Factor Xa and thrombin stimulate proinflammatory and profibrotic mediator production by retinal pigment epithelial cells: A role in vitreoretinal disorders?

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 251, Issue 7, 2013, Pages 1723-1733

  Bastiaans, Jeroen ^a,b   Van Meurs, Jan C ^a,b   Van Holten Neelen, Conny ^b   Nijenhuis, Marja Smits Te ^b   Kolijn Couwenberg, Marion J ^b   Van Hagen, P Martin ^b   Kuijpers, Robert W A M ^b   Hooijkaas, Herbert ^b   Dik, Willem A ^b  

^a ROTTERDAM EYE HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Cytokine antibody array; Factor Xa; Fibrosis; Inflammation; Retinal pigment epithelium; Thrombin; Vitreoretinal fibrotic disorders

Indexed keywords

BLOOD CLOTTING FACTOR 10A; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 3; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR BB; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BLOOD RETINA BARRIER; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; PATHOGENESIS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VITREORETINOPATHY;

CELL LINE; CYTOKINES; DIABETIC RETINOPATHY; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR XA; FIBROSIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MACULAR DEGENERATION; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, PAR-1; RETINAL DISEASES; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; THROMBIN; VITREORETINOPATHY, PROLIFERATIVE;

EID: 84879240805     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-013-2335-2     Document Type: Article

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