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Volumn 27, Issue 2 SUPPL., 2013, Pages 11-22

Nitric oxide and sphingolipids control apoptosis and autophagy with a significant impact on Alzheimer's disease

Author keywords

Alzheimer's disease; Apoptosis; Autophagy; Cell death; Nervous system; Neuroinflammation; Nitric oxide; Sphingolipids

Indexed keywords

CERAMIDE; COPPER ZINC SUPEROXIDE DISMUTASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SPHINGOLIPID;

EID: 84886788013     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (20)

References (120)
  • 1
    • 25144489068 scopus 로고    scopus 로고
    • Overview of cell death signaling pathways
    • Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther 2005; 4:139-63.
    • (2005) Cancer Biol Ther , vol.4 , pp. 139-163
    • Jin, Z.1    El-Deiry, W.S.2
  • 2
    • 84859871133 scopus 로고    scopus 로고
    • Signaling pathways that regulate life and cell death: Evolution of apoptosis in the context of self-defense
    • Munoz-Pinedo C. Signaling pathways that regulate life and cell death: evolution of apoptosis in the context of self-defense. Adv Exp Med Biol 2012; 738:124-43.
    • (2012) Adv Exp Med Biol , vol.738 , pp. 124-143
    • Munoz-Pinedo, C.1
  • 3
    • 69449095860 scopus 로고    scopus 로고
    • Caspases and kinases in a death grip
    • Kurokawa M, Kornbluth S. Caspases and kinases in a death grip. Cell 2009; 138:838-54.
    • (2009) Cell , vol.138 , pp. 838-854
    • Kurokawa, M.1    Kornbluth, S.2
  • 4
    • 79955479863 scopus 로고    scopus 로고
    • Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways
    • Tchikov V, Bertsch U, Fritsch J, Edelmann B, Schutze S. Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways. Eur J Cell Biol 2011; 90:467-75.
    • (2011) Eur J Cell Biol , vol.90 , pp. 467-475
    • Tchikov, V.1    Bertsch, U.2    Fritsch, J.3    Edelmann, B.4    Schutze, S.5
  • 5
    • 79960230433 scopus 로고    scopus 로고
    • Mitochondria in apoptosis: Bcl-2 2 members and mitochondrial dynamics
    • Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 2 members and mitochondrial dynamics. Dev Cell 2011; 21:92-101.
    • (2011) Dev Cell , vol.21 , pp. 92-101
    • Martinou, J.C.1    Youle, R.J.2
  • 6
    • 0034068601 scopus 로고    scopus 로고
    • Mitochondrial control of cell death
    • DOI 10.1038/74994
    • Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000; 6:513-9. (Pubitemid 30305900)
    • (2000) Nature Medicine , vol.6 , Issue.5 , pp. 513-519
    • Kroemer, G.1    Reed, J.C.2
  • 7
    • 0032568954 scopus 로고    scopus 로고
    • Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c
    • DOI 10.1074/jbc.273.26.16589
    • Kuwana T, Smith JJ, Muzio M, Dixit V, Newmeyer DD, Kornbluth S. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem 1998; 273:16589-94. (Pubitemid 28311447)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.26 , pp. 16589-16594
    • Kuwana, T.1    Smith, J.J.2    Muzio, M.3    Dixit, V.4    Newmeyer, D.D.5    Kornbluth, S.6
  • 9
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011; 147:728-41.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 10
    • 80053438277 scopus 로고    scopus 로고
    • Molecular machinery of macroautophagy and its deregulation in diseases
    • Wong AS, Cheung ZH, Ip NY. Molecular machinery of macroautophagy and its deregulation in diseases. Biochim Biophys Acta 2011; 1812:1490-7.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 1490-1497
    • Wong, A.S.1    Cheung, Z.H.2    Ip, N.Y.3
  • 11
    • 38749136302 scopus 로고    scopus 로고
    • Regulation of macroautophagy by mTOR and Beclin 1 complexes
    • DOI 10.1016/j.biochi.2007.08.014, PII S0300908407002283
    • Pattingre S, Espert L, Biard-Piechaczyk M, Codogno P. Regulation of macroautophagy by mTOR and Beclin 1 complexes. Biochimie 2008; 90:313-23. (Pubitemid 351181247)
    • (2008) Biochimie , vol.90 , Issue.2 , pp. 313-323
    • Pattingre, S.1    Espert, L.2    Biard-Piechaczyk, M.3    Codogno, P.4
  • 12
    • 77951221542 scopus 로고    scopus 로고
    • The role of the Atg1/ULK1 complex in autophagy regulation
    • Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010; 22:132-9.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 132-139
    • Mizushima, N.1
  • 14
    • 67549110195 scopus 로고    scopus 로고
    • A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
    • Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 2009; 5:649-62.
