Molecular adaptations to aerobic exercise training in skeletal muscle of older women

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 65 A, Issue 11, 2010, Pages 1201-1207

  Konopka, Adam R ^a   Douglass, Matthew D ^a   Kaminsky, Leonard A ^a   Jemiolo, Bozena ^a   Trappe, Todd A ^a   Trappe, Scott ^a   Harber, Matthew P ^a  

^a BALL STATE UNIVERSITY   (United States)

Author keywords

Aging; FOXO3A; Hypertrophy; Myostatin; PGC 1

Indexed keywords

BIOLOGICAL MARKER; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; MESSENGER RNA; MSTN PROTEIN, HUMAN; MYOSTATIN; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADAPTATION; AGED; ARTICLE; BIOPSY; BODY COMPOSITION; EXERCISE; FEMALE; GENE EXPRESSION; HUMAN; METABOLISM; MITOCHONDRION; MUSCLE STRENGTH; OXYGEN CONSUMPTION; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; WESTERN BLOTTING;

ADAPTATION, PHYSIOLOGICAL; AGED; BIOLOGICAL MARKERS; BIOPSY; BLOTTING, WESTERN; BODY COMPOSITION; EXERCISE; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MITOCHONDRIA; MUSCLE STRENGTH; MUSCLE, SKELETAL; MYOSTATIN; OXYGEN CONSUMPTION; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 77958076624     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glq109     Document Type: Article

References (43)

