-
1
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
-
J.P. Anderson, D.E. Walker, J.M. Goldstein, R. de Laat, K. Banducci, R.J. Caccavello, R. Barbour, J. Huang, K. Kling, and M. Lee Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease J. Biol. Chem. 281 2006 29739 29752
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 29739-29752
-
-
Anderson, J.P.1
Walker, D.E.2
Goldstein, J.M.3
De Laat, R.4
Banducci, K.5
Caccavello, R.J.6
Barbour, R.7
Huang, J.8
Kling, K.9
Lee, M.10
-
2
-
-
4644290985
-
Alpha-synuclein locus duplication as a cause of familial Parkinson's disease
-
M.-C. Chartier-Harlin, J. Kachergus, C. Roumier, V. Mouroux, X. Douay, S. Lincoln, C. Levecque, L. Larvor, J. Andrieux, and M. Hulihan Alpha-synuclein locus duplication as a cause of familial Parkinson's disease Lancet 364 2004 1167 1169
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.-C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Larvor, L.8
Andrieux, J.9
Hulihan, M.10
-
3
-
-
77949874828
-
Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation
-
C. Chatterjee, R.K. McGinty, B. Fierz, and T.W. Muir Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation Nat. Chem. Biol. 6 2010 267 269
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 267-269
-
-
Chatterjee, C.1
McGinty, R.K.2
Fierz, B.3
Muir, T.W.4
-
4
-
-
77949875253
-
Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis
-
J. Chen, Y. Ai, J. Wang, L. Haracska, and Z. Zhuang Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis Nat. Chem. Biol. 6 2010 270 272
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 270-272
-
-
Chen, J.1
Ai, Y.2
Wang, J.3
Haracska, L.4
Zhuang, Z.5
-
5
-
-
33744544785
-
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein
-
V. Dorval, and P.E. Fraser Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein J. Biol. Chem. 281 2006 9919 9924
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 9919-9924
-
-
Dorval, V.1
Fraser, P.E.2
-
6
-
-
65249185574
-
Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence
-
A.C.M. Ferreon, Y. Gambin, E.A. Lemke, and A.A. Deniz Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence Proc. Natl. Acad. Sci. USA 106 2009 5645 5650
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 5645-5650
-
-
Ferreon, A.C.M.1
Gambin, Y.2
Lemke, E.A.3
Deniz, A.A.4
-
7
-
-
33749841522
-
The aggregation and fibrillation of α-synuclein
-
A.L. Fink The aggregation and fibrillation of α-synuclein Acc. Chem. Res. 39 2006 628 634
-
(2006)
Acc. Chem. Res.
, vol.39
, pp. 628-634
-
-
Fink, A.L.1
-
9
-
-
58149380718
-
Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement
-
C.C. Jao, B.G. Hegde, J. Chen, I.S. Haworth, and R. Langen Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement Proc. Natl. Acad. Sci. USA 105 2008 19666 19671
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19666-19671
-
-
Jao, C.C.1
Hegde, B.G.2
Chen, J.3
Haworth, I.S.4
Langen, R.5
-
10
-
-
79959855550
-
Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation
-
Y.M. Kim, W.H. Jang, M.M. Quezado, Y. Oh, K.C. Chung, E. Junn, and M.M. Mouradian Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation J. Neurol. Sci. 307 2011 157 161
-
(2011)
