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McHutchison JG, Dusheiko G, Shiffman ML, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007; 357:2227-2236. Phase II placebo-controlled randomized clinical trial, 74 patients with HCV-related cirrhosis and thrombocytopenia randomly assigned to receive eltrombopag or placebo daily for 4 weeks demonstrated a dose-dependent increase in platelets allowing a greater number of patients to complete treatment for HCV.
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McHutchison JG, Dusheiko G, Shiffman ML, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007; 357:2227-2236. Phase II placebo-controlled randomized clinical trial, 74 patients with HCV-related cirrhosis and thrombocytopenia randomly assigned to receive eltrombopag or placebo daily for 4 weeks demonstrated a dose-dependent increase in platelets allowing a greater number of patients to complete treatment for HCV.
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Bussel JB, Cheng G, Saleh MN, et al. Elrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007; 357:2237-2247. Phase II placebo-controlled randomized clinical trial, 118 adults with chronic ITP and significant thrombocytopenia assigned to receive ertrombopag or placebo, demonstrated dose-dependent increase in platelets, decreased bleeding and minimal side effects.
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