-
1
-
-
0023218341
-
Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance
-
Ballem PJ, Segal GM, Stratton JR, et al. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 1987; 80:33-40. (Pubitemid 17097513)
-
(1987)
Journal of Clinical Investigation
, vol.80
, Issue.1
, pp. 33-40
-
-
Ballem, P.J.1
Segal, G.M.2
Stratton, J.R.3
-
2
-
-
0033853833
-
Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura
-
McMillan R. Autoantibodies and autoantigens in chronic immune thrombocytopenic purpura. Semin Hematol 2000; 37:239-248. (Pubitemid 30612902)
-
(2000)
Seminars in Hematology
, vol.37
, Issue.3
, pp. 239-248
-
-
McMillan, R.1
-
3
-
-
0842328846
-
Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
-
DOI 10.1182/blood-2003-08-2672
-
McMillan R, Wang L, Tomer A, et al. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP. Blood 2004; 103:1364-1369. (Pubitemid 38168649)
-
(2004)
Blood
, vol.103
, Issue.4
, pp. 1364-1369
-
-
McMillan, R.1
Wang, L.2
Tomer, A.3
Nichol, J.4
Pistillo, J.5
-
4
-
-
0043245959
-
Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
-
DOI 10.1182/blood-2002-05-1475
-
Chang M, Nakagawa PA, Williams SA, et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 2003; 102:887-895. (Pubitemid 36917780)
-
(2003)
Blood
, vol.102
, Issue.3
, pp. 887-895
-
-
Chang, M.1
Nakagawa, P.A.2
Williams, S.A.3
Schwartz, M.R.4
Imfeld, K.L.5
Buzby, J.S.6
Nugent, D.J.7
-
5
-
-
73249121880
-
Pathogenesis of chronic immune thrombocytopenia: Increased platelet destruction and/or decreased platelet production
-
Nugent D, McMillan R, Nichol JL, Slichter SJ. Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and/or decreased platelet production. Br J Haematol 2009; 146:585-596.
-
(2009)
Br J Haematol
, vol.146
, pp. 585-596
-
-
Nugent, D.1
McMillan, R.2
Nichol, J.L.3
Slichter, S.J.4
-
6
-
-
0344304488
-
Mechanisms of Action of Therapeutics in Idiopathic Thrombocytopenic Purpura
-
DOI 10.1097/00043426-200312001-00012
-
Cines DB, McKenzie SE, Siegel DL. Mechanisms of action of therapeutics in idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol 2003; 25 (Suppl 1):S52-S56. (Pubitemid 37517920)
-
(2003)
Journal of Pediatric Hematology/Oncology
, vol.25
, Issue.SUPPL. 1
-
-
Cines, D.B.1
McKenzie, S.E.2
Siegel, D.L.3
-
7
-
-
0346881171
-
AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl
-
DOI 10.1016/j.cyto.2003.05.001
-
Broudy VC, Lin NL. AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine 2004; 25:52-60. (Pubitemid 38018897)
-
(2004)
Cytokine
, vol.25
, Issue.2
, pp. 52-60
-
-
Broudy, V.C.1
Lin, N.L.2
-
8
-
-
10044296968
-
Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
-
DOI 10.1016/j.clpt.2004.08.010, PII S0009923604002784
-
Wang B, Nichol JL, Sullivan JT. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther 2004; 76:628-638. (Pubitemid 39601552)
-
(2004)
Clinical Pharmacology and Therapeutics
, vol.76
, Issue.6
, pp. 628-638
-
-
Wang, B.1
Nichol, J.L.2
Sullivan, J.T.3
-
9
-
-
33750035507
-
AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
-
DOI 10.1056/NEJMoa054626
-
Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesisstimulating protein, for chronic ITP. N Engl J Med 2006; 355:1672-1681. (Pubitemid 44583957)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.16
, pp. 1672-1681
-
-
Bussel, J.B.1
Kuter, D.J.2
George, J.N.3
McMillan, R.4
Aledort, L.M.5
Conklin, G.T.6
Lichtin, A.E.7
Lyons, R.M.8
Nieva, J.9
Wasser, J.S.10
Wiznitzer, I.11
Kelly, R.12
Chen, C.-F.13
Nichol, J.L.14
-
10
-
-
38649120593
-
Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: A double-blind randomised controlled trial
-
DOI 10.1016/S0140-6736(08)60203-2, PII S0140673608602032
-
Kuter DJ, Bussel JB, Lyons RM, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 2008; 371:395-403. (Pubitemid 351181334)
-
(2008)
The Lancet
, vol.371
, Issue.9610
, pp. 395-403
-
-
Kuter, D.J.1
Bussel, J.B.2
Lyons, R.M.3
Pullarkat, V.4
Gernsheimer, T.B.5
Senecal, F.M.6
Aledort, L.M.7
George, J.N.8
Kessler, C.M.9
Sanz, M.A.10
Liebman, H.A.11
Slovick, F.T.12
De Wolf, J.T.M.13
Bourgeois, E.14
Guthrie Jr., T.H.15
Newland, A.16
Wasser, J.S.17
Hamburg, S.I.18
Grande, C.19
Lefrere, F.20
Lichtin, A.E.21
Tarantino, M.D.22
Terebelo, H.R.23
Viallard, J.-F.24
Cuevas, F.J.25
Go, R.S.26
Henry, D.H.27
Redner, R.L.28
Rice, L.29
Schipperus, M.R.30
Guo, D.M.31
Nichol, J.L.32
more..
