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Volumn 37, Issue 11, 2013, Pages 1849-1861

Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes

Author keywords

14 3 3 Proteins; Ethanol; Phosphatidic Acid; Protein Synthesis; Rag GTPases

Indexed keywords

ALCOHOL; GUANOSINE TRIPHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE D; REGULATOR PROTEIN; RHEB PROTEIN; WORTMANNIN;

EID: 84886410024     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12174     Document Type: Article
Times cited : (20)

References (50)
  • 1
    • 73849101809 scopus 로고    scopus 로고
    • Key factors in mTOR regulation
    • Bai X, Jiang Y (2010) Key factors in mTOR regulation. Cell Mol Life Sci 67:239-253.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 239-253
    • Bai, X.1    Jiang, Y.2
  • 2
    • 65549158724 scopus 로고    scopus 로고
    • IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways
    • Bibollet-Bahena O, Almazan G (2009) IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways. J Neurochem 109:1440-1451.
    • (2009) J Neurochem , vol.109 , pp. 1440-1451
    • Bibollet-Bahena, O.1    Almazan, G.2
  • 3
    • 33644877400 scopus 로고    scopus 로고
    • 14-3-3 proteins: a number of functions for a numbered protein
    • Bridges D, Moorhead GB (2005) 14-3-3 proteins: a number of functions for a numbered protein. Sci STKE 2005:re10.
    • (2005) Sci STKE , vol.2005
    • Bridges, D.1    Moorhead, G.B.2
  • 4
    • 82455199123 scopus 로고    scopus 로고
    • The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin
    • Chen S, Synowsky S, Tinti M, MacKintosh C (2011) The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin. Trends Endocrinol Metab 22:429-436.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 429-436
    • Chen, S.1    Synowsky, S.2    Tinti, M.3    MacKintosh, C.4
  • 5
    • 70350545722 scopus 로고    scopus 로고
    • Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
    • Dibble CC, Asara JM, Manning BD (2009) Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 29:5657-5670.
    • (2009) Mol Cell Biol , vol.29 , pp. 5657-5670
    • Dibble, C.C.1    Asara, J.M.2    Manning, B.D.3
  • 6
    • 79851515753 scopus 로고    scopus 로고
    • Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism
    • Dickinson JM, Rasmussen BB (2011) Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism. Curr Opin Clin Nutr Metab Care 14:83-88.
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 83-88
    • Dickinson, J.M.1    Rasmussen, B.B.2
  • 7
    • 62749096589 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms
    • Dunlop EA, Tee AR (2009) Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cell Signal 21:827-835.
    • (2009) Cell Signal , vol.21 , pp. 827-835
    • Dunlop, E.A.1    Tee, A.R.2
  • 8
    • 77952749932 scopus 로고    scopus 로고
    • PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis
    • Faghiri Z, Bazan NG (2010) PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Exp Eye Res 90:718-725.
    • (2010) Exp Eye Res , vol.90 , pp. 718-725
    • Faghiri, Z.1    Bazan, N.G.2
  • 9
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294:1942-1945.
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 10
    • 68949103681 scopus 로고    scopus 로고
    • Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells
    • Foster DA (2009) Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells. Biochim Biophys Acta 1791:949-955.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 949-955
    • Foster, D.A.1
  • 11
    • 77953549575 scopus 로고    scopus 로고
    • Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection
    • Foster DA (2010) Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection. Cell Cycle 9:1291-1294.
    • (2010) Cell Cycle , vol.9 , pp. 1291-1294
    • Foster, D.A.1
  • 12
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony
    • Foster KG, Fingar DC (2010) Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem 285:14071-14077.
    • (2010) J Biol Chem , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 13
  • 15
    • 23144467910 scopus 로고    scopus 로고
    • An expanding role for mTOR in cancer
    • Guertin DA, Sabatini DM (2005) An expanding role for mTOR in cancer. Trends Mol Med 11:353-361.
    • (2005) Trends Mol Med , vol.11 , pp. 353-361
    • Guertin, D.A.1    Sabatini, D.M.2
  • 16
    • 0029122140 scopus 로고
