-
1
-
-
84863523592
-
-
From Bench to Clinic John Wiley and Sons, Inc., New Jersey
-
An Z. (2009) Therapeutic Monoclonal Antibodies. From Bench to Clinic. John Wiley and Sons, Inc., New Jersey, 711-762.
-
(2009)
Therapeutic Monoclonal Antibodies
, pp. 711-762
-
-
An, Z.1
-
2
-
-
0029617908
-
Reactive immunization
-
Wirsching P, Ashley JA, Lo CL, Janda KD, Lerner RA. (1995) Reactive immunization. Science 270, 1775-1782.
-
(1995)
Science
, vol.270
, pp. 1775-1782
-
-
Wirsching, P.1
Ashley, J.A.2
Lo, C.L.3
Janda, K.D.4
Lerner, R.A.5
-
3
-
-
0029590066
-
Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes
-
Wagner J, Lerner RA, Barbas CF, III. (1995) Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes. Science 270, 1797-1780.
-
(1995)
Science
, vol.270
, pp. 1797-1780
-
-
Wagner, J.1
Lerner, R.A.2
Barbas III, C.F.3
-
4
-
-
0031457319
-
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope
-
Barbas CF. III, Heine A, Zhong G, Hoffman T, Gramatikova S, Björnested R, et al. (1997) Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science 278, 2085-2092.
-
(1997)
Science
, vol.278
, pp. 2085-2092
-
-
Barbas III, C.F.1
Heine, A.2
Zhong, G.3
Hoffman, T.4
Gramatikova, S.5
Björnested, R.6
-
5
-
-
0038641840
-
Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst
-
RaderC, Sinha SC, PopkovM, LernerRA, BarbasCF. III. (2003) Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst. Proc. Natl. Acad. Sci.USA 100(9), 5396-5400.
-
(2003)
Proc. Natl. Acad. Sci.USA
, vol.100
, Issue.9
, pp. 5396-5400
-
-
Rader, C.1
Sinha, S.C.2
Popkov, M.3
Lerner, R.A.4
Barbas III, C.F.5
-
6
-
-
33846061734
-
Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies
-
Doppalapudi VR, Tryder N, Li L, Aja T, Griffith D, Liao F, et al. (2007) Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies. Bioorg. Med. Chem. Lett. 17, 501-506.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 501-506
-
-
Doppalapudi, V.R.1
Tryder, N.2
Li, L.3
Aja, T.4
Griffith, D.5
Liao, F.6
-
7
-
-
84886145431
-
-
30th National Medicinal Chemistry Meeting, June 25-29, University of Washington, Seattle
-
Liu D, Wood L, Wheeler W, Zhao J, Griffith D, Bradshaw C, et al. (2006) CCR5 Targeting CovX-Bodies. 30th National Medicinal Chemistry Meeting, June 25-29, University of Washington, Seattle.
-
(2006)
CCR5 Targeting CovX-Bodies
-
-
Liu, D.1
Wood, L.2
Wheeler, W.3
Zhao, J.4
Griffith, D.5
Bradshaw, C.6
-
8
-
-
0041825381
-
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy
-
Rader C,TurnerJM,Heine A,Shabat D,Sinha S,WilsonIA, et al. (2003) A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. J.Mol. Biol. 332, 889-899.
-
(2003)
J.Mol. Biol.
, vol.332
, pp. 889-899
-
-
Rader, C.1
Turner, J.M.2
Heine, A.3
Shabat, D.4
Sinha, S.5
Wilson, I.A.6
-
9
-
-
0026610881
-
Humanization of an anti-p185HER2 antibody for human cancer therapy
-
Carter P, Presta L, Gorman CM, Ridgway JB, Henner D,Wong WL, et al. (1992) Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc. Natl. Acad. Sci. USA 89 (10), 5434-5441.
-
(1992)
Proc Natl. Acad. Sci. USA
, vol.89
, Issue.10
, pp. 5434-5441
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
Ridgway, J.B.4
Henner, D.5
Wong, W.L.6
-
10
-
-
0033593356
-
Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire
-
de Wildt RM, Hoet RM, van Venrooij WJ, Tomlinson IM, Winter G. (1999) Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J. Mol. Biol. 285(3), 895-901.
-
(1999)
J. Mol. Biol.
, vol.285
, Issue.3
, pp. 895-901
-
-
de Wildt, R.M.1
Hoet, R.M.2
van Venrooij, W.J.3
Tomlinson, I.M.4
Winter, G.5
-
11
-
-
0034425742
-
Antibody arrays for high-throughput screening of antibodyantigen
-
de Wildt RM, Mundy CR, Gorick BD, Tomlinson IM. (2000) Antibody arrays for high-throughput screening of antibodyantigen. Nat. Biotechnol. 18(9), 989-994.
-
(2000)
Nat. Biotechnol.
, vol.18
, Issue.9
, pp. 989-994
-
-
de Wildt, R.M.1
Mundy, C.R.2
Gorick, B.D.3
Tomlinson, I.M.4
-
12
-
-
0020475449
-
A simple method for displaying the hydropathic character of a protein
-
Kyte J, Doolittle RF. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157(1), 105-132.
