BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells

Cell Proliferation

Volumn 45, Issue 4, 2012, Pages 335-344

  Yang, Q ^a   Lu, Z ^a   Singh, D ^a   Raj, J U ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALPONIN; COLLAGEN GEL; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; HISTONE LYSINE METHYLTRANSFERASE; HISTONE LYSINE METHYLTRANSFERASE G9A; N (1 BENZYL 4 PIPERIDINYL) 2 (HEXAHYDRO 4 METHYL 1H 1,4 DIAZEPIN 1 YL) 6,7 DIMETHOXY 4 QUINAZOLINAMINE; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA METHYLATION; DRUG EFFECT; FETUS; G2 PHASE CELL CYCLE CHECKPOINT; METHYLATION; NONHUMAN; PROTEIN EXPRESSION; PULMONARY ARTERY; SHEEP; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE FIBER;

ANIMALS; AZEPINES; BASE SEQUENCE; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; DNA METHYLATION; DNA PRIMERS; MASS SPECTROMETRY; MUSCLE, SMOOTH, VASCULAR; PLATELET-DERIVED GROWTH FACTOR; PULMONARY ARTERY; QUINAZOLINES; REAL-TIME POLYMERASE CHAIN REACTION; SHEEP;

OVIS;

EID: 84862904622     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2012.00828.x     Document Type: Article

References (25)

1. Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC et al. (2010) Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation 121, 2661-2671.
2. Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M et al. (2002) G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16, 1779-1791.
3. Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G et al. (2010) H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 70, 7830-7840.
4. Waggoner SA, Johannes GJ, Liebhaber SA (2009) Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest. J. Biol. Chem. 284, 9039-9049.
5. Lee EW, Lee MS, Camus S, Ghim J, Yang MR, Oh W et al. (2009) Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. EMBO J. 28, 2100-2113.
6. Kim JK, Esteve PO, Jacobsen SE, Pradhan S (2009) UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 37, 493-505.
7. Golovina VA, Blaustein MP (2006) Preparation of primary cultured mesenteric artery smooth muscle cells for fluorescent imaging and physiological studies. Nat. Protoc. 1, 2681-2687.
8. Yang Q, Liu S, Tian Y, Salwen HR, Chlenski A, Weinstein J et al. (2003) Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma. Cancer Res. 63, 6299-6310.
9. Yang Q, Tian Y, Ostler KR, Chlenski A, Guerrero LJ, Salwen HR et al. (2010) Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines. BMC Cancer 10, 286.
10. Shentu TP, Titushkin I, Singh DK, Gooch KJ, Subbaiah PV, Cho M et al. (2010) oxLDL-induced decrease in lipid order of membrane domains is inversely correlated with endothelial stiffness and network formation. Am. J. Physiol. Cell Physiol. 299, C218-C229.
11. Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C et al. (2010) DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res. 70, 5840-5850.
12. Albert M, Helin K (2010) Histone methyltransferases in cancer. Semin. Cell Dev. Biol. 21, 209-220.
13. Berger SL (2002) Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12, 142-148.
14. Shi Y. (2007) Histone lysine demethylases: emerging roles in development, physiology and disease. Nat. Rev. Genet. 8, 829-833.
15. Shinkai Y, Tachibana M (2011) H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev. 25, 781-788.
16. Kubicek S, O'Sullivan RJ, August EM, Hickey ER, Zhang Q, Teodoro ML et al. (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell 25, 473-481.
17. Shi Y, Do JT, Desponts C, Hahm HS, Scholer HR, Ding S (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2, 525-528.
18. Andrae J, Gallini R, Betsholtz C (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 22, 1276-1312.
19. Pietras K, Sjoblom T, Rubin K, Heldin CH, Ostman A (2003) PDGF receptors as cancer drug targets. Cancer Cell 3, 439-443.
20. ten Freyhaus H, Dagnell M, Leuchs M, Vantler M, Berghausen EM, Caglayan E et al. (2011) Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases. Am. J. Respir. Crit. Care Med. 183, 1092-1102.
21. Sakao S, Tatsumi K, Voelkel NF (2010) Reversible or irreversible remodeling in pulmonary arterial hypertension. Am. J. Respir. Cell Mol. Biol. 43, 629-634.
22. Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M (2006) Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res. 66, 9009-9016.
23. Frigola J, Sole X, Paz MF, Moreno V, Esteller M, Capella G et al. (2005) Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum. Mol. Genet. 14, 319-326.
24. Esteller M (2008) Epigenetics in cancer. N Engl. J. Med. 358, 1148-1159.
25. Reik W (2007) Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447, 425-432.