Sequence-specific apolipoprotein A-I effects on lecithin:cholesterol acyltransferase activity

Molecular and Cellular Biochemistry

Volumn 378, Issue 1-2, 2013, Pages 283-290

  Dergunov, Alexander D ^a  

^a NATIONAL MEDICAL RESEARCH CENTER FOR THERAPY AND PREVENTIVE MEDICINE   (Russian Federation)

Author keywords

Apolipoprotein; Apolipoprotein structure; Lecithin: cholesterol acyltransferase

Indexed keywords

APOLIPOPROTEIN A1; ARGININE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; NUCLEOPHILE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLUSTER ANALYSIS; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; MOLECULAR STABILITY; MUTATION; PROTEIN DOMAIN; SOLVOLYSIS; SURFACE PROPERTY; ALGORITHM; CHEMICAL MODEL; CHEMISTRY; GENETICS; HUMAN; KINETICS; MISSENSE MUTATION; PARTICLE SIZE; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE;

ALGORITHMS; APOLIPOPROTEIN A-I; CATALYTIC DOMAIN; CHOLESTEROL; CLUSTER ANALYSIS; HUMANS; KINETICS; MODELS, CHEMICAL; MUTATION, MISSENSE; PARTICLE SIZE; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; PHOSPHATIDYLCHOLINES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 84886774835     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1619-5     Document Type: Article

References (51)

