Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients

Radiology

Volumn 269, Issue 2, 2013, Pages 542-552

  Lukas, Carsten ^a   Sombekke, Madeleine H ^b   Bellenberg, Barbara ^a   Hahn, Horst K ^c   Popescu, Veronica ^b   Bendfeldt, Kerstin ^d   Radue, Ernst W ^d   Gass, Achim ^d   Borgwardt, Stefan J ^d   Kappos, Ludwig ^d   Naegelin, Yvonne ^d   Knol, Dirk L ^b   Polman, Chris H ^b   Geurts, Jeroen J G ^b   Barkhof, Frederik ^b   Vrenken, Hugo ^b  

^a ST JOSEF HOSPITAL   (Germany)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c FRAUNHOFER MEVIS   (Germany)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN ATROPHY; BRAIN DAMAGE; CERVICAL SPINAL CORD; COHORT ANALYSIS; COMPARATIVE STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PHYSICAL DISABILITY; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; SPINAL CORD ATROPHY; SPINAL CORD LESION; WALKING;

ADULT; ATROPHY; DISABILITY EVALUATION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; SPINAL CORD;

EID: 84886681717     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.13122566     Document Type: Article

References (60)

1. Tartaglino LM, Friedman DP, Flanders AE, Lublin FD, Knobler RL, Liem M. Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters. Radiology 1995;195(3):725-732.
2. Evangelou N, DeLuca GC, Owens T, Esiri MM. Pathological study of spinal cord atrophy in multiple sclerosis suggests limited role of local lesions. Brain 2005;128(Pt 1):29-34. (Pubitemid 40070517)
3. Kidd D, Thorpe JW, Thompson AJ, et al. Spinal cord MRI using multi-array coils and fast spin echo. II. Findings in multiple sclerosis. Neurology 1993;43(12):2632-2637. (Pubitemid 24004558)
4. Nijeholt GJ, van Walderveen MA, Castelijns JA, et al. Brain and spinal cord abnormalities in multiple sclerosis: correlation between MRI parameters, clinical subtypes and symptoms. Brain 1998;121(Pt 4):687-697. (Pubitemid 28162129)
5. Weier K, Mazraeh J, Naegelin Y, et al. Biplanar MRI for the assessment of the spinal cord in multiple sclerosis. Mult Scler 2012;18(11):1560-1569.
6. Honig LS, Sheremata WA. Magnetic resonance imaging of spinal cord lesions in multiple sclerosis. J Neurol Neurosurg Psychiatry 1989;52(4):459-466. (Pubitemid 19104502)
7. Miller DH, Leary SM. Primary-progressive multiple sclerosis. Lancet Neurol 2007;6(10):903-912. (Pubitemid 47405002)
8. Philpott C, Brotchie P. Comparison of MRI sequences for evaluation of multiple sclerosis of the cervical spinal cord at 3 T. Eur J Radiol 2011;80(3):780-785.
9. Campi A, Pontesilli S, Gerevini S, Scotti G. Comparison of MRI pulse sequences for investigation of lesions of the cervical spinal cord. Neuroradiology 2000;42(9):669-675.
10. Rocca MA, Mastronardo G, Horsfield MA, et al. Comparison of three MR sequences for the detection of cervical cord lesions in patients with multiple sclerosis. AJNR Am J Neuroradiol 1999;20(9):1710-1716. (Pubitemid 29498627)
11. Poonawalla AH, Hou P, Nelson FA, Wolinsky JS, Narayana PA. Cervical spinal cord lesions in multiple sclerosis: T1-weighted inversionrecovery MR imaging with phase-sensitive reconstruction. Radiology 2008;246(1):258-264. (Pubitemid 350305051)
12. Liu C, Edwards S, Gong Q, Roberts N, Blumhardt LD. Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis. J Neurol Neurosurg Psychiatry 1999;66(3):323-330. (Pubitemid 29103486)
13. Bakshi R, Dandamudi VS, Neema M, De C, Bermel RA. Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis. J Neuroimaging 2005;15(4, Suppl):30S-45S. (Pubitemid 43010530)
14. Rashid W, Davies GR, Chard DT, et al. Increasing cord atrophy in early relapsing-remitting multiple sclerosis: a 3 year study. J Neurol Neurosurg Psychiatry 2006;77(1):51-55. (Pubitemid 43022690)
