Proliferative Vitreoretinopathy after eye injuries: An overexpression of growth factors and cytokines leading to a retinal keloid

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Morescalchi, Francesco ^a   Duse, Sarah ^a   Gambicorti, Elena ^a   Romano, Mario R ^b,c   Costagliola, Ciro ^b   Semeraro, Francesco ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

^c Scuola di Medicina e Istituto Clinico Humanitas   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DAUNORUBICIN; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; FLUOROURACIL; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LOW MOLECULAR WEIGHT HEPARIN; LYMPHOTOXIN; PLATELET DERIVED GROWTH FACTOR; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA2; TRIAMCINOLONE; TRIAMCINOLONE ACETONIDE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SIGNAL PEPTIDE;

CATARACT; DISEASE PREDISPOSITION; EYE INJURY; GLAUCOMA; HISTOPATHOLOGY; HUMAN; KELOID; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DISEASE; REVIEW; VITREORETINOPATHY; ANIMAL; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RETINA; VISION; VITREOUS BODY;

ANIMALS; CYTOKINES; EYE INJURIES; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KELOID; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RETINA; VISION, OCULAR; VITREORETINOPATHY, PROLIFERATIVE; VITREOUS BODY;

EID: 84886451551     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/269787     Document Type: Review

References (129)

1. Schmidt G. W., Broman A. T., Hindman H. B., Grant M. P., Vision survival after open globe injury predicted by classification and regression tree analysis. Ophthalmology 2008 115 1 202 209 2-s2.0-37349123468 10.1016/j.ophtha.2007.04.008 (Pubitemid 350309421)
2. Négrel A.-D., Thylefors B., The global impact of eye injuries. Ophthalmic Epidemiology 1998 5 3 143 169 2-s2.0-0031695670 10.1076/opep.5.3.143. 8364 (Pubitemid 28474993)
3. Lee C.-H., Lee L., Kao L.-Y., Lin K.-K., Yang M.-L., Prognostic indicators of open globe injuries in children. American Journal of Emergency Medicine 2009 27 5 530 535 2-s2.0-66049111280 10.1016/j.ajem.2008.04.004
4. Kuhn F., Morris R., Witherspoon C. D., Heimann K., Jeffers J. B., Treister G., A standardized classification of ocular trauma. Ophthalmology 1996 103 2 240 243 2-s2.0-0030059971 (Pubitemid 26066204)
5. Pieramici D. J., Sternberg P. J., Aaberg T.M. S., Bridges W.Z. J., Capone A. J., Cardillo J. A., De Juan E. J., Kuhn F., Meredith T. A., Mieler W. F., Olsen T. W., Rubsamen P., Stout T., A system for classifying mechanical injuries of the eye (globe). American Journal of Ophthalmology 1997 123 6 820 831 2-s2.0-0030906386 (Pubitemid 27250929)
6. De Juan E. Jr., Sternberg P. Jr., Michels R. G., Penetrating ocular injuries. Types of injuries and visual results. Ophthalmology 1983 90 11 1318 1322 2-s2.0-0021014878 (Pubitemid 14200814)
7. Williams D. F., Mieler W. F., Abrams G. W., Lewis H., Results and prognostic factors in penetrating ocular injuries with retained intraocular foreign bodies. Ophthalmology 1988 95 7 911 916 2-s2.0-0023887852
8. Imrie F. R., Cox A., Foot B., MacEwen C. J., Surveillance of intraocular foreign bodies in the UK. Eye 2008 22 9 1141 1147 2-s2.0-52149096315 10.1038/sj.eye.6702868
9. Murillo-Lopez S. A., Perez A., Fernandez H., Suarez-Tata L., Magdalenic R., Fromow J., Dalma-Weiszhauz J., Penetrating ocular injury with retained intraocular foreign body: epidemiological factors, clinical features and visual outcome. Investigative Ophthalmology & Visual Science 2002 43, article 3059
10. Kruger E. F., Nguyen Q. D., Ramos-Lopez M., Lashkari K., Proliferative vitreoretinopathy after trauma. International Ophthalmology Clinics 2002 42 3 129 143 2-s2.0-0035986419 (Pubitemid 34804022)
11. Weller M., Wiedemann P., Heimann K., Proliferative vitreoretinopathy-is it anything more than wound healing at the wrong place? International Ophthalmology 1990 14 2 105 117 2-s2.0-0025345755 10.1007/BF00154210 (Pubitemid 20197618)
