Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6

European Journal of Pharmacology

Volumn 636, Issue 1-3, 2010, Pages 173-180

  Lee, Jongkyu ^a   Tae, Nara ^a   Lee, Jung Joon ^b   Kim, Taeho ^a   Lee, Jeong Hyung ^a  

^a Kangwon National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

COX 2; Eupatolide; INOS; MAPKs; NF B; TRAF6 degradation

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; EUPATOLID; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEASOME; PROTEIN KINASE B; SERINE DERIVATIVE; SESQUITERPENE LACTONE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; UBIQUITINATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL PRODUCTS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; SESQUITERPENES; TNF RECEPTOR-ASSOCIATED FACTOR 6; TRANSCRIPTION, GENETIC; UBIQUITINATION;

EID: 77952671172     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.03.021     Document Type: Article

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