-
1
-
-
25144489068
-
Overview of cell death signaling pathways
-
Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther 2005; 4:139-63.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 139-163
-
-
Jin, Z.1
El-Deiry, W.S.2
-
2
-
-
84859871133
-
Signaling pathways that regulate life and cell death: Evolution of apoptosis in the context of self-defense
-
Munoz-Pinedo C. Signaling pathways that regulate life and cell death: evolution of apoptosis in the context of self-defense. Adv Exp Med Biol 2012; 738:124-43.
-
(2012)
Adv Exp Med Biol
, vol.738
, pp. 124-143
-
-
Munoz-Pinedo, C.1
-
3
-
-
69449095860
-
Caspases and kinases in a death grip
-
Kurokawa M, Kornbluth S. Caspases and kinases in a death grip. Cell 2009; 138:838-54.
-
(2009)
Cell
, vol.138
, pp. 838-854
-
-
Kurokawa, M.1
Kornbluth, S.2
-
4
-
-
79955479863
-
Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways
-
Tchikov V, Bertsch U, Fritsch J, Edelmann B, Schutze S. Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways. Eur J Cell Biol 2011; 90:467-75.
-
(2011)
Eur J Cell Biol
, vol.90
, pp. 467-475
-
-
Tchikov, V.1
Bertsch, U.2
Fritsch, J.3
Edelmann, B.4
Schutze, S.5
-
5
-
-
79960230433
-
Mitochondria in apoptosis: Bcl-2 2 members and mitochondrial dynamics
-
Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 2 members and mitochondrial dynamics. Dev Cell 2011; 21:92-101.
-
(2011)
Dev Cell
, vol.21
, pp. 92-101
-
-
Martinou, J.C.1
Youle, R.J.2
-
6
-
-
0034068601
-
Mitochondrial control of cell death
-
DOI 10.1038/74994
-
Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000; 6:513-9. (Pubitemid 30305900)
-
(2000)
Nature Medicine
, vol.6
, Issue.5
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
7
-
-
0032568954
-
Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c
-
DOI 10.1074/jbc.273.26.16589
-
Kuwana T, Smith JJ, Muzio M, Dixit V, Newmeyer DD, Kornbluth S. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem 1998; 273:16589-94. (Pubitemid 28311447)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.26
, pp. 16589-16594
-
-
Kuwana, T.1
Smith, J.J.2
Muzio, M.3
Dixit, V.4
Newmeyer, D.D.5
Kornbluth, S.6
-
8
-
-
0033694859
-
BID-dependent and BID-independent pathways for BAX insertion into mitochondria
-
Ruffolo SC, Breckenridge DG, Nguyen M, Goping IS, Gross A, Korsmeyer SJ, Li H, Yuan J, Shore GC. BID-dependent and BID-independent pathways for BAX insertion into mitochondria. Cell Death Differ 2000; 7:1101-8.
-
(2000)
Cell Death Differ
, vol.7
, pp. 1101-1108
-
-
Ruffolo, S.C.1
Breckenridge, D.G.2
Nguyen, M.3
Goping, I.S.4
Gross, A.5
Korsmeyer, S.J.6
Li, H.7
Yuan, J.8
Shore, G.C.9
-
9
-
-
81055144784
-
Autophagy: Renovation of cells and tissues
-
Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147:728-41.
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
10
-
-
80053438277
-
Molecular machinery of macroautophagy and its deregulation in diseases
-
Wong AS, Cheung ZH, Ip NY. Molecular machinery of macroautophagy and its deregulation in diseases. Biochim Biophys Acta 2011; 1812:1490-7.
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 1490-1497
-
-
Wong, A.S.1
Cheung, Z.H.2
Ip, N.Y.3
-
11
-
-
38749136302
-
Regulation of macroautophagy by mTOR and Beclin 1 complexes
-
DOI 10.1016/j.biochi.2007.08.014, PII S0300908407002283
-
Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 2008; 90:313-23. (Pubitemid 351181247)
-
(2008)
Biochimie
, vol.90
, Issue.2
, pp. 313-323
-
-
Pattingre, S.1
Espert, L.2
Biard-Piechaczyk, M.3
Codogno, P.4
-
12
-
-
77951221542
-
The role of the Atg1/ULK1 complex in autophagy regulation
-
Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010; 22:132-9.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 132-139
-
-
Mizushima, N.1
-
13
-
-
70349644856
-
Atg101, a novel mammalian autophagy protein interacting with Atg13
-
Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N. Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 2009; 5:973-9.
-
(2009)
Autophagy
, vol.5
, pp. 973-979
-
-
Hosokawa, N.1
Sasaki, T.2
Iemura, S.3
Natsume, T.4
Hara, T.5
Mizushima, N.6
-
14
-
-
67549110195
-
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
-
Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 2009; 5:649-62.
-
(2009)
Autophagy
, vol.5
, pp. 649-662
-
-
Mercer, C.A.1
Kaliappan, A.2
Dennis, P.B.3
-
16
-
-
34548259958
-
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy*[S]
-
DOI 10.1074/jbc.M702824200
-
Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 2007; 282:24131-45. (Pubitemid 47328003)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.33
, pp. 24131-24145
-
-
Pankiv, S.1
Clausen, T.H.2
Lamark, T.3
Brech, A.4
Bruun, J.-A.5
Outzen, H.6
Overvatn, A.7
Bjorkoy, G.8
Johansen, T.9
-
17
-
-
37649017266
-
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
-
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, Ney PA. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 2007; 104:19500-5.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19500-19505
-
-
Schweers, R.L.1
Zhang, J.2
Randall, M.S.3
Loyd, M.R.4
Li, W.5
Dorsey, F.C.6
Kundu, M.7
Opferman, J.T.8
Cleveland, J.L.9
Miller, J.L.10
Ney, P.A.11
-
18
-
-
84872796543
-
Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis
-
Nistico R, Mango D, Mandolesi G, Piccinin S, Berretta N, Pignatelli M, Feligioni M, Musella A, Gentile A, Mori F, Bernardi G, Nicoletti F, Mercuri NB, Centonze D. Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis. PLoS One 2013; 8:e54666.
-
(2013)
PLoS One
, vol.8
-
-
Nistico, R.1
Mango, D.2
Mandolesi, G.3
Piccinin, S.4
Berretta, N.5
Pignatelli, M.6
Feligioni, M.7
Musella, A.8
Gentile, A.9
Mori, F.10
Bernardi, G.11
Nicoletti, F.12
Mercuri, N.B.13
Centonze, D.14
-
19
-
-
0034329742
-
Apoptosis in neurodegenerative disorders
-
Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000; 1:120-9.