-
(1982)
J. Mol. Biol.
, vol.157
, Issue.1
, pp. 105-132
-
-
Kyte, J.1
Doolittle, R.F.2
-
14
-
-
3843059231
-
Identification of CJC-1131- albumin bioconjugate as a stable and bioactive GLP-1(7-36) analog
-
Leger R, Thibaudeau K, Robitaille M, Quraishi O, van Wyk P, Bousquet-Gagnon N, et al. (2004) Identification of CJC-1131- albumin bioconjugate as a stable and bioactive GLP-1(7-36) analog. Bioorg. Med. Chem. Lett. 14(17), 4395-4398.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, Issue.17
, pp. 4395-4398
-
-
Leger, R.1
Thibaudeau, K.2
Robitaille, M.3
Quraishi, O.4
van Wyk, P.5
Bousquet-Gagnon, N.6
-
15
-
-
77956258920
-
Transferrin fusion technology: A novel approach to prolonging biological half-life of insulinotroic peptides
-
Kim B, Zhou J, Martin B, Carlson OD, Maudsley S, Greig NH, et al. (2010) Transferrin fusion technology: A novel approach to prolonging biological half-life of insulinotroic peptides. J. Pharmacol. Exp. Ther. 334(3), 682-692.
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.334
, Issue.3
, pp. 682-692
-
-
Kim, B.1
Zhou, J.2
Martin, B.3
Carlson, O.D.4
Maudsley, S.5
Greig, N.H.6
-
16
-
-
4043152053
-
Peptibodies: The new cool technology
-
Sutherland S. (2004) Peptibodies: The new cool technology. Drug Discov. Today 9(16), 683.
-
(2004)
Drug Discov. Today
, vol.9
, Issue.16
, pp. 683
-
-
Sutherland, S.1
-
17
-
-
77954890371
-
Targeting the ANGPT-TIE2 pathway in malignancy
-
Huang H, Bhat A, Woodnutt G, Lappe R. (2010) Targeting the ANGPT-TIE2 pathway in malignancy. Nat. Rev. Cancer 10(8), 575-585.
-
(2010)
Nat. Rev. Cancer
, vol.10
, Issue.8
, pp. 575-585
-
-
Huang, H.1
Bhat, A.2
Woodnutt, G.3
Lappe, R.4
-
18
-
-
79952271693
-
Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth
-
Huang H, Lai J, Do J, Liu D, Li L, Del Rosario J, et al. (2011) Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth. Clin. Cancer Res. 17(5), 1001-1011.
-
(2011)
Clin. Cancer Res.
, vol.17
, Issue.5
, pp. 1001-1011
-
-
Huang, H.1
Lai, J.2
Do, J.3
Liu, D.4
Li, L.5
Del Rosario, J.6
-
19
-
-
77954935349
-
First-in-Human Dose-Escalation Safety and PK Trial of a Novel Intravenous Humanized Monoclonal CovX Body Inhibiting Angiopoietin 2 [Abstract]
-
Abstract 2524.
-
Rosen LS, Mendelson DS, Cohen RB, Gordon MS, Goldman JW, Bear IK, et al. (2010). First-in-Human Dose-Escalation Safety and PK Trial of a Novel Intravenous Humanized Monoclonal CovX Body Inhibiting Angiopoietin 2 [Abstract]. J. Clin. Oncol. 28:15s, Abstract 2524.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 15
-
-
Rosen, L.S.1
Mendelson, D.S.2
Cohen, R.B.3
Gordon, M.S.4
Goldman, J.W.5
Bear, I.K.6
-
20
-
-
34249338085
-
Dynamic contrast enhanced magnetic resonance imaging in oncology drug development
-
Cheng HM. (2007) Dynamic contrast enhanced magnetic resonance imaging in oncology drug development. Curr. Clin. Pharmacol. 2(2), 111-122.
-
(2007)
Curr. Clin. Pharmacol.
, vol.2
, Issue.2
, pp. 111-122
-
-
Cheng, H.M.1
-
21
-
-
34248382009
-
Bispecific antibodies: molecules that enable novel therapeutic strategies
-
Fischer N, Leger O. (2007) Bispecific antibodies: molecules that enable novel therapeutic strategies. Pathobiology 74, 3-14.
-
(2007)
Pathobiology
, vol.74
, pp. 3-14
-
-
Fischer, N.1
Leger, O.2
-
22
-
-
67049155341
-
Single-chain antibodies as diagnostic tools and therapeutic agents
-
Hagemeyer CE, von Zur Muhlen C, von Elverfeldt D, Peter K. (2009) Single-chain antibodies as diagnostic tools and therapeutic agents. Thromb. Haemost. 101, 1012-1019.
-
(2009)
Thromb. Haemost.
, vol.101
, pp. 1012-1019
-
-
Hagemeyer, C.E.1
von Zur Muhlen, C.2
von Elverfeldt, D.3
Peter, K.4
-
23
-
-
55249104916
-
Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro
-
Robinson MK, Hodge KM, Horak E, Sundberg A L, Russeva M, Shaller CC, et al. (2008) Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro. Br. J. Cancer 99, 1415-1425.
