Separation of anti-ulcer flavonoids from Artemisia extracts by high-speed countercurrent chromatography

Food Chemistry

Volumn 129, Issue 2, 2011, Pages 679-683

  Yoon, Kee Dong ^a,b   Chin, Young Won ^a,c   Yang, Min Hye ^a   Kim, Jinwoong ^a  

^a Seoul National University   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Dongguk University   (South Korea)

Author keywords

Anti ulcer flavonoids; Artemisia princeps; Eupatilin; HSCCC; Jaceosidin

Indexed keywords

ANTI-ULCER FLAVONOIDS; ARTEMISIA PRINCEPS; EUPATILIN; HSCCC; JACEOSIDIN;

DISEASES; ETHANOL; HEXANE; LIQUID CHROMATOGRAPHY; METHANOL; ORGANIC SOLVENTS;

FLAVONOIDS;

ACETIC ACID ETHYL ESTER; ALCOHOL; ANTIULCER AGENT; ARTEMISIA PRINCEPS EXTRACT; CHLOROFORM; EUPATILIN; FLAVONOID; HEXANE; JACEOSIDIN; METHANOL; PLANT EXTRACT; UNCLASSIFIED DRUG; WATER;

ARTEMISIA; ARTEMISIA PRINCEPS; ARTICLE; COUNTER CURRENT CHROMATOGRAPHY; FLOW RATE; HIGH SPEED COUNTERCURRENT CHROMATOGRAPHY; NONHUMAN; SEPARATION TECHNIQUE; SOLVENT EXTRACTION;

ARTEMISIA; ARTEMISIA PRINCEPS;

EID: 79959986966     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.05.005     Document Type: Article

References (26)