    • (2009) Autophagy , vol.5 , pp. 649-662
    • Mercer, C.A.1    Kaliappan, A.2    Dennis, P.B.3
  • 19
    • 0034329742 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disorders
    • Mattson MP. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 2000; 1:120-9.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 120-129
    • Mattson, M.P.1
  • 20
    • 65549099222 scopus 로고    scopus 로고
    • All-you-can-eat: Autophagy in neurodegeneration and neuroprotection
    • Jaeger PA, Wyss-Coray T. All-you-can-eat: autophagy in neurodegeneration and neuroprotection. Mol Neurodegener 2009; 4:16.
    • (2009) Mol Neurodegener , vol.4 , pp. 16
    • Jaeger, P.A.1    Wyss-Coray, T.2
  • 21
    • 84857700077 scopus 로고    scopus 로고
    • Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: To die or not to die - that is the question
    • Rosello A, Warnes G, Meier UC. Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die - that is the question. Clin Exp Immunol 2012; 168:52-7.
    • (2012) Clin Exp Immunol , vol.168 , pp. 52-57
    • Rosello, A.1    Warnes, G.2    Meier, U.C.3
  • 22
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • DOI 10.1042/0264-6021:3570593
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357:593-615. (Pubitemid 32735142)
    • (2001) Biochemical Journal , vol.357 , Issue.3 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 23
    • 77955085839 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration and mechanisms of microglial killing of neurons
    • Brown GC, Neher JJ. Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 2010; 41:242-7.
    • (2010) Mol Neurobiol , vol.41 , pp. 242-247
    • Brown, G.C.1    Neher, J.J.2
  • 24
    • 0038486928 scopus 로고    scopus 로고
    • Protein interactions with nitric oxide synthases: Controlling the right time, the right place, and the right amount of nitric oxide
    • Kone BC, Kuncewicz T, Zhang W, Yu ZY. Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Am J Physiol Renal Physiol 2003; 285:F178-90. (Pubitemid 36871190)
    • (2003) American Journal of Physiology - Renal Physiology , vol.285 , Issue.2
    • Kone, B.C.1    Kuncewicz, T.2    Zhang, W.3    Yu, Z.-Y.4
  • 27
    • 0034687690 scopus 로고    scopus 로고
    • Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells
    • Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF. Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. Proc Natl Acad Sci U S A 2000;97:14334-9.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14334-14339
    • Felley-Bosco, E.1    Bender, F.C.2    Courjault-Gautier, F.3    Bron, C.4    Quest, A.F.5
  • 28
    • 0021443856 scopus 로고
    • Inositol trisphosphate and diacylglycerol as second messengers
    • Berridge MJ. Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 1984; 220:345-60.
    • (1984) Biochem J , vol.220 , pp. 345-360
    • Berridge, M.J.1
  • 29
    • 33845320488 scopus 로고    scopus 로고
    • Intracellular trafficking of sphingolipids: Relationship to biosynthesis
    • Futerman AH. Intracellular trafficking of sphingolipids: relationship to biosynthesis. Biochim Biophys Acta 2006; 1758:1885-92.
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1885-1892
    • Futerman, A.H.1
  • 30
    • 0023555012 scopus 로고
    • 3 pituitary cells
    • Kolesnick RN. 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J Biol Chem 1987; 262:16759-62. (Pubitemid 18019025)
    • (1987) Journal of Biological Chemistry , vol.262 , Issue.35 , pp. 16759-16762
    • Kolesnick, R.N.1
  • 31
    • 0024521516 scopus 로고
    • Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells
    • Kolesnick RN. Sphingomyelinase action inhibits phorbol ester-induced differentiation of human promyelocytic leukemic (HL-60) cells. J Biol Chem 1989; 264:7617-23. (Pubitemid 19119181)
    • (1989) Journal of Biological Chemistry , vol.264 , Issue.13 , pp. 7617-7623
    • Kolesnick, R.N.1
  • 32
    • 0025003424 scopus 로고
    • Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
    • Okazaki T, Bielawska A, Bell RM, Hannun YA. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem 1990; 265:15823-31.