12. Elner S. G., Elner MacKenzie Freeman V. M. H., Tolentino F. I., Albert A. M., Straatsma B. R., Flynn J. T., The pathology of anterior (peripheral) proliferative vitreoretinopathy. Transactions of the American Ophthalmological Society 1988 86 330 353 2-s2.0-0024218138 (Pubitemid 19101735)
13. Stödtler M., Holger M., Wiedemann P., Immunohistochemistry of anterior proliferative vitreoretinopathy. International Ophthalmology 1995 18 323 328
14. Colyer M. H., Chun D. W., Bower K. S., Dick J. S. B., Weichel E. D., Perforating globe injuries during operation Iraqi freedom. Ophthalmology 2008 115 11 2087.e2 2093.e2 2-s2.0-54949107721 10.1016/j.ophtha.2008.05.013
15. Cardillo J. A., Stout J. T., LaBree L., Azen S. P., Omphroy L., Cui J. Z., Kimura H., Hinton D. R., Ryan S. J., Post-traumatic proliferative vitreoretinopathy: the epidemiologic profile, onset, risk factors, and visual outcome. Ophthalmology 1997 104 7 1166 1173 2-s2.0-0030848404 (Pubitemid 27423861)
16. Mietz H., Kirchhof B., Heimann K., Anterior proliferative vitreoretinopathy in trauma and complicated retinal detachment. A histopathologic study. German Journal of Ophthalmology 1994 3 1 15 18 2-s2.0-0028249781
17. Cowley M., Conway B. P., Campochiaro P. A., Kaiser D., Gaskin H., Clinical risk factors for proliferative vitreoretinopathy. Archives of Ophthalmology 1989 107 8 1147 1151 2-s2.0-0024401908 (Pubitemid 19195640)
18. Angi M., Kalirai H., Coupland S. E., Damato B. E., Semeraro F., Romano M. R., Proteomic analyses of the vitreous humour. Mediators of Inflammation 2012 2012 7 148039 10.1155/2012/148039
19. Yu D.-Y., Cringle S. J., Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Progress in Retinal and Eye Research 2001 20 2 175 208 2-s2.0-0035136729 10.1016/S1350-9462(00)00027-6 (Pubitemid 32153715)
20. Campochiaro P. A., Bryan J. A. III, Conway B. P., Jaccoma E. H., Intravitreal chemotactic and mitogenic activity. Implication of blood-retinal barrier breakdown. Archives of Ophthalmology 1986 104 11 1685 1687 2-s2.0-0023024452 (Pubitemid 17174539)
21. Kon C. H., Asaria R. H. Y., Occleston N. L., Khaw P. T., Aylward G. W., Risk factors for proliferative vitreoretinopathy after primary vitrectomy: a prospective study. British Journal of Ophthalmology 2000 84 5 506 511 2-s2.0-0034117331 10.1136/bjo.84.5.506 (Pubitemid 30251712)
22. Kon C. H., Tranos P., Aylward G. W., Kirchoff B., Wong D., Risk factors in proliferative vitreoretinopathy. Vitreo-Retinal Surgery 2005 Berlin, Germany Springer
23. Abrams G. W., Azen S. P., McCuen B. W. II, Flynn H. W. Jr., Lai M. Y., Ryan S. J., Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow- up: silicone study report 11. Archives of Ophthalmology 1997 115 3 335 344 2-s2.0-0030968428
24. Kuhn F., Maisiak R., Mann L., Mester V., Morris R., Witherspoon C. D., The ocular trauma score (OTS). Ophthalmology Clinics of North America 2002 15 2 163 165 2-s2.0-0036592691 10.1016/S0896-1549(02)00007-X (Pubitemid 35007022)
25. Acar U., Tok O. Y., Acar D. E., Burcu A., Ornek F., A new ocular trauma score in pediatric penetrating eye injuries. Eye 2011 25 3 370 374 2-s2.0-79952607771 10.1038/eye.2010.211
26. Gupta A., Rahman I., Leatherbarrow B., Open globe injuries in children: factors predictive of a poor final visual acuity. Eye 2009 23 3 621 625 2-s2.0-62549150726 10.1038/eye.2008.32
27. Rostomian K., Thach A. B., Isfahani A., Pakkar A., Pakkar R., Borchert M., Open globe injuries in children. Journal of AAPOS 1998 2 4 234 238 2-s2.0-0032130890 (Pubitemid 128676820)
28. Lee C.-H., Lee L., Kao L.-Y., Lin K.-K., Yang M.-L., Prognostic indicators of open globe injuries in children. American Journal of Emergency Medicine 2009 27 5 530 535 2-s2.0-66049111280 10.1016/j.ajem.2008.04.004
29. Grieshaber M. C., Stegmann R., Penetrating eye injuries in South African children: aetiology and visual outcome. Eye 2006 20 7 789 795 2-s2.0-33748280966 10.1038/sj.eye.6702003 (Pubitemid 44316986)
30. Tok O., Tok L., Ozkaya D., Eraslan E., Ornek F., Bardak Y., Epidemiological characteristics and visual outcome after open globe injuries in children. Journal of AAPOS 2011 15 6 556 561 2-s2.0-83455246422 10.1016/j.jaapos.2011.06.012