1. Doherty TJ. Invited review: aging and sarcopenia. J Appl Physiol. 2003;95(4):1717-1727.
2. Nelson ME, Rejeski WJ, Blair SN, et al. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116(9):1094-1105.
3. Harber MP, Konopka AR, Douglass MD, et al. Aerobic exercise training improves whole muscle and single myofber size and function in older women. Am J Physiol Regul Integr Comp Physiol. 2009;297(5): R1452-R1459.
4. Raue U, Slivka D, Jemiolo B, Hollon C, Trappe S. Proteolytic gene expression differs at rest and after resistance exercise between young and old women. J Gerontol A Biol Sci Med Sci. 2007;62(12):1407-1412.
5. Raue U, Slivka D, Jemiolo B, Hollon C, Trappe S. Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women. J Appl Physiol. 2006;101(1):53-59.
6. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab. 2000;85(12):4481-4490.
7. Volpi E, Sheffeld-Moore M, Rasmussen BB, Wolfe RR. Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. JAMA. 2001;286(10):1206-1212.
8. Trappe T, Williams R, Carrithers J, et al. Infuence of age and resistance exercise on human skeletal muscle proteolysis: a microdialysis approach. J Physiol. 2004;554(Pt 3):803-813.
9. Dodd S, Hain B, Judge A. Hsp70 prevents disuse muscle atrophy in senescent rats. Biogerontology. 2009;10(5):605-611.
10. Senf SM, Dodd SL, McClung JM, Judge AR. Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy. FASEB J. 2008;22(11):3836-3845.
11. Sandri M, Lin J, Handschin C, et al. PGC-1 alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specifc gene transcription. Proc Natl Acad Sci \USA. 2006;103(44):16260-16265.
12. Trappe TA, Lindquist DM, Carrithers JA. Muscle-specifc atrophy of the quadriceps femoris with aging. J Appl Physiol. 2001;90(6): 2070-2074.
13. Yang Y, Creer A, Jemiolo B, Trappe S. Time course of myogenic and metabolic gene expression in response to acute exercise in human skeletal muscle. J Appl Physiol. 2005;98(5):1745-1752.
14. Louis E, Raue U, Yang Y, Jemiolo B, Trappe S. Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol. 2007;103(5): 1744-1751.
15. Harber MP, Crane JD, Dickinson JM, et al. Protein synthesis and the expression of growth-related genes are altered by running in human vastus lateralis and soleus muscles. Am J Physiol Regul Integr Comp Physiol. 2009;296(3):R708-R714.
16. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402-408.
17. Kim JS, Cross JM, Bamman MM. Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am J Physiol Endocrinol Metab. 2005;288(6): E1110-E1119.
18. Leger B, Derave W, De Bock K, Hespel P, Russell AP. Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced effciency of Akt phosphorylation. Rejuvenation Res. 2008;11(1):163-175B.
19. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997;387(6628):83-90.
20. Plant PJ, Brooks D, Faughnan M, et al. Cellular markers of muscle atrophy in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2010;42(4):461-471.
21. Roth SM, Martel GF, Ferrell RE, Metter EJ, Hurley BF, Rogers MA. Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. Exp Biol Med (Maywood). 2003;228(6):706-709.
22. Amirouche A, Durieux AC, Banzet S, et al. Down-regulation of Akt/ mammalian target of rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle. Endocrinology. 2009;150(1):286-294.
23. Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ. Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size. Am J Physiol Cell Physiol. 2009;296(6):C1258-C1270.
24. Urso ML, Chen YW, Scrimgeour AG, Lee PC, Lee KF, Clarkson PM. Alterations in mRNA expression and protein products following spinal cord injury in humans. J Physiol. 2007;579(Pt 3):877-892.
25. Williamson DL, Raue U, Slivka DR, Trappe S. Resistance exercise, skeletal muscle FOXO3A, and 85-year-old women. J Gerontol A Biol Sci Med Sci. 2010;65(4):335-343.
26. Sandri M, Sandri C, Gilbert A, et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 2004;117(3):399-412.
27. Stitt TN, Drujan D, Clarke BA, et al. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell. 2004;14(3): 395-403.
28. Fujita S, Rasmussen BB, Cadenas JG, et al. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes. 2007;56(6):1615-1622.
29. Hood DA. Invited review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol. 2001;90(3): 1137-1157.
30. Baar K, Wende AR, Jones TE, et al. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 2002;16(14):1879-1886.
31. Terada S, Tabata I. Effects of acute bouts of running and swimming exercise on PGC-1alpha protein expression in rat epitrochlearis and soleus muscle. Am J Physiol Endocrinol Metab. 2004;286(2): E208-E216.
32. Mathai AS, Bonen A, Benton CR, Robinson DL, Graham TE. Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle. J Appl Physiol. 2008;105(4):1098-1105.
33. Russell AP, Feilchenfeldt J, Schreiber S, et al. Endurance training in humans leads to fber type-specifc increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. Diabetes. 2003;52(12):2874-2881.
34. Pilegaard H, Saltin B, Neufer PD. Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol. 2003;546(Pt 3):851-858.
35. Wu Z, Puigserver P, Andersson U, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999;98(1):115-124.
36. Lanza IR, Short DK, Short KR, et al. Endurance exercise as a counter-measure for aging. Diabetes. 2008;57(11):2933-2942.
37. Wright DC, Han DH, Garcia-Roves PM, Geiger PC, Jones TE, Holloszy JO. Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression. J Biol Chem. 2007;282(1):194-199.
38. Leick L, Wojtaszewski JF, Johansen ST, et al. PGC-1alpha is not mandatory for exercise-and training-induced adaptive gene responses in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2008;294(2):E463-E474.
39. Dodd S, Hain B, Judge A. Hsp70 prevents disuse muscle atrophy in senescent rats. Biogerontology. 2009;10(6):605-611.
40. Khassaf M, Child RB, McArdle A, Brodie DA, Esanu C, Jackson MJ. Time course of responses of human skeletal muscle to oxidative stress induced by nondamaging exercise. J Appl Physiol. 2001;90(3): 1031-1035.
41. Morton JP, Maclaren DP, Cable NT, et al. Trained men display increased Basal heat shock protein content of skeletal muscle. Med Sci Sports Exerc. 2008;40(7):1255-1262.
42. Morton J. The exercise-induced stress response of skeletal muscle, with specifc emphasis on humans. Sports Med. 2009;39(8):643-662.
43. Kim JS, Kosek DJ, Petrella JK, Cross JM, Bamman MM. Resting and load-induced levels of myogenic gene transcripts differ between older adults with demonstrable sarcopenia and young men and women. J Appl Physiol. 2005;99(6):2149-2158.