15. Furby J, Hayton T, Anderson V, et al. Magnetic resonance imaging measures of brain and spinal cord atrophy correlate with clinical impairment in secondary progressive multiple sclerosis. Mult Scler 2008;14(8):1068-1075.
16. Frischer JM, Bramow S, Dal-Bianco A, et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009;132(Pt 5):1175-1189.
17. Bjartmar C, Kidd G, Mörk S, Rudick R, Trapp BD. Neurological disability correlates with spinal cord axonal loss and reduced Nacetyl aspartate in chronic multiple sclerosis patients. Ann Neurol 2000;48(6):893-901.
18. Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008;31:247-269.
19. gram analysis. J Neurol Neurosurg Psychiatry 2000;69(6):723-727.
20. Brex PA, Leary SM, O'Riordan JI, et al. Measurement of spinal cord area in clinically isolated syndromes suggestive of multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70(4):544-547. (Pubitemid 32269699)
21. Rocca MA, Horsfield MA, Sala S, et al. A multicenter assessment of cervical cord atrophy among MS clinical phenotypes. Neurology 2011;76(24):2096-2102.
22. Edwards SG, Gong QY, Liu C, et al. Infratentorial atrophy on magnetic resonance imaging and disability in multiple sclerosis. Brain 1999;122(Pt 2):291-301. (Pubitemid 29067211)
23. Losseff NA, Webb SL, O'Riordan JI, et al. Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 1996;119(Pt 3):701-708. (Pubitemid 26237169)
24. Grassiot B, Desgranges B, Eustache F, Defer G. Quantification and clinical relevance of brain atrophy in multiple sclerosis: a review. J Neurol 2009;256(9):1397-1412.
25. Poloni G, Minagar A, Haacke EM, Zivadinov R. Recent developments in imaging of multiple sclerosis. Neurologist 2011;17(4):185-204.
26. Cohen AB, Neema M, Arora A, et al. The relationships among MRI-defined spinal cord involvement, brain involvement, and disability in multiple sclerosis. J Neuroimaging 2012;22(2):122-128.
27. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald criteria." Ann Neurol 2005;58(6):840-846. (Pubitemid 41746873)
28. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50(1):121-127.
29. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46(4):907-911.
30. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33(11):1444-1452. (Pubitemid 14237132)
31. Fischer JS, Rudick RA, Cutter GR, Reingold SC. The Multiple Sclerosis Functional Composite Measure (MSFC): an integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Mult Scler 1999;5(4):244-250. (Pubitemid 29405620)
32. Smith SM, Zhang Y, Jenkinson M, et al. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 2002;17(1):479-489.
33. Bot JC, Barkhof F, Polman CH, et al. Spinal cord abnormalities in recently diagnosed MS patients: added value of spinal MRI examination. Neurology 2004;62(2):226-233. (Pubitemid 38167129)
34. Lukas C, Bellenberg B, Hahn HK, et al. Benefit of repetitive intrathecal triamcinolone acetonide therapy in predominantly spinal multiple sclerosis: prediction by upper spinal cord atrophy. Ther Adv Neurol Disord 2009;2(6):42-49.
35. Lukas C, Hahn HK, Bellenberg B, et al. Spinal cord atrophy in spinocerebellar ataxia type 3 and 6: impact on clinical disability. J Neurol 2008;255(8):1244-1249.
36. Goodkin DE, Ross JS, Medendorp SV, Konecsni J, Rudick RA. Magnetic resonance imaging lesion enlargement in multiple sclerosis: disease-related activity, chance occurrence, or measurement artifact? Arch Neurol 1992;49(3):261-263.
37. Ingle GT, Stevenson VL, Miller DH, Thompson AJ. Primary progressive multiple sclerosis: a 5-year clinical and MR study. Brain 2003;126(Pt 11):2528-2536. (Pubitemid 37314440)
38. Stevenson VL, Leary SM, Losseff NA, et al. Spinal cord atrophy and disability in MS: a longitudinal study. Neurology 1998;51(1):234-238. (Pubitemid 28345389)
39. Kidd D, Thorpe JW, Kendall BE, et al. MRI dynamics of brain and spinal cord in progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 1996;60(1):15-19. (Pubitemid 26012261)
