Cytoplasmic Diffusion of Dendrimers and Dendriplexes

Weissig/Organelle-Specific Nanotechnology

Volumn , Issue , 2010, Pages 35-54

  Florence, Alexander T ^a   Ruenraroengsak, Pakatip ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Dendrimers and dendriplexes cytoplasmic diffusion; Diffusion and uptake of dendrimer and dendriplexes; Diffusion coefficients and relative diffusion coefficients of parent dendrimers and dendriplexes in cell cytoplasm

Indexed keywords

EID: 84886076582     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470875780.ch3     Document Type: Chapter

References (64)

1. Tomalia, D. A. Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Prog. Polym. Sci. 30: 294-324 (2005).
2. Perumal, O. P., Inapagolla, R., Kannan S., and Kannan, R. M. The effect of surface functionality on cellular traffi cking of dendrimers. Biomaterial 29: 3469-3476 (2008).
3. El-Sayed, M., Kiani, M. F., Naimark, M. D., Hikal, A. H., and Ghandehari, H. Extravasation of poly(amidoamine) (PAMAM) dendrimers across microvascular network endothelium. Pharm. Res. 18: 23-28 (2001).
4. Preston, R. A., Murphy, R. F., and Jones, E. W. Apparent endocytosis of fl uorescein isothiocyanate-conjugated dextran by Saccharomyces cerevisiae refl ects uptake of low molecular weight impurities, not dextran. J. Cell Biol. 105: 1981-1987 (1987).
5. Lundberg, M. and Johansson, M. Positively charged DNA-binding proteins cause apparent cell membrane translocation. Biochem. Biophys. Res. Commun. 291: 367-371 (2002).
6. Richard, J. P., Melikov, K., Vives, E., Ramos, C., Verbeure, B., Gait, M. J., Chernomordik, L. V., and Lebleu, B. Cell-penetrating peptides: a reevaluation of the mechanism of cellular uptake. J. Biol. Chem. 278: 585-590 (2003).
7. Al-Jamal, K. T., Ruenraroengsak, P., Hartell, N., and Florence, A. T. An intrinsically fluorescent dendrimer as a nanoprobe of cell transport. J. Drug Target. 14: 405-412 (2006).
8. Dickinson, R. B. and Purich, D. I. Diffusion rate limitations in actin-based propulsion of hard and deformable particles. Biophys. J. 91: 1548-1563 (2006).
9. Ruenraroengsak, P. and Florence, A. T. The diffusion of latex nanospheres and the effective (microscopic) viscosity of HPMC gels. Int. J. Pharm. 298: 361-366 (2005).
10. Ellis, R. J. and Minton, A. P. Cell biology: join the crowd. Nature 425: 27-28 (2003).
11. Fulton, A. B. How crowded is the cytoplasm? Cell 30: 345-347 (1982).
12. Goodsell, D. S. Inside a living cell. TIBS 16: 203-206 (1991).
13. Luby-Phelps, K. Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area. Int. Rev. Cytol. 192: 189-221 (2000).
14. Medalia, O., Weber, I., Frangakis, A. S., Nicastro, D., Gerisch, G., and Baumeister, W. Macromolecular architecture in eukaryotic cells visualized by cryoelectron tomography. Science 298: 1209-1213 (2002).
15. Zimmerman, S. B. and Minton, A. P. Macromolecular crowding: biochemical, biophysical, and physiological consequences. Annu. Rev. Biophys. Biomol. Struct. 22: 27-65 (1993).
16. Kao, H. P., Abney, J. R., and Verkman, A. S. Determinants of the translational mobility of a small solute in cell cytoplasm. J. Cell Biol. 120: 175-184 (1993).
17. Furukawa, R., Arauz-Lara, J. L., and Ware, B. R. Self-diffusion and probe diffusion in dilute and semidilute aqueous solutions of dextran. Macromolecules 24: 599-605 (1991).
18. Phillies, G. D. J. The hydrodynamic scaling model for polymer self-diffusion. J. Phys. Chem. 93: 5029-5039 (1989).
19. Hou, L., Lanni, F., and Luby-Phelps, K. Tracer diffusion in F-actin and Ficoll mixtures. Toward a model for cytoplasm. Biophys. J. 58: 31-43 (1990).
20. Clegg, J. S. Properties and metabolism of the aqueous cytoplasm and its boundaries. Am. J. Physiol. 246: R133-R151 (1984).
21. Mastro, A. M., Babich, M. A., Taylor, W. D., and Keith, A. D. Diffusion of a small molecule in the cytoplasm of mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 81: 3414-3418 (1984).
