radix and its commercial products by using (1)H-NMR fingerprint analysis. Am. J. Chin. Med. 38: 205-218, 2010.
    • (2010) Am. J. Chin. Med. 38 , pp. 205-218
    • Lin, W.N.1    Lu, H.Y.2    Lee, M.S.3    Yang, S.Y.4    Chen, H.J.5    Chang, Y.S.6    Chang, W.T.7
  • 19
    • 53549096793 scopus 로고    scopus 로고
    • Differentiation of isomeric mal-onylated flavonoid glyconjugates in plant extracts with UPLC-ESI/MS/MS
    • Muth, D., E. Marsden-Edwards, P. Kachlicki and M. Stobiecki. Differentiation of isomeric mal-onylated flavonoid glyconjugates in plant extracts with UPLC-ESI/MS/MS. Phytochem. Anal. 19: 444-452, 2008.
    • (2008) Phytochem. Anal. , vol.19 , pp. 444-452
    • Muth, D.1    Marsden-Edwards, E.2    Kachlicki, P.3    Stobiecki, M.4
  • 20
    • 33747072624 scopus 로고    scopus 로고
    • Pharmacological activity of sanchi ginseng (Panax notoginseng)
    • Ng, T.B. Pharmacological activity of sanchi ginseng (Panax notoginseng). J. Pharm. Pharmacol. 58: 1007-1019, 2006.
    • (2006) J. Pharm. Pharmacol. , vol.58 , pp. 1007-1019
    • Ng, T.B.1
  • 22
    • 79954627696 scopus 로고    scopus 로고
    • Ginsenosides from American ginseng: Chemical and pharmacological diversity
    • Qi, L.W., C.Z. Wang and C.S. Yuan. Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry 72: 689-699, 2011a.
    • (2011) Phytochemistry , vol.72 , pp. 689-699
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 23
    • 79952012614 scopus 로고    scopus 로고
    • Isolation and analysis of ginseng: Advances and challenges
    • Qi, L.W., C.Z. Wang and C.S. Yuan. Isolation and analysis of ginseng: advances and challenges. Nat. Prod. Rep. 28: 467-495, 2011b.
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 467-495
    • Qi, L.W.1    Wang, C.Z.2    Yuan, C.S.3
  • 26
    • 34548169064 scopus 로고    scopus 로고
    • Commonly used antioxidant botanicals: Active constituents and their potential role in cardiovascular illness
    • Wang, C.Z., S.R. Mehendale and C.S. Yuan. Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness. Am. J. Chin. Med. 35: 543-558, 2007.
    • (2007) Am. J. Chin. Med. , vol.35 , pp. 543-558
    • Wang, C.Z.1    Mehendale, S.R.2    Yuan, C.S.3
  • 27
    • 33645759774 scopus 로고    scopus 로고
    • Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography
    • Wang, C.Z., J.A. Wu, E. McEntee and C.S. Yuan. Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography. J. Agric. Food. Chem. 54: 2261-2266, 2006.
    • (2006) J. Agric. Food. Chem. , vol.54 , pp. 2261-2266
    • Wang, C.Z.1    Wu, J.A.2    McEntee, E.3    Yuan, C.S.4
  • 28
    • 3042737049 scopus 로고    scopus 로고
    • Brief communication: American ginseng reduces warfarin's effect in healthy patients: A randomized, controlled trial
    • Yuan, C.S., G. Wei, L. Dey, T. Karrison, L. Nahlik, S. Maleckar, K. Kasza, M. Ang-Lee and J. Moss. Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled trial. Ann. Intern. Med. 141: 23-27, 2004.
    • (2004) Ann. Intern. Med. , vol.141 , pp. 23-27
    • Yuan, C.S.1    Wei, G.2    Dey, L.3    Karrison, T.4    Nahlik, L.5    Maleckar, S.6    Kasza, K.7    Ang-Lee, M.8    Moss, J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.