The Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis Offers Efficient Bystander Cell Killing for Suicide Gene Therapy of Cancer

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Sato, Takeya ^a   Neschadim, Anton ^b   Lavie, Arnon ^c   Yanagisawa, Teruyuki ^a   Medin, Jeffrey A ^d,e  

^a TOHOKU UNIVERSITY   (Japan)

^b CANADIAN BLOOD SERVICES   (Canada)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENOXOLONE; CONNEXIN 43; GAP JUNCTION PROTEIN; LENTIVIRUS VECTOR; PANNEXIN 1; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; ZIDOVUDINE; DTMP KINASE; NUCLEOSIDE MONOPHOSPHATE KINASE; PRODRUG; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CELL COMMUNICATION; CELL KILLING; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DISEASE MODEL; ENZYME PRODRUG THERAPY; GAP JUNCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SUICIDE GENE; SUICIDE GENE THERAPY; TUMOR REGRESSION; TUMOR XENOGRAFT; VIRAL GENE DELIVERY SYSTEM; ANALYSIS OF VARIANCE; APOPTOSIS; CELL PROLIFERATION; CHEMISTRY; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GENE THERAPY; GENETICS; HEK293 CELL LINE; METABOLISM; PHYSIOLOGY; PROCEDURES; PROSTATIC NEOPLASMS; SUICIDE TRANSGENE; TUMOR CELL LINE;

ANALYSIS OF VARIANCE; APOPTOSIS; BYSTANDER EFFECT; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; GENES, TRANSGENIC, SUICIDE; GENETIC THERAPY; HEK293 CELLS; HUMANS; MALE; MICROSCOPY, CONFOCAL; NUCLEOSIDE-PHOSPHATE KINASE; PRODRUGS; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; ZIDOVUDINE;

EID: 84886070529     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078711     Document Type: Article

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