(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2729-2732

  Ortar, Giorgio ^a   Petrocellis, Luciano De ^b   Morera, Ludovica ^a   Moriello, Aniello Schiano ^b   Orlando, Pierangelo ^c   Morera, Enrico ^a   Nalli, Marianna ^a   Marzo, Vincenzo Di ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

^d CNR   (Italy)

Author keywords

( ) Menthylamine derivatives; Transient receptor potential channels; TRPA1; TRPM8; TRPV1

Indexed keywords

1 (2 HYDROXYPHENYL) 4 (3 NITROPHENYL) 1,2,3,6 TETRAHYDROPYRIMIDIN 2 ONE; AMINE; CASPASE 3; CASPASE 7; MENTHOL; MENTHYLAMINE; PROTEIN INHIBITOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; IC 50; PROSTATE CARCINOMA; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; HUMANS; MENTHOL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRPM CATION CHANNELS;

EID: 77950865335     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.076     Document Type: Article

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