-
(2000)
Nat Rev Mol Cell Biol
, vol.1
, pp. 120-129
-
-
Mattson, M.P.1
-
20
-
-
65549099222
-
All-you-can-eat: Autophagy in neurodegeneration and neuroprotection
-
Jaeger PA, Wyss-Coray T. All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener 2009; 4:16.
-
(2009)
Mol Neurodegener
, vol.4
, pp. 16
-
-
Jaeger, P.A.1
Wyss-Coray, T.2
-
21
-
-
84857700077
-
Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: To die or not to die - that is the question
-
Rosello A, Warnes G, Meier UC. Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die - that is the question. Clin Exp Immunol 2012; 168:52-7.
-
(2012)
Clin Exp Immunol
, vol.168
, pp. 52-57
-
-
Rosello, A.1
Warnes, G.2
Meier, U.C.3
-
22
-
-
0035425503
-
Nitric oxide synthases: Structure, function and inhibition
-
DOI 10.1042/0264-6021:3570593
-
Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357:593-615. (Pubitemid 32735142)
-
(2001)
Biochemical Journal
, vol.357
, Issue.3
, pp. 593-615
-
-
Alderton, W.K.1
Cooper, C.E.2
Knowles, R.G.3
-
23
-
-
77955085839
-
Inflammatory neurodegeneration and mechanisms of microglial killing of neurons
-
Brown GC, Neher JJ. Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 2010; 41:242-7.
-
(2010)
Mol Neurobiol
, vol.41
, pp. 242-247
-
-
Brown, G.C.1
Neher, J.J.2
-
24
-
-
0038486928
-
Protein interactions with nitric oxide synthases: Controlling the right time, the right place, and the right amount of nitric oxide
-
Kone BC, Kuncewicz T, Zhang W, Yu ZY. Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Am J Physiol Renal Physiol 2003; 285:F178-90. (Pubitemid 36871190)
-
(2003)
American Journal of Physiology - Renal Physiology
, vol.285
, Issue.2
-
-
Kone, B.C.1
Kuncewicz, T.2
Zhang, W.3
Yu, Z.-Y.4
-
25
-
-
13344277364
-
Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
-
DOI 10.1016/S0092-8674(00)81053-3
-
Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 1996; 84:757-67. (Pubitemid 26094205)
-
(1996)
Cell
, vol.84
, Issue.5
, pp. 757-767
-
-
Brenman, J.E.1
Chao, D.S.2
Gee, S.H.3
McGee, A.W.4
Craven, S.E.5
Santillano, D.R.6
Wu, Z.7
Huang, F.8
Xia, H.9
Peters, M.F.10
Froehner, S.C.11
Bredt, D.S.12
-
27
-
-
0034687690
-
Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells
-
Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF. Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. Proc Natl Acad Sci U S A 2000;97:14334-9.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 14334-14339
-
-
Felley-Bosco, E.1
Bender, F.C.2
Courjault-Gautier, F.3
Bron, C.4
Quest, A.F.5
-
28
-
-
0021443856
-
Inositol trisphosphate and diacylglycerol as second messengers
-
Berridge MJ. Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 1984; 220:345-60.
-
(1984)
Biochem J
, vol.220
, pp. 345-360
-
-
Berridge, M.J.1
-
29
-
-
33845320488
-
Intracellular trafficking of sphingolipids: Relationship to biosynthesis
-
Futerman AH. Intracellular trafficking of sphingolipids: relationship to biosynthesis. Biochim Biophys Acta 2006; 1758:1885-92.
-
(2006)
Biochim Biophys Acta
, vol.1758
, pp. 1885-1892
-
-
Futerman, A.H.1
-
30
-
-
0023555012
-
3 pituitary cells
-
Kolesnick RN. 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J Biol Chem 1987; 262:16759-62. (Pubitemid 18019025)
-
(1987)
Journal of Biological Chemistry
, vol.262
, Issue.35
, pp. 16759-16762
-
-
Kolesnick, R.N.1
-
31
-
-
0024521516
-
Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells
-
Kolesnick RN. Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells. J Biol Chem 1989; 264:7617-23. (Pubitemid 19119181)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.13
, pp. 7617-7623
-
-
Kolesnick, R.N.1
-
32
-
-
0025003424
-
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
-
Okazaki T, Bielawska A, Bell RM, Hannun YA. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem 1990; 265:15823-31.
-
(1990)
J Biol Chem
, vol.265
, pp. 15823-15831
-
-
Okazaki, T.1
Bielawska, A.2
Bell, R.M.3
Hannun, Y.A.4
-
33
-
-
33749009744
-
The extended family of neutral sphingomyelinases
-
DOI 10.1021/bi061307z
-
Clarke CJ, Snook CF, Tani M, Matmati N, Marchesini N, Hannun YA. The extended family of neutral sphingomyelinases. Biochemistry 2006; 45:11247-56. (Pubitemid 44453973)
-
(2006)
Biochemistry
, vol.45
, Issue.38
, pp. 11247-11256
-
-
Clarke, C.J.1
Snook, C.F.2
Tani, M.3
Matmati, N.4
Marchesini, N.5
Hannun, Y.A.6
-
34
-
-
77954709548
-
The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation
-
Zeidan YH, Hannun YA. The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med 2010; 10:454-66.
-
(2010)
Curr Mol Med
, vol.10
, pp. 454-466
-
-
Zeidan, Y.H.1
Hannun, Y.A.2
-
36
-
-
0030796437
-
Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes
-
DOI 10.1074/jbc.272.37.23211
-
Sciorati C, Rovere P, Ferrarini M, Heltai S, Manfredi AA, Clementi E. Autocrine nitric oxide modulates CD95-induced apoptosis in gammadelta T lymphocytes. J Biol Chem 1997; 272:23211-5. (Pubitemid 27392455)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.37
, pp. 23211-23215
-
-
Sciorati, C.1
Rovere, P.2
Ferrarini, M.3
Heltai, S.4
Manfredi, A.A.5
Clementi, E.6
-
37
-
-
45249095327
-
Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: A link between inflammation and neuroprotection
-
DOI 10.1111/j.1471-4159.2008.05351.x
-
De Palma C, Falcone S, Panzeri C, Radice S, Bassi MT, Clementi E. Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection. J Neurochem 2008; 106:193-204. (Pubitemid 351840202)
-
(2008)
Journal of Neurochemistry
, vol.106
, Issue.1
, pp. 193-204
-
-
De Palma, C.1
Falcone, S.2
Panzeri, C.3
Radice, S.4
Bassi, M.T.5
Clementi, E.6
-
38
-
-
77956012154
-
Nitric oxide and neuronal death
-
Brown GC. Nitric oxide and neuronal death. Nitric Oxide 2010; 23:153-65.
