Characterization of the pharmacokinetics of dioscin in rat

Steroids

Volumn 70, Issue 8, 2005, Pages 525-530

  Li, Ke ^a   Tang, Yunbiao ^b   Fawcett, John Paul ^c   Gu, Jingkai ^b   Zhong, Dafang ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Dioscin; Excretion; Pharmacokinetics; Steroidal saponin; Tissue distribution

Indexed keywords

ACTIVATED CARBON; DIOSCIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; BILE FLOW; CHINESE MEDICINE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BILE LEVEL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG FECES LEVEL; DRUG URINE LEVEL; INTESTINE; NONHUMAN; RAT; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; BILE; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; DIOSGENIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; FEMALE; INJECTIONS, INTRAVENOUS; MALE; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; TISSUE DISTRIBUTION; URINE;

EID: 19344372601     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2004.11.014     Document Type: Article

References (13)

1. T. Nakamura, C. Komori, Y. Lee, F. Hashimoto, S. Yahara, and T. Nohara Cytotoxic activities of solanum steroidal glycosides Biol Pharm Bull 19 1996 564 566
2. Z. Wang, J.B. Zhou, Y. Ju, H. Zhang, M. Liu, and X. Li Effect of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells Biol Pharm Bull 24 2001 159 162
3. Q. Mi, D. Lantvit, E. Reyes-Lim, H. Chai, W. Zhao, and I.S. Lee Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests J Nat Prod 65 2002 842 850
4. J. Cai, M. Liu, Z. Wang, and Y. Ju Apoptosis induced by dioscin in hela cells Biol Pharm Bull 25 2002 193 196
5. H.C. Chiang, T.H. Tseng, C.J. Wang, C.F. Chen, and W.S. Kan Apoptosis induced by dioscin in hela cells Anticancer Res. 11 1991 1911 1917
6. M. Sautour, A.C. Mitaine-Offer, T. Miyamoto, A. Dongmo, and M.A. Lacaille-Dubois Antifungal steroid Saponins from Dioscorea cayenensis Planta Med 70 2004 90 92
7. M. Takechi, S. Shimada, and Y. Tanaka Structure-activity relationships of the saponins dioscin and dioscinin Phytochemistry 30 1991 3943 3944
8. T. Ikeda, J. Ando, A. Miyazono, X.H. Zhu, H. Tsumagari, and T. Nohara Anti-herpes virus activity of steroidal glycosides Biol Pharm Bull 23 2000 363 364
9. S.J. Deng, B. Yu, Y.Z. Hui, H. Yu, and X.W. Han Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7 Carbohydrate Res 317 1999 53 62
10. M. Li, X.W. Han, and B. Yu Synthesis of monomethylated derivatives and their antitumor activities Carbohydrate Res 338 2003 117 121
11. K. Li, Y.W. Wang, J.K. Gu, X.Y. Chen, and D.F. Zhong Determination of dioscin in rat plasma by high-performance liquid chromatography with tandem mass spectrometry detection J Chromatogr B 817 2005 271 275
12. C.P. Siegers, K. Rozman, and C.D. Klaassen Biliary excretion and enterohepatic circulation of paracetamol in the rat Xenobiotica 13 1983 591 596
13. P.J. Neuvonen, and E. Elonen Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenybutazone in man Eur J Clin Pharmacol 17 1980 51 57