31. la Cour M., Ehinger B., Fischbarg J., Retina. The Biology of the Eye 2006 Amsterdam, The Netherlands Elsevier 195 252
32. la Cour M., Tezel T., The retinal pigment epithelium. Advances in Organ Biology 2005 10 253 272 2-s2.0-33645910211 10.1016/S1569-2590(05)10009-3 (Pubitemid 43588820)
33. Lewis G., Mervin K., Valter K., Maslim J., Kappel P. J., Stone J., Fisher S., Limiting the proliferation and reactivity of retinal Muller cells during experimental retinal detachment: the value of oxygen supplementation. American Journal of Ophthalmology 1999 128 2 165 172 2-s2.0-0032770350 10.1016/S0002-9394(99)00103-8 (Pubitemid 29379768)
34. Mervin K., Valter K., Maslim J., Lewis G., Fisher S., Stone J., Limiting photoreceptor death and deconstruction during experimental Retinal detachment: the value of oxygen supplementation. American Journal of Ophthalmology 1999 128 2 155 164 2-s2.0-0032814064 10.1016/S0002-9394(99)00104-X (Pubitemid 29379767)
35. Sakai T., Lewis G. P., Linberg K. A., Fisher S. K., The ability of hyperoxia to limit the effects of experimental detachment in cone-dominated retina. Investigative Ophthalmology and Visual Science 2001 42 13 3264 3273 2-s2.0-0035656190 (Pubitemid 33740689)
36. Roos M. W., Theoretical estimation of retinal oxygenation during retinal detachment. Computers in Biology and Medicine 2007 37 6 890 896 2-s2.0-34047156554 10.1016/j.compbiomed.2006.09.005 (Pubitemid 46517526)
37. Anderson D. H., Stern W. H., Fisher S. K., Retinal detachment in the cat: the pigment epithelial-photoreceptor interface. Investigative Ophthalmology and Visual Science 1983 24 7 906 926 2-s2.0-0020526103 (Pubitemid 13036945)
38. Kroll A. J., Machemer R., Experimental retinal detachment in the owl monkey. III. Electron microscopy of retina and pigment epithelium. American Journal of Ophthalmology 1968 66 3 410 427 2-s2.0-0014324886
39. Cook B., Lewis G. P., Fisher S. K., Adler R., Apoptotic photoreceptor degeneration in experimental retinal detachment. Investigative Ophthalmology and Visual Science 1995 36 6 990 996 2-s2.0-0028935279
40. Nagar S., Krishnamoorthy V., Cherukuri P., Jain V., Dhingra N. K., Early remodeling in an inducible animal model of retinal degeneration. Neuroscience 2009 160 2 517 529 2-s2.0-64049097877 10.1016/j.neuroscience.2009.02.056
41. Fisher S. K., Lewis G. P., Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data. Vision Research 2003 43 8 887 897 2-s2.0-0037382282 10.1016/S0042-6989(02)00680-6 (Pubitemid 36369129)
42. Iandiev I., Uckermann O., Pannicke T., Wurm A., Tenckhoff S., Pietsch U.-C., Reichenbach A., Wiedemann P., Bringmann A., Uhlmann S., Glial cell reactivity in a porcine model of retinal detachment. Investigative Ophthalmology and Visual Science 2006 47 5 2161 2171 2-s2.0-33744723774 10.1167/iovs.05-0595 (Pubitemid 46768301)
43. Lewis G. P., Charteris D. G., Sethi C. S., Leitner W. P., Linberg K. A., Fisher S. K., The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment. Investigative Ophthalmology and Visual Science 2002 43 7 2412 2420 2-s2.0-0036293813 (Pubitemid 34700676)
44. Lewis G. P., Sethi C. S., Linberg K. A., Charteris D. G., Fisher S. K., Experimental retinal reattachment: a new perspective. Molecular Neurobiology 2003 28 2 159 175 2-s2.0-0742321907 10.1385/MN:28:2:159 (Pubitemid 38156430)
45. Velez G., Weingarden A. R., Tucker B. A., Lei H., Kazlauskas A., Young M. J., Retinal pigment epithelium and müller progenitor cell interaction increase müller progenitor cell expression of PDGFRalpha and ability to induce proliferative vitreoretinopathy in a rabbit model. Stem Cells International 2012 2012 1064 1086 10.1155/2012/106486
46. Johnsen E. O., Frøen R. C., Albert R., Omdal B. K., Sarang Z., Berta A., Nicolaissen B., Petrovski G., Moe M. C., Activation of neural progenitor cells in human eyes with proliferative vitreoretinopathy. Experimental Eye Research 2012 98 1 28 36 2-s2.0-84860234234 10.1016/j.exer.2012.03.008
47. Wilkins R. B., Kulwin D. R., Wound healing. Ophthalmology 1979 86 4 507 510 2-s2.0-0018574324 (Pubitemid 10165527)
