메뉴 건너뛰기




Volumn 40, Issue 5, 2013, Pages 319-325

Clinical indications for thrombopoietin and thrombopoietin-receptor agonists

Author keywords

Cirrhosis; Eltrombopag; ITP; Myelodysplastic syndrome; Romiplostim

Indexed keywords

AZACITIDINE; BOCEPREVIR; CYTOKINE RECEPTOR AGONIST; DECITABINE; ELTROMBOPAG; GROWTH FACTOR; LENALIDOMIDE; ORPHAN DRUG; PLACEBO; ROMIPLOSTIM; TELAPREVIR; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR;

EID: 84886617137     PISSN: 16603796     EISSN: 16603818     Source Type: Journal    
DOI: 10.1159/000355006     Document Type: Review
Times cited : (27)

References (69)
  • 2
    • 77953505982 scopus 로고    scopus 로고
    • Platelet-derived pooled platelet concentrates and apheresis platelet concentrates: Which product type should be used
    • Schrezenmeier H, Seifried E: Platelet-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be used? Vox Sang 2010;99:1-15.
    • (2010) Vox Sang , vol.99 , pp. 1-15
    • Schrezenmeier, H.1    Seifried, E.2
  • 3
    • 77958138353 scopus 로고    scopus 로고
    • Bericht zur Meldung nach 21 TFG für die Jahre 2008 und 2009
    • Henseler O, Helden M, Haschberger B, et al.: Bericht zur Meldung nach 21 TFG für die Jahre 2008 und 2009. Bundesgesundheitsbl 2010;53:1089-1103.
    • (2010) Bundesgesundheitsbl , vol.53 , pp. 1089-1103
    • Henseler, O.1    Helden, M.2    Haschberger, B.3
  • 4
    • 38949153807 scopus 로고    scopus 로고
    • Historical review: Megakaryopoiesis and thrombopoiesis
    • Kaushansky K: Historical review: megakaryopoiesis and thrombopoiesis. Blood 2008;111:981-986.
    • (2008) Blood , vol.111 , pp. 981-986
    • Kaushansky, K.1
  • 5
    • 84878486651 scopus 로고    scopus 로고
    • Advances in megakaryocytopoiesis: From bench to bedside
    • Deutsch VR, Tomer A: Advances in megakaryocytopoiesis: from bench to bedside. Br J Haematol 2013;161:778-793.
    • (2013) Br J Haematol , vol.161 , pp. 778-793
    • Deutsch, V.R.1    Tomer, A.2
  • 6
    • 0028775257 scopus 로고
    • Thrombopoietin: At last
    • Metcalf D: Thrombopoietin: At last. Nature 1994; 369:519-520.
    • (1994) Nature , vol.369 , pp. 519-520
    • Metcalf, D.1
  • 7
    • 0028302409 scopus 로고
    • Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
    • de Sauvage FJ, Hass PE, Spencer SD, et al: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994;369:533-538.
    • (1994) Nature , vol.369 , pp. 533-538
    • De Sauvage, F.J.1    Hass, P.E.2    Spencer, S.D.3
  • 8
    • 0028199208 scopus 로고
    • Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
    • Lok S, Kaushansky K, Holly RD, et a.: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994;369:565-568.
    • (1994) Nature , vol.369 , pp. 565-568
    • Lok, S.1    Kaushansky, K.2    Holly, R.D.3    Et, A.4
  • 9
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
    • Kaushansky K, Lok S, Holly RD, et al: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994;369:568-571.
    • (1994) Nature , vol.369 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 10
    • 0028343099 scopus 로고
    • Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
    • Bartley TD, Bogenberger J, Hunt P, et al: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994;77:1117-1124.
    • (1994) Cell , vol.77 , pp. 1117-1124
    • Bartley, T.D.1    Bogenberger, J.2    Hunt, P.3
  • 11
    • 0027992924 scopus 로고
    • Molecular cloning and chromosomal localization of the human thrombopoietin gene
    • Sohma Y, Akahori H, Seki N, et al: Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Lett 1994;353:57-61.
