Relationships of Genes and Early-Life Experience to the Neurobiology of Suicidal Behaviour

International Handbook of Suicide Prevention: Research, Policy and Practice

Volumn , Issue , 2011, Pages 133-150

  Mann, John J ^a   Currier, Dianne ^a  

^a New York State Psychiatric Institute ^*  (United States)

Author keywords

Alterations, in number of neurobiological systems associated with suicidal behaviour; Biological alterations in suicidal behaviour dysfunction in serotonergic system; Gene and early life experience relationship and neurobiology of suicidal behaviour; Genes and early life environment dysfunction in neurobiological systems, in adult suicide attempters and suicides; HPA axis, complexly interrelated with serotonergic and noradrenergic systems; HPA axis, the other major stress response system; Neurobiology of suicide, developmental factors childhood adversity, sexual or physical abuse; Stress response related genes and stress response systems, less studied with respect to candidate genes; Suicidal behaviour, in context of a diathesis predisposition, traits in multiple domains

Indexed keywords

EID: 84886203014     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119998556.ch8     Document Type: Chapter

References (132)

1. Agren, H. & Niklasson, F. (1986). Suicidal potential in depression: focus on CSF monoamine and purine metabolites. Psychopharmacology Bulletin, 22, 656-660.
2. Anguelova, M., Benkelfat, C., & Turecki, G. (2003). A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Molecular Psychiatry, 8, 646-653.
3. Arango, V., Ernsberger, P, Marzuk, P M., Chen, J.S., Tierney, H., Stanley, M., Reis, D. J., & Mann, J. J. (1990).&Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Archives of General Psychiatry, 47, 1038-1047.
4. Arango, V., Ernsberger, P., Sved, A. F., & Mann, J. J. (1993). Quantitative autoradiography of a1-and a2-adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Research, 630, 271-282.
5. Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre-and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research, 688, 121-133.
6. Arango, V., Underwood, M. D., & Mann, J. J. (1996). Fewer pigmented locus coeruleus neurons in suicide victims: Preliminary results. Biological Psychiatry, 39, 112-120.
7. Arango, V., Underwood, M. D., & Mann, J. J. (2002). Serotonin brain circuits involved in major depression and suicide. Progressive Brain Research, 136, 443-453.
8. Arango, V., Underwood, M. D., & Mann, J. J. (2003). Serotonin and neuropeptide circuitry in depression and suicide. Abstract. ACNP 42nd Annual Meeting.
9. Arato, M., Banki, C. M., Bissette, G., & Nemeroff, C. B. (1989). Elevated CSF CRF in suicide victims. Biological Psychiatry, 25, 355-359.
10. Arborelius, L. & Eklund, M. B. (2007). Both long and brief maternal separation produces persistent changes in tissue levels of brain monoamines in middle-aged female rats. Neuroscience, 145, 738-750.
11. Arborelius, L., Hawks, B. W., Owens, M. J., Plotsky, IP M., & Nemeroff, C. B. (2004). Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation. Psychopharmacology (Berlin), 176, 248-255.
12. Aston-Jones, G., Shipley, M. T., Chouvet, G., Ennis, M., van Bockstaele, E., Pieribone, V., Shiekhattar, R., Akaoka, H., Drolet, G., Astier, B., Charlety, P., Valentino, R. J., & Williams, J. T. (1991).&Afferent regulation of locus coeruleus neurons: Anatomy, physiology and pharmacology. Progress in Brain Research, 88, 47-75.
13. Avishai-Eliner, S., Eghbal-Ahmadi, M., Tabachnik, E., Brunson, K. L., & Baram, T. Z. (2001). Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA. Endocrinology, 142, 89-97.
14. Azmitia, E. C. & Gannon, P. J. (1986). The primate serotonergic system: a review of human and animal studies and a report on Macaca fascicularis. Advances in Neurology, 43, 407-468.
15. Bah, J., Lindstrom, M., Westberg, L., Manneras, L., Ryding, E., Henningsson, S., Melke, J., Rosen, I., Traskman-Bendz, L., & Eriksson, E. (2008). Serotonin transporter gene polymorphisms: effect on serotonin transporter availability in the brain of suicide attempters. Psychiatry Research, 162, 221-229.
