A siRNA system based on HSP70 promoter results in controllable and powerful gene silencing by heat-induction

Biotechnology Progress

Volumn 29, Issue 5, 2013, Pages 1289-1297

  Liao, Yi ^a   Feng, Jianguo ^a   Yi, Qian ^a   Cui, Hanwei ^a   He, Ling ^a   Tang, Liling ^a  

^a CHONGQING UNIVERSITY   (China)

Author keywords

Gene therapy; Heat induce; HSP70 promoter; RNAi; SiRNA

Indexed keywords

BREAST CANCER CELLS; GENE KNOCK DOWN; GENE SILENCING; HEAT-INDUCE; HSP70 PROMOTER; RNAI; SIRNA; SIRNA EXPRESSION VECTOR;

CELLS;

GENE THERAPY;

HEAT SHOCK PROTEIN 70; SMALL INTERFERING RNA;

BREAST TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENE VECTOR; GENETICS; HEAT; HUMAN; MCF 7 CELL LINE; PHYSIOLOGICAL STRESS; PLASMID; PROMOTER REGION; RNA INTERFERENCE;

BREAST NEOPLASMS; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HOT TEMPERATURE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MCF-7 CELLS; PLASMIDS; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL;

EID: 84886752569     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1781     Document Type: Article

References (53)

