Panax notoginseng saponins inhibit ischemia-induced apoptosis by activating PI3K/Akt pathway in cardiomyocytes

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 263-270

  Chen, Shaoxian ^a,b   Liu, Juli ^a,b   Liu, Xiaoying ^a   Fu, Yongheng ^a   Zhang, Mengzhen ^a   Lin, Qiuxiong ^a   Zhu, Jiening ^a   Mai, Liping ^a   Shan, Zhixin ^a   Yu, Xiyong ^a   Yang, Min ^a   Lin, Shuguang ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Akt; Apoptosis; Ischemia; p Akt; Panax notoginseng saponins

Indexed keywords

CARDIOVASCULAR AGENT; HERBACEOUS AGENT; PANAX NOTOGINSENG SAPONIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ENDDIASTOLIC PRESSURE; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PANAX NOTOGINSENG; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANNEXIN A5; APOPTOSIS; BLOTTING, WESTERN; CARDIOTONIC AGENTS; CELL LINE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; IN SITU NICK-END LABELING; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PANAX NOTOGINSENG; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SAPONINS; SIGNAL TRANSDUCTION; STROKE VOLUME; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

PANAX NOTOGINSENG; RATTUS;

EID: 80052033598     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.05.011     Document Type: Article

References (31)

1. R. Aikawa, M. Nawano, Y. Gu, H. Katagiri, T. Asano, W. Zhu, R. Nagai, and I. Komuro Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt Circulation 102 2000 2873 2879
2. P. Caroppi, F. Sinibaldi, L. Fiorucci, and R. Santucci Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome c as proapoptotic protein Current Medicinal Chemistry 2009
3. P. Chan, G.N. Thomas, and B. Tomlinson Protective effects of trilinolein extracted from panax notoginseng against cardiovascular disease Acta Pharmacologica Sinica 23 2002 1157 1162 (Pubitemid 35470341)
4. G.Z. Feuerstein Apoptosis in cardiac diseases - new opportunities for novel therapeutics for heart diseases Cardiovascular Drugs and Therapy 13 1999 289 294 (Pubitemid 29427985)
5. G.Z. Feuerstein Apoptosis - new opportunities for novel therapeutics for heart diseases Cardiovascular Drugs and Therapy 15 2001 547 551 (Pubitemid 34163941)
6. Y.H. Fu, Q.X. Lin, X.H. Li, H.W. Fei, Z.X. Shan, X.Z. Huang, X.Y. Liu, M. Yang, S.G. Lin, S.F. Zhou, Y.Y. Zhang, and X.Y. Yu A novel rat model of chronic heart failure following myocardial infarction Methods and Findings in Experimental and Clinical Pharmacology 31 2009 367 373
7. Y. Fujio, T. Nguyen, D. Wencker, R.N. Kitsis, and K. Walsh Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart Circulation 101 2000 660 667 (Pubitemid 30094738)
8. B.Y. Gao, X.J. Li, L. Liu, and B.H. Zhang Effect of panaxatriol saponins isolated from Panax notoginseng (PTS) on myocardial ischemic arrhythmia in mice and rats Yao Xue Xue Bao 27 1992 641 644
9. D.R. Green, and J.C. Reed Mitochondria and apoptosis Science 281 1998 1309 1312 (Pubitemid 28406816)
10. W.X. Guo, Q.N. Pye, K.S. Williamson, C.A. Stewart, K.L. Hensley, Y. Kotake, R.A. Floyd, and R.H. Broyles Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes Free Radical Biology and Medicine 39 2005 641 650 (Pubitemid 41112105)
11. A.B. Gustafsson, and R.A. Gottlieb Heart mitochondria: gates of life and death Cardiovascular Research 77 2008 334 343 (Pubitemid 351197632)
12. E. Jacotot, A. Deniaud, A. Borgne-Sanchez, Z. Touat, J.P. Briand, B.M. Le, and C. Brenner Therapeutic peptides: targeting the mitochondrion to modulate apoptosis Biochimica et Biophysica Acta 1757 2006 1312 1323 (Pubitemid 44442138)
