Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line

Journal of Steroid Biochemistry and Molecular Biology

Volumn 139, Issue , 2014, Pages 7-15

  Werminghaus, Pascal ^a,b   Haase, Matthias ^a   Hornsby, Peter J ^c   Schinner, Sven ^a   Schott, Matthias ^a   Malendowicz, Ludwik K ^d   Lammers, Bernhard J ^e   Goretzki, Peter E ^e   Müller Mattheis, Volker ^b   Giessing, Markus ^b   Willenberg, Holger S ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^e Lukaskrankenhaus GmbH   (Germany)

Author keywords

Adrenal; GLI1; Hedgehog; SHH; Tumor

Indexed keywords

CHLORMETHINE; CYCLOPAMINE; FORSKOLIN; HYDROCORTISONE; MESSENGER RNA; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN;

ADRENAL CELL; ADRENAL CORTEX; ADRENAL CORTEX ADENOMA; ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX CELL; ADRENAL CORTEX TUMOR; ADRENAL GLAND; ARTICLE; CARCINOGENESIS; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INHIBITION KINETICS; KIDNEY CANCER; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ADRENAL; GLI1; HEDGEHOG; SHH; TUMOR;

ADENOMA; ADRENAL CORTEX; ADRENAL GLAND NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION; HEDGEHOG PROTEINS; HUMANS; PRIMARY CELL CULTURE; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

ERINACEIDAE; MUS;

EID: 84886076009     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.09.007     Document Type: Article

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