    • (1994) FEBS Lett , vol.353 , pp. 57-61
    • Sohma, Y.1    Akahori, H.2    Seki, N.3
  • 12
    • 0028557354 scopus 로고
    • Human thrombopoietin: Gene structure, cDNA sequence, expression, and chromosomal localization
    • Foster DC, Sprecher CA, Grant FJ et al: Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization. Proc Natl Acad Sci U S A 1994;91:13023-13027.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 13023-13027
    • Foster, D.C.1    Sprecher, C.A.2    Grant, F.J.3
  • 13
    • 0028117771 scopus 로고
    • The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production
    • Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci U S A 1994;91:11104-11108.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11104-11108
    • Kuter, D.J.1    Beeler, D.L.2    Rosenberg, R.D.3
  • 15
    • 84928124468 scopus 로고    scopus 로고
    • Congenital Amegakaryocytic Thrombocytopenia. OMIM 604498
    • Congenital Amegakaryocytic Thrombocytopenia. OMIM 604498. http://omim.org/entry/604498.
  • 17
    • 0035174334 scopus 로고    scopus 로고
    • C-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia
    • Ballmaier M, Germeshausen M, Schulze H, et al: c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. Blood 2001;97: 139-146.
    • (2001) Blood , vol.97 , pp. 139-146
    • Ballmaier, M.1    Germeshausen, M.2    Schulze, H.3
  • 18
    • 33644795087 scopus 로고    scopus 로고
    • Congenital amegakaryocytic thrombocytopenia: A retrospective clinical analysis of 20 patients
    • King S, Germeshausen M, Strauss G, Welte K, Ballmaier M: Congenital amegakaryocytic thrombocytopenia: A retrospective clinical analysis of 20 patients. Br J Haematol 2005;131:636-644.
    • (2005) Br J Haematol , vol.131 , pp. 636-644
    • King, S.1    Germeshausen, M.2    Strauss, G.3    Welte, K.4    Ballmaier, M.5
  • 19
    • 84928124467 scopus 로고    scopus 로고
    • Thrombocythemia-1. OMIM 600044.0001
    • Thrombocythemia-1. OMIM 600044.0001. http:// omim.org/entry/600044#0001.
  • 20
    • 0031975482 scopus 로고    scopus 로고
    • An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia
    • Wiestner A, Schlemper RJ, van der Maas AP, Skoda RC: An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia. Nat Genet 1998;18:49-52.
    • (1998) Nat Genet , vol.18 , pp. 49-52
    • Wiestner, A.1    Schlemper, R.J.2    Van Der Maas, A.P.3    Skoda, R.C.4
  • 21
    • 0030966361 scopus 로고    scopus 로고
    • Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with Cancer
    • Vadhan-Raj S, Murray LJ, Bueso-Ramos C, et al: Stimulation of megakaryocyte and platelet production by a single dose of recombinant human thrombopoietin in patients with Cancer. Ann Intern Med 1997;126:673-681.
    • (1997) Ann Intern Med , vol.126 , pp. 673-681
    • Vadhan-Raj, S.1    Murray, L.J.2    Bueso-Ramos, C.3
  • 22
    • 0035469813 scopus 로고    scopus 로고
    • Thrombopoietin therapy increases platelet yields in healthy platelet donors
    • Kuter DJ, Goodnough LT, Romo J, et al: Thrombopoietin therapy increases platelet yields in healthy platelet donors. Blood 2001;98:1339-1345.
    • (2001) Blood , vol.98 , pp. 1339-1345
    • Kuter, D.J.1    Goodnough, L.T.2    Romo, J.3
  • 23
    • 0031049879 scopus 로고    scopus 로고
    • Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer
    • Fanucchi M, Glaspy J, Crawford J, et al: Effects of polyethylene glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. N Engl J Med 1997;336:404-409.
    • (1997) N Engl J Med , vol.336 , pp. 404-409
    • Fanucchi, M.1    Glaspy, J.2    Crawford, J.3
  • 24
    • 0034074551 scopus 로고    scopus 로고
    • Clinical experience with recombinant human thrombopoietin in chemotherapyinduced thrombocytopenia
    • Vadhan-Raj S: Clinical experience with recombinant human thrombopoietin in chemotherapyinduced thrombocytopenia. Semin Hematol 2000; 37(suppl4):S28-S34.
