Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High-Resolution Full Scan?

Mass Spectrometry for Drug Discovery and Drug Development

Volumn , Issue , 2013, Pages 403-425

  Dillen, Lieve ^a   Cuyckens, Filip ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

HPLC MS HPLC MS MS, orthogonal to immunoassay; New drug candidates, on small organic molecules; Peptides with MS, SRM TOF and duty cycles; SRM full scan HRMS, in peptide quantification; TOF orbital, resolution on MS signal sensitivity

Indexed keywords

EID: 84886126416     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118516157.ch15     Document Type: Chapter

References (49)

1. Vlieghe P, Lisowski V, Marinez J, Khrestchatisky M. Synthetic therapeutic peptides: science and market. Drug Discov Today 2010;15:40-56.
2. Reichert J, Pechon P, Tartar A, Dunn M. Development trends for peptide therapeutics; a comprehensive quantitative analysis of peptide therapeutics in clinical development (report summary). Peptide Therapeutic Foundation:2010.
3. Van Den Broek I, Sparidans RW, Schellens JHM, Beijnens JH. Sensitive liquid chromatography-tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples. Rapid Commun Mass Spectrom 2010;24(13):1842-50.
4. Van Den Broek I, Sparidans RW, Schellens JHM, Beijnens JH. Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B 2010;878:590-602.
5. Dillen L, Cools W, Vereyken L, Timmerman P. A screening UHPLC-MS/MS method for the analysis of amyloid peptides in cerebrospinal fluid of preclinical species. Bioanalysis 2011;3(1):45-55.
6. Hoofnagle A, Wener M. The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry. J Immunol Methods 2009;347:3-11.
7. Hewavitharana AK, Herath HMDR, Shaw PN, Cabot PJ, Kebarle P. Effect of solvent and electrospray mass spectrometer parameters on charge state distribution of peptides-a case study using liquid chromatography/mass spectrometry method development for beta-endorphin assay. Rapid Commun Mass Spectrom 2010;24:3510-4.
8. Campbell JL, Le Blanc JCY. Peptide and protein drug analysis by MS: challenges and opportunities for the discovery environment. Bioanalysis 2011;3(6):645-57.
9. MacLean B, Tomazela DM, Abbatiello SE, et al. Effect of collision energy optimization on the measurement of peptides by selected reaction monitoring (SRM) mass spectrometry. Anal Chem 2010;82:10116-24.
10. Kuhn E, Wu J, Karl J, Liao H, Zolg W, Guild B. Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards. Proteomics 2004;4(4):1175-86.
11. Hagman C, Ricke D, Ewert S, Bek S, Falchetto R, Bitsch F. Absolute quantification of monoclonal antibodies in biofluids by liquid chromatography-tandem mass spectrometry. Anal Chem 2008;80(4):491-8.
12. Klaassen T, Swandt S, Kapron JT, Roemer A. Validated quantitation method for a peptide in rat serum using liquid chromatography/high field asymmetric waveform ion mobility spectrometry. Rapid Commun Mass Spectrom 2009;23:2301-6.
13. Hao C, Campbell JL, Verkerk UH, Le Blanc JCY, Siu KWM. Performance and attributes of liquid chromatography-mass spectrometry with targeted charge separation in quantitative analysis of therapeutic peptides. J Am Soc Mass Spectrom 2011;22(1):67-74.
14. Campbell JL, Le Blanc JCY. Targeted ion parking for the quantitation of biotherapeutic proteins: concepts and preliminary data. J Am Soc Mass Spectrom 2010;21(12):2011-22.
15. Korfmacher W. High resolution mass spectrometry will dramatically change our drugdiscovery bioanalysis procedures. Bioanalysis 2011;3(11):1169-71.
16. Kaufmann A, Butcher P, Maden K, Walker S, Widmer M. Quantitative and confirmative performance of liquid chromatography coupled to high resolution mass spectrometry compared with tandem mass spectrometry. Rapid Commun Mass Spectrom 2011;25(7):979-92.
17. Soler C, Hamilton B, Furey A, James KJ, Manes J, Pico Y. Comparison of four mass analyzers for determining carbosulfan and its metabolite in citrus by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 2006;20:2151-64.
18. Kadar H, Veyrand B, Barbarossa A, et al. Development of an analytical strategy based on liquid chromatography-high resolution mass spectrometry for measuring perfluorinated compounds in human breast milk: application to the generation of preliminary data regarding perinatal exposure in France. Chemosphere 2011;85(3):473-80.
19. Jiwan JLH, Wallemacq P, Herent MF. HPLC-high resolution mass spectrometry in clinical laboratory? Clin Biochem 2011;44:136-47.
20. Taillon MP, Furtado M, Garofolo F. Challenges of developing a bioanalytical method for a macrolide immunosuppressant compound by LC-MS/MS. Bioanalysis 2011;3(1):1201-15.
21. Dillen L, Cools W, Vereyken L, Lorreyne W, Huybrechts T, de Vries R, Ghobarah H, Cuyckens F. Comparison of triple quadrupole and high resolution time of flight mass spectrometry for quantification of peptides. Bioanalysis 2012;4(3):565-79.
22. Van Den Broek I, Sparidans R, Schellens J, Beijnen J. Quantitative bioanalysis of peptides by liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B 2008;872:1-22.
23. Ewles M, Goodwin L. Bioanalytical approaches to analyzing peptides and proteins by LC-MS/MS. Bioanalysis 2011;3(12):1379-97.
24. Tamvakopoulos C. Mass spectrometry for the quantification of bioactive peptides in biological fluids. Mass Spectrom Rev 2007;26:389-402.