-
(2010)
Nitric Oxide
, vol.23
, pp. 153-165
-
-
Brown, G.C.1
-
39
-
-
36749005178
-
Mechanisms of inflammatory neurodegeneration: INOS and NADPH oxidase
-
DOI 10.1042/BST0351119
-
Brown GC. Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochem Soc Trans 2007; 35:1119-21. (Pubitemid 350206442)
-
(2007)
Biochemical Society Transactions
, vol.35
, Issue.5
, pp. 1119-1121
-
-
Brown, G.C.1
-
40
-
-
0042665423
-
Nitric oxide: NO apoptosis or turning it ON?
-
DOI 10.1038/sj.cdd.4401261
-
Brune B. Nitric oxide: NO apoptosis or turning it ON? Cell Death Differ 2003; 10:864-9. (Pubitemid 36939696)
-
(2003)
Cell Death and Differentiation
, vol.10
, Issue.8
, pp. 864-869
-
-
Brune, B.1
-
41
-
-
0035794181
-
Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death
-
Bulotta S, Barsacchi R, Rotiroti D, Borgese N, Clementi E. Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death. J Biol Chem 2001; 276:6529-36.
-
(2001)
J Biol Chem
, vol.276
, pp. 6529-6536
-
-
Bulotta, S.1
Barsacchi, R.2
Rotiroti, D.3
Borgese, N.4
Clementi, E.5
-
42
-
-
0037382346
-
Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: A novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt
-
DOI 10.1124/mol.63.4.886
-
Barsacchi R, Perrotta C, Bulotta S, Moncada S, Borgese N, Clementi E. Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt. Mol Pharmacol 2003; 63:886-95. (Pubitemid 36368996)
-
(2003)
Molecular Pharmacology
, vol.63
, Issue.4
, pp. 886-895
-
-
Barsacchi, R.1
Perrotta, C.2
Bulotta, S.3
Moncada, S.4
Borgese, N.5
Clementi, E.6
-
43
-
-
0033179393
-
Generation of nitric oxide by the inducible nitric oxide synthase protects gammadelta T cells from Mycobacterium tuberculosis-induced apoptosis
-
Sciorati C, Rovere P, Ferrarini M, Paolucci C, Heltai S, Vaiani R, Clementi E, Manfredi AA. Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis. J Immunol 1999; 163:1570-6. (Pubitemid 29352781)
-
(1999)
Journal of Immunology
, vol.163
, Issue.3
, pp. 1570-1576
-
-
Sciorati, C.1
Rovere, P.2
Ferrarini, M.3
Paolucci, C.4
Heltai, S.5
Vaiani, R.6
Clementi, E.7
Manfredi, A.A.8
-
44
-
-
0034624984
-
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide
-
De Nadai C, Sestili P, Cantoni O, Lievremont JP, Sciorati C, Barsacchi R, Moncada S, Meldolesi J, Clementi E. Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. Proc Natl Acad Sci U S A 2000; 97:5480-5.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5480-5485
-
-
De Nadai, C.1
Sestili, P.2
Cantoni, O.3
Lievremont, J.P.4
Sciorati, C.5
Barsacchi, R.6
Moncada, S.7
Meldolesi, J.8
Clementi, E.9
-
45
-
-
4644327020
-
Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3′,5′-monophosphate pathway: Key events in Escherichia coli-elicited apoptosis of dendritic cells
-
Falcone S, Perrotta C, De Palma C, Pisconti A, Sciorati C, Capobianco A, Rovere-Querini P, Manfredi AA, Clementi E. Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3′,5′- monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 2004; 173:4452-63. (Pubitemid 39280675)
-
(2004)
Journal of Immunology
, vol.173
, Issue.7
, pp. 4452-4463
-
-
Falcone, S.1
Perrotta, C.2
De Palma, C.3
Pisconti, A.4
Sciorati, C.5
Capobianco, A.6
Rovere-Querini, P.7
Manfredi, A.A.8
Clementi, E.9
-
46
-
-
34548052207
-
Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma
-
DOI 10.1158/0008-5472.CAN-07-0309
-
Perrotta C, Bizzozero L, Falcone S, Rovere-Querini P, Prinetti A, Schuchman EH, Sonnino S, Manfredi AA, Clementi E. Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma. Cancer Res 2007; 67:7559-64. (Pubitemid 47281347)
-
(2007)
Cancer Research
, vol.67
, Issue.16
, pp. 7559-7564
-
-
Perrotta, C.1
Bizzozero, L.2
Falcone, S.3
Rovere-Querini, P.4
Prinetti, A.5
Schuchman, E.H.6
Sonnino, S.7
Manfredi, A.A.8
Clementi, E.9
-
47
-
-
2442693091
-
Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells
-
Lacour S, Hammann A, Grazide S, Lagadic-Gossmann D, Athias A, Sergent O, Laurent G, Gambert P, Solary E, Dimanche-Boitrel MT. Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells. Cancer Res 2004; 64:3593-8.
-
(2004)
Cancer Res
, vol.64
, pp. 3593-3598
-
-
Lacour, S.1
Hammann, A.2
Grazide, S.3
Lagadic-Gossmann, D.4
Athias, A.5
Sergent, O.6
Laurent, G.7
Gambert, P.8
Solary, E.9
Dimanche-Boitrel, M.T.10
-
48
-
-
78650052094
-
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function
-
Perrotta C, Bizzozero L, Cazzato D, Morlacchi S, Assi E, Simbari F, Zhang Y, Gulbins E, Bassi MT, Rosa P, Clementi E. Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. J Biol Chem 2010; 285:40240-51.
