Dynamic education of macrophages in different areas of human tumors

Cancer Microenvironment

Volumn 5, Issue 3, 2012, Pages 195-201

  Wu, Yan ^a   Zheng, Limin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma (HCC); Immune editing; Inflammation; Macrophages (M ); Microenvironment

Indexed keywords

INTERLEUKIN 17; PROGRAMMED DEATH 1 LIGAND 1;

ANGIOGENESIS; CANCER INFILTRATION; CELL ACTIVATION; CELL FUNCTION; CELLS BY BODY ANATOMY; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; HUMAN; IMMUNOCOMPETENT CELL; MACROPHAGE; MONOCYTE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE; TH17 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

EID: 84885955149     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-012-0113-z     Document Type: Review

References (65)

1. Mueller MM, Fusenig NE (2004) Friends or foes—bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4:839-849
2. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674
3. van Zijl F, Mair M, Csiszar A et al (2009) Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 28:4022-4033
4. Tlsty TD, Coussens LM (2006) Tumor stroma and regulation of cancer development. Annu Rev Pathol 1:119-150
5. Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancerrelated inflammation. Nature 454:436-444
6. Rabinovich GA, Gabrilovich D, Sotomayor EM (2007) Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25:267-296
7. Zou W (2005) Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 5:263-274
8. Karin M, Lawrence T, Nizet V (2006) Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 124:823-835
9. Lewis CE, Pollard JW (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res 66:605-612
10. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953-964
11. Biswas SK, Mantovani A (2011) Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 11:889-896
12. Murdoch C, Muthana M, Coffelt SB, Lewis CE (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer 8:618-631
13. Budhu A, Forgues M, Ye QH et al (2006) Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10:99-111
14. Vakkila J, Lotze MT (2004) Inflammation and necrosis promote tumour growth. Nat Rev Immunol 4:641-648
15. Qian BZ, Pollard JW (2011) Macrophage diversity enhances tumor progression and metastasis. Cell 141:39-51
16. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23:549-555
17. Gao B, Jeong WI, Tian Z (2008) Liver: an organ with predominant innate immunity. Hepatology 47:729-736
18. Liu H, Pan Z, Li A et al (2008) Roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of hepatocellular carcinoma cells. Cell Mol Immunol 5:373-378
19. Llovet JM, Burroughs A, Bruix J (2003) Hepatocellular carcinoma. Lancet 362:1907-1917
20. Xu J, Ding T, He Q et al (2012) In situ molecular signature predict early recurrence in Hepatitis B virus-related hepatocellular carcinoma. J Hepatol, in press
21. Shi C, Pamer EG (2011) Monocyte recruitment during infection and inflammation. Nat Rev Immunol 11:762-774
22. Taylor PR, Martinez-Pomares L, Stacey M et al (2005) Macrophage receptors and immune recognition. Annu Rev Immunol 23:901-944
23. Lawrence T, Natoli G (2011) Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol 11:750-761
24. Kuang DM, Wu Y, Chen N et al (2007) Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood 110:587-595
25. Martinez FO, Helming L, Gordon S (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27:451-483
26. Krausgruber T, Blazek K, Smallie T et al (2011) IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 12:231-238
27. He M, Xu Z, Ding T, Kuang DM, Zheng L (2009) MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta. Cell Mol Immunol 6:343-352
28. Cheng J, Huo DH, Kuang DM et al (2007) Human macrophages promote the motility and invasiveness of osteopontin-knockdown tumor cells. Cancer Res 67:5141-5147
29. Yang M, Chen J, Su F et al (2011) Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer 10:117
30. Lewis CE, De Palma M, Naldini L (2007) Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res 67:8429-8432
31. Qian BZ, Li J, Zhang H et al (2011) CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475:222-225
32. Fu J, Xu D, Liu Z et al (2007) Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology 132:2328-2339
33. Gao Q, Qiu SJ, Fan J et al (2007) Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 25:2586-2593
34. Zou W (2006) Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6:295-307
35. Zhou J, Ding T, Pan W et al (2009) Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int J Cancer 125:1640-1648
36. Lob S, Konigsrainer A, Rammensee HG, Opelz G, Terness P (2009) Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? Nat Rev Cancer 9:445-452
37. Mellor AL, Munn DH (2004) IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4:762-774
38. Godin-Ethier J, Pelletier S, Hanafi LA et al (2009) Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance. J Immunol 183:7752-7760
39. Zhao Q, Kuang DM, Wu Y et al (2012) Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumorassociated macrophages. J Immunol 188:1117-1124
40. Kuang DM, Peng C, Zhao Q et al (2010) Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells. Hepatology 51:154-164
41. Ding T, Xu J, Wang F et al (2009) High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. Hum Pathol 40:381-389
42. Kuang DM, Peng C, Zhao Q et al (2010) Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J Immunol 185:1544-1549
43. Kuang DM, Zhao Q, Peng C et al (2009) Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 206:1327-1337
44. Kuang DM, Zhao Q, Wu Y et al (2011) Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol 54:948-955
45. Greenwald RJ, Freeman GJ, Sharpe AH (2005) The B7 family revisited. Annu Rev Immunol 23:515-548
46. Zou W, Chen L (2008) Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 8:467-477
47. Hou J, Tian L, Wei Y (2004) Cancer immunotherapy of targeting angiogenesis. Cell Mol Immunol 1:161-166
48. Weis SM, Cheresh DA (2011) Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med 17:1359-1370
49. Lewis CE, Hughes R (2007) Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Res 9:209
50. Lewis C, Murdoch C (2005) Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 167:627-635
51. Xu S, Cao X (2010) Interleukin-17 and its expanding biological functions. Cell Mol Immunol 7:164-174
52. Zou W, Restifo NP (2010) T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol 10:248-256
53. Zhang JP, Yan J, Xu J et al (2009) Increased intratumoral IL-17- producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol 50:980-989
54. Su X, Ye J, Hsueh EC et al (2010) Tumor microenvironments direct the recruitment and expansion of human Th17 cells. J Immunol 184:1630-1641
55. Yen HR, Harris TJ, Wada S et al (2009) Tc17 CD8 Tcells: functional plasticity and subset diversity. J Immunol 183:7161-7168
56. Li J, Huang ZF, Xiong G et al (2011) Distribution, characterization, and induction of CD8 regulatory T cells and IL-17-producing CD8 T cells in nasopharyngeal carcinoma. J Transl Med 9:189
57. Wang L, Yi T, Kortylewski M et al (2009) IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway. J Exp Med 206:1457-1464
58. Kryczek I, Wei S, Zou L et al (2007) Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol 178:6730-6733
59. Muranski P, Boni A, Antony PA et al (2008) Tumor-specific Th17- polarized cells eradicate large established melanoma. Blood 112:362-373
60. Nathan C (2006) Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6:173-182
61. Wu Y, Zhao Q, Peng C et al (2011) Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. J Pathol 225:438-447
62. Friedl P, Alexander S (2011) Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 147:992-1009
63. Kessenbrock K, Plaks V, Werb Z (2011) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52-67
64. Shi GM, Ke AW, Zhou J et al (2010) CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma. Hepatology 52:183-196
65. Zhao Q, Xiao X, Wu Y et al (2011) Interleukin-17-educated monocytes suppress cytotoxic T-cell function through B7-H1 in hepatocellular carcinoma patients. Eur J Immunol 41:2314-2322