-
11
-
-
78149479585
-
Romiplostim or standard of care in patients with immune thrombocytopenia
-
Kuter DJ, Rummel M, Boccia R, et al. Romiplostim or standard of care in patients with immune thrombocytopenia. N Engl J Med 2010; 363:1889-1899.
-
(2010)
N Engl J Med
, vol.363
, pp. 1889-1899
-
-
Kuter, D.J.1
Rummel, M.2
Boccia, R.3
-
12
-
-
79960104101
-
Romiplostim for the treatment of chronic immune thrombocytopenia in adult Japanese patients: A double-blind, randomized Phase III clinical trial
-
Shirasugi Y, Ando K, Miyazaki K, et al. Romiplostim for the treatment of chronic immune thrombocytopenia in adult Japanese patients: a double-blind, randomized Phase III clinical trial. Int J Hematol 2011; 94:71-80.
-
(2011)
Int J Hematol
, vol.94
, pp. 71-80
-
-
Shirasugi, Y.1
Ando, K.2
Miyazaki, K.3
-
13
-
-
84855189899
-
Romiplostim in children with chronic refractory ITP: Randomized placebo controlled study
-
Elalfy MS, Abdelmaksoud AA, Eltonbary KY. Romiplostim in children with chronic refractory ITP: randomized placebo controlled study. Ann Hematol 2011; 90:1341-1344.
-
(2011)
Ann Hematol
, vol.90
, pp. 1341-1344
-
-
Elalfy, M.S.1
Abdelmaksoud, A.A.2
Eltonbary, K.Y.3
-
14
-
-
79960114674
-
A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia
-
Bussel JB, Buchanan GR, Nugent DJ, et al. A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia. Blood 2011; 118:28-36.
-
(2011)
Blood
, vol.118
, pp. 28-36
-
-
Bussel, J.B.1
Buchanan, G.R.2
Nugent, D.J.3
-
15
-
-
80054830678
-
Romiplostim safety and efficacy for immune thrombocytopenia in clinical practice: 2-year results of 72 adults in a romiplostim compassionate-use program
-
Khellaf M, Michel M, Quittet P, et al. Romiplostim safety and efficacy for immune thrombocytopenia in clinical practice: 2-year results of 72 adults in a romiplostim compassionate-use program. Blood 2011; 118:4338-4345.
-
(2011)
Blood
, vol.118
, pp. 4338-4345
-
-
Khellaf, M.1
Michel, M.2
Quittet, P.3
-
16
-
-
63849111465
-
Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP
-
Bussel JB, Kuter DJ, Pullarkat V, et al. Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood 2009; 113:2161-2171.
-
(2009)
Blood
, vol.113
, pp. 2161-2171
-
-
Bussel, J.B.1
Kuter, D.J.2
Pullarkat, V.3
-
17
-
-
58449105994
-
Improved quality of life for romiplostimtreated patients with chronic immune thrombocytopenic purpura: Results from two randomized, placebo-controlled trials
-
George JN, Mathias SD, Go RS, et al. Improved quality of life for romiplostimtreated patients with chronic immune thrombocytopenic purpura: results from two randomized, placebo-controlled trials. Br J Haematol 2009; 144:409-415.