16. Baldessarini, R. J. & Hennen, J. (2004). Genetics of suicide: An overview. Harvard Review of Psychiatry, 12, 1-13.
17. Barr, C. S., Newman, T. K., Shannon, C., Parker, C., Dvoskin, R. L., Becker, M. L., Schwandt, M., Champoux, M., Lesch, K. P., Goldman, D., Suomi, S. J., & Higley, J. D. (2004). Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biological Psychiatry, 55, 733-738.
18. Bellivier, F., Chaste, P., & Malafosse, A. (2004). Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. American Journal of Medical Genetics, 124B, 87-91.
19. Bennett, A. J., Lesch, K. P., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., Champoux, M., Suomi, S. J., Linnoila, M. V., & Higley, J. D. (2002). Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry, 7, 118-122.
20. Bhagwagar, Z., Hinz, R., Taylor, M., Fancy, S., Cowen, P., & Grasby, P. (2006). Increased 5-HT(2A) receptor binding in euthymic, medication-free patients recovered from depression: A positron emission study with [(11)C]MDL 100,907. American Journal of Psychiatry, 163, 1580-1587.
21. Bhansali, P., Dunning, J., Singer, S. E., David, L., & Schmauss, C. (2007). Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heter-otrimeric G-protein Gq. Journal of Neuroscience, 27, 1467-1473.
22. Bradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., Gillespie, C. F., Berg, T., Evces, M., Newport, D. J., Stowe, Z. N., Heim, C. M., Nemeroff, C. B., Schwartz, A., Cubells, J. F., & Ressler, K. J. (2008). Influence of child abuse on adult depression: Moderation by the corticotro-pin-releasing hormone receptor gene. Archives of General Psychiatry, 65, 190-200.
23. Brent, D. A., & Mann, J. J. (2005). Family genetic studies, suicide, and suicidal behavior. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 133, 13-24.
24. Brent, D. A. & Melhem, N. (2008). Familial transmission of suicidal behavior. Psychiatric Clinics of North America, 31, 157-177.
25. Brent, D. A., Oquendo, M. A., Birmaher, B., Greenhill, L., Kolko, D., Stanley, B., Zelazney, J., Brodsky, B., Bridge, J., Ellis, S., Salazar, O., & Mann, J. J. (2002). Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempt-ers. Archives of General Psychiatry, 59, 801-807.
26. Brezo, J., Klempan, T., & Turecki, G. (2008). The genetics of suicide: a critical review of molecular studies. Psychiatric Clinics of North America, 31, 179-203.
27. Brodsky, B. S., Mann, J. J., Stanley, B., Tin, A., Oquendo, M., Birmaher, B., Greenhill, L., Kolko, D., Zelazny, B., Burke, A. K., Melhem, N. M., & Brent, D. (2008). Familial transmission of suicidal behavior: Factors mediating the relationship between childhood abuse and offspring suicide attempts. Journal of Clinical Psychiatry, 69, 584-596.
28. Brodsky, B. S. & Stanley, B. (2008). Adverse childhood experiences and suicidal behavior. Psychiatry Clinics of North America, 31, 223-235.
29. Brown, S. M. & Hariri, A. R. (2006). Neuroimaging studies of serotonin gene polymorphisms: Exploring the interplay of genes, brain, and behavior. Cognitive, Affective and Behavioral Neuroscience, 6, 44-52.
30. Brown, R. P., Stoll, P. M., Stokes, P. E., Frances, A., Sweeney, J., Kocsis, J. H., & Mann, J. J. (1988). Adrenocortical hyperactivity in depression: Effects of agitation, delusions, melancholia, and other illness variables. Psychiatry Research, 23, 167-178.
31. Brunner, J., Stalla, G. K., Stalla, J., Uhr, M., Grabner, A., Wetter, T. C., & Bronsich, T. (2001). Decreased corticotropin-releasing hormone (CRH) concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters. Journal of Psychiatric Research, 35, 1-9.
32. Brunner, H. G., Nelen, M., Breakefield, X. O., Ropers, H. H., & van Oost, B. A. (1993). Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science, 262, 578-580.
33. Brunson, K. L., Avishai-Eliner, S., Hatalski, C. G., & Baram, T.Z. (2001). Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin releasing hormone. Molecular Psychiatry, 6, 647-656.