22. Nicolay, K., Vander, T. A., and Dijkhuizen, R. M. In vivo diffusion spectroscopy: an overview. NMR Biomed. 8: 365-374 (1995).
23. Verkman, A. S., Armijo, M., and Fushimi, K. Construction and evaluation of a frequency-domain epifl uorescence microscope for lifetime and anisotropy decay measurements in subcellular domains. Biophys. Chem. 40: 117-125 (1991).
24. Luby-Phelps, K., Mujumdar, S., Mujumdar, R. B., Ernst, L. A., Galbraith, W., and Waggoner, A. S. A novel fl uorescence ratiometric method confi rms the low solvent viscosity of the cytoplasm. Biophys. J. 65: 236-242 (1993).
25. Luby-Phelps, K., Castle, P. E., Taylor, D. L., and Lanni, F. Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells. Proc. Natl. Acad. Sci. U.S.A. 84: 4910-4913 (1987).
26. Aschenbrenner, L., Naccache, S. N., and Hasson, T. Uncoated endocytic vesicles require the unconventional myosin, myo6, for rapid transport through actin barriers. Mol. Biol. Cell 15: 2253-2263 (2004).
27. Conner, S. D. and Schmid, S. L. Regulated portals of entry into the cell. Nature 422: 37-44 (2003).
28. Hong, S., Bielinska, A. U., Mecke, A., Keszler, B., Beals, J. L., Shi, X., Balogh, L., Orr, B. G., Baker, J. R., Jr., and Banaszak Holl, M. M. Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport. Bioconjug. Chem. 15: 774-782 (2004).
29. Hong, S., Leroueil, P. R., Janus, E. K., Peters, J. L., Kober, M. M., Islam, M. T., Orr, B. G., Baker, J. R., Jr., and Banaszak Holl, M. M. Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. Bioconjug. Chem. 17: 728-734 (2006).
30. Mecke, A., Lee, D. K., Ramamoorthy, A., Orr, B. G., and Banaszak Holl, M. M. Membrane thinning due to antimicrobial peptide binding: an atomic force microscopy study of MSI-78 in lipid bilayers. Biophys. J. 89: 4043-4050 (2005).
31. Mecke, A., Lee, D. K., Ramamoorthy, A., Orr, B. G., and Holl, M. M. Synthetic and natural polycationic polymer nanoparticles interact selectively with fl uid-phase domains of DMPC lipid bilayers. Langmuir 21: 8588-8590 (2005).
32. Mecke, A., Majoros, I. J., Patri, A. K., Baker, J. R., Jr., Holl, M. M., and Orr, B. G. Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group. Langmuir 21: 10348-10354 (2005).
33. Morris, M. C., Deshayes, S., Heitz, F., and Divita, G. Cell-penetrating peptides: from molecular mechanisms to therapeutics. Biol. Cell 100: 201-217 (2008).
34. Mislick, K. A. and Baldeschwieler, J. D. Evidence for the role of proteoglycans in cation-mediated gene transfer. Proc. Natl. Acad. Sci. U.S.A. 93: 12349-12354 (1996).
35. Manunta, M., Izzo, L., Duncan, R., and Jones, A. T. Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identifi cation of endosomal and lysosomal compartments in HepG2 cells combining single-step subcellular fractionation with fluorescent imaging. J. Drug Target. 15: 37-50 (2007).
36. Woodle, M. C. and Scaria, P. Cationic liposomes and nucleic acids. Curr. Opin. Colloid Interface Sci. 6: 78-84 (2001).
37. Manunta, M., Nichols, B. J., Tan, P. H., Sagoo, P., Harper, J., and George, A. J. Gene delivery by dendrimers operates via different pathways in different cells, but is enhanced by the presence of caveolin. J. Immunol. Methods 314: 134-146 (2006).
38. Elouahabi, A. and Ruysschaert, J. M. Formation and intracellular traffi cking of lipoplexes and polyplexes. Mol. Ther. 11: 336-347 (2005).
39. Ruenraroengsak, P., Al-Jamal, K. T., Hartell, N., Braeckmans, K., De Smedt, S. C., and Florence, A. T. Cell uptake, cytoplasmic diffusion and nuclear access of a 6.5 nm diameter dendrimer. Int. J. Pharm. 331: 215-219 (2007).
40. Sagidullin, A. I., Muzafarov, A. M., Krykin, M., Ozerin, A. N., Skirda, V. D., and Ignat'eva, G. M. Generalized concentration dependence of self-diffusion coeffi-cients in poly(allylcarbosilane) dendrimer solution. Macromolecules 35: 9472-9479 (2002).
41. Xia, T., Kovochich, M., Liong, M., Zink, J. I., and Nel, A. E. Cationic polystyrene nanosphere toxicity depends on cell-specifi c endocytic and mitochondrial injury pathways. ACS Nano 2: 85-96 (2008).