1. Frank PG, Marcel YL (2000) Apolipoprotein A-I: structurefunction relationships. J Lipid Res 41:853-872
2. Jonas A (2000) Lecithin cholesterol acyltransferase. Biochim Biophys Acta 1529:245-256
3. Dergunov AD, Shabrova EV, Dobretsov GE (2010) Composition, structure and substrate properties of reconstituted discoidal HDL with apolipoprotein A-I and cholesteryl ester. Spectrochim Acta A Mol Biomol Spectrosc 75:1100-1107
4. Sorci-Thomas M.G., Thomas MJ (2002) The effects of altered apolipoprotein A-I structure on plasma HDL concentration. Trends Cardiovasc Med 12:121-128
5. Tanaka M, Koyama M, Dhanasekaran P, Nguyen D, Nickel M, Lund-Katz S, Saito H, Phillips MC (2008) Influence of tertiary structure domain properties on the functionality of apolipoprotein A-I. Biochemistry 47:2172-2180
6. Chen B, Ren X, Neville T, Jerome WG, Hoyt DW, Sparks D, Ren G, Wang J (2009) Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal highdensity lipoprotein particles of different sizes. Protein Sci 18:921-935
7. Chetty PS, Mayne L, Lund-Katz S, Stranz D, Englander SW, Phillips MC (2009) Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci USA 106:19005-19010
8. Gu F, Jones MK, Chen J, Patterson JC, Catte A, Jerome WG, Li L, Segrest JP (2010) Structures of discoidal high density lipoproteins: a combined computational-experimental approach. J Biol Chem 285:4652-4665
9. Mei X, AtkinsonD(2011) Crystal structure of C-terminal truncated apolipoprotein A-I reveals the assembly of high density lipoprotein (HDL) by dimerization. J Biol Chem 286:38570-38582
10. Phillips JC, Wriggers W, Li Z, Jonas A, Schulten K (1997) Predicting the structure of apolipoprotein A-I in reconstituted high-density lipoprotein disks. Biophys J 73:2337-2346
11. Segrest JP, Jones MK, Klon AE, Sheldahl CJ, Hellinger M, De Loof H, Harvey SC (1999) A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein. J Biol Chem 274:31755-31758
12. Wu Z, Gogonea V, Lee X, Wagner MA, Li XM, Huang Y, Undurti A, May RP, Haertlein M, Moulin M, Gutsche I, Zaccai G, Didonato JA, Hazen SL (2009) Double superhelix model of high density lipoprotein. J Biol Chem 284:36605-36619
13. Dolphin PJ (1992) In: Rosseneu M (ed) Structure and function of apolipoproteins. CRC Press, Boca Raton, pp 295-362
14. Sorci-Thomas M.G., Bhat S, Thomas MJ (2009) Activation of lecithin:cholesterol acyltransferase by HDL ApoA-I central helices. Clin Lipidol 4:113-124
15. Wu Z, Wagner MA, Zheng L, Parks JS, Shy JM, Smith JD, Gogonea V, Hazen SL (2007) The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction. Nat Struct Mol Biol 14:861-868
16. Roosbeek S, Vanloo B, Duverger N, Caster H, Breyne J, De Beun I, Patel H, Vandekerckhove J, Shoulders C, Rosseneu M, Peelman F (2001) Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferase. J Lipid Res 42:31-40
17. Klimov AN, Kozhevnikova KA, Klueva NN, Belova EV (1992) On the mechanism of cholesterol interaction with apolipoproteins A-I and E. Chem Phys Lipids 62:229-237
18. Cheng Y, LeGall T, Oldfield CJ, Dunker AK, Uversky VN (2006) Abundance of intrinsic disorder in protein associated with cardiovascular disease. Biochemistry 45:10448-10460
19. Dergunov AD (2011) Local/bulk determinants of conformational stability of exchangeable apolipoproteins. Biochim Biophys Acta 1814:1169-1177
20. Rousset X, Vaisman B, Amar M, Sethi AA, Remaley AT (2009) Lecithin:cholesterol acyltransferase-from biochemistry to role in cardiovascular disease. Curr Opin Endocrinol Diabetes Obes 16:163-171
21. Dergunov AD (2011) Kinetic analysis of lecithin:cholesterol acyltransferase activity toward discoidal HDL. Lipids 46:1075-1079
22. Dergunov AD (2012) A mechanistic model of lecithin:cholesterol acyltransferase activity exploits discoidal HDL composition and structure. Arch Biochem Biophys 520:81-87
23. Li H, Papadopoulos V (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139:4991-4997
24. Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EY, Velasquez J, Kuhn P, Stevens RC (2008) A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure 16:897-905
25. Scott BR, McManus DC, Franklin V, McKenzie AG, Neville T, Sparks DL, Marcel YL (2001) The N-terminal globular domain and the first class A amphipathic helix of apolipoprotein A-I are important for lecithin:cholesterol acyltransferase activation and the maturation of high density lipoprotein in vivo. J Biol Chem 276:48716-48724
26. Weers PM, Patel AB, Wan LC, Guigard E, Kay CM, Hafiane A, McPherson R, Marcel YL, Kiss RS (2011) Novel N-terminal mutation of human apolipoprotein A-I reduces self-association and impairs LCAT activation. J Lipid Res 52:35-44
27. Holvoet P, Zhao Z, Vanloo B, Vos R, Deridder E, Dhoest A, Taveirne J, Brouwers E, Demarsin E, Engelborghs Y, Rosseneu M, Collen D, Brasseur R (1995) Phospholipid binding and lecithin-cholesterol acyltransferase activation properties of apolipoprotein A-I mutants. Biochemistry 34:13334-13342