-
(2010)
J Biol Chem
, vol.285
, pp. 40240-40251
-
-
Perrotta, C.1
Bizzozero, L.2
Cazzato, D.3
Morlacchi, S.4
Assi, E.5
Simbari, F.6
Zhang, Y.7
Gulbins, E.8
Bassi, M.T.9
Rosa, P.10
Clementi, E.11
-
49
-
-
0037401647
-
Regulation of death receptor signaling and apoptosis by ceramide
-
DOI 10.1016/S1043-6618(03)00052-5, PII S1043661803000525
-
Gulbins E. Regulation of death receptor signaling and apoptosis by ceramide. Pharmacol Res 2003; 47:393-9. (Pubitemid 36379201)
-
(2003)
Pharmacological Research
, vol.47
, Issue.5
, pp. 393-399
-
-
Gulbins, E.1
-
50
-
-
2342570273
-
Acid and neutral sphingomyelinases: Roles and mechanisms of regulation
-
DOI 10.1139/o03-091
-
Marchesini N, Hannun YA. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol 2004; 82:27-44. (Pubitemid 38580872)
-
(2004)
Biochemistry and Cell Biology
, vol.82
, Issue.1
, pp. 27-44
-
-
Marchesini, N.1
Hannun, Y.A.2
-
51
-
-
0033614470
-
Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells
-
DOI 10.1006/bbrc.1999.0582
-
Huwiler A, Dorsch S, Briner VA, van den Bosch H, Pfeilschifter J. Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells. Biochem Biophys Res Commun 1999; 258:60-5. (Pubitemid 29287002)
-
(1999)
Biochemical and Biophysical Research Communications
, vol.258
, Issue.1
, pp. 60-65
-
-
Huwiler, A.1
Dorsch, S.2
Briner, V.A.3
Van Den, B.H.4
Pfeilschifter, J.5
-
52
-
-
0033537839
-
Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3
-
Takeda Y, Tashima M, Takahashi A, Uchiyama T, Okazaki T. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J Biol Chem 1999; 274:10654-60.
-
(1999)
J Biol Chem
, vol.274
, pp. 10654-10660
-
-
Takeda, Y.1
Tashima, M.2
Takahashi, A.3
Uchiyama, T.4
Okazaki, T.5
-
53
-
-
0346577312
-
NO Induced Apoptosis of Vascular Smooth Muscle Cells Accompanied by Ceramide Increase
-
DOI 10.1002/jcp.10464
-
Pilane CM, LaBelle EF. NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. J Cell Physiol 2004; 199:310-5. (Pubitemid 38436757)
-
(2004)
Journal of Cellular Physiology
, vol.199
, Issue.2
, pp. 310-315
-
-
Pilane, C.M.1
Labelle, E.F.2
-
54
-
-
33846691177
-
Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: A novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis
-
DOI 10.1016/j.yexcr.2006.12.001, PII S0014482706004897
-
Castillo SS, Levy M, Wang C, Thaikoottathil JV, Khan E, Goldkorn T. Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis. Exp Cell Res 2007; 313:816-23. (Pubitemid 46198824)
-
(2007)
Experimental Cell Research
, vol.313
, Issue.4
, pp. 816-823
-
-
Castillo, S.S.1
Levy, M.2
Wang, C.3
Thaikoottathil, J.V.4
Khan, E.5
Goldkorn, T.6
-
55
-
-
21644455318
-
Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids
-
DOI 10.1002/jcp.20298
-
Pilane CM, Labelle EF. Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids. J Cell Physiol 2005; 204:423-7. (Pubitemid 40934636)
-
(2005)
Journal of Cellular Physiology
, vol.204
, Issue.2
, pp. 423-427
-
-
Pilane, C.M.1
LaBelle, E.F.2
-
56
-
-
82455175863
-
Interaction of the nitric oxide signaling system with the sphingomyelin cycle and peroxidation on transmission of toxic signal of tumor necrosis factor-alpha in ischemia-reperfusion
-
Mosc
-
Shupik MA, Vanin AF, Alessenko AV. Interaction of the nitric oxide signaling system with the sphingomyelin cycle and peroxidation on transmission of toxic signal of tumor necrosis factor-alpha in ischemia-reperfusion. Biochemistry (Mosc) 2011; 76:1197-209.
-
(2011)
Biochemistry
, vol.76
, pp. 1197-1209
-
-
Shupik, M.A.1
Vanin, A.F.2
Alessenko, A.V.3
-
57
-
-
84555195856
-
Autophagy, mitochondria and oxidative stress: Cross-talk and redox signalling
-
Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 2012; 441:523-40.
-
(2012)
Biochem J
, vol.441
, pp. 523-540
-
-
Lee, J.1
Giordano, S.2
Zhang, J.3
-
58
-
-
33846192839
-
Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?
-
Lavieu G, Scarlatti F, Sala G, Levade T, Ghidoni R, Botti J, Codogno P. Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy 2007; 3:45-7. (Pubitemid 46100712)
-
(2007)
Autophagy
, vol.3
, Issue.1
, pp. 45-47
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Levade, T.4
Ghidoni, R.5
Botti, J.6
Codogno, P.7
-
59
-
-
59149090850
-
Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy
-
Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B, Codogno P. Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem 2009; 284:2719-28.
-
(2009)
J Biol Chem
, vol.284
, pp. 2719-2728
-
-
Pattingre, S.1
Bauvy, C.2
Carpentier, S.3
Levade, T.4
Levine, B.5
Codogno, P.6
-
60
-
-
44949237240
-
JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
-
DOI 10.1016/j.molcel.2008.06.001, PII S1097276508003894
-
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30:678-88. (Pubitemid 351818252)
-
(2008)
Molecular Cell
, vol.30
, Issue.6
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
61
-
-
48249092267
-
Bcl-2 family members: Dual regulators of apoptosis and autophagy
-
Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008; 4:600-6.
-
(2008)
Autophagy
, vol.4
, pp. 600-606
-
-
Levine, B.1
Sinha, S.2
Kroemer, G.3
-
62
-
-
3042562282
-
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
-
DOI 10.1158/0008-5472.CAN-03-3084
-
Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 2004; 64:4286-93. (Pubitemid 38802435)
-
(2004)
Cancer Research
, vol.64
, Issue.12
, pp. 4286-4293
-
-
Daido, S.1
Kanzawa, T.2
Yamamoto, A.3
Takeuchi, H.4
Kondo, Y.5
Kondo, S.6
-
63
-
-
56249108080
-
Ceramide starves cells to death by downregulating nutrient transporter proteins
-
Guenther GG, Peralta ER, Rosales KR, Wong SY, Siskind LJ, Edinger AL. Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc Natl Acad Sci U S A 2008; 105:17402-7.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 17402-17407
-
-
Guenther, G.G.1
Peralta, E.R.2
Rosales, K.R.3
Wong, S.Y.4
Siskind, L.J.5
Edinger, A.L.6
-
64
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
DOI 10.1074/jbc.M506182200
-
Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R, Botti J, Codogno P. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 2006; 281:8518-27. (Pubitemid 43847954)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.13
, pp. 8518-8527
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
65
-
-
73649096618
-
Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation
-
Colie S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N. Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res 2009; 69:9346-53.
