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Volumn , Issue , 2013, Pages 571-582

CovX-Bodies

Author keywords

Bispecific antibody; CovX bodies; CovX Body technology; CVX 241 CVX 343; Scaffold antibody

Indexed keywords


EID: 84886197573     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118354599.ch38     Document Type: Chapter
Times cited : (5)

References (34)
  • 1
    • 84863523592 scopus 로고    scopus 로고
    • From Bench to Clinic John Wiley and Sons, Inc., New Jersey
    • An Z. (2009) Therapeutic Monoclonal Antibodies. From Bench to Clinic. John Wiley and Sons, Inc., New Jersey, 711-762.
    • (2009) Therapeutic Monoclonal Antibodies , pp. 711-762
    • An, Z.1
  • 3
    • 0029590066 scopus 로고
    • Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes
    • Wagner J, Lerner RA, Barbas CF, III. (1995) Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes. Science 270, 1797-1780.
    • (1995) Science , vol.270 , pp. 1797-1780
    • Wagner, J.1    Lerner, R.A.2    Barbas III, C.F.3
  • 4
    • 0031457319 scopus 로고    scopus 로고
    • Immune versus natural selection: antibody aldolases with enzymic rates but broader scope
    • Barbas CF. III, Heine A, Zhong G, Hoffman T, Gramatikova S, Björnested R, et al. (1997) Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science 278, 2085-2092.
    • (1997) Science , vol.278 , pp. 2085-2092
    • Barbas III, C.F.1    Heine, A.2    Zhong, G.3    Hoffman, T.4    Gramatikova, S.5    Björnested, R.6
  • 5
    • 0038641840 scopus 로고    scopus 로고
    • Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst
    • RaderC, Sinha SC, PopkovM, LernerRA, BarbasCF. III. (2003) Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst. Proc. Natl. Acad. Sci.USA 100(9), 5396-5400.
    • (2003) Proc. Natl. Acad. Sci.USA , vol.100 , Issue.9 , pp. 5396-5400
    • Rader, C.1    Sinha, S.C.2    Popkov, M.3    Lerner, R.A.4    Barbas III, C.F.5
  • 8
    • 0041825381 scopus 로고    scopus 로고
    • A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy
    • Rader C,TurnerJM,Heine A,Shabat D,Sinha S,WilsonIA, et al. (2003) A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. J.Mol. Biol. 332, 889-899.
    • (2003) J.Mol. Biol. , vol.332 , pp. 889-899
    • Rader, C.1    Turner, J.M.2    Heine, A.3    Shabat, D.4    Sinha, S.5    Wilson, I.A.6
  • 10
    • 0033593356 scopus 로고    scopus 로고
    • Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire
    • de Wildt RM, Hoet RM, van Venrooij WJ, Tomlinson IM, Winter G. (1999) Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J. Mol. Biol. 285(3), 895-901.
    • (1999) J. Mol. Biol. , vol.285 , Issue.3 , pp. 895-901
    • de Wildt, R.M.1    Hoet, R.M.2    van Venrooij, W.J.3    Tomlinson, I.M.4    Winter, G.5
  • 11
  • 12
    • 0020475449 scopus 로고
    • A simple method for displaying the hydropathic character of a protein
    • Kyte J, Doolittle RF. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157(1), 105-132.
    • (1982) J. Mol. Biol. , vol.157 , Issue.1 , pp. 105-132
    • Kyte, J.1    Doolittle, R.F.2
  • 15
    • 77956258920 scopus 로고    scopus 로고
    • Transferrin fusion technology: A novel approach to prolonging biological half-life of insulinotroic peptides
    • Kim B, Zhou J, Martin B, Carlson OD, Maudsley S, Greig NH, et al. (2010) Transferrin fusion technology: A novel approach to prolonging biological half-life of insulinotroic peptides. J. Pharmacol. Exp. Ther. 334(3), 682-692.
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , Issue.3 , pp. 682-692
    • Kim, B.1    Zhou, J.2    Martin, B.3    Carlson, O.D.4    Maudsley, S.5    Greig, N.H.6
  • 16
    • 4043152053 scopus 로고    scopus 로고
    • Peptibodies: The new cool technology
    • Sutherland S. (2004) Peptibodies: The new cool technology. Drug Discov. Today 9(16), 683.
    • (2004) Drug Discov. Today , vol.9 , Issue.16 , pp. 683
    • Sutherland, S.1
  • 17
    • 77954890371 scopus 로고    scopus 로고
    • Targeting the ANGPT-TIE2 pathway in malignancy
    • Huang H, Bhat A, Woodnutt G, Lappe R. (2010) Targeting the ANGPT-TIE2 pathway in malignancy. Nat. Rev. Cancer 10(8), 575-585.
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.8 , pp. 575-585
    • Huang, H.1    Bhat, A.2    Woodnutt, G.3    Lappe, R.4
  • 18
    • 79952271693 scopus 로고    scopus 로고
    • Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth
    • Huang H, Lai J, Do J, Liu D, Li L, Del Rosario J, et al. (2011) Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth. Clin. Cancer Res. 17(5), 1001-1011.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.5 , pp. 1001-1011