-
(2009)
Br J Haematol
, vol.144
, pp. 409-415
-
-
George, J.N.1
Mathias, S.D.2
Go, R.S.3
-
18
-
-
79952671578
-
Analysis of EQ-5D scores from two phase 3 clinical trials of romiplostim in the treatment of immune thrombocytopenia (ITP)
-
Sanz MA, Aledort L, Mathias SD, et al. Analysis of EQ-5D scores from two phase 3 clinical trials of romiplostim in the treatment of immune thrombocytopenia (ITP). Value Health 2011; 14:90-96.
-
(2011)
Value Health
, vol.14
, pp. 90-96
-
-
Sanz, M.A.1
Aledort, L.2
Mathias, S.D.3
-
19
-
-
80052572964
-
Reduced corticosteroid use in adult patients with primary immune thrombocytopenia receiving romiplostim
-
Michel M, te Boekhorst PA, Janssens A, et al. Reduced corticosteroid use in adult patients with primary immune thrombocytopenia receiving romiplostim. Hematology 2011; 16:274-277.
-
(2011)
Hematology
, vol.16
, pp. 274-277
-
-
Michel, M.1
Te Boekhorst, P.A.2
Janssens, A.3
-
20
-
-
84855770524
-
Pilot study of the effect of romiplostim on child health-related quality of life (HRQoL) and parental burden in immune thrombocytopenia (ITP)
-
Klaassen RJ, Mathias SD, Buchanan G, et al. Pilot study of the effect of romiplostim on child health-related quality of life (HRQoL) and parental burden in immune thrombocytopenia (ITP). Pediatr Blood Cancer 2012; 58:395-398.
-
(2012)
Pediatr Blood Cancer
, vol.58
, pp. 395-398
-
-
Klaassen, R.J.1
Mathias, S.D.2
Buchanan, G.3
-
21
-
-
0037103339
-
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics
-
DOI 10.1021/jm025535c
-
Duffy KJ, Shaw AN, Delorme E, et al. Identification of a pharmacophore for thrombopoietic activity of small, nonpeptidyl molecules. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics. J Med Chem 2002; 45:3573-3575. (Pubitemid 34856096)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.17
, pp. 3573-3575
-
-
Duffy, K.J.1
Shaw, A.N.2
Delorme, E.3
Dillon, S.B.4
Erickson-Miller, C.5
Giampa, L.6
Huang, Y.7
Keenan, R.M.8
Lamb, P.9
Liu, N.10
Miller, S.G.11
Price, A.T.12
Rosen, J.13
Smith, H.14
Wiggall, K.J.15
Zhang, L.16
Luengo, J.I.17
-
22
-
-
19944432021
-
Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist
-
DOI 10.1016/j.exphem.2004.09.006, PII S0301472X04003200
-
Erickson-Miller CL, DeLorme E, Tian SS, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol 2005; 33:85-93. (Pubitemid 40127647)
-
(2005)
Experimental Hematology
, vol.33
, Issue.1
, pp. 85-93
-
-
Erickson-Miller, C.L.1
DeLorme, E.2
Tian, S.-S.3
Hopson, C.B.4
Stark, K.5
Giampa, L.6
Valoret, E.I.7
Duffy, K.J.8
Luengo, J.L.9
Rosen, J.10
Miller, S.G.11
Dillon, S.B.12
Lamb, P.13
-
23
-
-
34249719511
-
Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
-
DOI 10.1182/blood-2006-11-057968
-
Jenkins JM, Williams D, Deng Y, et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007; 109:4739-4741. (Pubitemid 46827766)
-
(2007)
Blood
, vol.109
, Issue.11
, pp. 4739-4741
-
-
Jenkins, J.M.1
Williams, D.2
Deng, Y.3
Uhl, J.4
Kitchen, V.5
Collins, D.6
Erickson-Miller, C.L.7
-
24
-
-
36549001698
-
Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
-
DOI 10.1056/NEJMoa073275
-
Bussel JB, Cheng G, Saleh MN, et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007; 357:2237-2247. (Pubitemid 350190754)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.22
, pp. 2237-2247
-
-
Bussel, J.B.1
Cheng, G.2
Saleh, M.N.3
Psaila, B.4
Kovaleva, L.5
Meddeb, B.6
Kloczko, J.7
Hassani, H.8
Mayer, B.9
Stone, N.L.10
Arning, M.11
Provan, D.12
Jenkins, J.M.13
-
25
-
-
60249099882
-
Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: A randomised, double-blind, placebo-controlled trial
-
Bussel JB, Provan D, Shamsi T, et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet 2009; 373:641-648.
