The role of microRNAs in tumors

Archives of Pharmacal Research

Volumn 36, Issue 10, 2013, Pages 1169-1177

  Liu, Chuanxin ^a  

^a JINING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cancer; Leukemia; MicroRNAs; Tumorigenesis

Indexed keywords

MICRORNA; MICRORNA 101; MICRORNA 122; MICRORNA 124; MICRORNA 214; MICRORNA 29;

APOPTOSIS; BREAST CANCER; CANCER PROGNOSIS; CARCINOGENESIS; CELL CYCLE ARREST; CELL INVASION; CELL PROLIFERATION; COLORECTAL CANCER; DEVELOPMENT; DIAGNOSTIC PROCEDURE; HUMAN; LEUKEMIA; LIVER CANCER; NEOPLASM; PANCREAS CANCER; PREDICTIVE VALUE; PROTEIN FUNCTION; REVIEW; TUMOR SUPPRESSOR GENE; UPREGULATION;

CARCINOGENESIS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS;

EID: 84885950269     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0213-4     Document Type: Review

References (63)

1. Akao, Y., Y. Nakagawa, Y. Kitade, T. Kinoshita, and T. Naoe. 2007. Downregulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Science 98: 1914-1920.
2. Ali, S., H. Saleh, S. Sethi, F.H. Sarkar, and P.A. Philip. 2012. MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer. British journal of cancer 107: 1354-1360.
3. Ambros, V. 2004. The functions of animal microRNAs. Nature 431: 350-355.
4. Bartel, D.P. 2004. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
5. Berezikov, E., E. Cuppen, and R.H. Plasterk. 2006. Approaches to microRNA discovery. Nature Genetics 38 Suppl: S2-S7.
6. Bottoni, A., D. Piccin, F. Tagliati, A. Luchin, M.C. Zatelli, and E.C. Degli Uberti. 2005. miR-15a and miR-16-1 down-regulation in pituitary adenomas. Journal of Cellular Physiology 204: 280-285.
7. Calin, G.A., C.D. Dumitru, M. Shimizu, R. Bichi, S. Zupo, E. Noch, H. Aldler, S. Rattan, M. Keating, K. Rai, L. Rassenti, T. Kipps, M. Negrini, F. Bullrich, and C.M. Croce. 2002. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 99: 15524-15529.
8. Calin, G.A., C. Sevignani, C.D. Dumitru, T. Hyslop, E. Noch, S. Yendamuri, M. Shimizu, S. Rattan, F. Bullrich, M. Negrini, and C.M. Croce. 2004. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proceedings of the National Academy of Sciences of the United States of America 101: 2999-3004.
9. Castilla, M.A., J. Diaz-Martin, D. Sarrio, L. Romero-Perez, M.A. Lopez-Garcia, B. Vieites, M. Biscuola, S. Ramiro-Fuentes, C.M. Isacke, and J. Palacios. 2012. MicroRNA-200 family modulation in distinct breast cancer phenotypes. PloS one 7: e47709.
10. Chen, Z., L.Y. Chen, H.Y. Dai, P. Wang, S. Gao, and K. Wang. 2012. miR-301a promotes pancreatic cancer cell proliferation by directly inhibiting Bim expression. Journal of cellular biochemistry 113: 3229-3235.
11. Cho, H.M., H.S. Jeon, S.Y. Lee, K.J. Jeong, S.Y. Park, H.Y. Lee, J.U. Lee, J.H. Kim, S.J. Kwon, E. Choi, M.J. Na, J. Kang, and J.W. Son. 2011. microRNA-101 inhibits lung cancer invasion through the regulation of enhancer of zeste homolog 2. Experimental and therapeutic medicine 2: 963-967.
12. Dahiya, N., C.A. Sherman-Baust, T.L. Wang, B. Davidson, M. Shih Ie, Y. Zhang, W. Wood 3rd, K.G. Becker, and P.J. Morin. 2008. MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS ONE 3: e2436.
13. Fabbri, M., R. Garzon, A. Cimmino, Z. Liu, N. Zanesi, E. Callegari, S. Liu, H. Alder, S. Costinean, C. Fernandez-Cymering, S. Volinia, G. Guler, C.D. Morrison, K.K. Chan, G. Marcucci, G.A. Calin, K. Huebner, and C.M. Croce. 2007. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proceedings of the National Academy of Sciences of the United States of America 104: 15805-15810.
14. Faltejskova, P., M. Svoboda, K. Srutova, J. Mlcochova, A. Besse, J. Nekvindova, L. Radova, P. Fabian, K. Slaba, I. Kiss, R. Vyzula, and O. Slaby. 2012. Identification and functional screening of microRNAs highly deregulated in colorectal cancer. Journal of cellular and molecular medicine 16: 2655-2666.
