Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19

International Journal of Ophthalmology

Volumn 6, Issue 1, 2013, Pages 8-14

  Zhu, Jing ^a,b   Nguyen, Duy ^b   Hong, Ouyang ^b   Zhang, Xiao Hui ^c   Chen, Xiao Ming ^a   Zhang, Kang ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Connective tissue growth factor; Proliferative vitreoretinopathy; Rho associated protein kinase inhibitor; Transforming growth factor

Indexed keywords

EID: 84880756192     PISSN: 22223959     EISSN: 22274898     Source Type: Journal    
DOI: 10.3980/j.issn.2222-3959.2013.01.02     Document Type: Article

References (30)

1. Lee J, Ko M, Joo CK Rho plays a key role in TGF-β1 induced cytoskeletal rearrangement in human retinal pigment epithelium. J Cell Physiol. 2008;216(2):520-526.
2. Binder S, Stanzel BV, Krebs I, Glittenberg C. Transplantation of the RPE in AMD. Prog Retin Eye Res. 2007;26(5):516-554.
3. Bovolenta P, Cisneros E. Retinitis pigmentosa: cone photoreceptors starving to death. Nat Neurosci. 2009;12(1):5-6.
4. Walia S, Fishman GA Natural history of phenotypic changes in Stargardt macular dystrophy. Ophthalmic Genet. 2009;30(2):63-68.
5. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85(3):845-881.
6. Connor TB, Jr, Roberts AB, Sporn M, Danielpour D, Dart LL, Michels RG, de Bustros S, Enger C, Kato H, Lansing M. Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. J Clin Invest. 1989;83(5):1661.
7. van Setten G., Berglin L, Blalock TD, Schultz G. Detection of connective tissue growth factor in subretinal fluid following retinal detachment: possible contribution to subretinal scar formation, preliminary results. Ophthalmic Res. 2005;37(6):289-292.
8. Lee SC, Kwon OW, Seong GJ, Kim SH, Ahn JE, Kay ED Epitheliomesenchymal transdifferentiation of cultured RPE cells. Ophthalmic Res. 2001;33(2):80-86.
9. Chaqour B, Goppelt-Struebe M. Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN 2 proteins. FEBS J. 2006;273(16):3639-3649.
10. Brigstock DR. The CCN family: a new stimulus package. J Endocrinol. 2003;178(2):169-175.
11. He S, Chen Y, Khankan R., Barron E, Burton R, Zhu DH, Ryan SJ, Oliver N, Hinton DR Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci. 2008;49(9):4078-4088.
12. Frazier K, Williams S, Kothapalli D., Klapper H, Grotendorst GR Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. Invest Ophthalmol Vis Sci. 1996;107(3):404-411.
13. Kireeva ML, Latinkic BV, Kolesnikova TV, Chen CC, Yang GP, Abler AS, Lau LF Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Exp Cell Res. 1997;233(1):63-77.
14. Leask A. Transcriptional profiling of the scleroderma fibroblast reveals a potential role for connective tissue growth factor (CTGF) in pathological fibrosis. Keio J Med. 2004;53(2):74-77.
15. Matsuda S, Gomi F, Katayama T., Koyama Y, Tohyama M, Tano Y. Induction of connective tissue growth factor in retinal pigment epithelium cells by oxidative stress. Jpn J Ophthalmol. 2006;50(3):229-234.
16. Nagai N, Klimava A, Lee WH, Izumi-Nagai K, Handa JT CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways. Invest Ophthalmol Vis Sci. 2009;50(4):1903-1910.
17. Yang M, Huang H, Li J., Huang W, Wang H. Connective tissue growth factor increases matrix metalloproteinase-2 and suppresses tissue inhibitor of matrix metalloproteinase-2 production by cultured renal interstitial fibroblasts. Wound Repair Regen. 2007;15(6):817-824.
18. Scheiffarth O, Kampik A, Günther H, Mark K. Proteins of the extracellular matrix in vitreoretinal membranes. Graefes Arch Clin Exp Ophthalmol. 1988;226(4):357-361.
19. Slack JL, Liska DJ, Bornstein P. Regulation of expression of the type I collagen genes. Am J Med Genet. 2005;45(2):140-151.
20. Koga T, Awai M, Tsutsui J., Yue BY JT, Tanihara H. Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells. Exp Eye Res. 2006;82(3):362-370.
21. Nakamura Y, Hirano S, Suzuki K., Seki K, Sagara T, Nishida T. Signaling mechanism of TGF-beta1-induced collagen contraction mediated by bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2002;43(11):3465-3472.
22. Haydont V, Mathe D, Bourgier C., Abdelali J, Aigueperse J, Bourhis J., Vozenin-Brotons MC. Induction of CTGF by TGF-beta1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives. Radiother Oncol. 2005;76(2):219-225.
23. Rodrigues-Diez R., Carvajal-Gonzalez G, Sanchez-Lopez E, Rodriguez-Vita J, Rodrigues Diez R, Selgas R, Ortiz A., Egido J, Mezzano S, Ruiz-Ortega M. Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways. Pharm Res. 2008;25(10):2447- 2461.
24. Saika S, Kono-Saika S, Tanaka T., Yamanaka O, Ohnishi Y, Sato M., Muragaki Y, Ooshima A, Yoo J., Flanders KC. Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice. Lab Invest. 2004;84(10):1245-1258.
25. Itoh Y, Kimoto K, Imaizumi M., Nakatsuka K. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-[beta] 2 in human retinal pigment epithelial cells. Exp Eye Res. 2007;84(3):464-472.
26. Folger PA, Zekaria D, Grotendorst G., Masur SK Transforming growth factor-beta-stimulated connective tissue growth factor expression during corneal myofibroblast differentiation. Invest Ophthalmol Vis Sci. 2001;42(11):2534- 2541.
27. Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ. 1996;7(4):469-480.
28. Schaft TL, Mooy CM, Bruijn WC, Bosman FT, Jong PTVM. Immunohistochemical light and electron microscopy of basal laminar deposit. Graefes Arch Clin Exp Ophthalmol. 1994;232(1):40-46.
29. Espinosa-Heidmann DG, Suner IJ, Catanuto P, Hernandez EP, Marin-Castano ME, Cousins SW Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. Invest Ophthalmol Vis Sci. 2006;47(2):729-737.
30. Cicha I, Goppelt-Struebe M, Muehlich S., Yilmaz A, Raaz D, Daniel WG, Garlichs CD Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress. Atherosclerosis. 2008;196(1):136-145.