-
(2009)
Lancet
, vol.373
, pp. 641-648
-
-
Bussel, J.B.1
Provan, D.2
Shamsi, T.3
-
26
-
-
79251583872
-
Eltrombopag for management of chronic immune thrombocytopenia (RAISE): A 6-month, randomised, phase 3 study
-
Cheng G, Saleh MN, Marcher C, et al. Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study. Lancet 2011; 377:393-402.
-
(2011)
Lancet
, vol.377
, pp. 393-402
-
-
Cheng, G.1
Saleh, M.N.2
Marcher, C.3
-
27
-
-
84860324484
-
In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: No evidence of platelet activation
-
Psaila B, Bussel JB, LindenMD, et al. In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation. Blood 2012; 119:4066-4072.
-
(2012)
Blood
, vol.119
, pp. 4066-4072
-
-
Psaila, B.1
Bussel, J.B.2
Linden, M.D.3
-
28
-
-
80051964380
-
Metabolism and disposition of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, in healthy human subjects
-
Deng Y, Madatian A, Wire MB, et al. Metabolism and disposition of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, in healthy human subjects. Drug Metab Dispos 2011; 39:1734-1746.
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 1734-1746
-
-
Deng, Y.1
Madatian, A.2
Wire, M.B.3
-
29
-
-
79956071906
-
Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent
-
Takeuchi K, Sugiura T, Umeda S, et al. Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent. Drug Metab Dispos 2011; 39:1088-1096.
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 1088-1096
-
-
Takeuchi, K.1
Sugiura, T.2
Umeda, S.3
-
30
-
-
79955543812
-
Effect of hepatic or renal impairment on eltrombopag pharmacokinetics
-
Bauman JW, Vincent CT, Peng B, et al. Effect of hepatic or renal impairment on eltrombopag pharmacokinetics. J Clin Pharmacol 2011; 51:739-750.
-
(2011)
J Clin Pharmacol
, vol.51
, pp. 739-750
-
-
Bauman, J.W.1
Vincent, C.T.2
Peng, B.3
-
31
-
-
79955820299
-
Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura
-
Gibiansky E, Zhang J, Williams D, et al. Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura. J Clin Pharmacol 2011; 51:842-856.
-
(2011)
J Clin Pharmacol
, vol.51
, pp. 842-856
-
-
Gibiansky, E.1
Zhang, J.2
Williams, D.3
-
32
-
-
84860492392
-
A lower starting dose of eltrombopag is efficacious in Japanese patients with previously treated chronic immune thrombocytopenia (ITP)
-
Tomiyama Y, Miyakawa Y, Okamato S, et al. A lower starting dose of eltrombopag is efficacious in Japanese patients with previously treated chronic immune thrombocytopenia (ITP). J Thromb Haemost 2012; 10: 799-806.
-
(2012)
J Thromb Haemost
, vol.10
, pp. 799-806
-
-
Tomiyama, Y.1
Miyakawa, Y.2
Okamato, S.3
-
33
-
-
79953814561
-
Clinical pharmacokinetics, platelet response, and safety of eltrombopag at supratherapeutic doses of up to 200mg once daily in healthy volunteers
-
Matthys G, Park JW, McGuire S, et al. Clinical pharmacokinetics, platelet response, and safety of eltrombopag at supratherapeutic doses of up to 200mg once daily in healthy volunteers. J Clin Pharmacol 2011; 51:301-308.
-
(2011)
J Clin Pharmacol
, vol.51
, pp. 301-308
-
-
Matthys, G.1
Park, J.W.2
McGuire, S.3
-
34
-
-
79960989219
-
TPO receptor agonist for chronic idiopathic thrombocytopenic purpura
-
Zeng Y, Duan X, Xu J, Ni X. TPO receptor agonist for chronic idiopathic thrombocytopenic purpura. Cochrane Database Syst Rev 2011(7): CD008235.