J. Neurol. Sci.
, vol.307
, pp. 157-161
-
-
Kim, Y.M.1
Jang, W.H.2
Quezado, M.M.3
Oh, Y.4
Chung, K.C.5
Junn, E.6
Mouradian, M.M.7
-
11
-
-
40549090917
-
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death
-
J.T. Lee, T.C. Wheeler, L. Li, and L.S. Chin Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death Hum. Mol. Genet. 17 2008 906 917
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 906-917
-
-
Lee, J.T.1
Wheeler, T.C.2
Li, L.3
Chin, L.S.4
-
12
-
-
11144358336
-
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease
-
E. Liani, A. Eyal, E. Avraham, R. Shemer, R. Szargel, D. Berg, A. Bornemann, O. Riess, C.A. Ross, R. Rott, and S. Engelender Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease Proc. Natl. Acad. Sci. USA 101 2004 5500 5505
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 5500-5505
-
-
Liani, E.1
Eyal, A.2
Avraham, E.3
Shemer, R.4
Szargel, R.5
Berg, D.6
Bornemann, A.7
Riess, O.8
Ross, C.A.9
Rott, R.10
Engelender, S.11
-
13
-
-
84869109864
-
Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
K.C. Luk, V. Kehm, J. Carroll, B. Zhang, P. O'Brien, J.Q. Trojanowski, and V.M.Y. Lee Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice Science 338 2012 949 953
-
(2012)
Science
, vol.338
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
Zhang, B.4
O'Brien, P.5
Trojanowski, J.Q.6
Lee, V.M.Y.7
-
14
-
-
77957245642
-
Genetic mouse models of Parkinson's disease the state of the art
-
I. Magen, and M.-F. Chesselet Genetic mouse models of Parkinson's disease the state of the art Prog. Brain Res. 184 2010 53 87
-
(2010)
Prog. Brain Res.
, vol.184
, pp. 53-87
-
-
Magen, I.1
Chesselet, M.-F.2
-
15
-
-
84859142134
-
Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation
-
F. Meier, T. Abeywardana, A. Dhall, N.P. Marotta, J. Varkey, R. Langen, C. Chatterjee, and M.R. Pratt Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation J. Am. Chem. Soc. 134 2012 5468 5471
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 5468-5471
-
-
Meier, F.1
Abeywardana, T.2
Dhall, A.3
Marotta, N.P.4
Varkey, J.5
Langen, R.6
Chatterjee, C.7
Pratt, M.R.8
-
16
-
-
9144270205
-
Siah-1 facilitates ubiquitination and degradation of synphilin-1
-
Y. Nagano, H. Yamashita, T. Takahashi, S. Kishida, T. Nakamura, E. Iseki, N. Hattori, Y. Mizuno, A. Kikuchi, and M. Matsumoto Siah-1 facilitates ubiquitination and degradation of synphilin-1 J. Biol. Chem. 278 2003 51504 51514
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51504-51514
-
-
Nagano, Y.1
Yamashita, H.2
Takahashi, T.3
Kishida, S.4
Nakamura, T.5
Iseki, E.6
Hattori, N.7
Mizuno, Y.8
Kikuchi, A.9
Matsumoto, M.10
-
18
-
-
77955366745
-
Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: Implications for Parkinson's disease pathogenesis and therapies
-
A. Oueslati, M. Fournier, and H.A. Lashuel Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies Prog. Brain Res. 183 2010 115 145
-
(2010)
Prog. Brain Res.
, vol.183
, pp. 115-145
-
-
Oueslati, A.1
Fournier, M.2
Lashuel, H.A.3
-
19
-
-
0035887860
-
Induction of alpha-synuclein aggregation by intracellular nitrative insult
-
E. Paxinou, Q. Chen, M. Weisse, B.I. Giasson, E.H. Norris, S.M. Rueter, J.Q. Trojanowski, V.M. Lee, and H. Ischiropoulos Induction of alpha-synuclein aggregation by intracellular nitrative insult J. Neurosci. 21 2001 8053 8061
-
(2001)