42. Kaether, C. and Gerdes, H. H. Monitoring of protein secretion with green fluorescent protein. Methods Enzymol. 302: 11-19 (1999).
43. Bayele, H. K., Sakthivel, T., O'Donell, M., Pasi, K. J., Wilderspin, A. F., Lee, C. A., Toth, I., and Florence, A. T. Versatile peptide dendrimers for nucleic acid delivery. J. Pharm. Sci. 94: 446-457 (2005).
44. Arrio-Dupont, M., Foucault, G., Vacher, M., Devaux, P. F., and Cribier, S. Translational diffusion of globular proteins in the cytoplasm of cultured muscle cells. Biophys. J. 78: 901-907 (2000).
45. Tseng, Y. and Wirtz, D. Mechanics and multiple-particle tracking microheterogeneity of alpha-actinin-cross-linked actin fi lament networks. Biophys. J. 81: 1643- 1656 (2001).
46. Fushimi, K. and Verkman, A. S. Low viscosity in the aqueous domain of cell cytoplasm measured by picosecond polarization microfl uorimetry. J. Cell Biol. 112: 719-725 (1991).
47. Janson, L. W., Ragsdale, K., and Luby-Phelps, K. Mechanism and size cutoff for steric exclusion from actin-rich cytoplasmic domains. Biophys. J. 71: 1228-1234 (1996).
48. Luby-Phelps, K. Effect of cytoarchitecture on the transport and localization of protein synthetic machinery. J. Cell Biochem. 52: 140-147 (1993).
49. Provance, D. W. Jr., McDowall, A., Marko, M., and Luby-Phelps, K. Cytoarchitecture of size-excluding compartments in living cells. J. Cell Sci. 106 (2): 565-577 (1993).
50. Peters, R. Introduction to nucleocytoplasmic transport: molecules and mechanisms. Methods Mol. Biol. 322: 235-258 (2006).
51. Allen, T. D., Cronshaw, J. M., Bagley, S., Kiseleva, E., and Goldberg, M. W. The nuclear pore complex: mediator of translocation between nucleus and cytoplasm. J. Cell Sci. 113 (10): 1651-1659 (2000).
52. Rout, M. P., Aitchison, J. D., Suprapto, A., Hjertaas, K., Zhao, Y., and Chait, B. T. The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148: 635-651 (2000).
53. Lusk, C. P., Blobel, G., and King, M. C. Highway to the inner nuclear membrane: rules for the road. Nat. Rev. Mol. Cell Biol. 8: 414-420 (2007).
54. Bickel, T. and Bruinsma, R. The nuclear pore complex mystery and anomalous diffusion in reversible gels. Biophys. J. 83: 3079-3087 (2002).
55. Dingwall, C., Sharnick, S. V., and Laskey, R. A. A polypeptide domain that specifi es migration of nucleoplasmin into the nucleus. Cell 30: 449-458 (1982).
56. Tkachenko, A. G., Xie, H., Liu, Y., Coleman, D., Ryan, J., Glomm, W. R., Shipton, M. K., Franzen, S., and Feldheim, D. L. Cellular trajectories of peptide-modifi ed gold particle complexes: comparison of nuclear localization signals and peptide transduction domains. Bioconjug. Chem. 15: 482-490 (2004).
57. Salman, H., Zbaida, D., Rabin, Y., Chatenay, D., and Elbaum, M. Kinetics and mechanism of DNA uptake into the cell nucleus. Proc. Natl. Acad. Sci. U.S.A. 98: 7247-7252 (2001).
58. Degennes, P. G. Passive entry of a DNA molecule into a small pore. Proc. Natl. Acad. Sci., U.S.A. 96: 7262-7264 (1999).
59. Lukacs, G. L., Haggie, P., Seksek, O., Lechardeur, D., Freedman, N., and Verkman, A. S. Size-dependent DNA mobility in cytoplasm and nucleus. J. Biol. Chem. 275: 1625-1629 (2000).
60. Sakthivel, T., Toth, I., and Florence, A. T. Synthesis and physicochemical properties of lipophilic polyamide dendrimers. Pharm. Res. 15: 776-782 (1998).
61. Toth, I., Sakthivel, T., Wilderspin, A. F., Toth, I., Bayele, H. K., O'Donnell, M., Perry, D. J., Pasi, K. J., Lee, C. A., and Florence, A. T. Novel cationic lipidic peptide dendrimer vectors-in vitro gene delivery. STP Pharm. Sci. 9: 93-99 (1999).
62. Burke, B. Cell biology. Nuclear pore complex models gel. Science 314: 766-767 (2006).
63. Frey, S., Richter, R. P., and Gorlich, D. FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties. Science 314: 815-817 (2006).
64. Elbaum, M. Materials science. Polymers in the pore. Science 314: 766-767 (2006).