-
(2011)
Cochrane Database Syst Rev
, Issue.7
-
-
Zeng, Y.1
Duan, X.2
Xu, J.3
Ni, X.4
-
35
-
-
84866898636
-
Risk of thromboembolism treated with thrombopoietin receptor agonists in adult patients with thrombocytopenia: Systematic review and meta-analysis of randomized controlled trials
-
[Epub ahead of print]
-
Catala-Lopez F, Corrales I, Martin-Serrano G, et al. Risk of thromboembolism treated with thrombopoietin receptor agonists in adult patients with thrombocytopenia: systematic review and meta-analysis of randomized controlled trials. Med Clin (Barc) 2012. [Epub ahead of print]
-
(2012)
Med Clin (Barc)
-
-
Catala-Lopez, F.1
Corrales, I.2
Martin-Serrano, G.3
-
36
-
-
70449704426
-
Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim
-
Kuter DJ, Mufti GJ, Bain BJ, et al. Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim. Blood 2009; 114:3748-3756.
-
(2009)
Blood
, vol.114
, pp. 3748-3756
-
-
Kuter, D.J.1
Mufti, G.J.2
Bain, B.J.3
-
37
-
-
84855345560
-
Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities
-
Boiocchi L, Orazi A, Ghanima W, et al. Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities. Mod Pathol 2012; 25:65-74.
-
(2012)
Mod Pathol
, vol.25
, pp. 65-74
-
-
Boiocchi, L.1
Orazi, A.2
Ghanima, W.3
-
38
-
-
84865410944
-
Eltrombopag can stimulate trilineage hematopoiesis with transfusion independence in patients with refractory severe aplastic anemia: Results from a phase II trial
-
Olnes MJ, Scheinberg P, Calvo K, et al. Eltrombopag can stimulate trilineage hematopoiesis with transfusion independence in patients with refractory severe aplastic anemia: results from a phase II trial. ASH Annual Meeting Abstracts 2011; 118:54
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 54
-
-
Olnes, M.J.1
Scheinberg, P.2
Calvo, K.3
-
39
-
-
80053572889
-
Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents
-
Ghanima W, Junker P, Hasselbalch HC, et al. Fibroproliferative activity in patients with immune thrombocytopenia (ITP) treated with thrombopoietic agents. Br J Haematol 2011; 155:248-255.
-
(2011)
Br J Haematol
, vol.155
, pp. 248-255
-
-
Ghanima, W.1
Junker, P.2
Hasselbalch, H.C.3
-
40
-
-
84862268291
-
Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenic purpura (ITP) treated with eltrombopag: Data from the EXTEND study
-
Brynes RK, Orazi A, Verma S, et al. Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenic purpura (ITP) treated with eltrombopag: data from the EXTEND study. ASH Annual Meeting Abstracts 2011; 118:528.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 528
-
-
Brynes, R.K.1
Orazi, A.2
Verma, S.3
-
41
-
-
34247646400
-
The incidence and impact of thrombocytopenia in myelodysplasia syndromes
-
DOI 10.1002/cncr.22602
-
Kantarjian H, Giles F, List A, et al. The incidence and impact of thrombocytopenia in myelodysplastic syndromes. Cancer 2007; 109:1705-1714. (Pubitemid 46668530)
-
(2007)
Cancer
, vol.109
, Issue.9
, pp. 1705-1714
-
-
Kantarjian, H.1
Giles, F.2
List, A.3
Lyons, R.4
Sekeres, M.A.5
Pierce, S.6
Deuson, R.7
Leveque, J.8
-
42
-
-
75749124291
-
Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia
-
Kantarjian H, Fenaux P, Sekeres MA, et al. Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia. J Clin Oncol 2010; 28:437-444.
-
(2010)
J Clin Oncol
, vol.28
, pp. 437-444
-
-
Kantarjian, H.1
Fenaux, P.2
Sekeres, M.A.3
-
43
-
-
79952011926
-
Subcutaneous or intravenous administration of romiplostim in thrombocytopenic patients with lower risk myelodysplastic syndromes
-
Sekeres MA, Kantarjian H, Fenaux P, et al. Subcutaneous or intravenous administration of romiplostim in thrombocytopenic patients with lower risk myelodysplastic syndromes. Cancer 2011; 117:992-1000.