25. Niwa M, Enomoto K, Yamashita K. Measurement of the novel decaeptide cetrorelix in human plasma and urine by liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr B Biomed Sci Appl 1999;729(1-2):245-53.
26. Mirzaei H, Regnier F. Enhancing electrospray ionization efficiency of peptides by derivatization. Anal Chem 2006;78(12):4175-83.
27. Abian J, Oosterkamp AJ, Gelpí E. Comparison of conventional, narrow-bore and capillary liquid chromatography/mass spectrometry for electrospray ionization mass spectrometry: practical considerations. J Mass Spectrom 1999;34(4):244-54.
28. Roepstorff P, Fohlman J. Proposal for a common nomenclature for sequence ions in mass spectra of peptides. Biomed Mass Spectrom 1984;11(11):601.
29. Delinsky DC, Hill KT, White CS, Bartlett MG. Quantitation of the large polypeptide glucagon by protein precipitation and LC/MS. Biomed Chromatogr 2004;18(9):700-5.
30. van den Broek I, Sparidans RW, Huitema AD, Schellens JH, Beijnen JH. Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2006;837(1-2):49-58.
31. Shipkova P, Drexler DM, Langish R, Smalley J, Salyan ME, Sanders M. Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides. Rapid Commun Mass Spectrom 2008;22(9):1359-66.
32. Fierens C, Thienpont LM, Stöckl D, Willekens E, De Leenheer AP. Quantitative analysis of urinary C-peptide by liquid chromatography-tandem mass spectrometry with a stable isotopically labelled internal standard. J Chromatogr A 2000;896(1-2):275-8.
33. Oe T, Ackermann BL, Inoue K. Garner CO, Gelfanova V, Dean RA, Siemers ER, Holtzman DM, Farlow MR, Blair IA. Quantitative analysis of amyloid β peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 2006;20:3723-35.
34. Chang D, Kolis SJ, Linderholm KH, Julian TF, Nachi R, Dzerk AM, Lin PP, Lee JW, Bansal SK. Bioanalytical method development and validation for a large peptide HIV fusion inhibitor (Enfuvirtide, T-20) and its metabolite in human plasma using LC-MS/MS. J Pharm Biomed Anal 2005;38(3):487-96.
35. van den Broek I, Sparidans RW, Schellens JH, Beijnen JH. Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: measurement of chymotryptic fragments from the HIV-I fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2007;854:245-59.
36. Cuyckens F, Dillen L, Cools W, Bockx M, Vereyken L, de Vries R, Mortishire-Smith RJ. Extracting metabolite ions of peptide drugs from an in vivo matrix background. Bioanalysis 2012;4(3):595-604.
37. Chambers E, Lame ME, Diehl DM, Zhang Y. Analytical challenges in the development of a quantitative SPE/LC/MS/MS assay for amyloid beta peptides in cerebrospinal fluid. Poster at the 58th ASMS Conference Salt Lake City, US 2010.
38. Ismaiel OA, Yuan M, Jenkins RG, Karnes HG. Evaluation of 2-Dimensional Chromatographic Techniques for Eliminating Matrix Effects and Improving Bioanalysis of Peptides Using UPLC-MS/MS poster presentation at EBF symposium Barcelona 2010.
39. Hatziieremia S, Kostomitsopoulos N, Balafas V, Tamvakopoulos C. A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice. Rapid Commun Mass Spectrom 2007;21(15):2431-8.
40. Bredehöft M, Schänzer W, Thevis M. Quantification of human insulin-like growth factor-1 and qualitative detection of its analogues in plasma using liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom 2008;22(4):477-85.
41. Vatansever B, Lahrichi SL, Thiocone A, Salluce N, Mathieu M, Grouzmann E, Rochat B. Comparison between a linear ion trap and a triple quadrupole MS in the sensitive detection of large peptides at femtomole amounts on column. J Sep Sci 2010;33:2478-88.
42. Fortin T, Salvador A, Charrier JP, Lenz C, Bettsworth F, Lacoux X, Choquet G, Kastylevsky F, Lemoine J. Multiple reaction monitoring cubed for protein quantification at the low nanogram/milliliter level in nondepleted human serum. Anal Chem 2009;81:9343-52.
43. O'Connor D, Mortishire-Smith R. High-throughput bioanalysis with simultaneous acquisition of metabolic route data using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry. Anal Bioanal Chem 2006;385:114-21.
44. Zhang N, Yu S, Tiller P, Yeh S, Mahan E, Emary W. Quantitation of small molecules using high-resolution accurate mass spectrometers-a different approach for analysis of biological samples. Rapid Commun Mass Spectrom 2009;23(7):1085-944.
45. Bateman K, Kellman M, Muenster H, Papp R, Taylor L. Quantitative-qualitative data acquisition using a benchtop Orbitrap mass spectrometer. J Am Soc Mass Spectrom 2009;20(8):1441-50.
46. Fung E, Xia Y-Q, Aubry A-F, et al. Full scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma. J Chromatogr B 2011;879:2919-27.
47. Xia Y-Q, Lau J, Olah T, Jemal M. Targeted quantitative bioanalysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: an evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profile modes. Rapid Commun Mass Spectrom 2011;25:2863-28.
48. Ruan Q, Ji QC, Arnold ME, Humphreys WG, Zhu M. Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric detection of intact protein. Anal Chem 2011;83:8937-44.
49. Ramanathan R, Jemal M, Ramagiri S, Xia YQ, Humprheys WG, Olah T, Korfmacher WA. It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS. J Mass Spectrom 2011;46:595-601.