Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase

Journal of Biological Chemistry

Volumn 288, Issue 43, 2013, Pages 31069-31079

  Matsumura, Yoshihiro ^a,b   Sakai, Juro ^b   Skach, William R ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CHIP SUBSTRATES; COOPERATIVE INTERACTIONS; E3 LIGASE; ENDOPLASMIC RETICULUM; IN-CHIP; MULTIPLE DOMAINS; PROTEIN QUALITY CONTROL;

CELL MEMBRANES; OLIGOMERIZATION; OLIGOMERS;

PROTEINS;

ADENOSINE DIPHOSPHATE; C TERMINUS OF HSP70 INTERACTING PROTEIN E3 LIGASE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; MUTATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; QUALITY CONTROL; UBIQUITINATION;

CFTR; CHIP; CO-CHAPERONE; CYSTIC FIBROSIS; E3 UBIQUITIN LIGASE; ERAD; HEAT SHOCK PROTEIN; HSP70; RETICULOCYTE LYSATE; UBIQUITIN PROTEASOME PATHWAY;

ADENOSINE DIPHOSPHATE; AMINO ACID MOTIFS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOPLASMIC RETICULUM; HSC70 HEAT-SHOCK PROTEINS; HUMANS; MUTATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; UBIQUITIN-PROTEIN LIGASES;

EID: 84886649071     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.479345     Document Type: Article

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