34. Carballo, J. J., Harkavy-Friedman, J., Burke, A. K., Sher, L., Baca-Garcia, E., Sullivan, G. M., Grunebaum, M. F., Parsey, R. V., Mann, J. J., & Oquendo, M. A. (2008). Family history of suicidal behavior and early traumatic experiences: Additive effect on suicidality and course of bipolar illness? Journal of Affective Disorders, 109, 57-63.
35. Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science, i297, 851-854.
36. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McLay, J., Mill, J., Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389.
37. Cooper, S. J., Kelly, C. B., & King, D.J. (1992). 5-Hydroxyindoleacetic acid in cerebrospinal fluid and prediction of suicidal behaviour in schizophrenia. The Lancet, 340, 940-941.
38. Congdon, E. & Canli, T. (2008). A neurogenetic approach to impulsivity. Journal of Personality, 76, 1447-1483.
39. Coryell, W. & Schlesser, M. (2001). The dexamethasone suppression test and suicide prediction. American Journal of Psychiatry, 158, 748-753.
40. Currier, D. & Mann, J. J. (2008). Stress, genes and the biology of suicidal behavior. Psychiatric Clinics of North America, 31, 247-269.
41. Daniels, W. M., Pietersen, C. Y., Carstens, M. E., & Stein, D. J. (2004). Maternal separation in rats leads to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor. Metabolic Brain Disorders, 19, 3-14.
42. Du, L., Faludi, G., Palkovits, M. Demeter, E., Bakish, D., Lapierre, Y. D., Sotonyi, P, & Hrdina, P D. (1999). Frequency of long allele in serotonin transporter gene is increased in depressed suicide victims. Biological Psychiatry, 46, 196-201.
43. Du, L., Faludi, G., Palkovits, M., Sotonyi, P, Bakish, D., & Hrdina, P D. (2002). High activity-related allele of MAO-A gene associated with depressed suicide in males. Neuroreport, 13, 1195-1198.
44. Dunn, A. J., Swiergiel, A. H., & Palamarchouk, V. (2004). Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress. Annals of the New York Academy of Science, 1018, 25-34.
45. Engstrom, G., Alling, C., Blennow, K., Regnell, G., & Traskman-Bendz, L. (1999). Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters. Monoamine metabolites in 120 suicide attempters and 47 controls. European Neuropsychopharmacology, 9, 399-405.
46. Fan, J., Fossella, J., Sommer, T., Wu, Y., & Posner, M. I. (2003). Mapping the genetic variation of executive attention onto brain activity. Proceedings of the National Academy of Sciences of the United States of America, 100, 7406-7411.
47. Furmark, T., Appel, L., Henningsson, S., Ahs, F., Faria, V., Linnman, C., Pissiota, A., Frans, O., Bani, M., Bettica, P, Pich, E. M., Jacobsson, E., Wahlstedt, E., Oreland, L., Lanstrom, B., Eriksson, E., & Fredrikson, M. (2008). A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety. Journal of Neuroscience, 28, 13066-13074.
48. Galfalvy, H., Currier, D., Oquendo, M. A., Sullivan, G., Huang, Y. Y., & Mann, J. J. (2009). Lower CSF MHPG predicts short-term risk for suicide attempt. International Journal of Neuropsychopharmacology, 12, 1327-1335.
49. Gartside, S. E., Johnson, D. A., Leitch, M. M., Troakes, C., & Ingram, C. D. (2003). Early life adversity programs changes in central 5-HT neuronal function in adulthood. European Journal of Neuroscience, 17, 2401-2408.
50. Gibb, B. E., McGeary, J. E., Beevers, C. G., & Miller, I. W (2006). Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts in adult psychiatric inpatients. Suicide and Life Threatening Behavior, 36, 687-693.
51. Gross, C., Zhuang, X., Stark, K., Ramboz, S., Oosting, R., Kirby, L., Santarelli, L., Beck, S., & Hen, R., (2002). Serotonin 1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature, 416, 396-400.
52. Heim, C. & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49, 1023-1039.
53. Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001). Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. American Journal of Psychiatry, 158, 575-581.
54. Heim, C., Newport, D. J., Heit, S., Graham, Y. P., Wilcox, M., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2000). Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Journal of American Medical Association, 284, 592-597.