48. Cleary P. E., Ryan S. J., Histology of wound, vitreous, and retina in experimental posterior penetrating eye injury in the rhesus monkey. American Journal of Ophthalmology 1979 88 2 221 231 2-s2.0-0018358876 (Pubitemid 9211172)
49. Cleary P. E., Ryan S. J., Method of production and natural history of experimental posterior penetrating eye injury in the rhesus monkey. American Journal of Ophthalmology 1979 88 2 212 220 2-s2.0-0018384913 (Pubitemid 9211171)
50. Tang S., Scheiffarth O. F., Thurau S. R., Wildner G., Cells of the immune system and their cytokines in epiretinal membranes and in the vitreous of patients with proliferative diabetic retinopathy. Ophthalmic Research 1993 25 3 177 185 2-s2.0-0027269637 (Pubitemid 23197319)
51. Kirchhof B., Sorgente N., Pathogenesis of proliferative vitreoretinopathy. Modulation of retinal pigment epithelial cell functions by vitreous and macrophages. Developments in Ophthalmology 1989 16 1 53 2-s2.0-0024352772
52. Lashkari K., Rahimi N., Kazlauskas A., Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. Investigative Ophthalmology and Visual Science 1999 40 1 149 156 2-s2.0-0032930715 (Pubitemid 29029583)
53. Ikuno Y., Kazlauskas A., An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor α receptor. Investigative Ophthalmology and Visual Science 2002 43 7 2406 2411 2-s2.0-0036288026 (Pubitemid 34700675)
54. Bastiaans J., van Meurs J. C., van Holten-Neelen C., Nijenhuis M. S., Kolijn-Couwenberg M. J., van Hagen P. M., Kuijpers R. W., Hooijkaas H., Dik W. A., Factor Xa and thrombin stimulate proinflammatory and profibrotic mediator production by retinal pigment epithelial cells: a role in vitreoretinal disorders? Graefe's Archive for Clinical and Experimental Ophthalmology 2013 251 7 1723 1733
55. Lei H., Velez G., Hovland P., Hirose T., Kazlauskas A., Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Investigative Ophthalmology and Visual Science 2008 49 1 42 48 2-s2.0-39549100205 10.1167/iovs.07-0776
56. Casaroli-Marano R. P., Pagan R., Vilaró S., Epithelial-mesenchymal transition in proliferative vitreoretinopathy: intermediate filament protein expression in retinal pigment epithelial cells. Investigative Ophthalmology and Visual Science 1999 40 9 2062 2072 2-s2.0-0032841562 (Pubitemid 29365171)
57. Anderson D. H., Stern W. H., Fisher S. K., The onset of pigment epithelial proliferation after retinal detachment. Investigative Ophthalmology and Visual Science 1981 21 1 10 16 2-s2.0-0019520482 (Pubitemid 11018937)
58. Wiedemann P., Growth factors in retinal diseases: proliferative vitreoretinopathy, proliferative diabetic retinopathy, and retinal degeneration. Survey of Ophthalmology 1992 36 5 373 384 2-s2.0-0026574455 10.1016/0039-6257(92)90115-A
59. Tezel T. H., Kaplan H. J., Del Priore L. V., Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch's membrane. Investigative Ophthalmology and Visual Science 1999 40 2 467 476 2-s2.0-0032894965 (Pubitemid 29063845)
60. Tezel T. H., Del Priore L. V., Kaplan H. J., Reengineering of aged Bruch's membrane to enhance retinal pigment epithelium repopulation. Investigative Ophthalmology and Visual Science 2004 45 9 3337 3348 2-s2.0-4344600751 10.1167/iovs.04-0193 (Pubitemid 39121874)
61. Del Priore L. V., Hornbeck R., Kaplan H. J., Jones Z., Valentino T. L., Mosinger- Ogilvie J., Swinn M., Debridement of the pig retinal pigment epithelium in vivo. Archives of Ophthalmology 1995 113 7 939 944 2-s2.0-0028972596
62. Del Priore L. V., Kaplan H. J., Hornbeck R., Jones Z., Swinn M., Retinal pigment epithelial debridement as a model for the pathogenesis and treatment of macular degeneration. American Journal of Ophthalmology 1996 122 5 629 643 2-s2.0-0029842642 (Pubitemid 26371371)
63. Kiilgaard J. F., Prause J. U., Prause M., Scherfig E., Nissen M. H., La Cour M., Subretinal posterior pole injury induces selective proliferation of RPE cells in the periphery in in vivo studies in pigs. Investigative Ophthalmology and Visual Science 2007 48 1 355 360 2-s2.0-33846909313 10.1167/iovs.05-1565 (Pubitemid 47251424)
