Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferase

Journal of Lipid Research

Volumn 42, Issue 1, 2001, Pages 31-40

  Roosbeek, Stein ^a   Vanloo, Berlinda ^a   Duverger, Nicolas ^c   Caster, Hans ^a   Breyne, Joke ^a   De Beun, Iris ^a   Patel, Hetal ^d   Vandekerckhove, Joël ^b   Shoulders, Carol ^d   Rosseneu, Maryvonne ^a   Peelman, Frank ^a  

^a GHENT UNIVERSITY   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c SANOFI   (France)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Cholesterol; Enzyme; HDL; Lipoprotein

Indexed keywords

APOLIPOPROTEIN A1; ARGININE; CHOLESTEROL; COMPLEMENTARY DNA; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PHOSPHOLIPID; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CHOLESTEROL TRANSPORT; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE EXPRESSION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; APOLIPOPROTEIN A-I; ARGININE; CONSERVED SEQUENCE; ELECTROSTATICS; ENZYME ACTIVATION; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; PHOSPHOLIPIDS; PROTEIN BINDING; SEQUENCE ALIGNMENT;

EID: 0035130672     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Apolipoprotein A-I. Structure-function relationships
2. Apolipoprotein-mediated cellular cholesterol efflux
3. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
4. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
5. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
6. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
7. The plasma lecithin:cholesterol acyltransferase reaction
8. The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins
9. Isolation of the human HDL apoprotein A1 gene
10. Repeated helical pattern in apolipoprotein-A-I
11. A molecular theory of lipid-protein interactions in the plasma lipoproteins
12. Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation
13. A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein
14. Mode of assembly of amphipathic helical segments in model high-density lipoproteins
15. Predicting the structure of apolipoprotein A-I in reconstituted high-density lipoprotein disks
16. Investigation of the lipid domains and apolipoprotein orientation in reconstituted high density lipoproteins by fluorescence and IR methods
17. The structure of human lipoprotein A-I. Evidence for the "belt" model
18. The hydrophobic face orientation of apolipoprotein A-I amphipathic helix domain 143-164 regulates lecithin:cholesterol acyltransferase activation
19. Calculation of the total electrostatic energy of a macromolecular system: Solvation energies, binding energies, and conformational analysis
20. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
21. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
22. Identification of specific amphipathic alpha-helical sequence of human apolipoprotein A-IV involved in lecithin:cholesterol acyltransferase activation
23. Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions
24. LCAT activation properties of apoA-I CNBr fragments and conversion of discoidal complexes into spherical particles
25. Quantitative analysis of protein far UV circular dichroism spectra by neural networks
26. Expression and characterization of recombinant human lecithin:cholesterol acyltransferase
27. Quantitation of plasma free cholesterol and cholesteryl esters by high performance liquid chromatography. Study of a normal population
28. Evolution of mammalian apolipoprotein A-I and conservation of antigenicity: Correlation with primary and secondary structure
29. Regulation of lecithin cholesterol acyltransferase activity
30. Binding of lecithin:cholesterol acyltransferase to reconstituted high density lipoproteins is affected by their lipid but not apolipoprotein composition
31. Displacement of apoA-I from HDL by apoA-II or its C-terminal helix promotes the formation of pre-betal migrating particles and decreases LCAT activation
32. Lipid-free apolipoproteins A-I and A-II promote remodeling of reconstituted high density lipoproteins and alter their reactivity with lecithin:cholesterol acyltransferase
33. Anion effects on the reaction of lecithin-cholesterol acyltransferase with discoidal complexes of phosphatidylcholines apolipoprotein A-I cholesterol
34. A proposed architecture for lecithin cholesterol acyl transferase (LCAT): Identification of the catalytic triad and molecular modeling
35. Structure and function of lecithin cholesterol acyl transferase: New insights from structural predictions and animal models
36. Relationship between structure and biochemical phenotype of lecithin:cholesterol acyltransferase (LCAT) mutants causing fish-eye disease