-
(2011)
Cancer
, vol.117
, pp. 992-1000
-
-
Sekeres, M.A.1
Kantarjian, H.2
Fenaux, P.3
-
44
-
-
78049378253
-
Phase 2 study of romiplostim in patients with low-risk or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy
-
Kantarjian HM, Giles FJ, Greenberg PL, et al. Phase 2 study of romiplostim in patients with low-risk or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy. Blood 2010; 116:3163-3170.
-
(2010)
Blood
, vol.116
, pp. 3163-3170
-
-
Kantarjian, H.M.1
Giles, F.J.2
Greenberg, P.L.3
-
45
-
-
79952101422
-
Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on megakaryopoiesis of patients with lower risk myelodysplastic syndrome
-
Mavroudi I, Pyrovolaki K, Pavlaki K, et al. Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on megakaryopoiesis of patients with lower risk myelodysplastic syndrome. Leuk Res 2011; 35:323-328.
-
(2011)
Leuk Res
, vol.35
, pp. 323-328
-
-
Mavroudi, I.1
Pyrovolaki, K.2
Pavlaki, K.3
-
46
-
-
36549047972
-
Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
-
DOI 10.1056/NEJMoa073255
-
McHutchison JG, Dusheiko G, Shiffman ML, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007; 357:2227-2236. (Pubitemid 350190753)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.22
, pp. 2227-2236
-
-
McHutchison, J.G.1
Dusheiko, G.2
Shiffman, M.L.3
Rodriguez-Torres, M.4
Sigal, S.5
Bourliere, M.6
Berg, T.7
Gordon, S.C.8
Campbell, F.M.9
Theodore, D.10
Blackman, N.11
Jenkins, J.12
Afdhal, N.H.13
-
47
-
-
84874985053
-
Final results of open-label treatment with eltrombopag during ENABLE 1: A study of eltrombopag as an adjunct for antiviral treatment of hepatitis Cvirus associated with thrombocytopenia
-
Dusheiko G, Afdhal NH, Giannini E, et al. Final results of open-label treatment with eltrombopag during ENABLE 1: a study of eltrombopag as an adjunct for antiviral treatment of hepatitis Cvirus associated with thrombocytopenia. ASH Annual Meeting Abstracts 2011; 118:2232.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 2232
-
-
Dusheiko, G.1
Afdhal, N.H.2
Giannini, E.3
-
48
-
-
38949111420
-
Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia
-
DOI 10.1182/blood-2007-09-111492
-
Visco C, Ruggeri M, Laura Evangelista M, et al. Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia. Blood 2008; 111:1110-1116. (Pubitemid 351213389)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1110-1116
-
-
Visco, C.1
Ruggeri, M.2
Evangelista, M.L.3
Stasi, R.4
Zanotti, R.5
Giaretta, I.6
Ambrosetti, A.7
Madeo, D.8
Pizzolo, G.9
Rodeghiero, F.10
-
49
-
-
79953224842
-
Romiplostim for chronic lymphocytic leukemiaassociated immune thrombocytopenia
-
D'Arena G, Cascavilla N. Romiplostim for chronic lymphocytic leukemiaassociated immune thrombocytopenia. Leuk Lymphoma 2011; 52:701-704.
-
(2011)
Leuk Lymphoma
, vol.52
, pp. 701-704
-
-
D'Arena, G.1
Cascavilla, N.2
-
50
-
-
79953181294
-
Thrombopoietin receptor agonists can be used temporarily with patients suffering from refractory chronic lymphocytic leukemia-associated immunologic thrombocytopenia
-
Sinisalo M, Sankelo M, Itala-Remes M. Thrombopoietin receptor agonists can be used temporarily with patients suffering from refractory chronic lymphocytic leukemia-associated immunologic thrombocytopenia. Leuk Lymphoma 2011; 52:724-725.
-
(2011)
Leuk Lymphoma
, vol.52
, pp. 724-725
-
-
Sinisalo, M.1
Sankelo, M.2
Itala-Remes, M.3
-
51
-
-
78650669297
-
Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations
-
Pecci A, Gresele P, Klersy C, et al. Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations. Blood 2010; 116:5832-5837.
-
(2010)
Blood
, vol.116
, pp. 5832-5837
-
-
Pecci, A.1
Gresele, P.2
Klersy, C.3
-
52
-
-
84859567130
-
Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD
-
Leon C, Evert K, Dombrowski F, et al. Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD. Blood 2012; 119:3333-3341.