    • (2000) Semin Hematol , vol.37 , pp. S28-S34
    • Vadhan-Raj, S.1
  • 25
    • 0037111558 scopus 로고    scopus 로고
    • Recombinant human thrombopoietin: Basic biology and evaluation of clinical studies
    • Kuter DJ, Begley CG: Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 2002;100:3457-3469.
    • (2002) Blood , vol.100 , pp. 3457-3469
    • Kuter, D.J.1    Begley, C.G.2
  • 26
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J, Yang C, Xia Y, et al: Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001;98:3241-3248.
    • (2001) Blood , vol.98 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 29
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • Wang B, Nichol JL, Sullivan JT: Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004;76:628-638.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 628-638
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 30
    • 34249719511 scopus 로고    scopus 로고
    • Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
    • Jenkins JM, Williams D, Deng Y, et al: Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007;109: 4739-4741.
    • (2007) Blood , vol.109 , pp. 4739-4741
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3
  • 32
    • 69249240344 scopus 로고    scopus 로고
    • The ITP syndrome: Pathogenic and clinical diversity
    • Cines DB, Bussel JB, Liebman HA, Prak ETL: The ITP syndrome: pathogenic and clinical diversity. Blood 2009;113:6511-6221.
    • (2009) Blood , vol.113 , pp. 6511-6221
    • Cines, D.B.1    Bussel, J.B.2    Liebman, H.A.3    Prak, E.T.L.4
  • 33
    • 64049085194 scopus 로고    scopus 로고
    • Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura (ITP) of adults and children: Report from an international working group
    • Rodeghiero F, Stasi R, Gernsheimer T, et al: Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura (ITP) of adults and children: Report from an international working group. Blood 2009;113: 2386-2393.
    • (2009) Blood , vol.113 , pp. 2386-2393
    • Rodeghiero, F.1    Stasi, R.2    Gernsheimer, T.3
  • 34
    • 75649104701 scopus 로고    scopus 로고
    • International consensus report on the investigation and management of primary immune thrombocytopenia
    • Provan D, Stasi R, Newland AC, Blanchette VS, et al: International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115:168-186.
    • (2010) Blood , vol.115 , pp. 168-186
    • Provan, D.1    Stasi, R.2    Newland, A.C.3    Blanchette, V.S.4
  • 35
    • 80052141212 scopus 로고    scopus 로고
    • Thrombopoietin-receptor agonists in primary immune thrombocytopenia
    • Imbach P, Crowther M: Thrombopoietin-receptor agonists in primary immune thrombocytopenia. N Engl J Med 2011;365:734-741
    • (2011) N Engl J Med , vol.365 , pp. 734-741
    • Imbach, P.1    Crowther, M.2
  • 36
    • 0037100423 scopus 로고    scopus 로고
    • Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura
    • Nomura S, Dan K, Hotta T, et al: Effects of pegylated recombinant human megakaryocyte growth and development factor in patients with idiopathic thrombocytopenic purpura. Blood 2002;100:728-730.
    • (2002) Blood , vol.100 , pp. 728-730
    • Nomura, S.1    Dan, K.2    Hotta, T.3
  • 37
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel JB, Cheng G, Saleh MN, et al: Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007;357:2237-2247.
    • (2007) N Engl J Med , vol.357 , pp. 2237-2247
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.N.3
  • 38
    • 60249099882 scopus 로고    scopus 로고
    • Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: A randomised, double-blind, placebocontrolled trial
    • Bussel JB, Provan D, Shamsi T, et al: Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: A randomised, double-blind, placebocontrolled trial. Lancet 2009;373:641-648.
    • (2009) Lancet , vol.373 , pp. 641-648
    • Bussel, J.B.1    Provan, D.2    Shamsi, T.3
  • 39
    • 79251583872 scopus 로고    scopus 로고
    • Eltrombopag for management of chronic immune thrombocytopenia (RAISE): A 6-month, randomised, phase 3 study
    • Cheng G, Saleh MN, Marcher C, et al: Eltrombopag for management of chronic immune thrombocytopenia (RAISE): A 6-month, randomised, phase 3 study. Lancet 2011;377:393-402.
    • (2011) Lancet , vol.377 , pp. 393-402
    • Cheng, G.1    Saleh, M.N.2    Marcher, C.3
  • 40
    • 38649120593 scopus 로고    scopus 로고
    • Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: A double-blind randomised controlled trial
    • Kuter DJ, Bussel JB, Lyons RM, et al: Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: A double-blind randomised controlled trial. Lancet 2008;371:395-403.
