The Relationships among MRI-Defined Spinal Cord Involvement, Brain Involvement, and Disability in Multiple Sclerosis

Journal of Neuroimaging

Volumn 22, Issue 2, 2012, Pages 122-128

  Cohen, Adam B ^a   Neema, Mohit ^a   Arora, Ashish ^a   Dell'Oglio, Elisa ^a   Benedict, Ralph H B ^b   Tauhid, Shahamat ^a   Goldberg Zimring, Daniel ^d   Chavarro Nieto, Christian ^a   Ceccarelli, Antonella ^d   Klein, Joshua P ^a   Stankiewicz, James M ^a   Houtchens, Maria K ^a   Buckle, Guy J ^a   Alsop, David C ^c   Guttmann, Charles R G ^d   Bakshi, Rohit ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NONE

Author keywords

Gray matter; MRI; Multiple sclerosis; Spinal cord; Volumetrics; White matter

Indexed keywords

ADULT; ARTICLE; BRAIN; BRAIN SIZE; CERVICAL SPINAL CORD; CLINICAL ARTICLE; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; GRAY MATTER; HUMAN; MULTIPLE SCLEROSIS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL DISABILITY; RECURRENT DISEASE; SPINAL CORD ATROPHY; WHITE MATTER;

ADULT; ATROPHY; BRAIN; DISABILITY EVALUATION; DISEASE PROGRESSION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE FIBERS, MYELINATED; SPINAL CORD;

EID: 84859732182     PISSN: 10512284     EISSN: 15526569     Source Type: Journal    
DOI: 10.1111/j.1552-6569.2011.00589.x     Document Type: Article

References (42)

