A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions

Analytical Chemistry

Volumn 76, Issue 10, 2004, Pages 2922-2927

  Zhao, Hui Fen ^a   Kiyota, Taira ^a   Chowdhury, Shafinaz ^a   Purisima, Enrico ^a   Banville, Denis ^a   Konishi, Yasuo ^a   Shen, Shi Hsiang ^a,b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DRUG PRODUCTS; GENES; LIVING SYSTEMS STUDIES; SCREENING;

DRUG SCREENING; DRUGLIKE LIBRARY;

PROTEINS;

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; DOXYCYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN; PROTEIN P85; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; EMBRYO; GENE FUSION; GENETIC ANALYSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIBRARY; OPERATOR GENE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; REPRESSOR GENE; TET GENE; TWO HYBRID SYSTEM;

ANIMALS; DNA-BINDING PROTEINS; DOXYCYCLINE; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC ENGINEERING; HUMANS; PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TETRACYCLINE;

EID: 2442705551     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac035396m     Document Type: Article

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