-
(2012)
Blood
, vol.119
, pp. 3333-3341
-
-
Leon, C.1
Evert, K.2
Dombrowski, F.3
-
53
-
-
84872219989
-
Platelet function and response to thrombopoietin mimetics in Wiskott-Aldrich syndrome/X-linked thrombocytopenia
-
Bussel JB, Frelinger AL, III, Mitchell WB, et al. Platelet function and response to thrombopoietin mimetics in Wiskott-Aldrich syndrome/X-linked thrombocytopenia. ASH Annual Meeting Abstracts 2010; 116:1429.
-
(2010)
ASH Annual Meeting Abstracts
, vol.116
, pp. 1429
-
-
Bussel, J.B.1
Frelinger, A.L.2
Iii Mitchell, W.B.3
-
54
-
-
84865437630
-
Romiplostim in a case series of chemotherapyinduced thrombocytopenia
-
Parameswaran R, Soff GA. Romiplostim in a case series of chemotherapyinduced thrombocytopenia. ASH Annual Meeting Abstracts 2011; 118: 1170.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 1170
-
-
Parameswaran, R.1
Soff, G.A.2
-
55
-
-
79952708586
-
Efficacy of romiplostim in the treatment of chemotherapy induced thrombocytopenia (CIT) in a patient with mantle cell lymphoma
-
Demeter J, Istenes I, Fodor A, et al. Efficacy of romiplostim in the treatment of chemotherapy induced thrombocytopenia (CIT) in a patient with mantle cell lymphoma. Pathol Oncol Res 2011; 17:141-143.
-
(2011)
Pathol Oncol Res
, vol.17
, pp. 141-143
-
-
Demeter, J.1
Istenes, I.2
Fodor, A.3
-
56
-
-
84872206476
-
Phase i study of eltrombopag for promoting thrombopoiesis in patients undergoing stem cell transplantation after total body irradiation
-
Liesveld JL, Phillips GL, II, Becker MW, et al. Phase I study of eltrombopag for promoting thrombopoiesis in patients undergoing stem cell transplantation after total body irradiation. ASH Annual Meeting Abstracts 2011; 118:3295.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 3295
-
-
Liesveld, J.L.1
Phillips, G.L.2
Becker II, M.W.3
-
57
-
-
79952689335
-
Romiplostin may revert the thrombocytopenia in graft-versus-host disease
-
Ruiz-Delgado GJ, Lutz-Presno J, Ruiz-Arguelles GJ. Romiplostin may revert the thrombocytopenia in graft-versus-host disease. Hematology 2011; 16: 108-109.
-
(2011)
Hematology
, vol.16
, pp. 108-109
-
-
Ruiz-Delgado, G.J.1
Lutz-Presno, J.2
Ruiz-Arguelles, G.J.3
-
58
-
-
84872208855
-
Thrombopoietic agonists show efficacy in ITP related to allogeneic stem cell transplantation
-
O'Donovan EM, Rezvani K, Sargent J, et al. Thrombopoietic agonists show efficacy in ITP related to allogeneic stem cell transplantation. ASH Annual Meeting Abstracts 2011; 118:3292.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 3292
-
-
O'Donovan, E.M.1
Rezvani, K.2
Sargent, J.3
-
59
-
-
84865419300
-
Romiplostim [AMG531, Nplate(R)] for secondary failure of platelet recovery after allogeneic stem-cell transplantation
-
Calmettes C, Vigouroux S, Tabrizi R, Milpied N. Romiplostim [AMG531, Nplate(R)] for secondary failure of platelet recovery after allogeneic stem-cell transplantation. ASH Annual Meeting Abstracts 2011; 118:1994.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 1994
-
-
Calmettes, C.1
Vigouroux, S.2
Tabrizi, R.3
Milpied, N.4
-
60
-
-
84872205110
-
Use of romiplostim to facilitate platelet engraftment in allogeneic hematopoietic transplantation
-
Ojeda E, Garcia-Marco JA, Navarro B, et al. Use of romiplostim to facilitate platelet engraftment in allogeneic hematopoietic transplantation. ASH Annual Meeting Abstracts 2011; 118:1947.
-
(2011)
ASH Annual Meeting Abstracts
, vol.118
, pp. 1947
-
-
Ojeda, E.1
Garcia-Marco, J.A.2
Navarro, B.3
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