55. Henn, F. A. & Vollmayr, B. (2005). Stress models of depression: Forming genetically vulnerable strains. Neuroscience and Biobehavior Review, 29, 799-804.
56. Higley, J. D., Suomi, S. J., & Linnoila, M. (1992). A longitudinal assessment of CSF monoamine metabolite and plasma cortisol concentrations in young rhesus monkeys. Biological Psychiatry, 32, 127-145.
57. Hodgkinson, C. A., Yuan, Q., Xu, K., Shen, P., Heinz, E., Lobos, E. A., Binder, E. B., Cubells, J., Ehlers, C. L., Gelernter, J., Mann, J. J., Riley, B., Roy, A., Tabakoff, N., Todd, R. D., Zhou, Z., & Goldman, D. (2008). Addictions biology: Haplotype-based analysis for 130 candidate genes on a single array. Alcohol and Alcoholism, 43, 505-515.
58. Huang, Y. Y., Cate, S. P., Battistuzzi, C., Oquendo, M. A., Brent, D., & Mann, J.J. (2004). An association between a functional polymorphism in the monoamine oxidase A gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology, 29, 1498-1505.
59. Ichise, M., Vines, D. C., Gura, T., Anderson, G. M., Suomi, S. J., Higley, J. D., & Innis, R. B. (2006). Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer-and mother-reared rhesus monkeys. Journal of Neuroscience, 26, 4638-4643.
60. Jones, J. S., Stanley, B., Mann, J. J., Frances, A. J., Guido, J. R., Traskman-Bendz, L., Winchel, R., Brown, R. P., & Stanley, M. (1990). CSF 5-HIAA and HVA concentrations in elderly depressed patients who attempted suicide. American Journal of Psychiatry, 147, 1225-1227.
61. Kaufman, J., Birmaher, B., Perel, J., Dahl, R. E., Stull, S., Brent, D., Trubnick, L., Al-Shabbout, M., & Ryan. N. D. (1998). Serotonergic functioning in depressed abused children: Clinical and familial correlates. Biological Psychiatry, 44, 973-981.
62. Ke, L., Qi, Z. Y., Ping, Y., & Ren, C. Y. (2006). Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide. Brain Research, 1122, 24-26.
63. Kraemer, G. W., Ebert, M. H., Schmidt, D. E., & McKinney, W. T. (1989). A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys. Neuropsychopharmacology, 2, 175-189.
64. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., & Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-1531.
65. Lester, D. (1995). The concentration of neurotransmitter metabolites in the cerebrospinal fluid of suicidal individuals: a meta-analysis. Pharmacopsychiatry, 28, 45-50.
66. Leyton, M., Paquette, V., Gravel, IP, Rosa-Neto, P., Weston, F., Diksic, M., & Benkelfat, C. (2006). Alpha-[11C]Methyl-L-tryptophan trapping in the orbital and ventral medial prefrontal cortex of suicide attempters. European Neuropsychopharmacology, 16, 220-223.
67. Liu, D., Caldji, C., Sharma, S., Plotsky, P. M., & Meaney, M. J. (2000). Influence of neonatal rearing conditions on stress-induced adrenocorticotropin responses and norepinepherine release in the hypothalamic paraventricular nucleus. Journal of Neuroendocrinology, 12, 5-12.
68. Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P M., & Meaney, M. J. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science, 277, 1659-1662.
69. Lopez, V. A., Detera-Wadleigh, S., Cardona, I., Kassem, L., & McMahon, F. J. (2007). Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biological Psychiatry, 61, 181-186.
70. Lopez, J. F., Vazquez, D. M., Chalmers, D. T., & Watson, S. J. (1997). Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis. Implications for the neurobiology of suicide. Annals of the New York Academy of Science, 29, 106-134.
71. Maestripieri, D., McCormack, K., Lindell, S. G., Higley, J. D., & Sanchez, M. M. (2006). Influence of parenting style on the offspring's behaviour and CSF monoamine metabolite levels in cross-fostered and non-cross-fostered female rhesus macaques. Behavioral Brain Research, 175, 90-95.
72. Mann, J. J. (2003). Neurobiology of suicidal behaviour. National Review of Neuroscience, 4, 819-828.
73. Mann, J. J., Brent, D. A., & Arango, V. (2001). The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology, 24, 467-477.