1. R.-C. Alenjandro, E.C. Arturo, and D. Guillermo Sesquiterpene lactones and flavonoids from Artemisia ludoviciana ssp. mexicana Phytochemistry 33 1993 1113 1115
2. Bae, K. (1999). The medicinal plants of Korea (pp. 488-490). Seoul: Kyo-Hak.
3. M.-H. Bang, J.-K. Cho, M.-C. Song, D.-Y. Lee, M.-W. Han, and H.-G. Chung Development of biologically active compounds from edible plant sources XXII. Triterpenoids from the aerial parts of Sajabalssuk (Artemisia princeps Pampanini) Journal of the Korean Society of Applied Biological Chemistry 51 2008 223 227
4. M.-H. Bang, H.-G. Chung, M.-C. Song, J.-S. Yoo, D.-Y. Lee, and S.-Y. Kim Development of biologically active compounds from edible plant sources XVI. Isolation of sterols from the aerial parts of Sajabalssuk (Artemisia herba) Journal of the Korean Society of Applied Biological Chemistry 49 2006 140 144
5. M.-H. Bang, D.-H. Kim, J.-S. Yoo, D.-Y. Lee, M.-C. Song, and H.-J. Yang Development of biologically active compounds from edible plant sources XIV. Isolation and identification of flavonoids from the aerial parts of Sajabalssuk (Artemisia herba) Journal of the Korean Society of Applied Biological Chemistry 48 2005 418 420
6. Y.-H. Cho, and M.-H. Chiang Essential oil composition and antibacterial activity of Artemisia capillaris, Artemisia argyi, and Artemisia princeps Korean Journal of International Agriculture 13 2001 313 320
7. M. Clavin, S. Gorzalczany, A. Macho, E. Muñoz, G. Ferraro, and C. Acevedo Anti-inflammatory activity of flavonoids from Eupatorium arnottianum Journal of Ethnopharmacology 112 2007 585 589 (Pubitemid 47016880)
8. Y. Ito Golden rules and pitfalls in selecting optimum conditions for high-speed counter-current chromatography Journal of Chromatography A 1065 2005 145 168 (Pubitemid 40228728)
9. J.M. Jang, K.J. Park, D.G. Kim, H.J. Shim, B.O. Ahn, and S.H. Kim Pharmacokinetics of a new antigastritic agent, eupatilin, an active component of stillen(R), in rats The Journal of Applied Pharmacology 11 2003 163 168
10. Y. Jin, S.K. Han, and K.H. Row Extraction and purification of eupatilin from Artemisia princeps PAMPA Journal of the Korean Chemical Society 49 2005 196 200 (Pubitemid 40716640)
11. Jung, M. A.; Lee, K. W.; Surh, Y. J.; & Lee, H. J. (2006). Eupatilin for treating breast cancer. Kongkae Taeho Kongbo: Republic of Korea. Patent No. KR 2006121998 A 20061130, Application No. KR 2005-43891.
12. Y.-J. Kang, U.J. Jung, M.-K. Lee, H.-J. Kim, S.-M. Jeon, and Y.B. Park Eupatilin, isolated from Artemisia princeps Pampanini, enhances hepatic glucose metabolism and pancreatic cell function in type 2 diabetic mice Diabetes Research and Clinical Practice 82 2008 25 32
13. M.-J. Kim, J.-M. Han, Y.-Y. Jin, N.-I. Baek, M.-H. Bang, and H.-G. Chung In vitro antioxidant and anti-inflammatory activities of jaceosidin from Artemisia princeps Pampanini cv. Sajabal. KRIBB Archives of Pharmacal Research 31 2008 429 437
14. M.-J. Kim, D.-H. Kim, H.-K. Na, T.Y. Oh, C.-Y. Shin, and Y.-J. Surh Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells Journal of Environmental Pathology, Toxicology and Oncology 24 2005 261 269
15. K.S. Kim, S. Lee, K.-H. Kang, and B.-K. Kim Flavonol galactosides from Artemisia apiacea Natural Product Sciences 11 2005 10 12 (Pubitemid 40470587)
16. K.S. Kim, S. Lee, J.S. Shin, S.H. Shim, and B.-K. Kim Arteminin, a new coumarin from Artemisia apiacea Fitoterapia 73 2002 266 268 (Pubitemid 34603685)
17. D.-H. Kim, H.-K. Na, T.Y. Oh, C.-Y. Shin, and Y.-J. Surh Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells Journal of Environmental Pathology, Toxicology and Oncology 24 2005 251 259
18. S.H. Lee, E.-A. Bae, E.-K. Park, Y.-W. Shin, N.-I. Baek, and E.-J. Han Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity International Immunopharmacology 7 2007 1678 1684 (Pubitemid 350054929)
19. Lee, E.-B.; & Kang, S.-S. (1998). Antigastritis and antiulcer agent containing eupatilin, and isolation thereof. Kongkae Taeho Kongbo: Republic of Korea. Patent No. KR 127777, Application No. KR 1994-147.
20. K.R. Lee, O.P. Zee, J.H. Kwak, Y.S. Kim, K.H. Park, and K.A. Koo The polysaccharide fraction of Artemisia species Korean Journal of Pharmacognosy 24 1993 289 295
21. N.Q. Liu, F. Van der Kooy, and R. Verpoorte Artemisia afra: A potential flagship for African medicinal plants? South African Journal of Botany 75 2009 185 195
22. T. Nagao, F. Abe, J. Kinjo, and H. Okabe Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship Biological and Pharmaceutical Bulletin 25 2002 875 879 (Pubitemid 40022116)
23. T. Nakasugi, M. Nakashima, and K. Komai Antimutagens in Gaiyou (Artemisia argyi Levl. et Vant.) Journal of Agricultural and Food Chemistry 48 2000 3256 3266
24. G.F. Pauli, S.M. Pro, and J.B. Friesen Countercurrent separation of natural products Journal of Natural Products 71 2008 1489 1508
25. S.-N. Ryu, S.S. Kang, J.S. Kim, and B.I. Ku Quantitative analysis of eupatilin and jaceosidin in Artemisia herba Korean Journal of Crop Sciences 49 2004 452 456 (Pubitemid 40435062)
26. I.A. Sutherland, and D. Fisher Role of counter-current chromatography in the modernization of Chinese herbal medicines Journal of Chromatography A 1216 2009 740 753