    • (2008) Lancet , vol.371 , pp. 395-403
    • Kuter, D.J.1    Bussel, J.B.2    Lyons, R.M.3
  • 41
    • 78149479585 scopus 로고    scopus 로고
    • Romiplostim or standard of care in patients with immune thrombocytopenia
    • Kuter DJ, Rummel M, Boccia R, et al: Romiplostim or standard of care in patients with immune thrombocytopenia. N Engl J Med 2010;363:1889-1899.
    • (2010) N Engl J Med , vol.363 , pp. 1889-1899
    • Kuter, D.J.1    Rummel, M.2    Boccia, R.3
  • 42
    • 84866764098 scopus 로고    scopus 로고
    • Bleeding and mortality outcomes in ITP clinical trials: A review of thrombpoietin mimetics data
    • Altomare I, Wasser J, Pullarkat V: Bleeding and mortality outcomes in ITP clinical trials: A review of thrombpoietin mimetics data. Am J Hematol 2012;87:984-987.
    • (2012) Am J Hematol , vol.87 , pp. 984-987
    • Altomare, I.1    Wasser, J.2    Pullarkat, V.3
  • 43
    • 84886617800 scopus 로고    scopus 로고
    • Switching from romiplostim to eltrombobag or vice versa for immune thrombocytopenia: Efficacy and safety in 46 patients
    • December 8-11, Abstract 4651
    • Khellaf M, Viallard JF, Hamidou M: Switching from romiplostim to eltrombobag or vice versa for immune thrombocytopenia: efficacy and safety in 46 patients patients. 54th ASH Annual Meeting, December 8-11, 2012, Abstract 4651.
    • (2012) 54th ASH Annual Meeting
    • Khellaf, M.1    Viallard, J.F.2    Hamidou, M.3
  • 44
    • 84886621382 scopus 로고    scopus 로고
    • Idiopathic thrombocytopenia purpura resistant to eltrombopag, but cured with romiplostim
    • Piccin A, Amaddii G, Natolino F, et al: Idiopathic thrombocytopenia purpura resistant to eltrombopag, but cured with romiplostim. Blood Transfus 2013;17:1-2.
    • (2013) Blood Transfus , vol.17 , pp. 1-2
    • Piccin, A.1    Amaddii, G.2    Natolino, F.3
  • 45
    • 84928124466 scopus 로고    scopus 로고
    • Platelet kinetic study (PKS) may early identify a subset of patients with immune thrombocytopenia (ITP) probably cured by romiplostim
    • December 8-11, Abstract 1099
    • Iuliano F, Perricelli A, Iuliano E, et al: Platelet kinetic study (PKS) may early identify a subset of patients with immune thrombocytopenia (ITP) probably cured by romiplostim. Two years followup. 54th ASH Annual Meeting, December 8-11, 2012, Abstract 1099.
    • (2012) Two Years Followup. 54th ASH Annual Meeting
    • Iuliano, F.1    Perricelli, A.2    Iuliano, E.3
  • 46
    • 79955984501 scopus 로고    scopus 로고
    • American Society of Hematology. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia
    • Neunert C, Lim W, Crowther M, et al: American Society of Hematology. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood 2011; 117:4190-207.
    • (2011) Blood , vol.117 , pp. 4190-4207
    • Neunert, C.1    Lim, W.2    Crowther, M.3
  • 48
    • 34247646400 scopus 로고    scopus 로고
    • The incidence and impact of thrombocytopenia in myelodysplastic syndromes
    • Kantarjian H, Giles F, List A, et al: The incidence and impact of thrombocytopenia in myelodysplastic syndromes. Cancer 2007;109:1705-1714.
    • (2007) Cancer , vol.109 , pp. 1705-1714
    • Kantarjian, H.1    Giles, F.2    List, A.3
  • 49
    • 75749124291 scopus 로고    scopus 로고
    • Safety and efficacy of romiplostim in patients with lowerrisk myelodysplastic syndrome and thrombocytopenia
    • Kantarjian H, Fenaux P, Sekeres MA, et al: Safety and efficacy of romiplostim in patients with lowerrisk myelodysplastic syndrome and thrombocytopenia. J Clin Oncol 2010;28:437-444.