74. Mann, J. J. & Currier, D. (2007). A review of prospective studies of biologic predictors of suicidal behavior in mood disorders. Archives of Suicide Research, 11, 3-16.
75. Mann, J. J. & Currier, D. (2008). Suicide and attempted suicide. In S. H. Fatemi & P. J. Clayton (Eds.), The Medical Basis of Psychiatry, 3rd ed. (pp. 561-576). Philadelphia, PA: Humana Press.
76. Mann, J. J., Currier, D., Stanley, B., Oquendo, M. A., Amsel, L. V., & Ellis, S. P. (2006). Can biological tests assist prediction of suicide in mood disorders? International Journal of Neuropsychopharmacology, 9, 465-474.
77. Mann, J. J., Huang, Y. Y., Underwood, M. D., Kassir, S. A., Oppenhem, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000). A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives ofGeneral Psychiatry, 57, 729-738.
78. Mann, J. J. & Malone, K. M. (1997). Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biological Psychiatry, 41, 162-171.
79. Mann, J. J., Stanley, M., McBride, P A., & McEwen, B. S. (1986). Increased serotonin and ß-adrenergic receptor binding in the frontal cortices of suicide victims. Archives of General Psychiatry, 43, 954-959.
80. Matthews, K., Dalley, J. W., Matthews, C., Tsai, T. H., & Robbins, T. W. (2001). Periodic maternal separation of neonatal rats produces region-and gender-specific effects on biogenic amine content in postmortem adult brain. Synapse, 40, 1-10.
81. McGowan, P O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonte, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009). Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Natural Neuroscience, 12, 342-348.
82. Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P, Caldji, C., Sharma, S., Secki, J., & Plotsky, P. M. (1996). Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Developmental Neuroscience, 18, 49-72.
83. Meijer, O. C. & De Kloet, E. R. (1998). Corticosterone and serotonergic neurotransmission in the hippocampus: Functional implications of central corticosteriod receptor diversity. Critical Reviews in Neurobiology, 12, 1-20.
84. Meltzer, H. Y., Perline, R., Tricou, B. J., Lowy, M., & Robertson, A. (1984). Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. II. Relation to suicide, psychosis, and depressive symptoms. Archives ofGeneral Psychiatry, 41, 379-387.
85. Meyer, J. H. (2007). Imaging the serotonin transporter during major depressive disorder and anti-depressant treatment. Journal of Psychiatry andNeuroscience, 32, 86-102.
86. Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., Hariri, A. R., Pezawas, L., Blasi, G., Wabnitz, A., Honea, R., Verchinski, B., Callicott, J. H., Egan, M., Mattay, V., & Weinberger, D. R. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences of the United States of America, 103, 6269-6274.
87. Miller, H. L., Delgado, P. L., Salomon, R. M., Berman, R., Krystal, J. H., Heninger, G. R., & Charney, D. S. (1996). Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Archives of General Psychiatry, 53, 117-128.
88. Miller, J. M., Kinnally, E. L., Ogden, R. T., Oquendo, M. A., Mann, J. J., & Parsey, R. V. (2009). Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder. Synapse, 63, 565-573.
89. Nemeroff, C. B. (1988). The neurobiology of aging and the neurobiology of depression: Is there a relationship? Neurobiology and Aging, 9, 120-122.
90. Nordström, P, Samuelsson, M., Åsberg, M., Traskman-Bendz, L., Aberg-Wistedt, A., Nordin, C., & Bertilsson, L. (1994). CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide and Life Threatening Behavior, 24, 1-9.
91. Olivier, B., Pattij, T., Wood, S. J., Oosting, R., Sarnyai, Z., & Toth, M. (2001). The 5-HT(1A) receptor knockout mouse and anxiety. Behavioral Pharmacology, 12, 439-450.
92. Oquendo, M. A., Placidi, G. P., Malone, K. M., Campbell, C., Keilp, J., Brodsky, B., Kegeles, L. S., Cooper, T. B., Parsey, R. V., van Heertum, R. L., & Mann, J. J. (2003). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Archives of General Psychiatry, 60, 14-22.
93. Ordway, G. A., Widdowson, P S., Smith, K. S., & Halaris, A. (1994). Agonist binding to a2-adrenoceptors is elevated in the locus coeruleus from victims of suicide. Journal of Neuro-chemistry, 63, 617-624.
