Trade-offs between anti-aging dietary supplementation and exercise

Rejuvenation Research

Volumn 16, Issue 5, 2013, Pages 419-426

  Mendelsohn, Andrew R ^a   Larrick, James W ^a  

^a Panorama Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ASCORBIC ACID; OMEGA 3 FATTY ACID; PARACETAMOL; REACTIVE OXYGEN METABOLITE; RESVERATROL; SELENIUM; SIRTUIN 1;

AEROBIC EXERCISE; AGING; ANTIINFLAMMATORY ACTIVITY; BRONCHOSPASM; CANCER INCIDENCE; CANCER PREVENTION; COMMON COLD; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG INHIBITION; EXERCISE; FATTY ACID BLOOD LEVEL; HIGH RISK POPULATION; HUMAN; LONGEVITY; MEAL; META ANALYSIS (TOPIC); PRIORITY JOURNAL; PROSTATE CANCER; RESISTANCE TRAINING; REVIEW;

AGING; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CLINICAL TRIALS AS TOPIC; DIETARY SUPPLEMENTS; EXERCISE; FATTY ACIDS, OMEGA-3; HUMANS; LONGEVITY; MODELS, BIOLOGICAL;

EID: 84886033786     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2013.1484     Document Type: Review

References (57)

1. Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 1956;11:298-300.
2. Harman D. The biologic clock: The mitochondria? J Am Geriatr Soc 1972;20:145-147.
3. Ristow M, Schmeisser S. Extending life span by increasing oxidative stress. Free Radic Biol Med 2011;51:327-336.
4. Tapia PC. Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: "Mitohormesis" for health and vitality. Med Hypotheses 2006;66:832-843. (Pubitemid 43181634)
5. Mendelsohn AR, Larrick JW. Dietary restriction: Critical cofactors to separate health span from life span benefits. Rejuvenation Res 2012;15:523-529.
6. Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 2007;6:280-293. (Pubitemid 47468090)
7. Buchowski MS, Hongu N, Acra S, Wang L, Warolin J, Roberts LJ. Effect of modest caloric restriction on oxidative stress in women, a randomized trial. PLoS One 2012;7.
8. Hercberg S, Ezzedine K, Guinot C, Preziosi P, Galan P, Bertrais S, et al. Antioxidant supplementation increases the risk of skin cancers in women but not in men. J Nutr 2007;137:2098-2105. (Pubitemid 47367272)
9. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA 2007;297:842-857. (Pubitemid 46333949)
10. Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2013;1:CD000980.
11. Mohar DS, Malik S. The sirtuin system: The holy grail of resveratrol? J Clin Exp Cardiol 2012;3.
12. Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 2011;477:482-485.
13. Timmers S, Auwerx J, Schrauwen P. The journey of resveratrol from yeast to human. Aging 2012;4:146-158.
14. Cottart C-H, Nivet-Antoine V, Beaudeux J-L. Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans. Mol Nutr Food Res 2013; published online June 6, 2013, doi: 10.1002/mnfr.201200589.
15. Deckelbaum RJ, Torrejon C. The omega-3 fatty acid nutritional landscape: Health benefits and sources. J Nutr 2012;142:587S-591S.
16. Borghi C, Pareo I. Omega-3 in antiarrhythmic therapy: Cons position. High Blood Press Cardiovasc Prev Off J Ital Soc Hypertens 2012;19:207-211.
17. Trimarco B. Omega-3 in antiarrhythmic therapy: Pros position. High Blood Press Cardiovasc Prev Off J Ital Soc Hypertens 2012;19:201-205.
18. Schnohr P, Marott JL, Lange P, Jensen GB. Longevity in male and female joggers: The Copenhagen City Heart Study. Am J Epidemiol 2013;177:683-689.
19. Buchman AS, Yu L, Boyle PA, Shah RC, Bennett DA. Total daily physical activity and longevity in old age. Arch Intern Med 2012;172:444-446.
20. Davies KJA, Quintanilha AT, Brooks GA, Packer L. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun 1982;107:1198-1205. (Pubitemid 13222413)
21. Chevion S, Moran DS, Heled Y, Shani Y, Regev G, Abbou B, et al. Plasma antioxidant status and cell injury after severe physical exercise. Proc Natl Acad Sci USA 2003;100:5119-5123. (Pubitemid 36542668)
22. Powers RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 2006;20:174-184. (Pubitemid 43112936)
23. Konopka AR, Douglass MD, Kaminsky LA, Jemiolo B, Trappe TA, Trappe S, et al. Molecular adaptations to aerobic exercise training in skeletal muscle of older women. J Gerontol A Biol Sci Med Sci 2010;65A:1201-1207.
24. Konopka AR, Suer MK, Wolff CA, Harber MP. Markers of human skeletal muscle mitochondrial biogenesis and quality control: Effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci 2013; published online July 20, 2013, doi: 10.1093/gerona/glt107.
25. Patil HR, O'Keefe JH, Lavie CJ, Magalski A, Vogel RA, McCullough PA. Cardiovascular damage resulting from chronic excessive endurance exercise. Mol Med 2012;109: 312-321.
26. Ristow M, Zarse K, Oberbach A, Klöting N, Birringer M, Kiehntopf M, et al. Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci USA 2009;106:8665-8670.
27. Gomez-Cabrera M-C, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, et al. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 2008;87:142-149.