-
(2008)
Br. J. Cancer
, vol.99
, pp. 1415-1425
-
-
Robinson, M.K.1
Hodge, K.M.2
Horak, E.3
Sundberg, A.L.4
Russeva, M.5
Shaller, C.C.6
-
24
-
-
0033506366
-
High avidity scFv multimers, diabodies and triabodies
-
Hudson PJ, Kortt AA. (1999) High avidity scFv multimers, diabodies and triabodies. J. Immunol. Methods 231, 177-189.
-
(1999)
J. Immunol. Methods
, vol.231
, pp. 177-189
-
-
Hudson, P.J.1
Kortt, A.A.2
-
25
-
-
70350059390
-
Generation of bispecific and tandem diabodies
-
Kipriyanov SM. (2009) Generation of bispecific and tandem diabodies. Methods Mol. Biol. 562, 177-193.
-
(2009)
Methods Mol. Biol.
, vol.562
, pp. 177-193
-
-
Kipriyanov, S.M.1
-
26
-
-
62849095162
-
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
-
Bostrom J, Yu S, Kan D, Appleton BA, Lee CV, Billeci K, et al. (2009) Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science 323, 1610-1614.
-
(2009)
Science
, vol.323
, pp. 1610-1614
-
-
Bostrom, J.1
Yu, S.2
Kan, D.3
Appleton, B.A.4
Lee, C.V.5
Billeci, K.6
-
27
-
-
35948977323
-
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
-
Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, et al. (2007) Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat. Biotechnol. 25, 1290-1297.
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1290-1297
-
-
Wu, C.1
Ying, H.2
Grinnell, C.3
Bryant, S.4
Miller, R.5
Clabbers, A.6
-
28
-
-
66149174919
-
Site-specific polysialylation of an antitumor single-chain Fv fragment
-
Constantinou A, Epenetos AA, Hreczuk-Hirst D, Jain S, Wright M, Chester KA, et al. (2009). Site-specific polysialylation of an antitumor single-chain Fv fragment. Bioconjug. Chem. 20(5), 924-931.
-
(2009)
Bioconjug. Chem.
, vol.20
, Issue.5
, pp. 924-931
-
-
Constantinou, A.1
Epenetos, A.A.2
Hreczuk-Hirst, D.3
Jain, S.4
Wright, M.5
Chester, K.A.6
-
29
-
-
78651091039
-
Chemical generation of bispecific antibodies
-
Doppalapudi VR, Huang J, Liu D, Jin P, Liu B, Li L, et al. (2010) Chemical generation of bispecific antibodies. Proc. Natl. Acad. Sci. USA 107(52), 22611-22616.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, Issue.52
, pp. 22611-22616
-
-
Doppalapudi, V.R.1
Huang, J.2
Liu, D.3
Jin, P.4
Liu, B.5
Li, L.6
-
30
-
-
27944473690
-
VEGF as a key mediator of angiogenesis in cancer
-
Carmeliet P. (2005) VEGF as a key mediator of angiogenesis in cancer. Oncology 69(Suppl. 3), 4-10.
-
(2005)
Oncology
, vol.69
, Issue.SUPPL 3
, pp. 4-10
-
-
Carmeliet, P.1
-
32
-
-
0038118504
-
Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma
-
Moon WS, Rhyu KS, Kang MJ, Lee DG, Yu HC, Yeum JH, et al. (2003) Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma? Modern Pathol. 16, 552-557.
-
(2003)
Modern Pathol.
, vol.16
, pp. 552-557
-
-
Moon, W.S.1
Rhyu, K.S.2
Kang, M.J.3
Lee, D.G.4
Yu, H.C.5
Yeum, J.H.6
-
33
-
-
2442662270
-
Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma
-
Ochiumi T, Tanaka S, Oka S, Hiyama T, Ito M, Kitadai Y, et al. (2004) Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Int. J. Oncol. 24, 539-547.
-
(2004)
Int. J. Oncol.
, vol.24
, pp. 539-547
-
-
Ochiumi, T.1
Tanaka, S.2
Oka, S.3
Hiyama, T.4
Ito, M.5
Kitadai, Y.6
-
34
-
-
84886206452
-
-
71stAmerican Diabetes Association Scientific Sessions, June 23-28, San Diego CA
-
Huang J, Rolzin P, Osothprarop T, Ishino T,Wiese J, Retting K, et al. (2011) CVX-343 A long acting FGF-21 CovX-Body demonstrates prolonged antidiabetic efficacy in diabetic mouse models. 71stAmerican Diabetes Association Scientific Sessions, June 23-28, San Diego CA. 582 CovX-BODIES
-
(2011)
CVX-343 A long acting FGF-21 CovX-Body demonstrates prolonged antidiabetic efficacy in diabetic mouse models
-
-
Huang, J.1
Rolzin, P.2
Osothprarop, T.3
Ishino, T.4
Wiese, J.5
Retting, K.6
|