28. Chroni A, Kan HY, Shkodrani A, Liu T, Zannis VI (2005) Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice. Biochemistry 44:4108-4117
29. Sviridov D, Hoang A, Sawyer WH, Fidge NH (2000) Identification of a sequence of apolipoprotein A-I associated with the activation of lecithin:cholesterol acyltransferase. J Biol Chem 275:19707-19712
30. Chroni A, Duka A, Kan HY, Liu T, Zannis VI (2005) Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency. Biochemistry 44:14353-14366
31. Chroni A, Kan HY, Kypreos KE, Gorshkova IN, Shkodrani A, Zannis VI (2004) Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice. Biochemistry 43:10442-10457
32. Sorci-Thomas M.G., Curtiss L, Parks JS, Thomas MJ, Kearns MW, Landrum M (1998) The hydrophobic face orientation of apolipoprotein A-I amphipathic helix domain 143-164 regulates lecithin:cholesterol acyltransferase activation. J Biol Chem 273:11776-11782
33. Dhoest A, Zhao Z, De Geest B, Deridder E, Sillen A, Engelborghs Y, Collen D, Holvoet P (1997) Role of the Arg123-Tyr166 paired helix of apolipoprotein A-I in lecithin:cholesterol acyltransferase activation. J Biol Chem 272:15967-15972
34. Cho KH, Durbin DM, Jonas A (2001) Role of individual amino acids of apolipoprotein A-I in the activation of lecithin:cholesterol acyltransferase and in HDL rearrangements. J Lipid Res 42:379-389
35. Daum U, Langer C, Duverger N, Emmanuel F, Benoit P, Dene'fle P, Chirazi A, Cullen P, Pritchard PH, Bruckert E, Assmann G, von Eckardstein A (1999) Apolipoprotein A-I (R151C)Paris is defective in activation of lecithin:cholesterol acyltransferase but not in initial lipid binding, formation of reconstituted lipoproteins, or promotion of cholesterol efflux. J Mol Med (Berl) 77:614-622
36. Cho KH, Jonas A (2000) A key point mutation (V156E) affects the structure and functions of human apolipoprotein A-I. J Biol Chem 275:26821-26827
37. Han JM, Jeong TS, Lee WS, Choi I, Cho KH (2005) Structural and functional properties of V156K and A158E mutants of apolipoprotein A-I in the lipid-free and lipid-bound states. J Lipid Res 46:589-596
38. Daum U, Leren TP, Langer C, Chirazi A, Cullen P, Pritchard PH, Assmann G, von Eckardstein A (1999) Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoAI(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers. J Lipid Res 40:486-494
39. Koukos G, Chroni A, Duka A, Kardassis D, Zannis VI (2007) Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.Biochem J 406:167-174
40. Lange Y, Steck TL (2008) Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol. Prog Lipid Res 47:319-332
41. Bolin D.J., Jonas A (1996) Sphingomyelin inhibits the lecithincholesterol acyltransferase reaction with reconstituted high density lipoproteins by decreasing enzyme binding. J Biol Chem 271:19152-19158
42. Sparks DL, Frank PG, Neville TA (1998) Effect of the surface lipid composition of reconstituted LPA-I on apolipoprotein A-I structure and lecithin:cholesterol acyltransferase activity. Biochim Biophys Acta 1390:160-172
43. Subbaiah PV, Horvath P, Achar SB (2006) Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate. Biochemistry 45:5029-5038
44. Gursky O (2013) Crystal structure of D(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil. J Mol Biol 425:1-16
45. Emmanuel F, Steinmetz A, Rosseneu M, Brasseur R, Gosselet N, Attenot F, Cuine S, Seguret S, Latta M, Fruchart JC (1994) Identification of specific amphipathic alpha-helical sequence of human apolipoprotein A-IV involved in lecithin:cholesterol acyltransferase activation. J Biol Chem 269:29883-29890
46. Jonas A, Sweeny SA, Herbert PN (1984) Discoidal complexes of A and C apolipoproteins with lipids and their reactions with lecithin:cholesterol acyltransferase. J Biol Chem 259:6369-6375
47. Soutar AK, Garner CW, Baker HN, Sparrow JT, Jackson RL, Gotto AM, Smith LC (1975) Effect of the human plasma apolipoproteins and phosphatidylcholine acyl donor on the activity of lecithin:cholesterol acyltransferase. Biochemistry 14:3057-3064
48. Steinmetz A, Kaffarnik H, Utermann G (1985) Activation of phosphatidylcholine-sterol acyltransferase by human apolipoprotein E isoforms. Eur J Biochem 152:747-751
49. Adimoolam S, Jonas A (1997) Identification of a domain of lecithin-cholesterol acyltransferase that is involved in interfacial recognition. Biochem Biophys Res Commun 232:783-787
50. James PF, Dogovski C, Dobson RC, Bailey MF, Goldie KN, Karas JA, Scanlon DB, O'Hair RA, Perugini MA (2009) Aromatic residues in the C-terminal helix of human apoC-I mediate phospholipid interactions and particle morphology. J Lipid Res 50:1384-1394
51. Rojas C, Wang HH, Lively CR, Gustafson WG, Schulz LO, McFarland JT (1989) Spectral observation of an acyl-enzyme intermediate of lipoprotein lipase. Biochemistry 28:4475-4481