Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. part 2: Hits from softfocus kinase and other libraries

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 7750-7754

  Younis, Yassir ^a   Street, Leslie J ^a   Waterson, David ^b   Witty, Michael J ^b   Chibale, Kelly ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b ICC   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIDINE DERIVATIVE; AN 3661; ANTIPROTOZOAL AGENT; ARTEMISININ DERIVATIVE; CHLOROQUINE; MEFLOQUINE; PIPERAZINE; PYRAZOLE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG METABOLISM; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR LIBRARY; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PROCESS OPTIMIZATION; WHOLE CELL;

ADMINISTRATION, ORAL; ANTIMALARIALS; CHEMISTRY, PHARMACEUTICAL; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; MALARIA, FALCIPARUM; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886541468     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400279y     Document Type: Article

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