1. Chen Y, Cheng G, Mahato RI. RNAi for treating hepatitis B viral infection. Pharm Res. 2008;25:72-86.
2. Kawchuk LM, Martin RR, McPherson J. Sense and antisense RNA-mediated resistance to potato leafroll virus in russet burbank potato plants. Mol Plant Microbe Interact. 1991;4:247-253.
3. Cogoni C, Macino G. Post-transcriptional gene silencing across kingdoms. Curr Opin Genet Dev. 2000;10:638-643.
4. Cogoni C, Irelan JT, Schumacher M, Schmidhauser TJ, Selker EU, Macino G. Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation. EMBO J. 1996;15:3153-3163.
5. van Rij RP, Andino R. RNAi-A guide to gene silencing. Science. 2004;303:1978-1979.
6. Fire A, Xu SQ, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-811.
7. Romano N, Macino G. Quelling-transient inactivation of gene-expression in neurospora-crassa by transformation with homologous sequences. Mol Microbiol. 1992;6:3343-3353.
8. Hannon GJ, Rossi JJ. Unlocking the potential of the human genome with RNA interference. Nature. 2004;431:371-378.
9. Kappel S, Matthess Y, Zimmer B, Kaufmann M, Strebhardt K. Tumor inhibition by genomically integrated inducible RNAi-cassettes. Nucleic Acids Res. 2006;34:4527-4536.
10. Wilson JA, Jayasena S, Khvorova A, Sabatinos S, Rodrigue-Gervais IG, Arya S, Sarangi F, Harris-Brandts M, Beaulieu S, Richardson CD. RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells. Proc Natl Acad Sci USA. 2003;100:2783-2788.
11. Coburn GA, Cullen BR. Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J Virol. 2002;76:9225-9231.
12. Kang S, Hong YS. RNA interference in infectious tropical diseases. Korean J Parasitol. 2008;46:1-15.
13. Wang SQ, Shi ZQ, Liu W, Jules J, Feng X. Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing. BMC Biotechnol. 2006;6:50.
14. Sui G, Soohoo C, Affar el B, Gay F, Shi Y, Forrester WC, Shi Y. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA. 2002;99:5515-5520.
15. Miyagishi M, Taira K. U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol. 2002;20:497-500.
16. Aagaard L, Rossi JJ. RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev. 2007;59:75-86.
17. Johnson NA, Behm CA, Trowell SC. Heritable and inducible gene knockdown in C-elegans using Wormgate and the ORFeorne. Gene. 2005;359:26-34.
18. Tomoyasu Y, Miller SC, Tomita S, Schoppmeier M, Grossmann D, Bucher G. Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium. Genome Biol. 2008;9:R10.
19. Parry JJ, Sharma V, Andrews R, Moros EG, Piwnica-Worms D, Rogers BE. PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts. Cancer Gene Ther. 2009;16:161-170.
20. Yuan ZQ, Zhang Y, Li XL, Peng YZ, Huang YS, Yang ZC. HSP70 protects intestinal epithelial cells from hypoxia/reoxygenation injury via a mechanism that involves the mitochondrial pathways. Eur J Pharmacol. 2010;643:282-288.
21. Weber W, Fussenegger M. Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering. J Biotechnol. 2002;98:161-187.
22. Matsukura S, Jones PA, Takai D. Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Res. 2003;31:e77.
23. Corry PM, Armour EP. The heat shock response: role in radiation biology and cancer therapy. Int J Hyperther. 2005;21:769-778.
24. Raizada MK, Francis SC, Wang HW, Gelband CH, Reaves PY, Katovich MJ. Targeting of the renin-angiotensin system by antisense gene therapy: a possible strategy for the long-term control of hypertension. J Hypertens. 2000;18:353-362.
25. Yin DX, Zhu L, Schimke RT. Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression. Anal Biochem. 1996;235:195-201.
26. Tu J, Ha Hwang J, Chen T, Fan T, Guo X, Crum LA, Zhang D. Controllable in vivo hyperthermia effect induced by pulsed high intensity focused ultrasound with low duty cycles. Appl Phys Lett. 2012;101:124102.
27. Yu L, Fite BZ, Kruse DE, Mahakian L, Dumont E, Caskey CF, Ferrara KW. MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia. 2011 IEEE International Ultrasonics Symposium (Ius). 2012:1641-1644.
28. Cornelis F, Grenier N, Moonen CT, Quesson B. In vivo characterization of tissue thermal properties of the kidney during local hyperthermia induced by MR-guided high-intensity focused ultrasound. Nmr Biomed. 2011;24:799-806.
29. Huang Q, Hu JK, Lohr F, Zhang L, Braun R, Lanzen J, Little JB, Dewhirst MW, Li CY. Heat-induced gene expression as a novel targeted cancer gene therapy strategy. Cancer Res. 2000;60:3435-3439.
30. Lee YJ, Galoforo SS, Battle P, Lee H, Corry PM, Jessup JM. Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy. Cancer Gene Ther. 2001;8:397-404.
31. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods. 2001;25:402-408.
32. Li M, Yin Y, Hua H, Sun X, Luo T, Wang J, Jiang Y. The Reciprocal Regulation of gamma-Synuclein and IGF-I Receptor Expression Creates a Circuit That Modulates IGF-I Signaling. J Biol Chem. 2010;285:30480-30488.
33. Shi YE, Chen Y, Dackour R, Potters L, Wang S, Ding Q, Wang Z, Liu YE. Synuclein gamma stimulates membrane-initiated estrogen signaling by chaperoning estrogen receptor (ER)-alpha 36, a Variant of ER-alpha. Am J Pathol. 2010;177:964-973.
34. Martin TA, Gomez K, Watkins G, Douglas-Jones A, Mansel RE, Jiang WG. Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. Oncol Rep. 2006;16:207-212.
35. Wiznerowicz M, Szulc J, Trono D. Tuning silence: conditional systems for RNA interference. Nat Methods. 2006;3:682-688.
36. Gatz C, Frohberg C, Wendenburg R. Stringent repression and homogeneous de-repression by tetracycline of a modified Camv 35s promoter in intact transgenic tobacco plants. Plant J. 1992;2:397-404.
37. Mett VL, Lochhead LP, Reynolds PHS. Copper-controllable gene-expression system for whole plants. Proc Natl Acad Sci USA. 1993;90:4567-4571.
38. Ait-ali T, Rands C, Harberd NP. Flexible control of plant architecture and yield via switchable expression of Arabidopsis gai. Plant Biotechnol J. 2003;1:337-343.
39. Masclaux F, Charpenteau M, Takahashi T, Pont-Lezica R, Galaud JP. Gene silencing using a heat-inducible RNAi system in Arabidopsis. Biochem Bioph Res Commun. 2004;321:364-369.
40. Kunigal S, Lakka SS, Sodadasu PK, Estes N, Rao JS. Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. Int J Oncol. 2009;34:1209-1220.
41. Tummalapalli P, Gond CS, Dinh DH, Gujrati M, Rao JS. RNA interference-mediated targeting of urokinase plasminogen activator receptor and matrix metalloproteinase-9 gene expression in the IOMM-Lee malignant meningioma cell line inhibits tumor growth, tumor cell invasion and angiogenesis. Int J Oncol. 2007;31:5-17.
42. Ren XL, Xu YM, Bao W, Fu HJ, Wu CG, Zhao Y, Li ZK, Zhang J, Li SQ, Chen WQ, Wang T, Zhang R, Zhang LH, Qian GS, Chen SY, Jia LT, Yang AG. Inhibition of non-small cell lung cancer cell proliferation and tumor growth by vector-based small interfering RNAs targeting HER2/neu. Cancer Lett. 2009;281:134-143.
43. Lena AM, Giannetti P, Sporeno E, Ciliberto G, Savino R. Immune responses against tetracycline-dependent transactivators affect long-term expression of mouse erythropoietin delivered by a helper-dependent adenoviral vector. J Gene Med. 2005;7:1086-1096.
44. Pankiewicz R, Karlen Y, Imhof MO, Mermod N. Reversal of the silencing of tetracycline-controlled genes requires the coordinate action of distinctly acting transcription factors. J Gene Med. 2005;7:117-132.
45. Li CY, Dewhirst MW. Hyperthermia-regulated immunogene therapy. Int J Hyperther. 2002;18:586-596.
46. Leung TKC, Rajendran MY, Monfries C, Hall C, Lim L. The human heat-shock protein family-expression of a novel heat-inducible Hsp70 (Hsp70b′) and isolation of its Cdna and genomic DNA. Biochem J. 1990;267:125-132.
47. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci USA. 2004;101:6062-6067.
48. Sui G, Shi Y. Gene silencing by a DNA vector-based RNAi technology. Methods Mol Biol. 2005;309:205-218.
49. Yang W, Paschen W. Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter. Biochem Biophys Res Commun. 2008;365:521-527.
50. Noonberg SB, Scott GK, Benz CC. Evidence of post-transcriptional regulation of U6 small nuclear RNA. J Biol Chem. 1996;271:10477-10481.
51. Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 1996;56:941-943.
52. Vaupel PW. The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia. Klin Padiatr. 1997;209:243-249.
53. Guilhon E, Quesson B, Moraud-Gaudry F, de Verneuil H, Canioni P, Salomir R, Voisin P, Moonen CT. Image-guided control of transgene expression based on local hyperthermia. Mol Imaging. 2003;2:11-17.