-
3
-
-
0032189117
-
Treatment of breast cancer
-
Hortobagyi GN: Treatment of breast cancer. N Engl J Med 339: 974-984, 1998.
-
(1998)
N Engl J Med
, vol.339
, pp. 974-984
-
-
Hortobagyi, G.N.1
-
4
-
-
0042925297
-
Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1
-
Chen X, Yang L, Zhang N, et al: Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. Antimicrob Agents Chemother 47: 2810-2816, 2003.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 2810-2816
-
-
Chen, X.1
Yang, L.2
Zhang, N.3
-
5
-
-
49149088537
-
Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells
-
Mao X, Yu CR, Li WH and Li WX: Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells. Cell Res 18: 879-888, 2008.
-
(2008)
Cell Res
, vol.18
, pp. 879-888
-
-
Mao, X.1
Yu, C.R.2
Li, W.H.3
Li, W.X.4
-
6
-
-
64249097600
-
Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo
-
Yang H, Zhou P, Huang H, et al: Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int J Cancer 124: 2450-2459, 2009.
-
(2009)
Int J Cancer
, vol.124
, pp. 2450-2459
-
-
Yang, H.1
Zhou, P.2
Huang, H.3
-
7
-
-
84859883498
-
Inhibitory effects of β, β-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo
-
Wu YY, Wan LH, Zheng XW, et al: Inhibitory effects of β, β-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo. Phytother Res 26: 764-771, 2012.
-
(2012)
Phytother Res
, vol.26
, pp. 764-771
-
-
Wu, Y.Y.1
Wan, L.H.2
Zheng, X.W.3
-
8
-
-
13244284779
-
The effect of acetylshikonin isolated from Lithospermum canescens roots on tumor-induced cutaneous angiogenesis
-
Pietrosiuk A, Furmanowa M, Skopińiska-Rózewska E, et al: The effect of acetylshikonin isolated from Lithospermum canescens roots on tumor-induced cutaneous angiogenesis. Acta Pol Pharm 61: 379-382, 2004.
-
(2004)
Acta Pol Pharm
, vol.61
, pp. 379-382
-
-
Pietrosiuk, A.1
Furmanowa, M.2
Skopińiska-Rózewska, E.3
-
9
-
-
81855218666
-
Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma
-
Gong K and Li W: Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free Radic Biol Med 51: 2259-2271, 2011.
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 2259-2271
-
-
Gong, K.1
Li, W.2
-
10
-
-
0035976040
-
Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33
-
Kim SH, Kang IC, Yoon TJ, et al: Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33. Cancer Lett 172: 171-175, 2001.
-
(2001)
Cancer Lett
, vol.172
, pp. 171-175
-
-
Kim, S.H.1
Kang, I.C.2
Yoon, T.J.3
-
11
-
-
84951384024
-
A simplified method of evaluating dose-effect experiments
-
Litchfield JT Jr and Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96: 99-113, 1949.
-
(1949)
J Pharmacol Exp Ther
, vol.96
, pp. 99-113
-
-
Litchfield Jr., J.T.1
Wilcoxon, F.2
-
12
-
-
67651250306
-
Inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo
-
Zeng Y, Liu G and Zhou LM: Inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo. World J Gastroenterol 15: 1816-1820, 2009.
-
(2009)
World J Gastroenterol
, vol.15
, pp. 1816-1820
-
-
Zeng, Y.1
Liu, G.2
Zhou, L.M.3
-
14
-
-
79953795868
-
Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition
-
Lu L, Qin A, Huang H, et al: Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition. Eur J Pharmacol 658: 242-247, 2011.
-
(2011)
Eur J Pharmacol
, vol.658
, pp. 242-247
-
-
Lu, L.1
Qin, A.2
Huang, H.3
-
16
-
-
0027102381
-
Modifying effects of fungal and herb metabolites on azoxymethane-induced intestinal carcinogenesis in rats
-
Yoshimi N, Wang A, Morishita Y, et al: Modifying effects of fungal and herb metabolites on azoxymethane-induced intestinal carcinogenesis in rats. Jpn J Cancer Res 83: 1273-1278, 1992.