64. Del Priore L. V., Tezel T. H., Kaplan H. J., Maculoplasty for age-related macular degeneration: reengineering Bruch's membrane and the human macula. Progress in Retinal and Eye Research 2006 25 6 539 562 2-s2.0-33750523637 10.1016/j.preteyeres.2006.08.001 (Pubitemid 44666508)
65. Glaser B. M., Cardin A., Biscoe B., Proliferative vitreoretinopathy: the mechanism of development of vitreoretinal traction. Ophthalmology 1987 94 4 327 332 2-s2.0-0023124396 (Pubitemid 17056017)
66. Harris A. K., Stopak D., Wild P., Fibroblast traction as a mechanism for collagen morphogenesis. Nature 1981 290 5803 249 251 2-s2.0-0019459687 (Pubitemid 11149655)
67. Bochaton-Piallat M.-L., Kapetanios A. D., Donati G., Redard M., Gabbiani G., Pournaras C. J., TGF- β 1, TGF- β receptor II and ED-A fibronectin expression in myofibroblast of vitreoretinopathy. Investigative Ophthalmology and Visual Science 2000 41 8 2336 2342 2-s2.0-0034218680 (Pubitemid 30451011)
68. Parmeggiani F., Campa C., Costagliola C., Incorvaia C., Sheridan C., Semeraro F., De Nadai K., Sebastiani A., Inflammatory mediators and angiogenic factors in choroidal neovascularization: pathogenetic interactions and therapeutic implications. Mediators of Inflammation 2010 2010 2-s2.0-77957899993 10.1155/2010/546826 546826
69. Cassidy L., Barry P., Shaw C., Duffy J., Kennedy S., Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. British Journal of Ophthalmology 1998 82 2 181 185 2-s2.0-0031976174 (Pubitemid 28176995)
70. Raica M., Cimpean A. M., Platelet-derived growth factor (PDGF)/PDGF receptors (PDGFR) axis as target for antitumor and antiangiogenic therapy. Pharmaceuticals 2010 3 3 572 599 2-s2.0-77950391566 10.3390/ph3030572
71. Heldin C. H., Westermark B., Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Regulation 1990 1 8 555 566 2-s2.0-0025464639
72. Hoch R. V., Soriano P., Roles of PDGF in animal development. Development 2003 130 20 4769 4784 2-s2.0-0142243109 10.1242/dev.00721 (Pubitemid 37321862)
73. Lei H., Hovland P., Velez G., Haran A., Gilbertson D., Hirose T., Kazlauskas A., A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Investigative Ophthalmology and Visual Science 2007 48 5 2335 2342 2-s2.0-34250155972 10.1167/iovs.06-0965 (Pubitemid 351261314)
74. Cui J., Lei H., Samad A., Basavanthappa S., Maberley D., Matsubara J., Kazlauskas A., PDGF receptors are activated in human epiretinal membranes. Experimental Eye Research 2009 88 3 438 444 2-s2.0-61549117508 10.1016/j.exer.2008.10.020
75. Campochiaro P. A., Hackett S. F., Vinores S. A., Freund J., Csaky C., LaRochelle W., Henderer J., Johnson M., Rodriguez I. R., Friedman Z., Derevjanik N., Dooner J., Platelet-derived growth factor is an autocrine growth stimulator in retinal pigmented epithelial cells. Journal of Cell Science 1994 107 9 2459 2469 2-s2.0-0028015919 (Pubitemid 24292494)
76. Yamada H., Yamada E., Ando A., Seo M.-S., Esumi N., Okamoto N., Vinores M., LaRochelle W., Zack D. J., Campochiaro P. A., Platelet-derived growth factor-A-induced retinal gliosis protects against ischemic retinopathy. American Journal of Pathology 2000 156 2 477 487 2-s2.0-0033903434 (Pubitemid 30643803)
77. Mori K., Gehlbach P., Ando A., Dyer G., Lipinsky E., Chaudhry A. G., Hackett S. F., Campochiaro P. A., Retina-specific expression of PDGF-B versus PDGF-A: vascular versus nonvascular proliferative retinopathy. Investigative Ophthalmology and Visual Science 2002 43 6 2001 2006 2-s2.0-0036268132 (Pubitemid 34587053)
78. Ikuno Y., Leong F.-L., Kazlauskas A., Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor. Investigative Ophthalmology and Visual Science 2000 41 10 3107 3116 2-s2.0-0033828125
79. Lei H., Velez G., Hovland P., Hirose T., Gilbertson D., Kazlauskas A., Growth factors outside the PDGF family drive experimental PVR. Investigative Ophthalmology and Visual Science 2009 50 7 3394 3403 2-s2.0-67649970870 10.1167/iovs.08-3042
80. Pennock S., Kazlauskas A., Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses. Molecular and Cellular Biology 2012 32 10 1955 1966
81. Pennock S., Kim D., Mukai S., Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. American Journal of Pathology 2013 182 5 1659 1670
