Eupatolide inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through ROS-dependent heme oxygenase-1 induction

Phytotherapy Research

Volumn 27, Issue 11, 2013, Pages 1700-1707

  Kim, Namho ^a   Hwangbo, Cheol ^a   Lee, Suhyun ^a   Lee, Jeong Hyung ^a  

^a Kangwon National University   (South Korea)

Author keywords

eupatolide; heme oxygenase 1; migration; proliferation; vascular smooth muscle cell

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; EUPATOLID; HEME OXYGENASE 1; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SESQUITERPENE LACTONE DERIVATIVE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; AORTA MEDIA; ARTICLE; BIOACCUMULATION; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION;

INULA BRITANNICA; RATTUS;

EUPATOLIDE; HEME OXYGENASE-1; MIGRATION; PROLIFERATION; VASCULAR SMOOTH MUSCLE CELL;

ACETYLCYSTEINE; ANIMALS; ANTHRACENES; AORTA; BUTADIENES; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHROMONES; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); IMIDAZOLES; INULA; MALE; MORPHOLINES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-E2-RELATED FACTOR 2; NITRILES; PLATELET-DERIVED GROWTH FACTOR; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SESQUITERPENES;

EID: 84886292344     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4924     Document Type: Article

References (33)

1. Alam J, Stewart D, Touchard C, Boinapally S, Choi AM, Cook JL,. 1999. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274: 26071-26078.
2. Chen JS, Huang PH, Wang CH, et al,. 2011. Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract. Atherosclerosis 214: 301-309.
3. Feng J, Zhang P, Chen X, He G,. 2011. PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygenase-1 expression in rat vascular smooth muscle cells. J Cell Biochem 112: 1524-1531.
4. 2 involves KEAP1 disulfide formation. J Biol Chem 285: 8463-8471.
5. Itoh K, Wakabayashi N, Katoh Y, et al,. 1999. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13: 76-86.
6. Jin HZ, Lee D, Lee JH, Lee K, et al,. 2006. New sesquiterpene dimers from Inula britannica inhibit NF-κB activation and NO and TNF-α production in LPS-stimulated RAW264.7 cells. Planta Med 72: 40-45.
7. Juan SH, Lee TS, Tseng KW, et al,. 2001. Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation 104: 1519-1525.
8. Jun MS, Kim HS, Kim YM, et al,. 2012. Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice. Phytother Res 26: 605-612.
9. Kang MI, Kobayashi A, Wakabayashi N, Kim SG, Yamamoto M,. 2004. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci USA 101: 2046-2051.
10. Kher N, Marsh JD,. 2004. Pathobiology of atherosclerosis-a brief review. Semin Thromb Hemost 30: 665-672.
11. Kim JY, Cho HJ, Sir JJ, et al,. 2009. Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia. Cardiovasc Res 82: 550-560.
12. Kobayashi M, Yamamoto M,. 2005. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 7: 385-394.
13. 2-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase-1. Phytother Res 26: 988-994.
14. Lee J, Tae N, Lee JJ, Kim T, Lee JH,. 2010. Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. Eur J Pharmacol 636: 173-180.
15. Lee S, Seo J, Ryoo S, Cuong TD, Min BS, Lee JH,. 2012. Malabaricone C inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through induction of heme oxygenase-1. J Cell Biochem 113: 2866-2876.
16. Liu XM, Peyton KJ, Shebib AR, Wang H, Durante W,. 2011. Compound C stimulates heme oxygenase-1 gene expression via the Nrf2-ARE pathway to preserve human endothelial cell survival. Biochem Pharmacol 82: 371-379.
17. Loboda A, Jazwa A, Grochot-Przeczek A, et al,. 2008. Heme oxygenase-1 and the vascular bed: From molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 10: 1767-1812.
18. Lüscher TF, Steffel J, Eberli FR, et al,. 2007. Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications. Circulation 115: 1051-1058.
19. Maines MD, Panahian N,. 2001. The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? Adv Exp Med Biol 502: 249-272.
20. Morse D, Lin L, Choi AM, Ryter SW,. 2009. Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. Free Radic Biol Med 47: 1-12.
21. Nakao A, Murase N, Ho C, Toyokawa H, Billiar TR, Kanno S,. 2005. Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury. Circulation 112: 587-591.
22. Ollinger R, Yamashita K, Bilban M, et al,. 2007. Bilirubin and biliverdin treatment of atherosclerotic diseases. Cell Cycle 6: 39-43.
23. Owens GK, Kumar MS, Wamhoff BR,. 2004. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801.
24. Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S,. 2010. Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem Pharmacol 80: 1895-903.
25. Peterson SJ, Frishman WH, Abraham NG,. 2009. Targeting heme oxygenase: therapeutic implications for diseases of the cardiovascular system. Cardiol Rev 17: 99-111.
26. Raines EW,. PDGF and cardiovascular disease. 2004. Cytokine Growth Factor Rev 15: 237-254.
27. Rodriguez AI, Gangopadhyay A, Kelley EE, Pagano PJ, Zuckerbraun BS, Bauer PM,. 2010. HO-1 and CO decrease platelet-derived growth factor-induced vascular smooth muscle cell migration via inhibition of Nox1. Arterioscler Thromb Vasc Biol 30: 98-104.
28. Schwartz SM,. 1997. Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest 100: S87-S89.
29. Seidel P, Goulet S, Hostettler K, Tamm M, Roth M,. 2010. DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1. Respir Res 11: 145.
30. Song QH, Kobayashi T, Iijima K, Hong T, Cyong JC,. 2000. Hepatoprotective effects of Inula britannica on hepatic injury in mice. Phytother Res 14: 180-186.
31. Wang Y, Lindstedt KA, Kovanen PT,. 1995. Mast cell granule remnants carry LDL into smooth muscle cells of synthetic phenotype and induce their conversion into foam cells. Arterioscler Thromb Vasc Biol 15: 801-810.
32. Yet SF, Layne MD, Liu X, et al,. 2003. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J 17: 1759-1761.
33. Xu XL, Huang YJ, Chen XF, Lin DY, Zhang W,. 2012. 2,3,4',5- tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation of vascular smooth muscle cells: involvement of NO/cGMP/PKG pathway. Phytother Res 26: 1068-1074.