28. Petersen AC, McKenna MJ, Medved I, Murphy KT, Brown MJ, Della Gatta P, et al. Infusion with the antioxidant Nacetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle: NAC and exercise-induced cell signalling. Acta Physiol 2012;204:382-392.
29. Jiménez-Jiménez R, Cuevas MJ, Almar M, Lima E, García-López D, De Paz JA, et al. Eccentric training impairs NF-kappaB activation and over-expression of inflammationrelated genes induced by acute eccentric exercise in the elderly. Mech Ageing Dev 2008;129:313-321.
30. Gliemann L, Schmidt JF, Olesen J, Biensø RS, Peronard SL, Grandjean SU, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol 2013; published online August 16, 2013, doi: 10.1113/jphysiol.2013.258061
31. Peter K, Nawroth P, Conradt C, Nordt T, Weiss T, Boehme M, et al. Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, e-selectin, pselectin, and thrombomodulin. Arterioscler Thromb Vasc Biol 1997;17:505-512. (Pubitemid 27133140)
32. Matos RS, Baroncini LAV, Précoma LB, Winter G, Lambach PH, Caron EY, et al. Resveratrol causes antiatherogenic effects in an animal model of atherosclerosis. Arq Bras Cardiol 2012;98:136-142.
33. Menzies KJ, Singh K, Saleem A, Hood DA. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. J Biol Chem 2013;288:6968-6979.
34. Murase T, Haramizu S, Ota N, Hase T. Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice. Biogerontology 2009;10:423-434.
35. Price NL, Gomes AP, Ling AJY, Duarte FV, Martin-Montalvo A, North BJ, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 2012;15:675-690.
36. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006;127:1109-1122. (Pubitemid 44894520)
37. Dolinsky VW, Jones KE, Sidhu RS, Haykowsky M, Czubryt MP, Gordon T, et al. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. J Physiol 2012;590:2783-2799.
38. Hart N, Sarga L, Csende Z, Koltai E, Koch LG, Britton SL, et al. Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc 2013; online February 17, 2013.
39. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 2013;110:3507-3512.
40. Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab 2012;16:658-664.
41. Skrobuk P, von Kraemer S, Semenova MM, Zitting A, Koistinen HA. Acute exposure to resveratrol inhibits AMPK activity in human skeletal muscle cells. Diabetologia 2012;55: 3051-3060.
42. Bailey DM, McEneny J, Mathieu-Costello O, Henry RR, James PE, McCord JM, et al. Sedentary aging increases resting and exercise-induced intramuscular free radical formation. J Appl Physiol 2010;109:449-456.
43. Hemilä H. Vitamin C may alleviate exercise-induced bronchoconstriction: A meta-analysis. BMJ Open 2013;3: e002416.
44. Schachter EN, Schlesinger A. The attenuation of exerciseinduced bronchospasm by ascorbic acid. Ann Allergy 1982; 49:146-151. (Pubitemid 12030892)
45. Cohen HA, Neuman I, Nahum H. Blocking effect of vitamin C in exercise-induced asthma. Arch Pediatr Adolesc Med 1997;151:367-370. (Pubitemid 27184549)
46. Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exerciseinduced bronchoconstriction in patients with asthma. Respir Med 2007;101:1770-1778. (Pubitemid 46930706)
47. Hemilä H. Vitamin C and common cold incidence: A review of studies with subjects under heavy physical stress. Int J Sports Med 1996;17:379-383. (Pubitemid 26261471)
48. Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, et al. Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women. Clin Sci 2011;121:267-78.
49. Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, et al. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: A randomized controlled trial. Am J Clin Nutr 2011;93:402-412.
50. Rodacki CL, Rodacki AL, Pereira G, Naliwaiko K, Coelho I, Pequito D, et al. Fish-oil supplementation enhances the effects of strength training in elderly women. Am J Clin Nutr 2012;95:428-436.
51. Brasky TM, Darke AK, Song X, Tangen CM, Goodman PJ, Thompson IM, et al. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT Trial. J Natl Cancer Inst 2013;105:1132-1141.
52. Brasky TM, Till C, White E, Neuhouser ML, Song X, Goodman P, et al. Serum phospholipid fatty acids and prostate cancer risk: Results from the Prostate Cancer Prevention Trial. Am J Epidemiol 2011;173:1429-1439.
53. Park S-Y, Wilkens LR, Henning SM, Le Marchand L, Gao K, Goodman MT, et al. Circulating fatty acids and prostate cancer risk in a nested case-control study: The Multiethnic Cohort. Cancer Causes Control CCC 2009;20:211-223.
54. Crowe FL, Allen NE, Appleby PN, Overvad K, Aardestrup IV, Johnsen NF, et al. Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2008;88: 1353-1363.
55. Al-Gubory KH. Mitochondria: Omega-3 in the route of mitochondrial reactive oxygen species. Int J Biochem Cell Biol 2012;44:1569-1573.
56. Di Giuseppe D, Wallin A, Bottai M, Askling J, Wolk A. Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: A prospective cohort study of women. Ann Rheum Dis 2013; doi:10.1136/annrheumdis-2013-203338.
57. Maggini S, Beveridge S, Suter M. A combination of highdose vitamin C plus zinc for the common cold. J Int Med Res 2012;40:28-42.