82. Zheng Y., Ikuno Y., Ohj M., Kusaka S., Jiang R., Çekiç O., Sawa M., Tano Y., Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Japanese Journal of Ophthalmology 2003 47 2 158 165 2-s2.0-0037624768 10.1016/S0021-5155(02)00698-6 (Pubitemid 36547825)
83. Lei H., Kazlauskas A., Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor α and thereby promote proliferation and survival of cells. Journal of Biological Chemistry 2009 284 10 6329 6336 2-s2.0-65249157149 10.1074/jbc.M808426200
84. Velez G., Weingarden A. R., Lei H., Kazlauskas A., Gao G., SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified Müller cell-induced rabbit models. Investigative Ophthalmology & Visual Science 2013 54 2 1392 1397
85. Pfeffer B. A., Flanders K. C., Guerin C. J., Danielpour D., Anderson D. H., Transforming growth factor beta 2 is the predominant isoform in the neural retina, retinal pigment epithelium-choroid and vitreous of the monkey eye. Experimental Eye Research 1994 59 3 323 333 2-s2.0-0027946201 10.1006/exer.1994.1114 (Pubitemid 24326996)
86. Connor T. B. Jr., Roberts A. B., Sporn M. B., Danielpour D., Dart L. L., Michels R. G., De Bustros S., Enger C., Kato H., Lansing M., Hayashi H., Glaser B. M., Correlation of fibrosis and transforming growth factor- β type 2 levels in the eye. Journal of Clinical Investigation 1989 83 5 1661 1666 2-s2.0-0024559791 (Pubitemid 19124123)
87. Kon C. H., Occleston N. L., Aylward G. W., Khaw P. T., Expression of vitreous cytokines in proliferative vitreoretinopathy: a prospective study. Investigative Ophthalmology and Visual Science 1999 40 3 705 712 2-s2.0-0033054280 (Pubitemid 29109449)
88. Yokoyama K., Kimoto K., Itoh Y., Nakatsuka K., Matsuo N., Yoshioka H., Kubota T., The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF- β 2 in human retinal pigment epithelial cells. Graefe's Archive for Clinical and Experimental Ophthalmology 2012 250 1 15 23 2-s2.0-84857373600 10.1007/s00417-011-1766-x
89. Kimoto K., Nakatsuka K., Matsuo N., Yoshioka H., p38 MAPK mediates the expression of type I collagen induced by TGF- β 2 in human retinal pigment epithelial cells ARPE-19. Investigative Ophthalmology and Visual Science 2004 45 7 2431 2437 2-s2.0-3142579185 10.1167/iovs.03-1276 (Pubitemid 38902619)
90. Carrington L., McLeod D., Boulton M., IL-10 and antibodies to TGF- β 2 and PDGF inhibit RPE-mediated retinal contraction. Investigative Ophthalmology and Visual Science 2000 41 5 1210 1216 2-s2.0-0034069958 (Pubitemid 30187562)
91. Nassar K., Lüke J., Lüke M., Kamal M., Abd El-Nabi E., Soliman M., Rohrbach M., Grisanti S., The novel use of decorin in prevention of the development of proliferative vitreoretinopathy (PVR). Graefe's Archive for Clinical and Experimental Ophthalmology 2011 249 11 1649 1660 2-s2.0-80755128427 10.1007/s00417-011-1730-9
92. Kita T., Molecular mechanisms of preretinal membrane contraction in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Nippon Ganka Gakkai Zasshi 2010 114 11 927 934 2-s2.0-79952114202
93. Hoerster R., Muether P. S., Vierkotten S., Hermann M. M., Kirchhof B., Fauser S., Upregulation of TGF-ß1 in experimental proliferative vitreoretinopathy is accompanied by epithelial to mesenchymal transition. Graefe's Archive for Clinical and Experimental Ophthalmology 2013 10.1007/s00417-013-2377-5
94. Zhu J., Nguyen D., Ouyang H., Zhang X. H., Chen X. M., Zhang K., Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF- β in ARPE-19. International Journal of Ophthalmology 2013 6 1 8 14
95. Spoettl T., Hausmann M., Klebl F., Dirmeier A., Klump B., Hoffmann J., Herfarth H., Timmer A., Rogler G., Serum soluble TNF receptor I and II levels correlate with disease activity in IBD patients. Inflammatory Bowel Diseases 2007 13 6 727 732 2-s2.0-34250345556 10.1002/ibd.20107 (Pubitemid 46909987)
96. Rojas J., Fernandez I., Pastor J. C., Garcia-Gutierrez M. T., Sanabria M. R., Brion M., Coco R. M., Ruiz-Moreno J. M., Garcia-Arumi J., Elizalde J., Ruiz-Miguel M., Gallardo J. M., Corrales R. M., Carracedo A., A strong genetic association between the tumor necrosis factor locus and proliferative vitreoretinopathy: the Retina 4 Project. Ophthalmology 2010 117 12 2417.e2 2423.e2 2-s2.0-78649897880 10.1016/j.ophtha.2010.03.059