40. Thorpe JW, Kidd D, Moseley IF, et al. Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology 1996;46(2):373-378. (Pubitemid 26081316)
41. Capra R, Marcianò N, Vignolo LA, Chiesa A, Gasparotti R. Gadolinium-pentetic acid magnetic resonance imaging in patients with relapsing remitting multiple sclerosis. Arch Neurol 1992;49(7):687-689.
42. Zivadinov R, Bakshi R. Role of MRI in multiple sclerosis. I. inflammation and lesions. Front Biosci 2004;9:665-683. (Pubitemid 39043742)
43. Rashid W, Davies GR, Chard DT, et al. Upper cervical cord area in early relapsing-remitting multiple sclerosis: cross-sectional study of factors influencing cord size. J Magn Reson Imaging 2006;23(4):473-476.
44. Bergers E, Bot JC, van der Valk P, et al. Diffuse signal abnormalities in the spinal cord in multiple sclerosis: direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology. Ann Neurol 2002;51(5):652-656.
45. Lin X, Blumhardt LD, Constantinescu CS. The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study. Acta Neurol Scand 2003;108(6):401-406. (Pubitemid 37464119)
46. Filippi M, Bozzali M, Horsfield MA, et al. A conventional and magnetization transfer MRI study of the cervical cord in patients with MS. Neurology 2000;54(1):207-213. (Pubitemid 30038761)
47. Rovaris M, Bozzali M, Santuccio G, et al. Relative contributions of brain and cervical cord pathology to multiple sclerosis disability: a study with magnetisation transfer ratio histogram analysis. J Neurol Neurosurg Psychiatry 2000;69(6):723-727.
48. Agosta F, Benedetti B, Rocca MA, et al. Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI. Neurology 2005;64(4):631-635. (Pubitemid 40261890)
49. Valsasina P, Rocca MA, Agosta F, et al. Mean diffusivity and fractional anisotropy histogram analysis of the cervical cord in MS patients. Neuroimage 2005;26(3):822-828. (Pubitemid 40834236)
50. Bonati U, Fisniku LK, Altmann DR, et al. Cervical cord and brain grey matter atrophy independently associate with long-term MS disability. J Neurol Neurosurg Psychiatry 2011;82(4):471-472.
51. Battaglini M, Jenkinson M, De Stefano N. Evaluating and reducing the impact of white matter lesions on brain volume measurements. Hum Brain Mapp 2012;33(9):2062-2071.
52. Chard DT, Jackson JS, Miller DH, Wheeler-Kingshott CA. Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes. J Magn Reson Imaging 2010;32(1):223-228.
53. Sdika M, Pelletier D. Nonrigid registration of multiple sclerosis brain images using lesion inpainting for morphometry or lesion mapping. Hum Brain Mapp 2009;30(4):1060-1067.
54. Gelineau-Morel R, Tomassini V, Jenkinson M, Johansen-Berg H, Matthews PM, Palace J. The effect of hypointense white matter lesions on automated gray matter segmentation in multiple sclerosis. Hum Brain Mapp 2012;33(12):2802-2814.
55. Nakamura K, Fisher E. Segmentation of brain magnetic resonance images for measurement of gray matter atrophy in multiple sclerosis patients. Neuroimage 2009;44(3):769-776.
56. Zivadinov R, Banas AC, Yella V, Abdelrahman N, Weinstock-Guttman B, Dwyer MG. Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol 2008;29(2):319-325. (Pubitemid 351287890)
57. Song F, Huan Y, Yin H, et al. Normalized upper cervical spinal cord atrophy in multiple sclerosis. J Neuroimaging 2008;18(3):320-327.
58. Healy BC, Arora A, Hayden DL, et al. Approaches to normalization of spinal cord volume: application to multiple sclerosis. J Neuroimaging 2012;22(3):e12-e19.
59. Horsfield MA, Sala S, Neema M, et al. Rapid semi-automatic segmentation of the spinal cord from magnetic resonance images: application in multiple sclerosis. Neuroimage 2010;50(2):446-455.
60. Lin X, Tench CR, Turner B, Blumhardt LD, Constantinescu CS. Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial. J Neurol Neurosurg Psychiatry 2003;74(8):1090-1094.