15. Fan, C. G., C. M. Wang, C. Tian, Y. Wang, L. Li, W. S. Sun, R. F. Li, and Y. G. Liu. 2011. miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. Oncology reports 26: 1281-1286.
16. Fassina, A., F. Marino, M. Siri, R. Zambello, L. Ventura, M. Fassan, F. Simonato, and R. Cappellesso. 2012. The miR-17-92 microRNA cluster: A novel diagnostic tool in large B-cell malignancies. Laboratory investigation; a journal of technical methods and pathology 92: 1574-1582.
17. Guo, J., Y. Miao, B. Xiao, R. Huan, Z. Jiang, D. Meng, and Y. Wang. 2009. Differential expression of microRNA species in human gastric cancer versus non-tumorous tissues. Journal of Gastroenterology and Hepatology 24: 652-657.
18. Hao, J., S. Zhang, Y. Zhou, C. Liu, X. Hu, and C. Shao. 2011. MicroRNA 421 suppresses DPC4/Smad4 in pancreatic cancer. Biochemical and biophysical research communications 406: 552-557.
19. Hatley, M.E., D.M. Patrick, M.R. Garcia, J.A. Richardson, R. Bassel-Duby, E. Van Rooij, and E.N. Olson. 2010. Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer cell 18: 282-293.
20. Iorio, M.V., M. Ferracin, C.G. Liu, A. Veronese, R. Spizzo, S. Sabbioni, E. Magri, M. Pedriali, M. Fabbri, M. Campiglio, S. Menard, J.P. Palazzo, A. Rosenberg, P. Musiani, S. Volinia, I. Nenci, G.A. Calin, P. Querzoli, M. Negrini, and C.M. Croce. 2005. MicroRNA gene expression deregulation in human breast cancer. Cancer Research 65: 7065-7070.
21. Ji, M., E. Rao, H. Ramachandrareddy, Y. Shen, C. Jiang, J. Chen, Y. Hu, A. Rizzino, W.C. Chan, K. Fu, and T.W. Mckeithan. 2011. The miR-17-92 microRNA cluster is regulated by multiple mechanisms in B-cell malignancies. The American journal of pathology 179: 1645-1656.
22. Lagos-Quintana, M., Rauhut, R., Lendeckel, W., and T. Tuschl. 2001. Identification of novel genes coding for small expressed RNAs. Science (New York, N.Y 294:853-8.
23. Le, H. B., Zhu, W. Y., Chen, D. D., He, J. Y., Huang, Y. Y., Liu, X. G., and Y. K. Zhang. 2012. Evaluation of dynamic change of serum miR-21 and miR-24 in pre- and post-operative lung carcinoma patients. Medical oncology (Northwood, London, England) 29:3190-7.
24. Lee, R.C., R.L. Feinbaum, and V. Ambros. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854.
25. Li, J.M., R.H. Zhao, S.T. Li, C.X. Xie, H.H. Jiang, W.J. Ding, P. Du, W. Chen, M. Yang, and L. Cui. 2012. Down-regulation of fecal miR-143 and miR-145 as potential markers for colorectal cancer. Saudi medical journal 33: 24-29.
26. Liu, M., N. Lang, M. Qiu, F. Xu, Q. Li, Q. Tang, J. Chen, X. Chen, S. Zhang, Z. Liu, J. Zhou, Y. Zhu, Y. Deng, Y. Zheng, and F. Bi. 2011. miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells. International journal of cancer 128: 1269-1279.
27. Liu, B., X. Wu, B. Liu, C. Wang, Y. Liu, Q. Zhou, and K. Xu. 2012a. MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN. Biochimica et biophysica acta 1822: 1692-1704.
28. Liu, X.H., K.H. Lu, K.M. Wang, M. Sun, E.B. Zhang, J.S. Yang, D.D. Yin, Z.L. Liu, J. Zhou, Z.J. Liu, W. De, and Z.X. Wang. 2012b. MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5. BMC cancer 12: 348.
29. Meng, F., R. Henson, H. Wehbe-Janek, K. Ghoshal, S.T. Jacob, and T. Patel. 2007. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658.
30. Michael, M.Z., O.C. Sm, N.G. Van Holst Pellekaan, G.P. Young, and R.J. James. 2003. Reduced accumulation of specific microRNAs in colorectal neoplasia. Molecular Cancer Research 1: 882-891.
31. Mitchell, P.S., R.K. Parkin, E.M. Kroh, B.R. Fritz, S.K. Wyman, E.L. Pogosova-Agadjanyan, A. Peterson, J. Noteboom, K.C. O'briant, A. Allen, D.W. Lin, N. Urban, C.W. Drescher, B.S. Knudsen, D.L. Stirewalt, R. Gentleman, R.L. Vessella, P.S. Nelson, D.B. Martin, and M. Tewari. 2008. Circulating microRNAs as stable blood-based markers for cancer detection. Proceedings of the National Academy of Sciences of the United States of America 105: 10513-10518.