    • (1990) J Biol Chem , vol.265 , pp. 15823-15831
    • Okazaki, T.1    Bielawska, A.2    Bell, R.M.3    Hannun, Y.A.4
  • 34
    • 77954709548 scopus 로고    scopus 로고
    • The acid sphingomyelinase/ceramide pathway: Biomedical significance and mechanisms of regulation
    • Zeidan YH, Hannun YA. The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med 2010; 10:454-66.
    • (2010) Curr Mol Med , vol.10 , pp. 454-466
    • Zeidan, Y.H.1    Hannun, Y.A.2
  • 37
    • 45249095327 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: A link between inflammation and neuroprotection
    • DOI 10.1111/j.1471-4159.2008.05351.x
    • De Palma C, Falcone S, Panzeri C, Radice S, Bassi MT, Clementi E. Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection. J Neurochem 2008; 106:193-204. (Pubitemid 351840202)
    • (2008) Journal of Neurochemistry , vol.106 , Issue.1 , pp. 193-204
    • De Palma, C.1    Falcone, S.2    Panzeri, C.3    Radice, S.4    Bassi, M.T.5    Clementi, E.6
  • 38
    • 77956012154 scopus 로고    scopus 로고
    • Nitric oxide and neuronal death
    • Brown GC. Nitric oxide and neuronal death. Nitric Oxide 2010; 23:153-65.
    • (2010) Nitric Oxide , vol.23 , pp. 153-165
    • Brown, G.C.1
  • 39
    • 36749005178 scopus 로고    scopus 로고
    • Mechanisms of inflammatory neurodegeneration: INOS and NADPH oxidase
    • DOI 10.1042/BST0351119
    • Brown GC. Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochem Soc Trans 2007; 35:1119-21. (Pubitemid 350206442)
    • (2007) Biochemical Society Transactions , vol.35 , Issue.5 , pp. 1119-1121
    • Brown, G.C.1
  • 40
    • 0042665423 scopus 로고    scopus 로고
    • Nitric oxide: NO apoptosis or turning it ON?
    • DOI 10.1038/sj.cdd.4401261
    • Brune B. Nitric oxide: NO apoptosis or turning it ON? Cell Death Differ 2003; 10:864-9. (Pubitemid 36939696)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.8 , pp. 864-869
    • Brune, B.1
  • 41
    • 0035794181 scopus 로고    scopus 로고
    • Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death
    • Bulotta S, Barsacchi R, Rotiroti D, Borgese N, Clementi E. Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death. J Biol Chem 2001; 276:6529-36.
    • (2001) J Biol Chem , vol.276 , pp. 6529-6536
    • Bulotta, S.1    Barsacchi, R.2    Rotiroti, D.3    Borgese, N.4    Clementi, E.5
  • 42
    • 0037382346 scopus 로고    scopus 로고
    • Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: A novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt
    • DOI 10.1124/mol.63.4.886
    • Barsacchi R, Perrotta C, Bulotta S, Moncada S, Borgese N, Clementi E. Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt. Mol Pharmacol 2003; 63:886-95. (Pubitemid 36368996)
    • (2003) Molecular Pharmacology , vol.63 , Issue.4 , pp. 886-895
    • Barsacchi, R.1    Perrotta, C.2    Bulotta, S.3    Moncada, S.4    Borgese, N.5    Clementi, E.6
  • 43
    • 0033179393 scopus 로고    scopus 로고
    • Generation of nitric oxide by the inducible nitric oxide synthase protects gammadelta T cells from Mycobacterium tuberculosis-induced apoptosis
    • Sciorati C, Rovere P, Ferrarini M, Paolucci C, Heltai S, Vaiani R, Clementi E, Manfredi AA. Generation of nitric oxide by the inducible nitric oxide synthase protects gamma delta T cells from Mycobacterium tuberculosis-induced apoptosis. J Immunol 1999; 163:1570-6. (Pubitemid 29352781)
    • (1999) Journal of Immunology , vol.163 , Issue.3 , pp. 1570-1576
    • Sciorati, C.1    Rovere, P.2    Ferrarini, M.3    Paolucci, C.4    Heltai, S.5    Vaiani, R.6    Clementi, E.7    Manfredi, A.A.8
  • 45
    • 4644327020 scopus 로고    scopus 로고
    • Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3′,5′-monophosphate pathway: Key events in Escherichia coli-elicited apoptosis of dendritic cells
    • Falcone S, Perrotta C, De Palma C, Pisconti A, Sciorati C, Capobianco A, Rovere-Querini P, Manfredi AA, Clementi E. Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3′,5′- monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol 2004; 173:4452-63. (Pubitemid 39280675)
    • (2004) Journal of Immunology , vol.173 , Issue.7 , pp. 4452-4463
    • Falcone, S.1    Perrotta, C.2    De Palma, C.3    Pisconti, A.4    Sciorati, C.5    Capobianco, A.6    Rovere-Querini, P.7    Manfredi, A.A.8    Clementi, E.9
  • 49
    • 0037401647 scopus 로고    scopus 로고
    • Regulation of death receptor signaling and apoptosis by ceramide
    • DOI 10.1016/S1043-6618(03)00052-5, PII S1043661803000525
    • Gulbins E. Regulation of death receptor signaling and apoptosis by ceramide. Pharmacol Res 2003; 47:393-9. (Pubitemid 36379201)
    • (2003) Pharmacological Research , vol.47 , Issue.5 , pp. 393-399
    • Gulbins, E.1
  • 50
    • 2342570273 scopus 로고    scopus 로고
    • Acid and neutral sphingomyelinases: Roles and mechanisms of regulation
    • DOI 10.1139/o03-091
    • Marchesini N, Hannun YA. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol 2004; 82:27-44. (Pubitemid 38580872)
    • (2004) Biochemistry and Cell Biology , vol.82 , Issue.1 , pp. 27-44
    • Marchesini, N.1    Hannun, Y.A.2
  • 52
    • 0033537839 scopus 로고    scopus 로고
    • Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3
    • Takeda Y, Tashima M, Takahashi A, Uchiyama T, Okazaki T. Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J Biol Chem 1999; 274:10654-60.
    • (1999) J Biol Chem , vol.274 , pp. 10654-10660
    • Takeda, Y.1    Tashima, M.2    Takahashi, A.3    Uchiyama, T.4    Okazaki, T.5
  • 53
    • 0346577312 scopus 로고    scopus 로고
    • NO Induced Apoptosis of Vascular Smooth Muscle Cells Accompanied by Ceramide Increase
    • DOI 10.1002/jcp.10464
    • Pilane CM, LaBelle EF. NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. J Cell Physiol 2004; 199:310-5. (Pubitemid 38436757)
    • (2004) Journal of Cellular Physiology , vol.199 , Issue.2 , pp. 310-315
    • Pilane, C.M.1    Labelle, E.F.2
  • 54
    • 33846691177 scopus 로고    scopus 로고
    • Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: A novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis
    • DOI 10.1016/j.yexcr.2006.12.001, PII S0014482706004897
    • Castillo SS, Levy M, Wang C, Thaikoottathil JV, Khan E, Goldkorn T. Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis. Exp Cell Res 2007; 313:816-23. (Pubitemid 46198824)
    • (2007) Experimental Cell Research , vol.313 , Issue.4 , pp. 816-823
    • Castillo, S.S.1    Levy, M.2    Wang, C.3    Thaikoottathil, J.V.4    Khan, E.5    Goldkorn, T.6
  • 55
    • 21644455318 scopus 로고    scopus 로고
    • Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids
    • DOI 10.1002/jcp.20298
    • Pilane CM, Labelle EF. Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids. J Cell Physiol 2005; 204:423-7. (Pubitemid 40934636)
    • (2005) Journal of Cellular Physiology , vol.204 , Issue.2 , pp. 423-427
    • Pilane, C.M.1    LaBelle, E.F.2
  • 56
    • 82455175863 scopus 로고    scopus 로고
    • Interaction of the nitric oxide signaling system with the sphingomyelin cycle and peroxidation on transmission of toxic signal of tumor necrosis factor-alpha in ischemia-reperfusion
    • Mosc
    • Shupik MA, Vanin AF, Alessenko AV. Interaction of the nitric oxide signaling system with the sphingomyelin cycle and peroxidation on transmission of toxic signal of tumor necrosis factor-alpha in ischemia-reperfusion. Biochemistry (Mosc) 2011; 76:1197-209.
