Transforming growth factor-β (TGF-β)-mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 signaling activation

Journal of Biological Chemistry

Volumn 288, Issue 42, 2013, Pages 30708-30719

  Liu, Yan ^a,b   Liu, Heng ^a,c   Meyer, Christoph ^a   Li, Jun ^d,e   Nadalin, Silvio ^d   Königsrainer, Alfred ^d   Weng, Honglei ^a   Dooley, Steven ^a   Ten Dijke, Peter ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX PRODUCTION; HEPATIC STELLATE CELLS; LIVER FIBROGENESIS; SIGNALING NETWORKS; TRANSFORMING GROWTH FACTORS;

COLLAGEN; MUSCULOSKELETAL SYSTEM; SIGNALING;

CELL SIGNALING;

CONNECTIVE TISSUE GROWTH FACTOR; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; HUMAN TISSUE; LIVER; LIVER FIBROSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ERK; JAK KINASE; JUN N-TERMINAL KINASE (JNK); LIVER FIBROSIS; MAP KINASES (MAPKS); PI 3-KINASE (PI3K); SMAD TRANSCRIPTION FACTOR;

CELL LINE, TRANSFORMED; CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HUMANS; JANUS KINASE 1; LIVER CIRRHOSIS; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; SMAD3 PROTEIN; STAT3 TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84886921890     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.478685     Document Type: Article

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