32. Moriyama, T., K. Ohuchida, K. Mizumoto, J. Yu, N. Sato, T. Nabae, S. Takahata, H. Toma, E. Nagai, and M. Tanaka. 2009. MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance. Molecular Cancer Therapeutics 8: 1067-1074.
33. Nakata, K., K. Ohuchida, K. Mizumoto, T. Kayashima, N. Ikenaga, H. Sakai, C. Lin, H. Fujita, T. Otsuka, S. Aishima, E. Nagai, Y. Oda, and M. Tanaka. 2011. MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis. Surgery 150: 916-922.
34. Ng, E.K., W.W. Chong, H. Jin, E.K. Lam, V.Y. Shin, J. Yu, T.C. Poon, S.S. Ng, and J.J. Sung. 2009. Differential expression of microRNAs in plasma of patients with colorectal cancer: A potential marker for colorectal cancer screening. Gut 58: 1375-1381.
35. Pekarsky, Y., U. Santanam, A. Cimmino, A. Palamarchuk, A. Efanov, V. Maximov, S. Volinia, H. Alder, C.G. Liu, L. Rassenti, G.A. Calin, J.P. Hagan, T. Kipps, and C.M. Croce. 2006. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Research 66: 11590-11593.
36. Pineles, B.L., R. Romero, D. Montenegro, A.L. Tarca, Y.M. Han, Y.M. Kim, S. Draghici, J. Espinoza, J.P. Kusanovic, P. Mittal, S.S. Hassan, and C.J. Kim. 2007. Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia. American Journal of Obstetrics and Gynecology 196(261): e1-e6.
37. Pospisil, V., K. Vargova, J. Kokavec, J. Rybarova, F. Savvulidi, A. Jonasova, E. Necas, J. Zavadil, P. Laslo, and T. Stopka. 2011. Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. The EMBO journal 30: 4450-4464.
38. Reinhart, B.J., F.J. Slack, M. Basson, A.E. Pasquinelli, J.C. Bettinger, A.E. Rougvie, H.R. Horvitz, and G. Ruvkun. 2000. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901-906.
39. Roldo, C., E. Missiaglia, J.P. Hagan, M. Falconi, P. Capelli, S. Bersani, G.A. Calin, S. Volinia, C.G. Liu, A. Scarpa, and C.M. Croce. 2006. MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. Journal of Clinical Oncology 24: 4677-4684.
40. Salim, H., N.S. Akbar, D. Zong, A.H. Vaculova, R. Lewensohn, A. Moshfegh, K. Viktorsson, and B. Zhivotovsky. 2012. miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence. British journal of cancer 107: 1361-1373.
41. Shen, L., J. Li, L. Xu, J. Ma, H. Li, X. Xiao, J. Zhao, and L. Fang. 2012. miR-497 induces apoptosis of breast cancer cells by targeting Bcl-w. Experimental and therapeutic medicine 3: 475-480.
42. Shi, W., K. Gerster, N.M. Alajez, J. Tsang, L. Waldron, M. Pintilie, A.B. Hui, J. Sykes, C. P'ng, N. Miller, D. Mccready, A. Fyles, and F.F. Liu. 2011. MicroRNA-301 mediates proliferation and invasion in human breast cancer. Cancer research 71: 2926-2937.
43. Si, H., X. Sun, Y. Chen, Y. Cao, S. Chen, H. Wang, and C. Hu. 2013. Circulating microRNA-92a and microRNA-21 as novel minimally invasive biomarkers for primary breast cancer. Journal of cancer research and clinical oncology 139(2): 223-229.
44. Takamizawa, J., H. Konishi, K. Yanagisawa, S. Tomida, H. Osada, H. Endoh, T. Harano, Y. Yatabe, M. Nagino, Y. Nimura, T. Mitsudomi, and T. Takahashi. 2004. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Research 64: 3753-3756.
45. Tsai, W.C., P.W. Hsu, T.C. Lai, G.Y. Chau, C.W. Lin, C.M. Chen, C.D. Lin, Y.L. Liao, J.L. Wang, Y.P. Chau, M.T. Hsu, M. Hsiao, H.D. Huang, and A.P. Tsou. 2009. MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. Hepatology (Baltimore, MD 49: 1571-1582.
46. Wang, Y., A.T. Lee, J.Z. Ma, J. Wang, J. Ren, Y. Yang, E. Tantoso, K.B. Li, L.L. Ooi, P. Tan, and C.G. Lee. 2008. Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. The Journal of biological chemistry 283: 13205-13215.