    • (2011) Biochemistry , vol.76 , pp. 1197-1209
    • Shupik, M.A.1    Vanin, A.F.2    Alessenko, A.V.3
  • 57
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria and oxidative stress: Cross-talk and redox signalling
    • Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 2012; 441:523-40.
    • (2012) Biochem J , vol.441 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 58
    • 33846192839 scopus 로고    scopus 로고
    • Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?
    • Lavieu G, Scarlatti F, Sala G, Levade T, Ghidoni R, Botti J, Codogno P. Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? Autophagy 2007; 3:45-7. (Pubitemid 46100712)
    • (2007) Autophagy , vol.3 , Issue.1 , pp. 45-47
    • Lavieu, G.1    Scarlatti, F.2    Sala, G.3    Levade, T.4    Ghidoni, R.5    Botti, J.6    Codogno, P.7
  • 59
  • 60
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
    • DOI 10.1016/j.molcel.2008.06.001, PII S1097276508003894
    • Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30:678-88. (Pubitemid 351818252)
    • (2008) Molecular Cell , vol.30 , Issue.6 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 61
    • 48249092267 scopus 로고    scopus 로고
    • Bcl-2 family members: Dual regulators of apoptosis and autophagy
    • Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008; 4:600-6.
    • (2008) Autophagy , vol.4 , pp. 600-606
    • Levine, B.1    Sinha, S.2    Kroemer, G.3
  • 62
    • 3042562282 scopus 로고    scopus 로고
    • Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells
    • DOI 10.1158/0008-5472.CAN-03-3084
    • Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 2004; 64:4286-93. (Pubitemid 38802435)
    • (2004) Cancer Research , vol.64 , Issue.12 , pp. 4286-4293
    • Daido, S.1    Kanzawa, T.2    Yamamoto, A.3    Takeuchi, H.4    Kondo, Y.5    Kondo, S.6
  • 66
    • 77953771709 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function
    • Serra M, Saba JD. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul 2010; 50:349-62.
    • (2010) Adv Enzyme Regul , vol.50 , pp. 349-362
    • Serra, M.1    Saba, J.D.2
  • 69
    • 49349090155 scopus 로고    scopus 로고
    • Huntington's disease: Degradation of mutant huntingtin by autophagy
    • Sarkar S, Rubinsztein DC. Huntington's disease: degradation of mutant huntingtin by autophagy. Febs J 2008; 275:4263-70.
    • (2008) Febs J , vol.275 , pp. 4263-4270
    • Sarkar, S.1    Rubinsztein, D.C.2
  • 71
    • 34047213199 scopus 로고    scopus 로고
    • Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes
    • DOI 10.1016/j.niox.2006.10.007, PII S1089860306004356
    • Rabkin SW, Klassen SS. Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes. Nitric Oxide 2007; 16:339-47. (Pubitemid 46541669)
    • (2007) Nitric Oxide - Biology and Chemistry , vol.16 , Issue.3 , pp. 339-347
    • Rabkin, S.W.1    Klassen, S.S.2
  • 73
    • 33644819311 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: A novel pathway relevant to the pathophysiology of endothelium
    • De Palma C, Meacci E, Perrotta C, Bruni P, Clementi E. Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium. Arterioscler Thromb Vasc Biol 2006; 26:99-105.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 99-105
    • De Palma, C.1    Meacci, E.2    Perrotta, C.3    Bruni, P.4    Clementi, E.5
  • 74
    • 77951913548 scopus 로고    scopus 로고
    • Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide
    • Bethesda
    • Perrotta C, Clementi E. Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide. Physiology (Bethesda) 2010; 25:64-71.
    • (2010) Physiology , vol.25 , pp. 64-71
    • Perrotta, C.1    Clementi, E.2
  • 75
    • 78649790233 scopus 로고    scopus 로고
    • Sphingolipids in neurodegeneration
    • Haughey NJ. Sphingolipids in neurodegeneration. Neuromolecular Med 2010; 12:301-5.
    • (2010) Neuromolecular Med , vol.12 , pp. 301-305
    • Haughey, N.J.1
  • 76
    • 58849160520 scopus 로고    scopus 로고
    • Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death
    • Jana A, Hogan EL, Pahan K. Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death. J Neurol Sci 2009; 278:5-15.