J. Neurosci.
, vol.21
, pp. 8053-8061
-
-
Paxinou, E.1
Chen, Q.2
Weisse, M.3
Giasson, B.I.4
Norris, E.H.5
Rueter, S.M.6
Trojanowski, J.Q.7
Lee, V.M.8
Ischiropoulos, H.9
-
20
-
-
0029872844
-
Use of 2, 2′-dithiobis (5-nitropyridine) for the heterodimerization of cysteine containing peptides. Introduction of the 5-nitro-2-pyridinesulfenyl group
-
F. Rabanal, W.F. DeGrado, and P.L. Dutton Use of 2, 2′-dithiobis (5-nitropyridine) for the heterodimerization of cysteine containing peptides. Introduction of the 5-nitro-2-pyridinesulfenyl group Tetrahedron Lett. 37 1996 1347 1350
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 1347-1350
-
-
Rabanal, F.1
Degrado, W.F.2
Dutton, P.L.3
-
21
-
-
41249090880
-
Monoubiquitylation of α-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells
-
R. Rott, R. Szargel, J. Haskin, V. Shani, A. Shainskaya, I. Manov, E. Liani, E. Avraham, and S. Engelender Monoubiquitylation of α-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells J. Biol. Chem. 283 2008 3316 3328
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3316-3328
-
-
Rott, R.1
Szargel, R.2
Haskin, J.3
Shani, V.4
Shainskaya, A.5
Manov, I.6
Liani, E.7
Avraham, E.8
Engelender, S.9
-
22
-
-
81755185877
-
α-Synuclein fate is determined by USP9X-regulated monoubiquitination
-
R. Rott, R. Szargel, J. Haskin, R. Bandopadhyay, A.J. Lees, V. Shani, and S. Engelender α-Synuclein fate is determined by USP9X-regulated monoubiquitination Proc. Natl. Acad. Sci. USA 108 2011 18666 18671
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 18666-18671
-
-
Rott, R.1
Szargel, R.2
Haskin, J.3
Bandopadhyay, R.4
Lees, A.J.5
Shani, V.6
Engelender, S.7
-
23
-
-
84867398821
-
The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation
-
N. Shabek, Y. Herman-Bachinsky, S. Buchsbaum, O. Lewinson, M. Haj-Yahya, M. Hejjaoui, H.A. Lashuel, T. Sommer, A. Brik, and A. Ciechanover The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation Mol. Cell 48 2012 87 97
-
(2012)
Mol. Cell
, vol.48
, pp. 87-97
-
-
Shabek, N.1
Herman-Bachinsky, Y.2
Buchsbaum, S.3
Lewinson, O.4
Haj-Yahya, M.5
Hejjaoui, M.6
Lashuel, H.A.7
Sommer, T.8
Brik, A.9
Ciechanover, A.10
-
24
-
-
84863893133
-
Ultrafast protein splicing is common among cyanobacterial split inteins: Implications for protein engineering
-
N.H. Shah, G.P. Dann, M. Vila-Perelló, Z. Liu, and T.W. Muir Ultrafast protein splicing is common among cyanobacterial split inteins: implications for protein engineering J. Am. Chem. Soc. 134 2012 11338 11341
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 11338-11341
-
-
Shah, N.H.1
Dann, G.P.2
Vila-Perelló, M.3
Liu, Z.4
Muir, T.W.5
-
25
-
-
0242300619
-
Alpha-Synuclein locus triplication causes Parkinson's disease
-
A.B. Singleton, M. Farrer, J. Johnson, A. Singleton, S. Hague, J. Kachergus, M. Hulihan, T. Peuralinna, A. Dutra, and R. Nussbaum alpha-Synuclein locus triplication causes Parkinson's disease Science 302 2003 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
-
26
-
-
0041589248
-
Alpha-Synuclein is degraded by both autophagy and the proteasome
-
J.L. Webb, B. Ravikumar, J. Atkins, J.N. Skepper, and D.C. Rubinsztein Alpha-Synuclein is degraded by both autophagy and the proteasome J. Biol. Chem. 278 2003 25009 25013
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztein, D.C.5
-
27
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
P.H. Weinreb, W. Zhen, A.W. Poon, K.A. Conway, and P.T. Lansbury Jr. NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded Biochemistry 35 1996 13709 13715
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury, Jr.P.T.5
-
28
-
-
23144449208
-
Ubiquitin and ubiquitin-like proteins as multifunctional signals
-
R.L. Welchman, C. Gordon, and R.J. Mayer Ubiquitin and ubiquitin-like proteins as multifunctional signals Nat. Rev. Mol. Cell Biol. 6 2005 599 609
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 599-609
-
-
Welchman, R.L.1
Gordon, C.2
Mayer, R.J.3
|