-
(2009)
Cancer Res
, vol.69
, pp. 9346-9353
-
-
Colie, S.1
Van Veldhoven, P.P.2
Kedjouar, B.3
Bedia, C.4
Albinet, V.5
Sorli, S.C.6
Garcia, V.7
Djavaheri-Mergny, M.8
Bauvy, C.9
Codogno, P.10
Levade, T.11
Andrieu-Abadie, N.12
-
66
-
-
77953771709
-
Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
-
Serra M, Saba JD. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul 2010; 50:349-62.
-
(2010)
Adv Enzyme Regul
, vol.50
, pp. 349-362
-
-
Serra, M.1
Saba, J.D.2
-
68
-
-
79959886743
-
Complex inhibitory effects of nitric oxide on autophagy
-
Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC. Complex inhibitory effects of nitric oxide on autophagy. Mol Cell 2011; 43:19-32.
-
(2011)
Mol Cell
, vol.43
, pp. 19-32
-
-
Sarkar, S.1
Korolchuk, V.I.2
Renna, M.3
Imarisio, S.4
Fleming, A.5
Williams, A.6
Garcia-Arencibia, M.7
Rose, C.8
Luo, S.9
Underwood, B.R.10
Kroemer, G.11
O'Kane, C.J.12
Rubinsztein, D.C.13
-
69
-
-
49349090155
-
Huntington's disease: Degradation of mutant huntingtin by autophagy
-
Sarkar S, Rubinsztein DC. Huntington's disease: degradation of mutant huntingtin by autophagy. Febs J 2008; 275:4263-70.
-
(2008)
Febs J
, vol.275
, pp. 4263-4270
-
-
Sarkar, S.1
Rubinsztein, D.C.2
-
70
-
-
39749127025
-
Synergistic antiglioma action of hyperthermia and nitric oxide
-
Janjetovic K, Misirkic M, Vucicevic L, Harhaji L, Trajkovic V. Synergistic antiglioma action of hyperthermia and nitric oxide. Eur J Pharmacol 2008; 583:1-10.
-
(2008)
Eur J Pharmacol
, vol.583
, pp. 1-10
-
-
Janjetovic, K.1
Misirkic, M.2
Vucicevic, L.3
Harhaji, L.4
Trajkovic, V.5
-
71
-
-
34047213199
-
Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes
-
DOI 10.1016/j.niox.2006.10.007, PII S1089860306004356
-
Rabkin SW, Klassen SS. Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes. Nitric Oxide 2007; 16:339-47. (Pubitemid 46541669)
-
(2007)
Nitric Oxide - Biology and Chemistry
, vol.16
, Issue.3
, pp. 339-347
-
-
Rabkin, S.W.1
Klassen, S.S.2
-
72
-
-
33748028841
-
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
-
DOI 10.1038/sj.emboj.7601253, PII 7601253
-
Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Graber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, Ellisman MH, Perkins GA, Bossy-Wetzel E. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. Embo J 2006; 25:3900-11. (Pubitemid 44300275)
-
(2006)
EMBO Journal
, vol.25
, Issue.16
, pp. 3900-3911
-
-
Barsoum, M.J.1
Yuan, H.2
Gerencser, A.A.3
Liot, G.4
Kushnareva, Y.5
Graber, S.6
Kovacs, I.7
Lee, W.D.8
Waggoner, J.9
Cui, J.10
White, A.D.11
Bossy, B.12
Martinou, J.-C.13
Youle, R.J.14
Lipton, S.A.15
Ellisman, M.H.16
Perkins, G.A.17
Bossy-Wetzel, E.18
-
73
-
-
33644819311
-
Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: A novel pathway relevant to the pathophysiology of endothelium
-
De Palma C, Meacci E, Perrotta C, Bruni P, Clementi E. Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium. Arterioscler Thromb Vasc Biol 2006; 26:99-105.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 99-105
-
-
De Palma, C.1
Meacci, E.2
Perrotta, C.3
Bruni, P.4
Clementi, E.5
-
74
-
-
77951913548
-
Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide
-
Bethesda
-
Perrotta C, Clementi E. Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide. Physiology (Bethesda) 2010; 25:64-71.
-
(2010)
Physiology
, vol.25
, pp. 64-71
-
-
Perrotta, C.1
Clementi, E.2
-
75
-
-
78649790233
-
Sphingolipids in neurodegeneration
-
Haughey NJ. Sphingolipids in neurodegeneration. Neuromolecular Med 2010; 12:301-5.
-
(2010)
Neuromolecular Med
, vol.12
, pp. 301-305
-
-
Haughey, N.J.1
-
76
-
-
58849160520
-
Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death
-
Jana A, Hogan EL, Pahan K. Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death. J Neurol Sci 2009; 278:5-15.
-
(2009)
J Neurol Sci
, vol.278
, pp. 5-15
-
-
Jana, A.1
Hogan, E.L.2
Pahan, K.3
-
77
-
-
77955088249
-
Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders
-
Piccinini M, Scandroglio F, Prioni S, Buccinna B, Loberto N, Aureli M, Chigomo V, Lupino E, DeMarco G, Lomartire A, Rinaudo MT, Sonnino S, Prinetti A. Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders. Mol Neurobiol 2010; 41:314-40.
-
(2010)
Mol Neurobiol
, vol.41
, pp. 314-340
-
-
Piccinini, M.1
Scandroglio, F.2
Prioni, S.3
Buccinna, B.4
Loberto, N.5
Aureli, M.6
Chigomo, V.7
Lupino, E.8
DeMarco, G.9
Lomartire, A.10
Rinaudo, M.T.11
Sonnino, S.12
Prinetti, A.13
-
78
-
-
84872284081
-
Ceramide function in the brain: When a slight tilt is enough
-
Mencarelli C, Martinez-Martinez P. Ceramide function in the brain: when a slight tilt is enough. Cell Mol Life Sci 2013; 70:181-203.
-
(2013)
Cell Mol Life Sci
, vol.70
, pp. 181-203
-
-
Mencarelli, C.1
Martinez-Martinez, P.2
-
80
-
-
84865049615
-
Sphingolipids: Critical players in Alzheimer's disease
-
van Echten-Deckert G, Walter J. Sphingolipids: critical players in Alzheimer's disease. Prog Lipid Res 2012; 51:378-93.
-
(2012)
Prog Lipid Res
, vol.51
, pp. 378-393
-
-
Van Echten-Deckert, G.1
Walter, J.2
-
81
-
-
33748047499
-
Bioactive sphingolipids in the modulation of the inflammatory response
-
DOI 10.1016/j.pharmthera.2006.04.004, PII S016372580600060X
-
El Alwani M, Wu BX, Obeid LM, Hannun YA. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther 2006; 112:171-83. (Pubitemid 44301491)
-
(2006)
Pharmacology and Therapeutics
, vol.112
, Issue.1
, pp. 171-183
-
-
El, A.M.1
Wu, B.X.2
Obeid, L.M.3
Hannun, Y.A.4
-
82
-
-
77953293446
-
Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation
-
Snider AJ, Orr Gandy KA, Obeid LM. Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie 2010; 92:707-15.