94. Owens, M. J. & Nemeroff, C. B. (1991). Physiology and pharmacology of corticotropin-releasing factor. Pharmacology Review, 43, 425-473.
95. Pandey, G. N., Dwivedi, Y., Rizavi, H. S., Ren, X., Pandey, S. R., Pesold, C., Roberts, R. C., Conley, R. R., & Tamminga, C. A. (2002). Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. American Journal of Psychiatry, 159, 419-429.
96. Parsey, R. V., Hastings, R. S., Oquendo, M. A., Xianzhang, H., Goldman, D., Huang, Y., Simpson, N., Arcement, J., Huang, Y., Ogden, T., van Heertum, R. L., Arango, V., & Mann, J. J. (2006). Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. American Journal of Psychiatry, 163, 48-51.
97. Parsey, R. V., Oquendo, M. A., Simpson, N. R., Ogden, R. T., van Heertum, R., Arango, V., & Mann, J. J. (2002). Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT(1A) receptor binding potential measured by PET using [C-11]WAY-100635. Brain Research, 954, 173-182.
98. Passamonti, L., Fera, F., Magariello, A., Cerasa, A., Gioia, M. C., Muglia, M., Nicoletti, G., Gallo, O., Provinciali, L., & Quattrone, A. (2006). Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: New insight into the neural correlates of impul-sivity. Biological Psychiatry, 59, 334-340.
99. Pine, D. S., Coplan, J. D., Wasserman, G. A., Miller, L. S., Fried, J. E., Davies, M., Cooper, T. B., Greenhill, L., Shaffer, D., & Parsons, B. (1997). Neuroendocrine response to fenfluramine challenge in boys: Associations with aggressive behavior and adverse rearing. Archives of General Psychiatry, 54, 839-846.
100. Plotsky, P. M. & Meaney, M. J. (1993). Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Research and Molecular Brain Research, 18, 195-200.
101. Prochazka, H. & Agren, H. (2003). Self-rated aggression and cerebral monoaminergic turnover. Sex differences in patients with persistent depressive disorder. European Archives of Psychiatry and Clinical Neuroscience, 253, 185-92.
102. Reuter, M., Esslinger, C., Montag, C., Lis, S., Gallhofer, B., & Kirsch, P (2008). A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: a genetic imaging study. Biological Psychology, 79, 111-117.
103. Rinne, T., Westenberg, H. G., Den Boer, J. A., & van den Brink, W. (2000). Serotonergic blunting to meta-chlorophenylpiperazine (m-CPP) highly correlates with sustained childhood abuse in impulsive and autoaggressive female borderline patients. Biological Psychiatry, 47, 548-556.
104. Roy, A., Hu, X.Z., Janal, M. N., & Goldman, D. (2007). Interaction between childhood trauma and serotonin transporter gene variation in suicide. Neuropsychopharmacology, 32, 2046-2052.
105. Rujescu, D., Giegling, I., Bondy, B., Gietl, A., Zill, P., & Moller H. J. (2002). Association of anger-related traits with SNPs in the TPH gene. Molecular Psychiatry, 7, 1023-1029.
106. Ryding, E., Lindstrom, M., & Traskman-Bendz, L. (2008). The role of dopamine and serotonin in suicidal behaviour and aggression. Progress in Brain Research, 172, 307-315.
107. Sadikot, A. F. & Parent, A. (1990). The monoaminergic innervation of the amygdala in the squirrel monkey: an immunohistochemical study. Neuroscience, 36, 431-447.
108. Schulsinger, F., Kety, S. S., Rosenthal, D., & Wender, P H. (1979). A family study of suicide. In M. Schou, & E. Stromgren (Eds.), Origin, Prevention and Treatment of Affective Disorders. New York: Academic Press.
109. Sequeira, A. & Turecki, G. (2006). Genome wide gene expression studies in mood disorders. OMICS, 10, 444-454.
110. Sher, L., Carballo, J. J., Grunebaum, M. F., Burke, M. F., Zalsman, A. K., Huang, G., & Mann, J. J. (2006). A prospective study of the association of cerebrospinal fluid monoamine metabolite levels with lethality of suicide attempts in patients with bipolar disorder. Bipolar Disorders, 8, 543-550.
