A liquid chromatography/mass spectrometry-based generic detection method for biochemical assay and hit discovery of histone methyltransferases

Analytical Biochemistry

Volumn 443, Issue 2, 2013, Pages 214-221

  Li, Shu ^a   Gu, X Justin ^b   Hao, Qin ^a   Fan, Hong ^b   Li, Ling ^b   Zhou, Shaolian ^b   Zhao, Kehao ^b   Chan, Ho Man ^b   Wang, Y Karen ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b Novartis Institute of BioMedical Research   (China)

Author keywords

Assay; Histone; LC MS; Methyltransferase; S Adenosyl homocysteine

Indexed keywords

ALKYLATION; ASSAYS; PROTEINS; SPECTROMETRY;

EPIGENETIC MODIFICATION; HISTONE; HISTONE METHYLTRANSFERASES; HOMOCYSTEINES; LC/MS; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; METHYLTRANSFERASES; POST-TRANSLATIONAL MODIFICATIONS;

LIQUID CHROMATOGRAPHY;

HISTONE METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; ENZYME ACTIVITY; HISTONE METHYLATION; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ASSAY; HISTONE; LC/MS; METHYLTRANSFERASE; S-ADENOSYL HOMOCYSTEINE;

CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; ENZYME ASSAYS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; S-ADENOSYLHOMOCYSTEINE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84885983109     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2013.08.029     Document Type: Article

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