Combination of preparative HPLC and HSCCC methods to separate phosphodiesterase inhibitors from Eucommia ulmoides bark guided by ultrafiltration-based ligand screening

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 12, 2013, Pages 4213-4223

  Shi, Shu Yun ^a,b   Peng, Mi Jun ^a   Zhang, Yu Ping ^b   Peng, Sheng ^a  

^a JISHOU UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Eucommia ulmoides; High speed countercurrent chromatography; Lignan; Phosphodiesterase inhibitors; Preparative highperformance liquid chromatography; Ultrafiltration

Indexed keywords

BINARY ALLOYS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; ESTERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGANDS; MASS SPECTROMETRY; ULTRAFILTRATION;

ELECTROSPRAY IONIZATION MASS SPECTROMETRY; EUCOMMIA ULMOIDES; HIGH THROUGHPUT SCREENING; HIGH-SPEED COUNTER CURRENT CHROMATOGRAPHY; LIGNAN; PHARMACOLOGICAL PROPERTIES; PHOSPHODIESTERASE INHIBITORS; PREPARATIVE ISOLATION;

ENZYME INHIBITION;

LIGAND; PHOSPHODIESTERASE INHIBITOR; PLANT EXTRACT;

ANIMAL; ARTICLE; BARK; CATTLE; CHEMISTRY; COUNTER CURRENT CHROMATOGRAPHY; DRUG SCREENING; EUCOMMIACEAE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METHODOLOGY; ULTRAFILTRATION;

ANIMALS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUNTERCURRENT DISTRIBUTION; DRUG EVALUATION, PRECLINICAL; EUCOMMIACEAE; LIGANDS; PHOSPHODIESTERASE INHIBITORS; PLANT BARK; PLANT EXTRACTS; ULTRAFILTRATION;

EID: 84886250421     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-6806-4     Document Type: Article

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