    • (2009) J Neurol Sci , vol.278 , pp. 5-15
    • Jana, A.1    Hogan, E.L.2    Pahan, K.3
  • 78
    • 84872284081 scopus 로고    scopus 로고
    • Ceramide function in the brain: When a slight tilt is enough
    • Mencarelli C, Martinez-Martinez P. Ceramide function in the brain: when a slight tilt is enough. Cell Mol Life Sci 2013; 70:181-203.
    • (2013) Cell Mol Life Sci , vol.70 , pp. 181-203
    • Mencarelli, C.1    Martinez-Martinez, P.2
  • 80
    • 84865049615 scopus 로고    scopus 로고
    • Sphingolipids: Critical players in Alzheimer's disease
    • van Echten-Deckert G, Walter J. Sphingolipids: critical players in Alzheimer's disease. Prog Lipid Res 2012; 51:378-93.
    • (2012) Prog Lipid Res , vol.51 , pp. 378-393
    • Van Echten-Deckert, G.1    Walter, J.2
  • 81
    • 33748047499 scopus 로고    scopus 로고
    • Bioactive sphingolipids in the modulation of the inflammatory response
    • DOI 10.1016/j.pharmthera.2006.04.004, PII S016372580600060X
    • El Alwani M, Wu BX, Obeid LM, Hannun YA. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther 2006; 112:171-83. (Pubitemid 44301491)
    • (2006) Pharmacology and Therapeutics , vol.112 , Issue.1 , pp. 171-183
    • El, A.M.1    Wu, B.X.2    Obeid, L.M.3    Hannun, Y.A.4
  • 82
    • 77953293446 scopus 로고    scopus 로고
    • Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation
    • Snider AJ, Orr Gandy KA, Obeid LM. Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie 2010; 92:707-15.
    • (2010) Biochimie , vol.92 , pp. 707-715
    • Snider, A.J.1    Orr Gandy, K.A.2    Obeid, L.M.3
  • 83
    • 70350133784 scopus 로고    scopus 로고
    • Sphingolipids in inflammation: Pathological implications and potential therapeutic targets
    • Nixon GF. Sphingolipids in inflammation: pathological implications and potential therapeutic targets. Br J Pharmacol 2009; 158:982-93.
    • (2009) Br J Pharmacol , vol.158 , pp. 982-993
    • Nixon, G.F.1
  • 86
    • 34547659848 scopus 로고    scopus 로고
    • Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice
    • Sakata A, Ochiai T, Shimeno H, Hikishima S, Yokomatsu T, Shibuya S, Toda A, Eyanagi R, Soeda S. Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium-induced colitis in mice. Immunology 2007; 122:54-64.
    • (2007) Immunology , vol.122 , pp. 54-64
    • Sakata, A.1    Ochiai, T.2    Shimeno, H.3    Hikishima, S.4    Yokomatsu, T.5    Shibuya, S.6    Toda, A.7    Eyanagi, R.8    Soeda, S.9
  • 89
    • 77953461364 scopus 로고    scopus 로고
    • The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis
    • Becker KA, Riethmuller J, Zhang Y, Gulbins E. The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis. Open Respir Med J 2010; 4:39-47.
    • (2010) Open Respir Med J , vol.4 , pp. 39-47
    • Becker, K.A.1    Riethmuller, J.2    Zhang, Y.3    Gulbins, E.4
  • 90
    • 45949095358 scopus 로고    scopus 로고
    • Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide
    • DOI 10.1189/jlb.0108076
    • Sun Y, Fox T, Adhikary G, Kester M, Pearlman E. Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J Leukoc Biol 2008; 83:1512-21. (Pubitemid 351960333)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.6 , pp. 1512-1521
    • Sun, Y.1    Fox, T.2    Adhikary, G.3    Kester, M.4    Pearlman, E.5
  • 91
    • 78650645373 scopus 로고    scopus 로고
    • Ceramide and ceramide 1-phosphate are negative regulators of TNF-alpha production induced by lipopolysaccharide
    • Jozefowski S, Czerkies M, Lukasik A, Bielawska A, Bielawski J, Kwiatkowska K, Sobota A. Ceramide and ceramide 1-phosphate are negative regulators of TNF-alpha production induced by lipopolysaccharide. J Immunol 2010; 185:6960-73.