    • (2010) J Clin Oncol , vol.28 , pp. 437-444
    • Kantarjian, H.1    Fenaux, P.2    Sekeres, M.A.3
  • 50
    • 78049378253 scopus 로고    scopus 로고
    • Phase 2 study of romiplostim in patients with low-or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy
    • Kantarjian H, Giles FJ, Greenberg PL, et al: Phase 2 study of romiplostim in patients with low-or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy. Blood 2010;116:3163-3170.
    • (2010) Blood , vol.116 , pp. 3163-3170
    • Kantarjian, H.1    Giles, F.J.2    Greenberg, P.L.3
  • 51
    • 84870064401 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase 2 study evaluating the efficacy and safety of romiplostim treatment of patients with low or intermediate-1 risk myelodysplastic syndrome receiving lenalidomide
    • Wang ES, Lyons RM, Larson RA, et al: A randomized, double-blind, placebo-controlled phase 2 study evaluating the efficacy and safety of romiplostim treatment of patients with low or intermediate-1 risk myelodysplastic syndrome receiving lenalidomide. J Hematol Oncol 2012;25:71-83.
    • (2012) J Hematol Oncol , vol.25 , pp. 71-83
    • Wang, E.S.1    Lyons, R.M.2    Larson, R.A.3
  • 52
    • 84872039897 scopus 로고    scopus 로고
    • A randomized controlled trial of romiplostim in patients with low-or intermediaterisk myelodysplastic syndrome receiving decitabine
    • Greenberg PL, Guillermo Garcia-Manero G, Moore M, et al: A randomized controlled trial of romiplostim in patients with low-or intermediaterisk myelodysplastic syndrome receiving decitabine. Leuk Lymphoma 2013;54:321-328.
    • (2013) Leuk Lymphoma , vol.54 , pp. 321-328
    • Greenberg, P.L.1    Guillermo Garcia-Manero, G.2    Moore, M.3
  • 53
    • 84863454665 scopus 로고    scopus 로고
    • Leukaemic transformation with romiplostim
    • Gardner K, Mathe S, Sahu S: Leukaemic transformation with romiplostim. Br J Haematol 2012;158: 153.
    • (2012) Br J Haematol , vol.158 , pp. 153
    • Gardner, K.1    Mathe, S.2    Sahu, S.3
  • 55
    • 84867336974 scopus 로고    scopus 로고
    • Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: An open-label, multicentre, randomised study
    • Wandt H, Schaefer-Eckart K, Wendelin K, et al: Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: An open-label, multicentre, randomised study. Lancet 2012;380:1309-1316.
    • (2012) Lancet , vol.380 , pp. 1309-1316
    • Wandt, H.1    Schaefer-Eckart, K.2    Wendelin, K.3
  • 56
    • 84877624763 scopus 로고    scopus 로고
    • A noprophylaxis platelet-transfusion strategy for hematologic cancers
    • Stanworth SJ, Estcourt LJ, Powter G, et al: A noprophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med 2013;368:1171-1780.
    • (2013) N Engl J Med , vol.368 , pp. 1171-1780
    • Stanworth, S.J.1    Estcourt, L.J.2    Powter, G.3
  • 57
    • 55749105715 scopus 로고    scopus 로고
    • The use of secondgeneration thrombopoietic agents for chemotherapy-induced thrombocytopenia
    • Levy B, Arnason JE, Bussel JB: The use of secondgeneration thrombopoietic agents for chemotherapy-induced thrombocytopenia. Curr Opin Oncol 2008;20:690-696.
    • (2008) Curr Opin Oncol , vol.20 , pp. 690-696
    • Levy, B.1    Arnason, J.E.2    Bussel, J.B.3
  • 58
    • 0034655649 scopus 로고    scopus 로고
    • A double blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia
    • Schiffer CA, Miller K, Larson RA, et al: A double blind, placebo-controlled trial of pegylated recombinant human megakaryocyte growth and development factor as an adjunct to induction and consolidation therapy for patients with acute myeloid leukemia. Blood 2000;95:2530-2535.