    • ESBRA 1994 Award Lecture. Phosphatidylethanol formation: specific effects of ethanol mediated via phospholipase D
    • Gustavsson L (1995) ESBRA 1994 Award Lecture. Phosphatidylethanol formation: specific effects of ethanol mediated via phospholipase D. Alcohol Alcohol 30:391-406.
    • (1995) Alcohol Alcohol , vol.30 , pp. 391-406
    • Gustavsson, L.1
  • 17
    • 33746354908 scopus 로고    scopus 로고
    • Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes
    • Hong-Brown LQ, Brown CR, Huber DS, Lang CH (2006) Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes. Alcohol Clin Exp Res 30:1297-1307.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 1297-1307
    • Hong-Brown, L.Q.1    Brown, C.R.2    Huber, D.S.3    Lang, C.H.4
  • 18
    • 33947530921 scopus 로고    scopus 로고
    • Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes
    • Hong-Brown LQ, Brown CR, Huber DS, Lang CH (2007) Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes. J Biol Chem 282:3702-3712.
    • (2007) J Biol Chem , vol.282 , pp. 3702-3712
    • Hong-Brown, L.Q.1    Brown, C.R.2    Huber, D.S.3    Lang, C.H.4
  • 19
    • 77951728579 scopus 로고    scopus 로고
    • Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction
    • Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH (2010) Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. J Cell Biochem 109:1172-1184.
    • (2010) J Cell Biochem , vol.109 , pp. 1172-1184
    • Hong-Brown, L.Q.1    Brown, C.R.2    Kazi, A.A.3    Huber, D.S.4    Pruznak, A.M.5    Lang, C.H.6
  • 20
    • 84861172622 scopus 로고    scopus 로고
    • Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine
    • Hong-Brown LQ, Brown CR, Kazi AA, Navaratnarajah M, Lang CH (2012a) Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Am J Physiol Cell Physiol 302:C1557-C1565.
    • (2012) Am J Physiol Cell Physiol , vol.302
    • Hong-Brown, L.Q.1    Brown, C.R.2    Kazi, A.A.3    Navaratnarajah, M.4    Lang, C.H.5
  • 22
    • 84886376540 scopus 로고    scopus 로고
    • Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes
    • Hong-Brown LQ, Kazi AA, Lang CH (2012b) Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes. World J Biol Chem 3:110-120.
    • (2012) World J Biol Chem , vol.3 , pp. 110-120
    • Hong-Brown, L.Q.1    Kazi, A.A.2    Lang, C.H.3
  • 23
    • 33645241260 scopus 로고    scopus 로고
    • The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
    • Hornberger TA, Chu WK, Mak YW, Hsiung JW, Huang SA, Chien S (2006) The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc Natl Acad Sci U S A 103:4741-4746.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4741-4746
    • Hornberger, T.A.1    Chu, W.K.2    Mak, Y.W.3    Hsiung, J.W.4    Huang, S.A.5    Chien, S.6
  • 24
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL (2003a) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 25
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648-657.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 26
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL (2003b) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 27
    • 84862815824 scopus 로고    scopus 로고
    • Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners
    • Jang JH, Lee CS, Hwang D, Ryu SH (2012) Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners. Prog Lipid Res 51:71-81.
    • (2012) Prog Lipid Res , vol.51 , pp. 71-81
    • Jang, J.H.1    Lee, C.S.2    Hwang, D.3    Ryu, S.H.4
  • 29
    • 77949673390 scopus 로고    scopus 로고
    • Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake
    • Kim JH, Park JM, Yea K, Kim HW, Suh PG, Ryu SH (2010) Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake. PLoS ONE 5:e9600.
    • (2010) PLoS ONE , vol.5
    • Kim, J.H.1    Park, J.M.2    Yea, K.3    Kim, H.W.4    Suh, P.G.5    Ryu, S.H.6
  • 30
    • 0342672731 scopus 로고    scopus 로고
    • Ethanol inhibits astroglial cell proliferation by disruption of phospholipase D-mediated signaling
    • Kotter K, Klein J (1999) Ethanol inhibits astroglial cell proliferation by disruption of phospholipase D-mediated signaling. J Neurochem 73:2517-2523.
    • (1999) J Neurochem , vol.73 , pp. 2517-2523
    • Kotter, K.1    Klein, J.2
  • 31
    • 33947674706 scopus 로고    scopus 로고
    • Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR
    • Lehman N, Ledford B, Di Fulvio M, Frondorf K, McPhail LC, Gomez-Cambronero J (2007) Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR. FASEB J 21:1075-1087.