    • (2010) J Immunol , vol.185 , pp. 6960-6973
    • Jozefowski, S.1    Czerkies, M.2    Lukasik, A.3    Bielawska, A.4    Bielawski, J.5    Kwiatkowska, K.6    Sobota, A.7
  • 92
    • 77954232042 scopus 로고    scopus 로고
    • Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages
    • Rozenova KA, Deevska GM, Karakashian AA, Nikolova-Karakashian MN. Studies on the role of acid sphingomyelinase and ceramide in the regulation of tumor necrosis factor alpha (TNFalpha)-converting enzyme activity and TNFalpha secretion in macrophages. J Biol Chem 2010; 285:21103-13.
    • (2010) J Biol Chem , vol.285 , pp. 21103-21113
    • Rozenova, K.A.1    Deevska, G.M.2    Karakashian, A.A.3    Nikolova-Karakashian, M.N.4
  • 93
    • 77956318603 scopus 로고    scopus 로고
    • Nitric oxide signaling in brain function, dysfunction, and dementia
    • Steinert JR, Chernova T, Forsythe ID. Nitric oxide signaling in brain function, dysfunction, and dementia. Neuroscientist 2010; 16:435-52.
    • (2010) Neuroscientist , vol.16 , pp. 435-452
    • Steinert, J.R.1    Chernova, T.2    Forsythe, I.D.3
  • 95
    • 33947695576 scopus 로고    scopus 로고
    • Nitric oxide in the injured spinal cord: Synthases cross-talk, oxidative stress and inflammation
    • DOI 10.1016/j.brainresrev.2007.01.013, PII S0165017307000197
    • Conti A, Miscusi M, Cardali S, Germano A, Suzuki H, Cuzzocrea S, Tomasello F. Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation. Brain Res Rev 2007; 54:205-18. (Pubitemid 46498169)
    • (2007) Brain Research Reviews , vol.54 , Issue.1 , pp. 205-218
    • Conti, A.1    Miscusi, M.2    Cardali, S.3    Germano, A.4    Suzuki, H.5    Cuzzocrea, S.6    Tomasello, F.7
  • 96
    • 74449093467 scopus 로고    scopus 로고
    • Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
    • Nayak D, Huo Y, Kwang WX, Pushparaj PN, Kumar SD, Ling EA, Dheen ST. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience 2010; 166:132-44.
    • (2010) Neuroscience , vol.166 , pp. 132-144
    • Nayak, D.1    Huo, Y.2    Kwang, W.X.3    Pushparaj, P.N.4    Kumar, S.D.5    Ling, E.A.6    Dheen, S.T.7
  • 97
    • 81155154302 scopus 로고    scopus 로고
    • Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia
    • Neniskyte U, Neher JJ, Brown GC. Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia. J Biol Chem 2011; 286:39904-13.
    • (2011) J Biol Chem , vol.286 , pp. 39904-39913
    • Neniskyte, U.1    Neher, J.J.2    Brown, G.C.3
  • 98
    • 84865468329 scopus 로고    scopus 로고
    • The genetics and neuropathology of Alzheimer's disease
    • Schellenberg GD, Montine TJ. The genetics and neuropathology of Alzheimer's disease. Acta Neuropathol 2012; 124:305-23.
    • (2012) Acta Neuropathol , vol.124 , pp. 305-323
    • Schellenberg, G.D.1    Montine, T.J.2
  • 100
    • 78649780371 scopus 로고    scopus 로고
    • Alterations of the sphingolipid pathway in Alzheimer's disease: New biomarkers and treatment targets?
    • Mielke MM, Lyketsos CG. Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets? Neuromolecular Med 2010; 12:331-40.
    • (2010) Neuromolecular Med , vol.12 , pp. 331-340
    • Mielke, M.M.1    Lyketsos, C.G.2
  • 101
    • 74149083982 scopus 로고    scopus 로고
    • Deregulation of sphingolipid metabolism in Alzheimer's disease
    • He X, Huang Y, Li B, Gong CX, Schuchman EH. Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging 2010; 31:398-408.
    • (2010) Neurobiol Aging , vol.31 , pp. 398-408
    • He, X.1    Huang, Y.2    Li, B.3    Gong, C.X.4    Schuchman, E.H.5
  • 102
    • 84878491154 scopus 로고    scopus 로고
    • Phospholipids and Alzheimer's disease: Alterations, mechanisms and potential biomarkers
    • Kosicek M, Hecimovic S. Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers. Int J Mol Sci 2013; 14:1310-22.