    • (2000) Blood , vol.95 , pp. 2530-2535
    • Schiffer, C.A.1    Miller, K.2    Larson, R.A.3
  • 59
    • 0033485568 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEGrHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia
    • Archimbaud E, Ottmann OG, Yin JA, et al: A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEGrHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia. Blood 1999;94:3694-3701.
    • (1999) Blood , vol.94 , pp. 3694-3701
    • Archimbaud, E.1    Ottmann, O.G.2    Yin, J.A.3
  • 60
    • 77956793813 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, dose ranging study to assess the efficacy and safety of eltrombopag in patients receiving carbopolatin/ paclitaxel for advanced solid tumors
    • Kellum A, Jagiello-Gruszfeld A, Bondarenko IN, et al: A randomized, double-blind, placebo-controlled, dose ranging study to assess the efficacy and safety of eltrombopag in patients receiving carbopolatin/ paclitaxel for advanced solid tumors. Curr Med Res Opin 2010;26:2339-2346.
    • (2010) Curr Med Res Opin , vol.26 , pp. 2339-2346
    • Kellum, A.1    Jagiello-Gruszfeld, A.2    Bondarenko, I.N.3
  • 61
    • 84878664407 scopus 로고    scopus 로고
    • Population PD/PD modeling of eltrombopag in subjects with advanced solid tumors with chemotherapy-induced thrombocytopenia
    • Hayes S, Mudd PN Jr, Ouellet D, et al: Population PD/PD modeling of eltrombopag in subjects with advanced solid tumors with chemotherapy-induced thrombocytopenia. Cancer Chemother Pharmacol 2013;71:1507-1520.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 1507-1520
    • Hayes, S.1    Mudd, P.N.2    Ouellet, D.3
  • 62
    • 84880255951 scopus 로고    scopus 로고
    • Pathophysiology and management of thrombocytopenia in bone marrow failure: Possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes
    • Townsley DM, Desmond R, Dunbar CE, Young NS: Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes. Int J Hematol 2013;98:48-55.
    • (2013) Int J Hematol , vol.98 , pp. 48-55
    • Townsley, D.M.1    Desmond, R.2    Dunbar, C.E.3    Young, N.S.4
  • 64
    • 84863524725 scopus 로고    scopus 로고
    • Eltrombopag and improved hematopoiesis in refractory aplastic anemia
    • Olnes MJ, Scheinberg P, Calvo KR, et al: Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med 2012;367:11-19.
    • (2012) N Engl J Med , vol.367 , pp. 11-19
    • Olnes, M.J.1    Scheinberg, P.2    Calvo, K.R.3
  • 65
    • 84870341588 scopus 로고    scopus 로고
    • Eltrombopag fails to improve severe thrombocytopenia in late-stage dyskeratosis congenita and Diamond-Blackfan anaemia
    • Trautman K, Jakob C, von Grunhagen U, et al: Eltrombopag fails to improve severe thrombocytopenia in late-stage dyskeratosis congenita and Diamond-Blackfan anaemia. Thromb Haemost 2012; 108:397-398.
    • (2012) Thromb Haemost , vol.108 , pp. 397-398
    • Trautman, K.1    Jakob, C.2    Von Grunhagen, U.3
  • 66
    • 66149190551 scopus 로고    scopus 로고
    • Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis
    • Qamar AA, Grace ND, Groszmann RJ, et al: Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis. Clin Gastroenterol Hepatol 2009;7:689-695.
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 689-695
    • Qamar, A.A.1    Grace, N.D.2    Groszmann, R.J.3
  • 67
    • 43049158112 scopus 로고    scopus 로고
    • Thrombocytopenia associated with chronic liver disease
    • Afdhal N, McHutchison J, Brown R, et al: Thrombocytopenia associated with chronic liver disease. J Hepatol 2008;48:1000-1007.
    • (2008) J Hepatol , vol.48 , pp. 1000-1007
    • Afdhal, N.1    McHutchison, J.2    Brown, R.3
  • 68
    • 36549047972 scopus 로고    scopus 로고
    • Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
    • McHutchison JG, Dusheiko G, Shiffman ML, et al: Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007;357:2227-2236.
    • (2007) N Engl J Med , vol.357 , pp. 2227-2236
    • McHutchison, J.G.1    Dusheiko, G.2    Shiffman, M.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.