    • (2007) FASEB J , vol.21 , pp. 1075-1087
    • Lehman, N.1    Ledford, B.2    Di Fulvio, M.3    Frondorf, K.4    McPhail, L.C.5    Gomez-Cambronero, J.6
  • 32
    • 0242496906 scopus 로고    scopus 로고
    • Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway
    • Lim HK, Choi YA, Park W, Lee T, Ryu SH, Kim SY, Kim JR, Kim JH, Baek SH (2003) Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of rapamycin-p70 S6 kinase 1 pathway. J Biol Chem 278:45117-45127.
    • (2003) J Biol Chem , vol.278 , pp. 45117-45127
    • Lim, H.K.1    Choi, Y.A.2    Park, W.3    Lee, T.4    Ryu, S.H.5    Kim, S.Y.6    Kim, J.R.7    Kim, J.H.8    Baek, S.H.9
  • 34
    • 77954695619 scopus 로고    scopus 로고
    • Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic Beta cells
    • Ma WN, Park SY, Han JS (2010) Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic Beta cells. Exp Mol Med 42:456-464.
    • (2010) Exp Mol Med , vol.42 , pp. 456-464
    • Ma, W.N.1    Park, S.Y.2    Han, J.S.3
  • 35
    • 60549096247 scopus 로고    scopus 로고
    • Akt-dependent and -independent mechanisms of mTOR regulation in cancer
    • Memmott RM, Dennis PA (2009) Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal 21:656-664.
    • (2009) Cell Signal , vol.21 , pp. 656-664
    • Memmott, R.M.1    Dennis, P.A.2
  • 37
    • 67651096033 scopus 로고    scopus 로고
    • The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions
    • O'Neil TK, Duffy LR, Frey JW, Hornberger TA (2009) The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions. J Physiol 587:3691-3701.
    • (2009) J Physiol , vol.587 , pp. 3691-3701
    • O'Neil, T.K.1    Duffy, L.R.2    Frey, J.W.3    Hornberger, T.A.4
  • 38
    • 77957820670 scopus 로고    scopus 로고
    • Protein kinase B (AKT) mediates phospholipase D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells
    • Patel S, Djerdjouri B, Raoul-Des-Essarts Y, Dang PM, El-Benna J, Perianin A (2010) Protein kinase B (AKT) mediates phospholipase D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells. J Biol Chem 285:32055-32063.
    • (2010) J Biol Chem , vol.285 , pp. 32055-32063
    • Patel, S.1    Djerdjouri, B.2    Raoul-Des-Essarts, Y.3    Dang, P.M.4    El-Benna, J.5    Perianin, A.6
  • 39
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM (2010) Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141:290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 42
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441:424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 44
    • 62849111751 scopus 로고    scopus 로고
    • Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin
    • Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA (2009) Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol 29:1411-1420.
    • (2009) Mol Cell Biol , vol.29 , pp. 1411-1420
    • Toschi, A.1    Lee, E.2    Xu, L.3    Garcia, A.4    Gadir, N.5    Foster, D.A.6
  • 45
    • 4644262182 scopus 로고    scopus 로고
    • Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils
    • Tou JS, Gill JS (2005) Lysophosphatidic acid increases phosphatidic acid formation, phospholipase D activity and degranulation by human neutrophils. Cell Signal 17:77-82.
    • (2005) Cell Signal , vol.17 , pp. 77-82
    • Tou, J.S.1    Gill, J.S.2
  • 48
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 49
    • 79960387847 scopus 로고    scopus 로고
    • Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1)
    • Xu L, Salloum D, Medlin PS, Saqcena M, Yellen P, Perrella B, Foster DA (2011) Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem 286:25477-25486.
    • (2011) J Biol Chem , vol.286 , pp. 25477-25486
    • Xu, L.1    Salloum, D.2    Medlin, P.S.3    Saqcena, M.4    Yellen, P.5    Perrella, B.6    Foster, D.A.7
  • 50
    • 33744943819 scopus 로고    scopus 로고
    • Phospholipase D couples survival and migration signals in stress response of human cancer cells
    • Zheng Y, Rodrik V, Toschi A, Shi M, Hui L, Shen Y, Foster DA (2006) Phospholipase D couples survival and migration signals in stress response of human cancer cells. J Biol Chem 281:15862-15868.
    • (2006) J Biol Chem , vol.281 , pp. 15862-15868
    • Zheng, Y.1    Rodrik, V.2    Toschi, A.3    Shi, M.4    Hui, L.5    Shen, Y.6    Foster, D.A.7


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