13. S.G. Kennedy, A.J. Wagner, S.D. Conzen, J. Jordan, A. Bellacosa, P.N. Tsichlis, and N. Hay The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal Genes and Development 11 1997 701 713 (Pubitemid 27157159)
14. G. Kroemer, and J.C. Reed Mitochondrial control of cell death Nature Medicine 6 2000 513 519 (Pubitemid 30305900)
15. H. Li, C.Q. Deng, B.Y. Chen, S.P. Zhang, Y. Liang, and X.G. Luo Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion Journal of Ethnopharmacology 121 2009 412 418
16. J.D. Ly, D.R. Grubb, and A. Lawen The mitochondrial membrane potential (Δdeltapsi(m)) in apoptosis; an update Apoptosis 8 2003 115 128 (Pubitemid 36553052)
17. T. Matsui, L. Li, M. del, Y. Fukui, T.F. Franke, R.J. Hajjar, and A. Rosenzweig Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro Circulation 100 1999 2373 2379
18. T. Matsui, J. Tao, M.F. del, K.H. Lee, L. Li, M. Picard, T.L. Force, T.F. Franke, R.J. Hajjar, and A. Rosenzweig Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo Circulation 104 2001 330 335 (Pubitemid 32666956)
19. S. Miyamoto, A.N. Murphy, and J.H. Brown Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue Journal of Bioenergetics And Biomembranes 41 2009 169 180
20. C.J. Mullonkal, and L.H. Toledo-Pereyra Akt in ischemia and reperfusion Journal of Investigative Surgery 20 2007 195 203 (Pubitemid 47050383)
21. S. Negoro, H. Oh, E. Tone, K. Kunisada, Y. Fujio, K. Walsh, T. Kishimoto, and K. Yamauchi-Takihara Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction Circulation 103 2001 555 561 (Pubitemid 32116241)
22. T.B. Ng Pharmacological activity of sanchi ginseng (Panax notoginseng) Journal of Pharmacy and Pharmacology 58 2006 1007 1019 (Pubitemid 44213633)
23. M. Ohno, G. Takemura, A. Ohno, J. Misao, Y. Hayakawa, S. Minatoguchi, T. Fujiwara, and H. Fujiwara "Apoptotic" myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with in situ nick end-labeling Circulation 98 1998 1422 1430 (Pubitemid 28462803)
24. R. Rossini, M. Senni, G. Musumeci, P. Ferrazzi, and A. Gavazzi Prevention of left ventricular remodelling after acute myocardial infarction: an update Recent Patents on Cardiovascular Drug Discovery 5 2010 196 207
25. A. Saraste, K. Pulkki, M. Kallajoki, K. Henriksen, M. Parvinen, and L.M. Voipio-Pulkki Apoptosis in human acute myocardial infarction Circulation 95 1997 320 323 (Pubitemid 27056193)
26. L.S. Steelman, K.M. Stadelman, W.H. Chappell, S. Horn, J. Basecke, M. Cervello, F. Nicoletti, M. Libra, F. Stivala, A.M. Martelli, and J.A. McCubrey Akt as a therapeutic target in cancer Expert Opinion on Therapeutic Targets 12 2008 1139 1165
27. J.B. Wan, S.M. Lee, J.D. Wang, N. Wang, C.W. He, Y.T. Wang, and J.X. Kang Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion Journal of Agricultural and Food Chemistry 57 2009 6692 6697
28. Y. Wu, Z.Y. Xia, Q.T. Meng, J. Zhu, S. Lei, J. Xu, and J. Dou Shen-Fu injection preconditioning inhibits myocardial ischemia-reperfusion injury in diabetic rats: activation of eNOS via the PI3K/Akt pathway Journal of Biomedicine and Biotechnology 2011 2011 384627
29. K. Yamashita, J. Kajstura, D.J. Discher, B.J. Wasserlauf, N.H. Bishopric, P. Anversa, and K.A. Webster Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1 Circulation Research 88 2001 609 614 (Pubitemid 32275797)
30. J.Y. Yang, H.Y. Yeh, K. Lin, and P.H. Wang Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium Journal of Molecular and Cellular Cardiology 46 2009 919 926
31. N. Zamzami, and G. Kroemer The mitochondrion in apoptosis: how Pandora's box opens Nature Reviews Molecular Cell Biology 2 2001 67 71 (Pubitemid 33676964)