Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 8073-8088

  Vidler, Lewis R ^a   Filippakopoulos, Panagis ^b,c   Fedorov, Oleg ^b   Picaud, Sarah ^b   Martin, Sarah ^b   Tomsett, Michael ^a   Woodward, Hannah ^a   Brown, Nathan ^a   Knapp, Stefan ^b   Hoelder, Swen ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROMODOMAIN 4; BROMODOMAIN 4 INHIBITOR; LYSINE; PEPTIDES AND PROTEINS; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; EPIGENETICS; MOLECULAR DOCKING; PHARMACOPHORE; VIRTUAL REALITY;

COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 84886504602     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4011302     Document Type: Article

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