-
(2010)
Biochimie
, vol.92
, pp. 707-715
-
-
Snider, A.J.1
Orr Gandy, K.A.2
Obeid, L.M.3
-
83
-
-
70350133784
-
Sphingolipids in inflammation: Pathological implications and potential therapeutic targets
-
Nixon GF. Sphingolipids in inflammation: pathological implications and potential therapeutic targets. Br J Pharmacol 2009; 158:982-93.
-
(2009)
Br J Pharmacol
, vol.158
, pp. 982-993
-
-
Nixon, G.F.1
-
84
-
-
11144354259
-
PAF-mediated pulmonary edema: A new role for acid sphingomyelinase and ceramide
-
DOI 10.1038/nm977
-
Goggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schutze S, Gulbins E, Uhlig S. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med 2004; 10:155-60. (Pubitemid 38524885)
-
(2004)
Nature Medicine
, vol.10
, Issue.2
, pp. 155-160
-
-
Goggell, R.1
Winoto-Morbach, S.2
Vielhaber, G.3
Imai, Y.4
Lindner, K.5
Brade, L.6
Brade, H.7
Ehlers, S.8
Slutsky, A.S.9
Schutze, S.10
Gulbins, E.11
Uhlig, S.12
-
85
-
-
38749119748
-
Ceramide: A key signaling molecule in a guinea pig model of allergic asthmatic response and airway inflammation
-
DOI 10.1124/jpet.107.131565
-
Masini E, Giannini L, Nistri S, Cinci L, Mastroianni R, Xu W, Comhair SA, Li D, Cuzzocrea S, Matuschak GM, Salvemini D. Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation. J Pharmacol Exp Ther 2008; 324:548-57. (Pubitemid 351185855)
-
(2008)
Journal of Pharmacology and Experimental Therapeutics
, vol.324
, Issue.2
, pp. 548-557
-
-
Masini, E.1
Giannini, L.2
Nistri, S.3
Cinci, L.4
Mastroianni, R.5
Xu, W.6
Comhair, S.A.A.7
Li, D.8
Cuzzocrea, S.9
Matuschak, G.M.10
Salvemini, D.11
-
86
-
-
34547659848
-
Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice
-
Sakata A, Ochiai T, Shimeno H, Hikishima S, Yokomatsu T, Shibuya S, Toda A, Eyanagi R, Soeda S. Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice. Immunology 2007; 122:54-64.
-
(2007)
Immunology
, vol.122
, pp. 54-64
-
-
Sakata, A.1
Ochiai, T.2
Shimeno, H.3
Hikishima, S.4
Yokomatsu, T.5
Shibuya, S.6
Toda, A.7
Eyanagi, R.8
Soeda, S.9
-
87
-
-
84876921937
-
Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia
-
Jung JS, Shin KO, Lee YM, Shin JA, Park EM, Jeong J, Kim DH, Choi JW, Kim HS. Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia. Biochim Biophys Acta 2013;
-
(2013)
Biochim Biophys Acta
-
-
Jung, J.S.1
Shin, K.O.2
Lee, Y.M.3
Shin, J.A.4
Park, E.M.5
Jeong, J.6
Kim, D.H.7
Choi, J.W.8
Kim, H.S.9
-
88
-
-
41849092177
-
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
-
DOI 10.1038/nm1748, PII NM1748
-
Teichgraber V, Ulrich M, Endlich N, Riethmuller J, Wilker B, De Oliveira-Munding CC, van Heeckeren AM, Barr ML, von Kurthy G, Schmid KW, Weller M, Tummler B, Lang F, Grassme H, Doring G, Gulbins E. Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med 2008; 14:382-91. (Pubitemid 351499396)
-
(2008)
Nature Medicine
, vol.14
, Issue.4
, pp. 382-391
-
-
Teichgraber, V.1
Ulrich, M.2
Endlich, N.3
Riethmuller, J.4
Wilker, B.5
De Oliveira-Munding, C.C.6
Van Heeckeren, A.M.7
Barr, M.L.8
Von Kurthy, G.9
Schmid, K.W.10
Weller, M.11
Tummler, B.12
Lang, F.13
Grassme, H.14
Doring, G.15
Gulbins, E.16
-
89
-
-
77953461364
-
The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis
-
Becker KA, Riethmuller J, Zhang Y, Gulbins E. The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis. Open Respir Med J 2010; 4:39-47.
-
(2010)
Open Respir Med J
, vol.4
, pp. 39-47
-
-
Becker, K.A.1
Riethmuller, J.2
Zhang, Y.3
Gulbins, E.4
-
90
-
-
45949095358
-
Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide
-
DOI 10.1189/jlb.0108076
-
Sun Y, Fox T, Adhikary G, Kester M, Pearlman E. Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J Leukoc Biol 2008; 83:1512-21. (Pubitemid 351960333)
-
(2008)
Journal of Leukocyte Biology
, vol.83
, Issue.6
, pp. 1512-1521
-
-
Sun, Y.1
Fox, T.2
Adhikary, G.3
Kester, M.4
Pearlman, E.5
-
91
-
-
78650645373
-
Ceramide and ceramide 1-phosphate are negative regulators of TNF-alpha production induced by lipopolysaccharide
-
Jozefowski S, Czerkies M, Lukasik A, Bielawska A, Bielawski J, Kwiatkowska K, Sobota A. Ceramide and ceramide 1-phosphate are negative regulators of TNF-alpha production induced by lipopolysaccharide. J Immunol 2010; 185:6960-73.
-
(2010)
J Immunol
, vol.185
, pp. 6960-6973
-
-
Jozefowski, S.1
Czerkies, M.2
Lukasik, A.3
Bielawska, A.4
Bielawski, J.5
Kwiatkowska, K.6
Sobota, A.7
-
92
-
-
77954232042
-
Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages
-
Rozenova KA, Deevska GM, Karakashian AA, Nikolova-Karakashian MN. Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages. J Biol Chem 2010; 285:21103-13.
-
(2010)
J Biol Chem
, vol.285
, pp. 21103-21113
-
-
Rozenova, K.A.1
Deevska, G.M.2
Karakashian, A.A.3
Nikolova-Karakashian, M.N.4
-
93
-
-
77956318603
-
Nitric oxide signaling in brain function, dysfunction, and dementia
-
Steinert JR, Chernova T, Forsythe ID. Nitric oxide signaling in brain function, dysfunction, and dementia. Neuroscientist 2010; 16:435-52.