1. Cifelli A, Arridge, M, Jezzard, P, et al. Thalamic neurodegeneration in multiple sclerosis. Ann Neurol 2002;52:650-653.
2. DeLuca GC, Ebers GC, Esiri MM. Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts. Brain 2004;127:1009-1018.
3. Evangelou N, DeLuca GC, Owens T, et al. Pathological study of spinal cord atrophy in multiple sclerosis suggests limited role of local lesions. Brain 2005;128:29-34.
4. Gilmore CP, DeLuca GC, Bö L, et al. Spinal cord neuronal pathology in multiple clerosis. Brain Pathol 2009;19:642-649.
5. Peterson JW, Bö L, Mörk S, et al. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001;50:389-400.
6. Vogt J, Paul F, Aktas O, et al. Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. Ann Neurol 2009;66:310-322.
7. Brex PA, Leary SM, O'Riordan JIJ, et al. Measurement of spinal cord area in clinically isolated syndromes suggestive of multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70:544-547.
8. Fisher E, Rudick RA, Simon JH, et al. Eight-year follow-up study of brain atrophy in patients with MS. Neurology 2002;59:1412-1420.
9. Liu C, Edwards S, Gong Q, et al. Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis. J Neurol Neurosurg Psychiatry 1999;66:323-330.
10. Sanfilipo MP, Benedict RH, Weinstock-Guttman B, et al. Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis. Neurology 2006;66:685-692.
11. Bermel RA, Bakshi R. The measurement and clinical relevance of brain atrophy in multiple sclerosis. Lancet Neurol 2006;5:158-170.
12. Lin X, Tench CR, Evangelou N, et al. Measurement of spinal cord atrophy in multiple sclerosis. J Neuroimaging 2004;14:20S-26S.
13. Zivadinov R, Leist T. Clinical-magnetic resonance imaging correlations in multiple sclerosis. J Neuroimaging 2005;15:10S-21S.
14. Filippi M, Campi A, Colombo B, et al. A spinal cord MRI study of benign and secondary progressive multiple sclerosis. J Neurol 1996;243:502-505.
15. Furby J, Hayton T, Anderson V, et al. Magnetic resonance imaging measures of brain and spinal cord atrophy correlate with clinical impairment in secondary progressive multiple sclerosis. Mult Scler 2008;14:1068-1075.
16. Lin X, Tench CR, Turner B, et al. Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial. J Neurol Neurosurg Psychiatry 2003;74:1090-1094.
17. Lin X, Blumhardt LD, Constantinescu CS. The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study. Acta Neurol Scand 2003;108:401-406.
18. Sanfilipo MP, Benedict RH, Sharma J, et al. The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction. Neuroimage 2005;26:1068-1077.
19. Stevenson VL, Leary SM, Losseff NA, et al. Spinal cord atrophy and disability in MS: a longitudinal study. Neurology 1998;51:234-238.
20. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria. Ann Neurol 2005;58:840-846.
21. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-1452.
22. Fischer JS, Rudick RA, Cutter GR, et al. The Multiple Sclerosis Functional Composite Measure (MSFC): an integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Mult Scler 1999;5:244-250.
23. Klein J, Arora A, Neema M, et al. A 3T MRI investigation of the topography of whole spinal cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol (in press).
24. Stankiewicz JM, Neema M, Alsop DC, et al. Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study. J Neurol Sci 2009;279:99-105.
25. Stankiewicz JM, Glanz BI, Healy BC, et al. Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. J Neuroimaging [Epub ahead of print, Nov. 6, 2009.
26. Deichmann R, Schwarzbauer C, Turner R. Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T. Neuroimage 2004;21:757-767.
27. Tardif CL, Collins DL, Pike GB. Sensitivity of voxel-based morphometry analysis to choice of imaging protocol at 3 T. Neuroimage 2009;44:827-838.
28. Liptak Z, Berger AM, Sampat MP, et al. Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis. AJNR Am J Neuroradiol 2008;29:1465-1470.
29. Ashburner J, Friston KJ. Unified segmentation. Neuroimage 2005;26:839-851.
30. Chard DT, Griffin CM, Parker GJ, et al. Brain atrophy in clinically early relapsing-remitting multiple sclerosis. Brain 2002;125:327-337.
31. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Assoc; 1988.
32. Jasperse B, Vrenken H, Sanz-Arigita E, et al. Regional brain atrophy development is related to specific aspects of clinical dysfunction in multiple sclerosis. Neuroimage 2007;38:529-537.
33. Khaleeli Z, Sastre-Garriga J, Ciccarelli O, et al. Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2007. 78(10):1076-1082.
34. Tjoa CW, Benedict RH, Weinstock-Guttman B, et al. MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis. J Neurol Sci 2005;234:17-24.
35. Vaithianathar L, Tench CR, Morgan PS, et al. Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis-a quantitative T1 relaxation time mapping approach. J Neurol 2003;250:307-315.
36. Agosta F, Absinta M, Sormani MP, et al. In vivo assessment of cervical cord damage in MS patients: a longitudinal diffusion tensor MRI study. Brain 2007;130:2211-2219.
37. Rovaris M, Judica E, Ceccarelli A, et al. Absence of diffuse cervical cord tissue damage in early, non-disabling relapsing-remitting MS: a preliminary study. Mult Scler 2008;14:853-856.
38. Sombekke MH, Lukas C, Crusius JB, et al. HLA-DRB1*1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis. Arch Neurol 2009;66:1531-1536.
39. Horsfield MA, Rovaris M, Rocca MA, et al. Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences. J Neurol Sci 2003;216:169-177.
40. Losseff NA, Webb SL, O'Riordan JI, et al. Spinal cord atrophy and disability in multiple sclerosis. A new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 1996;119:701-708.
41. Mann RS, Constantinescu CS, Tench CR. Upper cervical spinal cord cross-sectional area in relapsing remitting multiple sclerosis: application of a new technique for measuring cross-sectional area on magnetic resonance images. J Magn Reson Imaging 2007;26:61-65.
42. Zivadinov R, Banas AC, Yella V, et al. Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis. AJNR Am J Neuroradiol 2008;29:319-325.