    • Huang, H.1    Lai, J.2    Do, J.3    Liu, D.4    Li, L.5    Del Rosario, J.6
  • 19
    • 77954935349 scopus 로고    scopus 로고
    • First-in-Human Dose-Escalation Safety and PK Trial of a Novel Intravenous Humanized Monoclonal CovX Body Inhibiting Angiopoietin 2 [Abstract]
    • Abstract 2524.
    • Rosen LS, Mendelson DS, Cohen RB, Gordon MS, Goldman JW, Bear IK, et al. (2010). First-in-Human Dose-Escalation Safety and PK Trial of a Novel Intravenous Humanized Monoclonal CovX Body Inhibiting Angiopoietin 2 [Abstract]. J. Clin. Oncol. 28:15s, Abstract 2524.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 15
    • Rosen, L.S.1    Mendelson, D.S.2    Cohen, R.B.3    Gordon, M.S.4    Goldman, J.W.5    Bear, I.K.6
  • 20
    • 34249338085 scopus 로고    scopus 로고
    • Dynamic contrast enhanced magnetic resonance imaging in oncology drug development
    • Cheng HM. (2007) Dynamic contrast enhanced magnetic resonance imaging in oncology drug development. Curr. Clin. Pharmacol. 2(2), 111-122.
    • (2007) Curr. Clin. Pharmacol. , vol.2 , Issue.2 , pp. 111-122
    • Cheng, H.M.1
  • 21
    • 34248382009 scopus 로고    scopus 로고
    • Bispecific antibodies: molecules that enable novel therapeutic strategies
    • Fischer N, Leger O. (2007) Bispecific antibodies: molecules that enable novel therapeutic strategies. Pathobiology 74, 3-14.
    • (2007) Pathobiology , vol.74 , pp. 3-14
    • Fischer, N.1    Leger, O.2
  • 23
    • 55249104916 scopus 로고    scopus 로고
    • Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro
    • Robinson MK, Hodge KM, Horak E, Sundberg A L, Russeva M, Shaller CC, et al. (2008) Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro. Br. J. Cancer 99, 1415-1425.
    • (2008) Br. J. Cancer , vol.99 , pp. 1415-1425
    • Robinson, M.K.1    Hodge, K.M.2    Horak, E.3    Sundberg, A.L.4    Russeva, M.5    Shaller, C.C.6
  • 24
    • 0033506366 scopus 로고    scopus 로고
    • High avidity scFv multimers, diabodies and triabodies
    • Hudson PJ, Kortt AA. (1999) High avidity scFv multimers, diabodies and triabodies. J. Immunol. Methods 231, 177-189.
    • (1999) J. Immunol. Methods , vol.231 , pp. 177-189
    • Hudson, P.J.1    Kortt, A.A.2
  • 25
    • 70350059390 scopus 로고    scopus 로고
    • Generation of bispecific and tandem diabodies
    • Kipriyanov SM. (2009) Generation of bispecific and tandem diabodies. Methods Mol. Biol. 562, 177-193.
    • (2009) Methods Mol. Biol. , vol.562 , pp. 177-193
    • Kipriyanov, S.M.1
  • 26
    • 62849095162 scopus 로고    scopus 로고
    • Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
    • Bostrom J, Yu S, Kan D, Appleton BA, Lee CV, Billeci K, et al. (2009) Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science 323, 1610-1614.
    • (2009) Science , vol.323 , pp. 1610-1614
    • Bostrom, J.1    Yu, S.2    Kan, D.3    Appleton, B.A.4    Lee, C.V.5    Billeci, K.6
  • 27
    • 35948977323 scopus 로고    scopus 로고
    • Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
    • Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, et al. (2007) Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat. Biotechnol. 25, 1290-1297.
    • (2007) Nat. Biotechnol. , vol.25 , pp. 1290-1297
    • Wu, C.1    Ying, H.2    Grinnell, C.3    Bryant, S.4    Miller, R.5    Clabbers, A.6
  • 30
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. (2005) VEGF as a key mediator of angiogenesis in cancer. Oncology 69(Suppl. 3), 4-10.
    • (2005) Oncology , vol.69 , Issue.SUPPL 3 , pp. 4-10
    • Carmeliet, P.1
  • 31
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. (2003) The biology of VEGF and its receptors. Nat. Med. 9, 669-676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 32
    • 0038118504 scopus 로고    scopus 로고
    • Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma
    • Moon WS, Rhyu KS, Kang MJ, Lee DG, Yu HC, Yeum JH, et al. (2003) Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma? Modern Pathol. 16, 552-557.
    • (2003) Modern Pathol. , vol.16 , pp. 552-557
    • Moon, W.S.1    Rhyu, K.S.2    Kang, M.J.3    Lee, D.G.4    Yu, H.C.5    Yeum, J.H.6
  • 33
    • 2442662270 scopus 로고    scopus 로고
    • Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma
    • Ochiumi T, Tanaka S, Oka S, Hiyama T, Ito M, Kitadai Y, et al. (2004) Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Int. J. Oncol. 24, 539-547.
    • (2004) Int. J. Oncol. , vol.24 , pp. 539-547
    • Ochiumi, T.1    Tanaka, S.2    Oka, S.3    Hiyama, T.4    Ito, M.5    Kitadai, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.