-
(2010)
Neuroscientist
, vol.16
, pp. 435-452
-
-
Steinert, J.R.1
Chernova, T.2
Forsythe, I.D.3
-
94
-
-
38149099884
-
A Golgi fragmentation pathway in neurodegeneration
-
Nakagomi S, Barsoum MJ, Bossy-Wetzel E, Sutterlin C, Malhotra V, Lipton SA. A Golgi fragmentation pathway in neurodegeneration. Neurobiol Dis 2008; 29:221-31.
-
(2008)
Neurobiol Dis
, vol.29
, pp. 221-231
-
-
Nakagomi, S.1
Barsoum, M.J.2
Bossy-Wetzel, E.3
Sutterlin, C.4
Malhotra, V.5
Lipton, S.A.6
-
95
-
-
33947695576
-
Nitric oxide in the injured spinal cord: Synthases cross-talk, oxidative stress and inflammation
-
DOI 10.1016/j.brainresrev.2007.01.013, PII S0165017307000197
-
Conti A, Miscusi M, Cardali S, Germano A, Suzuki H, Cuzzocrea S, Tomasello F. Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation. Brain Res Rev 2007; 54:205-18. (Pubitemid 46498169)
-
(2007)
Brain Research Reviews
, vol.54
, Issue.1
, pp. 205-218
-
-
Conti, A.1
Miscusi, M.2
Cardali, S.3
Germano, A.4
Suzuki, H.5
Cuzzocrea, S.6
Tomasello, F.7
-
96
-
-
74449093467
-
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
-
Nayak D, Huo Y, Kwang WX, Pushparaj PN, Kumar SD, Ling EA, Dheen ST. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience 2010; 166:132-44.
-
(2010)
Neuroscience
, vol.166
, pp. 132-144
-
-
Nayak, D.1
Huo, Y.2
Kwang, W.X.3
Pushparaj, P.N.4
Kumar, S.D.5
Ling, E.A.6
Dheen, S.T.7
-
97
-
-
81155154302
-
Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia
-
Neniskyte U, Neher JJ, Brown GC. Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia. J Biol Chem 2011; 286:39904-13.
-
(2011)
J Biol Chem
, vol.286
, pp. 39904-39913
-
-
Neniskyte, U.1
Neher, J.J.2
Brown, G.C.3
-
98
-
-
84865468329
-
The genetics and neuropathology of Alzheimer's disease
-
Schellenberg GD, Montine TJ. The genetics and neuropathology of Alzheimer's disease. Acta Neuropathol 2012; 124:305-23.
-
(2012)
Acta Neuropathol
, vol.124
, pp. 305-323
-
-
Schellenberg, G.D.1
Montine, T.J.2
-
99
-
-
84872483349
-
Age-related changes of hippocampal synaptic plasticity in AbetaPP-null mice are restored by NGF through p75NTR
-
La Rosa LR, Matrone C, Ferraina C, Panico MB, Piccirilli S, Di Certo MG, Strimpakos G, Mercuri NB, Calissano P, D'Amelio M, Nistico R. Age-related changes of hippocampal synaptic plasticity in AbetaPP-null mice are restored by NGF through p75NTR. J Alzheimers Dis 2013; 33:265-72.
-
(2013)
J Alzheimers Dis
, vol.33
, pp. 265-272
-
-
La Rosa, L.R.1
Matrone, C.2
Ferraina, C.3
Panico, M.B.4
Piccirilli, S.5
Di Certo, M.G.6
Strimpakos, G.7
Mercuri, N.B.8
Calissano, P.9
D'Amelio, M.10
Nistico, R.11
-
100
-
-
78649780371
-
Alterations of the sphingolipid pathway in Alzheimer's disease: New biomarkers and treatment targets?
-
Mielke MM, Lyketsos CG. Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets? Neuromolecular Med 2010; 12:331-40.
-
(2010)
Neuromolecular Med
, vol.12
, pp. 331-340
-
-
Mielke, M.M.1
Lyketsos, C.G.2
-
101
-
-
74149083982
-
Deregulation of sphingolipid metabolism in Alzheimer's disease
-
He X, Huang Y, Li B, Gong CX, Schuchman EH. Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging 2010; 31:398-408.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 398-408
-
-
He, X.1
Huang, Y.2
Li, B.3
Gong, C.X.4
Schuchman, E.H.5
-
102
-
-
84878491154
-
Phospholipids and Alzheimer's disease: Alterations, mechanisms and potential biomarkers
-
Kosicek M, Hecimovic S. Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers. Int J Mol Sci 2013; 14:1310-22.
-
(2013)
Int J Mol Sci
, vol.14
, pp. 1310-1322
-
-
Kosicek, M.1
Hecimovic, S.2
-
103
-
-
1242338183
-
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
-
DOI 10.1073/pnas.0305799101
-
Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci U S A 2004; 101:2070-5. (Pubitemid 38229016)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.7
, pp. 2070-2075
-
-
Cutler, R.G.1
Kelly, J.2
Storie, K.3
Pedersen, W.A.4
Tammara, A.5
Hatanpaa, K.6
Troncoso, J.C.7
Mattson, M.P.8
-
104
-
-
35448979511
-
Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons
-
DOI 10.1111/j.1460-9568.2007.05797.x
-
Patil S, Melrose J, Chan C. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. Eur J Neurosci 2007; 26:2131-41. (Pubitemid 47620475)
-
(2007)
European Journal of Neuroscience
, vol.26
, Issue.8
, pp. 2131-2141
-
-
Patil, S.1
Melrose, J.2
Chan, C.3
-
105
-
-
1642482817
-
Modulation of Amyloid Precursor Protein Cleavage by Cellular Sphingolipids
-
DOI 10.1074/jbc.M309832200
-
Sawamura N, Ko M, Yu W, Zou K, Hanada K, Suzuki T, Gong JS, Yanagisawa K, Michikawa M. Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J Biol Chem 2004; 279:11984-91. (Pubitemid 38401704)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.12
, pp. 11984-11991
-
-
Sawamura, N.1
Ko, M.2
Yu, W.3
Zou, K.4
Hanada, K.5
Suzuki, T.6
Gong, J.-S.7
Yanagisawa, K.8
Michikawa, M.9
-
106
-
-
0037490159
-
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis
-
DOI 10.1074/jbc.M300466200
-
Puglielli L, Ellis BC, Saunders AJ, Kovacs DM. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem 2003; 278:19777-83. (Pubitemid 36799164)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.22
, pp. 19777-19783
-
-
Puglielli, L.1
Ellis, B.C.2
Saunders, A.J.3
Kovacs, D.M.4
-
107
-
-
34248392684
-
Microglial activation and its implications in the brain diseases
-
DOI 10.2174/092986707780597961
-
Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem 2007; 14:1189-97. (Pubitemid 46739320)
-
(2007)
Current Medicinal Chemistry
, vol.14
, Issue.11
, pp. 1189-1197
-
-
Dheen, S.T.1
Kaur, C.2
Ling, E.-A.3
-
108
-
-
9644272489
-
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
-
DOI 10.1074/jbc.M405600200
-
Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Muller-Spahn F, Haass C, Czech C, Pradier L, Muller WE, Eckert A. Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem 2004; 279:50310-20. (Pubitemid 39577847)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.48
, pp. 50310-50320
-
-
Keil, U.1
Bonert, A.2
Marques, C.A.3
Scherping, I.4
Weyermann, J.5
Strosznajder, J.B.6
Muller-Spahn, F.7
Haass, C.8
Czech, C.9
Pradier, L.10
Muller, W.E.11
Eckert, A.12
-
109
-
-
84856053860
-
Nitric oxide in neurodegeneration: Potential benefits of non-steroidal anti-inflammatories
-
Doherty GH. Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories. Neurosci Bull 2011; 27:366-82.