97. Ware L. B., Matthay M. A., Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. American Journal of Physiology 2002 282 5 L924 L940 2-s2.0-0036080893 (Pubitemid 34654608)
98. Roitt I., Brostoff J., Male D., Cell-mediated immune reactions. Immunology 1998 10 5th London, UK Mosby 121 138
99. Symeonidis C., Papakonstantinou E., Androudi S., Tsaousis K. T., Tsinopoulos I., Brazitikos P., Karakiulakis G., Diza E., Dimitrakos S. A., Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade. Cytokine 2012 59 1 184 190 2-s2.0-84860641776 10.1016/j.cyto.2012.04.019
100. Kenarova B., Voinov L., Apostolov C., Vladimirova R., Misheva A., Levels of some cytokines in subretinal fluid in proliferative vitreoretinopathy and rhegmatogenous retinal detachment. European Journal of Ophthalmology 1997 7 1 64 67 2-s2.0-0030894233 (Pubitemid 27140444)
101. Cleary P. E., Minckler D. W., Ryan S. J., Ultrastructure of traction retinal detachment in rhesus monkey eyes after a posterior penetrating ocular injury. American Journal of Ophthalmology 1980 90 6 829 845 2-s2.0-0019159203 (Pubitemid 11199136)
102. Deshmane S. L., Kremlev S., Amini S., Sawaya B. E., Monocyte chemoattractant protein-1 (MCP-1): an overview. Journal of Interferon and Cytokine Research 2009 29 6 313 325 2-s2.0-66149172257 10.1089/jir.2008.0027
103. Abu El-Asrar A. M., Van Damme J., Put W., Veckeneer M., Dralands L., Billiau A., Missotten L., Monocyte chemotactic protein-1 in proliferative vitreoretinal disorders. American Journal of Ophthalmology 1997 123 5 599 606 2-s2.0-0030911504 (Pubitemid 27203280)
104. Kirchhof B., Strategies to influence PVR development. Graefe's Archive for Clinical and Experimental Ophthalmology 2004 242 8 699 703 2-s2.0-4544361714 10.1007/s00417-004-0978-8 (Pubitemid 39242847)
105. Anderson D. H., Guerin C. J., Erickson P. A., Stern W. H., Fisher S. K., Morphological recovery in the reattached retina. Investigative Ophthalmology & Visual Science 1986 27 168 183 (Pubitemid 16129783)
106. Blumenkranz M., Hernandez E., Ophir A., Norton E. W. D., 5-fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. Ophthalmology 1984 91 2 122 130 2-s2.0-0021360271 (Pubitemid 14193854)
107. Stern W. H., Lewis G. P., Erickson P. A., Fluorouracil therapy for proliferative vitreoretinopathy after vitrectomy. American Journal of Ophthalmology 1983 96 1 33 42 2-s2.0-0020622557 (Pubitemid 13073319)
108. Blumenkranz M. S., Hartzer M. K., Iverson D., An overview of potential applications of heparin in vitreoretinal surgery. Retina 1992 12 3, supplement S71 S74 2-s2.0-0026675777
109. Asaria R. H. Y., Kon C. H., Bunce C., Charteris D. G., Wong D., Khaw P. T., Aylward G. W., Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy: results from a randomized, double-blind, controlled clinical trial. Ophthalmology 2001 108 7 1179 1183 2-s2.0-0034977919 10.1016/S0161- 6420(01)00589-9 (Pubitemid 32568123)
110. Wickham L., Bunce C., Wong D., McGurn D., Charteris D. G., Randomized controlled trial of combined 5-fluorouracil and low-molecular-weight heparin in the management of unselected rhegmatogenous retinal detachments undergoing primary vitrectomy. Ophthalmology 2007 114 4 698 704 2-s2.0-33947595650 10.1016/j.ophtha.2006.08.042 (Pubitemid 46483695)
111. Sundaram V., Barsam A., Virgili G., Intravitreal low molecular weight heparin and 5-Fluorouracil for the prevention of proliferative vitreoretinopathy following retinal reattachment surgery. Cochrane Database of Systematic Reviews 2010 7 CD006421 2-s2.0-77955504704
112. Weller M., Heimann K., Wiedemann P., Cytotoxic effects of daunomycin on retinal pigment epithelium in vitro. Graefe's Archive for Clinical and Experimental Ophthalmology 1987 225 5 235 238 2-s2.0-0023189433
113. Wiedemann P., Lemmen K., Schmiedl R., Heimann K., Intraocular daunorubicin for the treatment and prophylaxis of traumatic proliferative vitreoretinopathy. American Journal of Ophthalmology 1987 104 1 10 14 2-s2.0-0023191880 (Pubitemid 17088758)