111. Smith, H. R., Daunais, J. B., Nader, M. A., & Porrino, L. J. (1999). Distribution of [3H]citalo-pram binding sites in the nonhuman primate brain. Annals of the New York Academy of Science, 877, 700-702.
112. Stanley, M. & Mann, J. J. (1983). Increased serotonin-2 binding sites in frontal cortex of suicide victims. The Lancet, i:214-216.
113. Stein, M. B., Yehuda, R., Koverola, C., & Hanna, C. (1997). Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biological Psychiatry, 42, 680-686.
114. Stoff, D. M. & Mann, J. J. (1997). Suicide research. Overview and introduction. Annals of the New York Academy of Science, 836, 1-11.
115. Sunnqvist, C., Westrin, A., & Traskman-Bendz, L. (2008). Suicide attempters: Biological stressmarkers and adverse life events. European Archives of Psychiatry and Clinical Neuroscience, 258, 456-462.
116. Tiihonen, J., Kuikka, J. T., Bergström, K. A., Karhu, J., Viinamaki, H., Lehtonen, J., Hallikainen, T., Yang, J., & Haloka, P. (1997). Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour. European Journal of Nuclear Medicine, 24, 1253-1260.
117. Traskman-Bendz, L., Alling, C., Oreland, L., Regnell, G., Vinge, E., & Ohman, R. (1992). Prediction of suicidal behavior from biologic tests. Journal of Clinical Psychopharmacology, 12, 21S-26S.
118. Tyrka, A. R., Price, L. H., Gelernter, J., Schepker, C., Anderson, G. M., & Carpenter, L. L. (2009). Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. Biological Psychiatry, 66, 681-685.
119. Uher, R. & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Molecular Psychiatry, 13, 131-146.
120. van Heeringen, K., Audenaert, K., Van de Wiele, L., & Verstraete, A. (2000). Cortisol in violent suicidal behaviour: association with personality and monoaminergic activity. Journal of Affective Disorders, 60, 181-189.
121. van Heeringen, C., Audenaert, K., Van Laere, K., Dumont, F., Slegers, G., Mertens, J., & Dierckx, R. A. (2003). Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide. Journal of Affective Disorders, 74, 149-158.
122. Virkkunen, M., De Jong, J., Bartko, J., & Linnoila, M. (1989). Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Archives of General Psychiatry, 46, 604-606.
123. Voracek, M. & Loibl, L. M. (2007). Genetics of suicide: a systematic review of twin studies. Wiener Klinische Wochenschrift, 119, 463-475.
124. Wasserman, D., Sokolowski, M., Rozanov, V., & Wasserman, J. (2007). The CRHR1 gene: A marker for suicidality in depressed males exposed to low stress. Genes, Brain and Behavior, 7, 14-19.
125. Weaver, I. C., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7, 847-854.
126. Weaver, I. C., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005). Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. Journal of Neuroscience, 25, 11045-11054.
127. Weiss, G. K., Ratner, A., Voltura, A., Savage, D., Lucero, K., & Castillo, N. (1994). The effect of two different types of stress on locus coeruleus alpha-2 receptor binding. Brain Research Bulletin, 33, 219-221.
128. Wender, P. H., Kety, S. S., Rosenthal, D., Schulsinger, F., Ortmann, J., & Lunde, I. (1986). Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Archives of General Psychiatry, 43, 923-929.
129. Ystgaard, M., Hestetun, I., Loeb, M., & Mehlum, L. (2004). Is there a specific relationship between childhood sexual and physical abuse and repeated suicidal behavior? Child Abuse and Neglect, 28, 863-875.
130. Zhou, Z., Roy, A., Lipsky, R., Kuchipudi, K., Zhu, G., Taubman, J., Enoch, M., Virkkunen, M., & Goldman, D. (2005). Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Archives of General Psychiatry, 62, 1109-1118.
131. Zill, P, Baghai, T. C., Zwanzger, P, Schule, C., Eser, D., Rupprecht, R., Moller, H. J., Bondy, B., & Ackenheil, M. (2004). SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Molecular Psychiatry, 9, 1030-1036.
132. Zill, P., Buttner, A., Eisenmenger, W., Moller, H. J., Bondy, B., & Ackenheil, M. (2004). Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biological Psychiatry, 56, 581-586.