47. Wang, C., B. Song, W. Song, J. Liu, A. Sun, D. Wu, H. Yu, J. Lian, L. Chen, and J. Han. 2011a. Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1 alpha in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. Journal of gastroenterology and hepatology 26: 1630-1637.
48. Wang, C.M., Y. Wang, C.G. Fan, F.F. Xu, W.S. Sun, Y.G. Liu, and J.H. Jia. 2011b. miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma. Biochemical and biophysical research communications 411: 586-592.
49. Weiss, F.U., I.J. Marques, J.M. Woltering, D.H. Vlecken, A. Aghdassi, L.I. Partecke, C.D. Heidecke, M.M. Lerch, and C.P. Bagowski. 2009. Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer. Gastroenterology 137(2136-45): e1-e7.
50. Wong, P., M. Iwasaki, T.C. Somervaille, F. Ficara, C. Carico, C. Arnold, C.Z. Chen, and M.L. Cleary. 2010. The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer research 70: 3833-3842.
51. Wu, Y., Li, X. F., Yang, J. H., Liao, X. Y., and Y. Z. Chen. 2012. [microRNAs expression profile in acute promyelocytic leukemia cell differentiation induced by all-trans retinoic acid and arsenic trioxide]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 33:546-51.
52. Yang, Z., S. Chen, X. Luan, Y. Li, M. Liu, X. Li, T. Liu, and H. Tang. 2009. MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells. IUBMB Life 61: 1075-1082.
53. Yoon, S.O., S.M. Chun, E.H. Han, J. Choi, S.J. Jang, S.A. Koh, S. Hwang, and E. Yu. 2011. Deregulated expression of microRNA-221 with the potential for prognostic biomarkers in surgically resected hepatocellular carcinoma. Human pathology 42: 1391-1400.
54. Yu, J., K. Ohuchida, K. Mizumoto, H. Fujita, K. Nakata, and M. Tanaka. 2010. MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion. Cancer biology & therapy 10: 748-757.
55. Zanette, D.L., F. Rivadavia, G.A. Molfetta, F.G. Barbuzano, R. Proto-Siqueira, W.A. Silva-Jr, R.P. Falcao, and M. A. Zago. 2007. miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas/Sociedade Brasileira de Biofisica. [et al, 40, 1435-1440].
56. Zhang, X.J., H. Ye, C.W. Zeng, B. He, H. Zhang, and Y.Q. Chen. 2010. Dysregulation of miR-15a and miR-214 in human pancreatic cancer. Journal of hematology & oncology 3: 46.
57. Zhang, Y., L.X. Yan, Q.N. Wu, Z.M. Du, J. Chen, D.Z. Liao, M.Y. Huang, J.H. Hou, Q.L. Wu, M.S. Zeng, W.L. Huang, Y.X. Zeng, and J.Y. Shao. 2011. miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer research 71: 3552-3562.
58. Zhang, X., J. Zeng, M. Zhou, B. Li, Y. Zhang, T. Huang, L. Wang, J. Jia, and C. Chen. 2012. The tumor suppressive role of miRNA-370 by targeting FoxM1 in acute myeloid leukemia. Molecular cancer 11: 56.
59. Zhao, L., Y. Sun, Y. Hou, Q. Peng, L. Wang, H. Luo, X. Tang, Z. Zeng, and M. Liu. 2012. MiRNA expression analysis of cancer-associated fibroblasts and normal fibroblasts in breast cancer. The international journal of biochemistry & cell biology 44: 2051-2059.
60. Zhao, G., J. Zhang, Y. Liu, Q. Qin, B. Wang, K. Tian, L. Liu, X. Li, Y. Niu, S.C. Deng, and C.Y. Wang. 2013. MiR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKalpha1. Molecular cancer therapeutics 12(1): 83-93.
61. Zheng, F., Y.J. Liao, M.Y. Cai, Y.H. Liu, T.H. Liu, S.P. Chen, X.W. Bian, X.Y. Guan, M.C. Lin, Y.X. Zeng, H.F. Kung, and D. Xie. 2012. The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 61: 278-289.
62. Zhou, W., X. Li, F. Liu, Z. Xiao, M. He, S. Shen, and S. Liu. 2012. MiR-135a promotes growth and invasion of colorectal cancer via metastasis suppressor 1 in vitro. Acta biochimica et biophysica Sinica 44: 838-846.
63. Zhu, S., M.L. Si, H. Wu, and Y.Y. Mo. 2007. MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). The Journal of biological chemistry 282: 14328-14336.