2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside inhibits proliferation of vascular smooth muscle cells: Involvement of NO/cGMP/PKG pathway

Phytotherapy Research

Volumn 26, Issue 7, 2012, Pages 1068-1074

  Xu, Xiao Le ^a   Huang, Yan Juan ^a   Chen, Xiang Fan ^a   Lin, Dan Yan ^a   Zhang, Wei ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

2,3,4 ,5 tetrahydroxystilbene 2 O d glucoside; cell proliferation; NO cGMP PKG pathway; platelet derived growth factor; vascular smooth muscle cells

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2,3,4',5 TETRAHYDOXYSTILBENE 2 O BETA DEXTRO GLUCOSIDE; KT 5823; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR BB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; FLOW CYTOMETRY; MALE; MOLECULAR MECHANICS; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CARBAZOLES; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSIDES; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXADIAZOLES; POLYGONUM; PROTO-ONCOGENE PROTEINS C-SIS; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STILBENES;

POLYGONUM MULTIFLORUM;

EID: 84863724623     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3691     Document Type: Article

References (25)

1. Browner NC, Dey NB, Bloch KD, Lincoln TM,. 2004. Regulation of cGMP-dependent protein kinase expression by soluble guanylyl cyclase in vascular smooth muscle cells. J Biol Chem 279: 46631-46636.
2. Buchwalow IB, Podzuweit T, Bocker W, et al,. 2002. Vascular smooth muscle and nitric oxide synthase. FASEB J 16: 500-508.
3. Buchwalow IB, Podzuweit T, Samoilova VE, et al,. 2004. An in situ evidence for autocrine function of NO in the vasculature. Nitric Oxide 10: 203-212.
4. Costa RS, Assreuy J,. 2005. Multiple potassium channels mediate nitric oxide-induced inhibition of rat vascular smooth muscle cell proliferation. Nitric Oxide 13: 145-151.
5. Cui HH, Tian Y, Ling SY,. 2009. The effective mechanism of 2,3,5,4'-tetrahydroxystilbene-2-O-β- d -glucoside in anti-atherosclerosis. Prog Mod Biomed 9: 3968-3971 (in Chinese with an English abstract).
6. Dzau VJ, Braun-Dullaeus RC, Sedding DG,. 2002. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat Med 8: 1249-1256.
7. Jaffe EA, Nachman RL, Becker CG, Minick CR,. 1973. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52: 2745-2756.
8. Jeremy JY, Rowe D, Emsley AM, Newby AC,. 1999. Nitric oxide and the proliferation of vascular smooth muscle cells. Cardiovasc Res 43: 580-594.
9. Kemp-Harper B, Schmidt HH,. 2009. cGMP in the vasculature. Handb Exp Pharmacol 191: 447-467.
10. Lincoln TM, Wu X, Sellak H, Dey N, Choi CS,. 2006. Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase. Front Biosci 11: 356-367.
11. Liu QL, Xiao JH, Ma R, Ban Y, Wang JL,. 2007. Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β- d -glucoside on lipoprotein oxidation and proliferation of coronary arterial smooth cells. J Asian Nat Prod Res 9: 689-697.
12. Makino T, Ono T, Muso E, Honda G,. 2002. Effect of Perilla frutescens on nitric oxide production and DNA synthesis in cultured murine vascular smooth muscle cells. Phytother Res 16: 19-23.
13. Murad F,. 2006. Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. N Engl J Med 355: 2003-2011.
14. Napoli C, Ignarro LJ,. 2009. Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. Arch Pharm Res 32: 1103-1108.
15. Naryzhny SN,. 2008. Proliferating cell nuclear antigen: a proteomics view. Cell Mol Life Sci 65: 3789-3808.
16. Ross R., 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809.
17. Rudijanto A,. 2007. The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis. Acta Med Indones 39: 86-93.
18. Sachinidis A, Locher R, Vetter W, Tatje D, Hoppe J,. 1990. Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells. J Biol Chem 265: 10238-10243.
19. Uchida K, Sasahara M, Morigami N, Hazamab F, Kinoshitaa M,. 1996. Expression of platelet derived growth factor beta-chain in neointimal smooth muscle cells of balloon injured rabbit femoral arteries. Atherosclerosis 124: 9-23.
20. Villalobo A,. 2006. Nitric oxide and cell proliferation. FEBS J 273: 2329-2344.
21. Xu XL, Huang YJ, Wang YQ, Chen XF, Zhang W,. 2011. 2,3,4',5- Tetrahydroxystilbene-2-O-β- d -glucoside inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells by regulating the cell cycle. Clin Exp Pharmacol Physiol 38: 307-313.
22. Zhang W, Wang CH, Li F, Zhu WZ,. 2008. 2,3,4',5-Tetrahydroxystilbene-2-O- β- d -glucoside suppresses matrix metalloproteinase expression and inflammation in atherosclerotic rats. Clin Exp Pharmacol Physiol 35: 310-316.
23. Zhang W, Xu XL, Wang YQ, Wang CH, Zhu WZ,. 2009. Effects of 2,3,4',5-tetrahydroxystilbene-2-O-β- d -glucoside on vascular endothelial dysfunction in atherogenic-diet rats. Planta Med 75: 1209-1214.
24. 2+ in the inhibition by crocetin of angiotensin II-induced ERK1/2 activation in vascular smooth muscle cells. Eur J Pharmacol 554: 85-91.
25. Zuckerbraun BS, Stoyanovsky DA, Sengupta R, et al,. 2007. Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA. Am J Physiol Cell Physiol 292: C824-C831.