-
(1992)
Jpn J Cancer Res
, vol.83
, pp. 1273-1278
-
-
Yoshimi, N.1
Wang, A.2
Morishita, Y.3
-
17
-
-
0028916381
-
Acylshikonin analogues: Synthesis and inhibition of DNA topoisomerase-I
-
Ahn BZ, Baik KU, Kweon GR, et al: Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I. J Med Chem 38: 1044-1047, 1995.
-
(1995)
J Med Chem
, vol.38
, pp. 1044-1047
-
-
Ahn, B.Z.1
Baik, K.U.2
Kweon, G.R.3
-
18
-
-
0008742582
-
Inhibition of topoisomerase I by naphthoquinone derivatives
-
Plyta ZF, Li T, Papageorgiou VP, et al: Inhibition of topoisomerase I by naphthoquinone derivatives. Bioorg Med Chem Lett 8: 3385-3390, 1998.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 3385-3390
-
-
Plyta, Z.F.1
Li, T.2
Papageorgiou, V.P.3
-
19
-
-
33746377985
-
SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor
-
Yang F, Chen Y, Duan W, et al: SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor. Int J Cancer 119: 1184-1193, 2006.
-
(2006)
Int J Cancer
, vol.119
, pp. 1184-1193
-
-
Yang, F.1
Chen, Y.2
Duan, W.3
-
20
-
-
0033866725
-
Inhibition of growth and regulation of IGFs and VEGF in human prostate cancer cell lines by shikonin analogue 93/637 (SA)
-
Gaddipati JP, Mani H, Shefali, et al: Inhibition of growth and regulation of IGFs and VEGF in human prostate cancer cell lines by shikonin analogue 93/637 (SA). Anticancer Res 20: 2547-2552, 2000.
-
(2000)
Anticancer Res
, vol.20
, pp. 2547-2552
-
-
Gaddipati, J.P.1
Mani, H.2
Shefali3
-
21
-
-
77952397814
-
Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells
-
Chang IC, Huang YJ, Chiang TI, et al: Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. Biol Pharm Bull 33: 816-824, 2010.
-
(2010)
Biol Pharm Bull
, vol.33
, pp. 816-824
-
-
Chang, I.C.1
Huang, Y.J.2
Chiang, T.I.3
-
22
-
-
84864128355
-
β, β-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo
-
Zhen-Jun S, Yuan-Yuan Z, Ying-Ying F, et al: β, β-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo. Biochem Pharmacol 84: 507-512, 2012.
-
(2012)
Biochem Pharmacol
, vol.84
, pp. 507-512
-
-
Zhen-Jun, S.1
Yuan-Yuan, Z.2
Ying-Ying, F.3
-
23
-
-
0036463405
-
A matter of life and death
-
Green DR and Evan GI: A matter of life and death. Cancer Cell 1: 19-30, 2002.
-
(2002)
Cancer Cell
, vol.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
24
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
Adams JM and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998.
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
25
-
-
0027166048
-
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
-
Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.
-
(1993)
Cell
, vol.74
, pp. 609-619
-
-
Oltvai, Z.N.1
Milliman, C.L.2
Korsmeyer, S.J.3
-
26
-
-
62449233322
-
NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy
-
Shen HM and Tergaonkar V: NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy. Apoptosis 14: 348-363, 2009.
-
(2009)
Apoptosis
, vol.14
, pp. 348-363
-
-
Shen, H.M.1
Tergaonkar, V.2
-
27
-
-
26944443968
-
Distinct roles of IκB proteins in regulating constitutive NF-κB activity
-
Tergaonkar V, Correa RG, Ikawa M and Verma IM: Distinct roles of IκB proteins in regulating constitutive NF-κB activity. Nat Cell Biol 7: 921-923, 2005.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 921-923
-
-
Tergaonkar, V.1
Correa, R.G.2
Ikawa, M.3
Verma, I.M.4
-
28
-
-
33846323310
-
A fourth IκB protein within the NF-κB signaling module
-
Basak S, Kim H, Kearns JD, et al: A fourth IκB protein within the NF-κB signaling module. Cell 128: 369-381, 2007.
-
(2007)
Cell
, vol.128
, pp. 369-381
-
-
Basak, S.1
Kim, H.2
Kearns, J.D.3
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