    • (2013) Int J Mol Sci , vol.14 , pp. 1310-1322
    • Kosicek, M.1    Hecimovic, S.2
  • 104
    • 35448979511 scopus 로고    scopus 로고
    • Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons
    • DOI 10.1111/j.1460-9568.2007.05797.x
    • Patil S, Melrose J, Chan C. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. Eur J Neurosci 2007; 26:2131-41. (Pubitemid 47620475)
    • (2007) European Journal of Neuroscience , vol.26 , Issue.8 , pp. 2131-2141
    • Patil, S.1    Melrose, J.2    Chan, C.3
  • 106
    • 0037490159 scopus 로고    scopus 로고
    • Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis
    • DOI 10.1074/jbc.M300466200
    • Puglielli L, Ellis BC, Saunders AJ, Kovacs DM. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem 2003; 278:19777-83. (Pubitemid 36799164)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.22 , pp. 19777-19783
    • Puglielli, L.1    Ellis, B.C.2    Saunders, A.J.3    Kovacs, D.M.4
  • 107
    • 34248392684 scopus 로고    scopus 로고
    • Microglial activation and its implications in the brain diseases
    • DOI 10.2174/092986707780597961
    • Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem 2007; 14:1189-97. (Pubitemid 46739320)
    • (2007) Current Medicinal Chemistry , vol.14 , Issue.11 , pp. 1189-1197
    • Dheen, S.T.1    Kaur, C.2    Ling, E.-A.3
  • 109
    • 84856053860 scopus 로고    scopus 로고
    • Nitric oxide in neurodegeneration: Potential benefits of non-steroidal anti-inflammatories
    • Doherty GH. Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories. Neurosci Bull 2011; 27:366-82.
    • (2011) Neurosci Bull , vol.27 , pp. 366-382
    • Doherty, G.H.1
  • 110
    • 3042586648 scopus 로고    scopus 로고
    • Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E
    • DOI 10.1016/j.freeradbiomed.2004.04.007, PII S0891584904003107
    • Ayasolla K, Khan M, Singh AK, Singh I. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med 2004; 37:325-38. (Pubitemid 38833999)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.3 , pp. 325-338
    • Ayasolla, K.1    Khan, M.2    Singh, A.K.3    Singh, I.4
  • 111
    • 0028153979 scopus 로고
    • Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients
    • DOI 10.1016/0022-510X(94)90155-4
    • Kuiper MA, Visser JJ, Bergmans PL, Scheltens P, Wolters EC. Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients. J Neurol Sci 1994; 121:46-9. (Pubitemid 24025245)
    • (1994) Journal of the Neurological Sciences , vol.121 , Issue.1 , pp. 46-49
    • Kuiper, M.A.1    Visser, J.J.2    Bergmans, P.L.M.3    Scheltens, P.4    Wolters, E.C.5
  • 112
    • 77955088377 scopus 로고    scopus 로고
    • Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease
    • Domek-Lopacinska KU, Strosznajder JB. Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease. Mol Neurobiol 2010; 41:129-37.
    • (2010) Mol Neurobiol , vol.41 , pp. 129-137
    • Domek-Lopacinska, K.U.1    Strosznajder, J.B.2
  • 117
    • 66349120877 scopus 로고    scopus 로고
    • Autophagy protects neuron from Abeta-induced cytotoxicity
    • Hung SY, Huang WP, Liou HC, Fu WM. Autophagy protects neuron from Abeta-induced cytotoxicity. Autophagy 2009; 5:502-10.
    • (2009) Autophagy , vol.5 , pp. 502-510
    • Hung, S.Y.1    Huang, W.P.2    Liou, H.C.3    Fu, W.M.4
  • 119
    • 77955629596 scopus 로고    scopus 로고
    • New therapeutic strategy for Parkinson's and Alzheimer's disease
    • Esposito E, Cuzzocrea S. New therapeutic strategy for Parkinson's and Alzheimer's disease. Curr Med Chem 2010; 17:2764-74.
    • (2010) Curr Med Chem , vol.17 , pp. 2764-2774
    • Esposito, E.1    Cuzzocrea, S.2


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