In Vitro Screening: Screening by Nuclear Magnetic Resonance

Protein Surface Recognition: Approaches for Drug Discovery

Volumn , Issue , 2010, Pages 237-271

  Giralt, Ernest ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

3D structure of therapeutic target making structure based designs impossible; Binding kinetics, highly influential in STD and CSP experiments; Biochemical assays, compounds evaluated based on interactions isolated targets in artificial environment; Chemical Shift Perturbation (CSP) NMR experiment, for studying ligand and protein interactions; High throughput screening (HTS) versatile tools in development of potential drugs targeting protein protein interactions; In vitro screening by nuclear magnetic resonance and high throughput screening methods; NMR, molecular recognition at protein surfaces impact on drug discovery; Protein protein interactions changes in chemical shifts and peaks, corresponding to labeled protein; Saturation Transfer Difference (STD) NMR experiment, studying protein ligand interactions; Signal window (SW), providing measurement of signal magnitude

Indexed keywords

EID: 84886128181     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470972137.ch9     Document Type: Chapter

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