-
(2011)
Neurosci Bull
, vol.27
, pp. 366-382
-
-
Doherty, G.H.1
-
110
-
-
3042586648
-
Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E
-
DOI 10.1016/j.freeradbiomed.2004.04.007, PII S0891584904003107
-
Ayasolla K, Khan M, Singh AK, Singh I. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med 2004; 37:325-38. (Pubitemid 38833999)
-
(2004)
Free Radical Biology and Medicine
, vol.37
, Issue.3
, pp. 325-338
-
-
Ayasolla, K.1
Khan, M.2
Singh, A.K.3
Singh, I.4
-
111
-
-
0028153979
-
Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients
-
DOI 10.1016/0022-510X(94)90155-4
-
Kuiper MA, Visser JJ, Bergmans PL, Scheltens P, Wolters EC. Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients. J Neurol Sci 1994; 121:46-9. (Pubitemid 24025245)
-
(1994)
Journal of the Neurological Sciences
, vol.121
, Issue.1
, pp. 46-49
-
-
Kuiper, M.A.1
Visser, J.J.2
Bergmans, P.L.M.3
Scheltens, P.4
Wolters, E.C.5
-
112
-
-
77955088377
-
Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease
-
Domek-Lopacinska KU, Strosznajder JB. Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease. Mol Neurobiol 2010; 41:129-37.
-
(2010)
Mol Neurobiol
, vol.41
, pp. 129-137
-
-
Domek-Lopacinska, K.U.1
Strosznajder, J.B.2
-
113
-
-
67649342620
-
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model
-
Puzzo D, Staniszewski A, Deng SX, Privitera L, Leznik E, Liu S, Zhang H, Feng Y, Palmeri A, Landry DW, Arancio O. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci 2009; 29:8075-86.
-
(2009)
J Neurosci
, vol.29
, pp. 8075-8086
-
-
Puzzo, D.1
Staniszewski, A.2
Deng, S.X.3
Privitera, L.4
Leznik, E.5
Liu, S.6
Zhang, H.7
Feng, Y.8
Palmeri, A.9
Landry, D.W.10
Arancio, O.11
-
114
-
-
34249937267
-
Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis
-
DOI 10.1002/ana.21115
-
Lunemann JD, Schmidt J, Schmid D, Barthel K, Wrede A, Dalakas MC, Munz C. Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis. Ann Neurol 2007; 61:476-83. (Pubitemid 46878775)
-
(2007)
Annals of Neurology
, vol.61
, Issue.5
, pp. 476-483
-
-
Lunemann, J.D.1
Schmidt, J.2
Schmid, D.3
Barthel, K.4
Wrede, A.5
Dalakas, M.C.6
Munz, C.7
-
115
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008; 118:2190-9.
-
(2008)
J Clin Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
Wyss-Coray, T.11
-
116
-
-
84859743802
-
Autophagy: A double-edged sword in Alzheimer's disease
-
Tung YT, Wang BJ, Hu MK, Hsu WM, Lee H, Huang WP, Liao YF. Autophagy: a double-edged sword in Alzheimer's disease. J Biosci 2012; 37:157-65.
-
(2012)
J Biosci
, vol.37
, pp. 157-165
-
-
Tung, Y.T.1
Wang, B.J.2
Hu, M.K.3
Hsu, W.M.4
Lee, H.5
Huang, W.P.6
Liao, Y.F.7
-
117
-
-
66349120877
-
Autophagy protects neuron from Abeta-induced cytotoxicity
-
Hung SY, Huang WP, Liou HC, Fu WM. Autophagy protects neuron from Abeta-induced cytotoxicity. Autophagy 2009; 5:502-10.
-
(2009)
Autophagy
, vol.5
, pp. 502-510
-
-
Hung, S.Y.1
Huang, W.P.2
Liou, H.C.3
Fu, W.M.4
-
118
-
-
79551552043
-
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation
-
Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J. Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation. J Neurosci 2011; 31:1837-49.
-
(2011)
J Neurosci
, vol.31
, pp. 1837-1849
-
-
Tamboli, I.Y.1
Hampel, H.2
Tien, N.T.3
Tolksdorf, K.4
Breiden, B.5
Mathews, P.M.6
Saftig, P.7
Sandhoff, K.8
Walter, J.9
-
119
-
-
77955629596
-
New therapeutic strategy for Parkinson's and Alzheimer's disease
-
Esposito E, Cuzzocrea S. New therapeutic strategy for Parkinson's and Alzheimer's disease. Curr Med Chem 2010; 17:2764-74.
-
(2010)
Curr Med Chem
, vol.17
, pp. 2764-2774
-
-
Esposito, E.1
Cuzzocrea, S.2
-
120
-
-
84880060576
-
Targeting synaptic dysfunction in Alzheimer's disease therapy
-
Nistico R, Pignatelli M, Piccinin S, Mercuri NB, Collingridge G. Targeting synaptic dysfunction in Alzheimer's disease therapy. Mol Neurobiol 2012; 46:572-87.
-
(2012)
Mol Neurobiol
, vol.46
, pp. 572-587
-
-
Nistico, R.1
Pignatelli, M.2
Piccinin, S.3
Mercuri, N.B.4
Collingridge, G.5
|