114. Wiedemann P., Hilgers R. D., Bauer P., Heimann K., Adjunctive daunorubicin in the treatment of proliferative vitreoretinopathy: results of a multicenter clinical trial. American Journal of Ophthalmology 1998 126 4 550 559 2-s2.0-0032189992 10.1016/S0002-9394(98)00115-9 (Pubitemid 28475919)
115. Campochiaro P. A., Hackett S. F., Conway B. P., Retinoic acid promotes density-dependent growth arrest in human retinal pigment epithelial cells. Investigative Ophthalmology and Visual Science 1991 32 1 65 72 2-s2.0-0026025783
116. Fekrat S., De Juan E. Jr., Campochiaro P. A., The effect of oral 13-cis-retinoic acid on retinal redetachment after surgical repair in eyes with proliferative vitreoretinopathy. Ophthalmology 1995 102 3 412 418 2-s2.0-0028911038
117. Chang Y.-C., Hu D.-N., Wu W.-C., Effect of oral 13-cis-retinoic acid treatment on postoperative clinical outcome of eyes with proliferative vitreoretinopathy. American Journal of Ophthalmology 2008 146 3 440.e1 446.e1 2-s2.0-49749103241 10.1016/j.ajo.2008.05.002
118. Umazume K., Liu L., Scott P. A., de Castro J. P., McDonald K., Kaplan H. J., Tamiya S., Inhibition of PVR with a tyrosine kinase inhibitor, Dasatinib, in the swine. Investigative Ophthalmology & Visual Science 2013 54 2 1150 1159
119. Andrews A., Balciunaite E., Leong F. L., Tallquist M., Soriano P., Refojo M., Kazlauskas A., Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Investigative Ophthalmology and Visual Science 1999 40 11 2683 2689 2-s2.0-0032831078 (Pubitemid 29455500)
120. Ciulla T. A., Walker J. D., Fong D. S., Criswell M. H., Corticosteroids in posterior segment disease: an update on new delivery systems and new indications. Current Opinion in Ophthalmology 2004 15 3 211 220 2-s2.0-2442547705 10.1097/01.icu.0000120711.35941.76 (Pubitemid 38638866)
121. Durant S., Duval D., Homo-Delarche F., Factors involved in the control of fibroblast proliferation by glucocorticoids: a review. Endocrine Reviews 1986 7 3 254 269 2-s2.0-0022759549
122. Bali E., Feron E. J., Peperkamp E., Veckeneer M., Mulder P. G., Van Meurs J. C., The effect of a preoperative subconjuntival injection of dexamethasone on blood-retinal barrier breakdown following scleral buckling retinal detachment surgery: a prospective randomized placebo-controlled double blind clinical trial. Graefe's Archive for Clinical and Experimental Ophthalmology 2010 248 7 957 962 2-s2.0-77955656514 10.1007/s00417-010-1319-8
123. Leibovich S. J., Ross R., The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. American Journal of Pathology 1975 78 1 71 100 2-s2.0-0016428338
124. Tano Y., Chandler D., Machemer R., Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide. American Journal of Ophthalmology 1980 90 6 810 816 2-s2.0-0019215723 (Pubitemid 11199134)
125. Jonas J. B., Hayler J. K., Panda-Jonas S., Intravitreal injection of crystalline cortisone as adjunctive treatment of proliferative vitreoretinopathy. British Journal of Ophthalmology 2000 84 9 1064 1067 2-s2.0-0033825585 10.1136/bjo.84.9.1064
126. Hoerster R., Hermann M. M., Rosentreter A., Profibrotic cytokines in aqueous humour correlate with aqueous flare in patients with rhegmatogenous retinal detachment. British Journal of Ophthalmology 2013 97 4 450 453
127. Reibaldi M., Russo A., Longo A., Bonfiglio V., Uva M. G., Gagliano C., Toro M. D., Avitabile T., Rhegmatogenous retinal detachment with a high risk of proliferative vitreoretinopathy treated with episcleral surgery and an intravitreal dexamethasone 0. 7-mg implant. Case Reports in Ophthalmology 2013 244 1 79 83
128. Lei H., Velez G., Cui J., Samad A., Maberley D., Matsubara J., Kazlauskas A., N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. American Journal of Pathology 2010 177 1 132 140 2-s2.0-77954579454 10.2353/ajpath.2010.090604
129. Pennock S., Rheaume M.-A., Mukai S., Kazlauskas A., A novel strategy to develop therapeutic approaches to prevent Proliferative vitreoretinopathy. American Journal of Pathology 2011 179 6 2931 2940 2-s2.0-81255157506 10.1016/j.ajpath.2011.08.043